CJC 1295 No DAC 10mg

▎ CJC1295 Tsis muaj DAC Structure

▎ CJC1295 Tsis Muaj Kev Tshawb Fawb DAC

Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm CJC1295 tsis muaj DAC?

Kev loj hlob hormone-tso cov tshuaj hormones (GHRH) yog siv rau hauv kev kho mob los txhim kho qhov tso tawm ntawm kev loj hlob hormone (GH), tab sis nws muaj qhov txwv loj, uas yog, nws lub sijhawm ua haujlwm luv luv ^[1] . Qhov no txwv tsis pub siv dav hauv kev kho mob ntawm GHRH thiab ua rau cov kws tshawb fawb nrhiav kev ua haujlwm ntev dua. CJC1295 tsis muaj DAC yog cov tshuaj peptide raws li 30 amino acids. Nws tuaj yeem ua rau lub qog pituitary tso tawm cov tshuaj hormones loj hlob (GH). Cov tshuaj peptide no txawv ntawm cov tshuaj peptide ib txwm muaj. Nws qhov tshwj xeeb yog nyob rau hauv lub xub ntiag ntawm ib pawg neeg reactive maleimide propionic acid, uas tuaj yeem khi rau cov dawb thiols ntawm cov ntshav plasma proteins. Ib zaug khi rau plasma proteins, lub sijhawm ua haujlwm ntawm CJC1295 tsis muaj DAC hauv cov ntshav tau ntev heev. Piv nrog rau cov tshuaj peptide uas tsis muaj kev cuam tshuam, cov tshuaj peptide tsis muaj zog yuav raug tshem tawm sai sai ntawm lub cev, thaum khi CJC1295 tsis muaj DAC tuaj yeem nyob twj ywm hauv cov ntshav ntev dua. Qhov kev khi no ua rau CJC1295 tsis muaj DAC cov tshuaj uas muaj cov nyhuv tshwj xeeb.

CJC1295 tsis muaj DAC yog dab tsi?

Txhawb nqa lub caj pas pituitary kom tso tawm cov tshuaj hormones: Cov tshuaj no tuaj yeem ua rau lub caj pas pituitary tso tawm cov tshuaj hormones (GH). Thaum CJC1295 tsis muaj DAC nkag mus rau hauv lub cev, nws ua haujlwm ntawm lub caj pas pituitary los ntawm ib qho kev ua haujlwm tshwj xeeb, ua rau cov hlwb pituitary kom tso tawm GH. Tshwj xeeb, nws tuaj yeem khi rau cov receptors tshwj xeeb rau ntawm lub ntsej muag pituitary, pib ua ntau txoj hauv kev ntawm cov teeb liab hloov pauv, thaum kawg ua rau muaj kev nce hauv synthesis thiab tso tawm ntawm GH ^{[1, 2]}.

Kev khi rau cov ntshav plasma proteins: CJC1295 tsis muaj DAC muaj qhov tshwj xeeb, uas yog, muaj ib pawg reactive hauv nws cov qauv, uas tuaj yeem khi rau cov dawb thiols ntawm cov ntshav plasma proteins. Qhov kev khi no ua rau lub sijhawm ntev uas cov tshuaj tseem ua haujlwm hauv cov ntshav. Piv nrog cov tshuaj peptide uas tsis muaj kev cuam tshuam, qhov khi CJC1295 tsis muaj DAC muaj lub neej ntev dua ^[2] . Qee qhov kev tshawb fawb tau pom tias CJC-1295 suav nrog cov pab pawg neeg ua haujlwm zoo ntawm C-terminus, uas tso cai rau nws khi rau cov ntshav plasma protein xws li ntshav albumin. Ib zaug khi, nws tuaj yeem txhawb nqa GH ntau lawm hauv tib neeg rau ntau tshaj rau hnub tom qab kev tswj hwm ib leeg (Timms M, 2019, a).

Ua kom muaj qhov tso tawm ntawm cov tshuaj hormones loj hlob: Tom qab ib qho kev txhaj tshuaj ntawm CJC1295 tsis muaj DAC, nws yuav ua rau muaj qhov nce ntxiv ntawm qhov nruab nrab plasma GH concentration. Qhov kev nce no tuaj yeem kav ntev li 6 hnub lossis ntev dua, nrog kev nce ntxiv ntawm 2 mus rau 10 zaug ^[2-4] . Hauv kev tshawb fawb, tom qab cov neeg laus noj qab haus huv tau txais kev txhaj tshuaj subcutaneous ntawm CJC-1295, muaj qhov nce ntxiv, kev nce qib ntawm GH. Qhov kwv yees ib nrab ntawm lub neej ntawm CJC-1295 yog 5.8 - 8.1 hnub (Teichman SL, 2006). Hauv GHRH knockout (GHRHKO) nas, cov khoom zoo sib xws kuj tau pom. Kev tswj hwm txhua hnub ntawm CJC1295 tuaj yeem tswj hwm lub cev muaj pes tsawg leeg thiab kev loj hlob ^[5].

Kev cuam tshuam rau kev tso tawm ntawm insulin-zoo li kev loj hlob yam I: CJC1295 tsis muaj DAC tseem yuav cuam tshuam rau kev tso tawm ntawm insulin-zoo li kev loj hlob yam I (IGF-I). Qhov nruab nrab plasma IGF-I concentration yuav nce nyob rau hauv ib koob tshuaj, nrog rau kev nce ntau ntawm 1.5 mus rau 3 zaug, thiab lub sijhawm ntev yog 9 - 11 hnub ^[2-4] . Tom qab ntau qhov kev tswj hwm ntawm CJC1295 tsis muaj DAC koob tshuaj, qhov nruab nrab IGF-I theem tseem siab dua li theem pib mus txog 28 hnub (Teichman SL, 2006). Hauv GHRHKO nas, CJC1295 kuj ua rau muaj qhov nce ntawm tag nrho cov pituitary RNA thiab GH mRNA, qhia txog kev loj hlob ntawm kev loj hlob hormone-secreting hlwb ^[5].

Plasma disappearance curves ntawm CJC-1295 tom qab ib zaug sc txhaj. Qhia tau tias yog SD ib nrab-lub neej.

Source: PubMed ^[1]

Dab tsi yog qhov sib txawv ntawm cov txheej txheem kev kho mob ntawm CJC1295 tsis muaj DAC rau cov neeg mob uas muaj kev loj hlob hormone tsis txaus ntawm ntau pawg hnub nyoog?

Cov menyuam yaus: Cov menyuam yaus nyob rau lub sijhawm tseem ceeb ntawm kev loj hlob thiab kev loj hlob, thiab kev loj hlob hormone plays lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm lawv cov pob txha, cov leeg, thiab cov kabmob. Kev loj hlob hormone deficiency tuaj yeem ua rau muaj teeb meem xws li kev loj hlob qeeb, luv stature, thiab ncua hnub nyoog pob txha hauv cov menyuam yaus.

CJC1295 tsis muaj DAC txhawb kev loj hlob thiab kev loj hlob ntawm cov menyuam yaus los ntawm kev txhawb nqa lub caj pas pituitary kom zais cov tshuaj hormones loj hlob. Nws tuaj yeem nce qhov tso tawm thiab lub sijhawm ntawm cov tshuaj hormones loj hlob, thiab nce qib ntawm kev loj hlob hormone thiab insulin zoo li kev loj hlob - I (IGF-I) hauv cov ntshav ^[3] . IGF-I yog tus neeg nruab nrab tseem ceeb ntawm qhov kev txiav txim ntawm kev loj hlob hormone. Nws tuaj yeem txhawb kev loj hlob ntawm tes, kev sib txawv, thiab kev tsim cov protein, thiab muaj lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov pob txha, cov leeg, thiab cov kabmob. CJC1295 tsis muaj DAC tseem tuaj yeem txhawb kev nce cov pob txha metabolism hauv cov cim xws li osteocalcin thiab alkaline phosphatase, uas yog pab rau kev loj hlob thiab mineralization ntawm cov pob txha. Tsis tas li ntawd, CJC1295 tsis muaj DAC tsis muaj kev cuam tshuam rau cov thyroid ua haujlwm thiab muaj kev nyab xeeb siab.

Cov neeg laus: 

Cov neeg laus uas muaj cov tshuaj hormones tsis txaus tuaj yeem ntsib teeb meem xws li cov leeg nqaij tsis muaj zog, rog rog, tsis muaj zog ntawm lub cev, muaj kev pheej hmoo ntawm cov kab mob plawv, thiab osteoporosis. Piv nrog rau cov neeg mob menyuam yaus, kev loj hlob thiab kev loj hlob ntawm cov neeg laus cov neeg mob tau ua tiav, thiab kev kho mob tseem ceeb ntawm kev txhim kho cov metabolism hauv kev ua haujlwm thiab lub neej zoo. Cov txheej txheem kev kho mob ntawm CJC1295 tsis muaj DAC hauv cov neeg mob laus feem ntau yog txhawm rau txhim kho cov leeg nqaij, txo cov rog rog, txhim kho lub plawv ua haujlwm, ncua kev laus, thiab tiv thaiv pob txha los ntawm kev nce qib ntawm cov tshuaj hormones loj hlob thiab IGF-I. Cov kev tshawb fawb tau pom tias CJC1295 tsis muaj DAC tuaj yeem ua rau lub cev tsis muaj zog ntawm cov neeg mob laus, txo cov rog subcutaneous, txhim kho cov tshuaj insulin, thiab txo cov kev pheej hmoo ntawm cov kab mob plawv. Tsis tas li ntawd, CJC1295 tsis muaj DAC tseem tuaj yeem txhawb kev loj hlob thiab mineralization ntawm cov pob txha, ua kom cov pob txha ceev, thiab tiv thaiv osteoporosis ^{[3, 5]}.

Cov neeg laus: 

Nrog rau kev loj hlob ntawm lub hnub nyoog, qhov tso tawm ntawm kev loj hlob hormone hauv tib neeg lub cev maj mam txo, ua rau muaj teeb meem xws li cov leeg nqaij tsis muaj zog, muaj roj ntau ntxiv, osteoporosis, thiab txo qis kev tiv thaiv. Cov neeg laus uas muaj cov tshuaj hormones loj hlob tsis muaj peev xwm muaj kab mob ntau dua, thiab kev kho mob nyuaj dua. Cov txheej txheem kev kho mob ntawm CJC1295 tsis muaj DAC hauv cov neeg mob laus zoo ib yam li cov neeg mob laus, tab sis qhov ntau npaum li cas yuav tsum tau kho kom zoo dua thiab cov tshuaj tiv thaiv tsis zoo yuav tsum tau saib xyuas. Vim qhov poob ntawm lub cev ua haujlwm ntawm cov neeg mob laus thiab tsis muaj peev xwm ua kom metabolize thiab tshem tawm cov tshuaj, qhov ntau npaum li cas ntawm cov tshuaj yuav tsum raug txo kom tsis txhob muaj cov tshuaj sib xyaw thiab qhov tshwm sim ntawm qhov tshwm sim tsis zoo.

Kev tshawb fawb ntsig txog

Dab tsi yog qhov cuam tshuam ntawm CJC1295 tsis muaj DAC?

Txhawb nqa lub secretion ntawm kev loj hlob hormone: 

Raws li ib qho piv txwv ntawm kev loj hlob hormone-tso hormone (GHRH), CJC1295 tsis muaj DAC tuaj yeem khi rau GHRH receptors nyob rau hauv lub caj pas pituitary thiab txhawb cov synthesis thiab tso tawm ntawm kev loj hlob hormone los ntawm kev loj hlob hormone hlwb. Kev loj hlob hormone yog qhov tseem ceeb rau lub cev kev loj hlob thiab kev loj hlob, metabolism, thiab cov txheej txheem kho cov ntaub so ntswg. Hauv qee qhov kev tshawb fawb, tom qab siv CJC1295 tsis muaj DAC, kev nce qib ntawm cov tshuaj hormones hauv cov ntshav tuaj yeem pom, uas pab txhawb kev loj hlob thiab kho cov ntaub so ntswg xws li cov pob txha thiab cov leeg.

Regulating metabolism: 

Kev loj hlob hormone plays lub luag haujlwm tseem ceeb hauv kev tswj cov metabolism. CJC1295 tsis muaj DAC cuam tshuam ncaj qha rau cov txheej txheem metabolic los ntawm kev txhawb nqa kev tso tawm ntawm kev loj hlob hormone. Nws tuaj yeem txhawb kev rog rog, ua kom cov rog siv los ua lub zog, uas yuav pab txo cov rog hauv lub cev thiab txhim kho lub cev cov rog. Nyob rau tib lub sijhawm, nws tseem tuaj yeem txhawb kev tsim cov protein, ua kom cov protein ntau hauv cov leeg nqaij, uas pab txhim kho cov leeg nqaij zoo thiab lub zog, thiab txhim kho lub cev kev tawm dag zog thiab kev ua siab ntev. Tsis tas li ntawd, CJC1295 tsis muaj DAC kuj muaj qee yam cuam tshuam rau cov metabolism hauv qabzib, thiab tuaj yeem ua rau cov tshuaj insulin rhiab heev, uas pab tswj cov ntshav qabzib ib txwm muaj.

Txhawb cov ntaub so ntswg kho thiab rov tsim dua tshiab: 

Kev loj hlob hormone plays lub luag haujlwm tseem ceeb hauv kev kho thiab rov tsim cov ntaub so ntswg puas. CJC1295 tsis muaj DAC txhawb nqa kev tso tawm ntawm cov tshuaj hormones loj hlob, uas nyob rau hauv lem stimulates cell proliferation thiab sib txawv, accelerates qhov txhab zoo, thiab txhawb kev kho cov ntaub so ntswg puas. Hauv qee qhov kev sim tsiaj thiab kev tshawb fawb soj ntsuam, nws tau pom tias nws muaj txiaj ntsig zoo rau kev kho pob txha, kho cov leeg mob, thiab kho qhov txhab ntawm daim tawv nqaij, thiab lwm yam, thiab muaj qhov tseem ceeb rau kev txhim kho lub cev rov qab muaj peev xwm thiab rov ua haujlwm ntawm cov ntaub so ntswg puas.

Dab tsi yog daim ntawv thov teb ntawm CJC1295 tsis muaj DAC?

Kev kho mob ntawm kev loj hlob hormone deficiency: 

Rau cov neeg mob uas tsis muaj kev loj hlob hormone tsis txaus, CJC-1295 Tsis muaj DAC tuaj yeem txhawb nqa qhov tso tawm ntawm kev loj hlob hormone, yog li txhawb kev loj hlob thiab kev loj hlob ntawm lub cev. Nws tuaj yeem muab kev kho mob tshiab rau cov neeg mob uas muaj cov lus teb tsis zoo rau kev kho cov tshuaj hormones loj hlob ^[3].

Kev tswj cov kab mob metabolic: 

Kev loj hlob hormone plays lub luag haujlwm tseem ceeb hauv kev tswj hwm lub cev cov txheej txheem metabolic. CJC-1295 Yog tsis muaj DAC tuaj yeem txhim kho cov tshuaj insulin, tswj cov roj metabolism, thiab lwm yam los ntawm kev ua kom lub zais ntawm cov tshuaj hormones loj hlob, thiab tej zaum yuav muaj qee yam kev kho mob rau cov kab mob metabolic xws li ntshav qab zib thiab rog ^[3].

Rejuvenation ntawm daim tawv nqaij: 

Kev loj hlob hormone tuaj yeem txhawb cov synthesis ntawm collagen, ua kom tawv nqaij elasticity, thiab txo cov wrinkles. CJC-1295 Yog tsis muaj DAC tuaj yeem ua tiav daim tawv nqaij rejuvenation los ntawm stimulating lub secretion ntawm kev loj hlob hormone ^[6].

Txhim kho lub cev ua haujlwm: 

Nrog rau lub hnub nyoog nce, ntau yam haujlwm ntawm lub cev yuav maj mam poob. Kev loj hlob hormone tuaj yeem ua rau cov leeg muaj zog, txhim kho pob txha ceev, thiab txhim khu kev tiv thaiv, thiab lwm yam CJC-1295 Tsis muaj DAC tuaj yeem pab ncua kev laus thiab txhim kho lub neej zoo ntawm cov neeg laus ^[3].

Ua kom cov leeg muaj zog: 

Kev loj hlob hormone tuaj yeem txhawb kev tsim cov protein thiab ua kom cov leeg nqaij. Rau cov neeg ncaws pob thiab cov neeg nyiam kev qoj ib ce, CJC-1295 Tsis muaj DAC tuaj yeem pab txhim kho cov leeg nqaij thiab kev ua siab ntev ^[6].

Txhawb kev tawm dag zog rov qab: 

Tom qab kev tawm dag zog siab, lub cev xav tau sijhawm kom rov zoo. Kev loj hlob hormone tuaj yeem nrawm kho cov ntaub so ntswg puas thiab txo cov inflammatory teb. CJC-1295 Tsis muaj DAC tuaj yeem pab txo lub sijhawm rov qab los tom qab kev tawm dag zog thiab txhim kho kev tawm dag zog ^[3].

Anti-aging: 

Nrog rau kev mloog zoo rau kev tiv thaiv kev laus, CJC1295 tsis muaj DAC kuj tau txiav txim siab los ntawm qee tus neeg kom muaj peev xwm tiv thaiv kev laus. Kev loj hlob hormone thiab IGF-I ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub cev kev ua haujlwm ntawm lub cev thiab kho cov ntaub so ntswg. Yog li, cov tshuaj no tuaj yeem cuam tshuam rau txoj kev laus los ntawm kev tswj hwm cov yam ntxwv no ^[3].

Raws li ib qho analogue ntawm kev loj hlob hormone-tso cov tshuaj hormones, CJC1295 tsis muaj DAC muaj cov teebmeem tseem ceeb. Nws tuaj yeem ua rau lub caj pas pituitary tso tawm cov tshuaj hormones loj hlob, tswj kev tso tawm ntawm insulin zoo li kev loj hlob yam I, thiab yog li cuam tshuam rau kev loj hlob thiab cov metabolism hauv lub cev. Hauv kev tshawb fawb tshawb fawb, nws muab kev pabcuam tseem ceeb rau kev tshawb nrhiav cov txheej txheem ntawm kev ua haujlwm ntawm kev loj hlob hormone thiab txhawb kev nce qib ntawm cov kev xav uas cuam tshuam. Hauv kev siv tshuaj kho mob, rau cov neeg mob uas muaj kev loj hlob hormone tsis txaus, nws yuav tsum ua kom lub zais ntawm cov tshuaj endogenous loj hlob thiab txhim kho kev loj hlob thiab kev loj hlob thiab metabolic abnormality. Nws kuj qhia tau hais tias muaj peev xwm tswj hwm cov qib tshuaj hormones thiab tiv thaiv kev laus ntawm kev tshawb fawb los tiv thaiv kev laus. Zuag qhia tag nrho, nws tseem ceeb heev nyob rau hauv ob qho tib si kev tshawb fawb tshawb fawb thiab chaw kho mob, coj cov cib fim tshiab rau kev tshawb fawb thiab kev kho mob.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Teichman SL yog tus kws tshaj lij nrog kev paub nplua nuj thiab kev cuam tshuam hauv kev kho mob thiab kev txhim kho tshuaj. Nws muaj kev sib raug zoo nrog ntau lub koom haum paub zoo thiab kev lag luam, suav nrog Cov Koom Haum Concentr Analges Inc, Teichman Drug Dev Consulting, Wroclaw Medical University, BEAT Biotherapeut Corp, Corthera Inc thiab nws cov tuam txhab koom nrog Corthera, Chiasma, ARYx Therapeut Inc, thiab lwm yam. Tsis tas li ntawd, nws kuj tseem cuam tshuam nrog cov tsev kawm ntawv qib siab Albertin thiab cov tsev kho mob xws li Albertstein. tias nws muaj keeb kwm tob hauv kev tshawb fawb kho mob thiab kev kho mob. Nws cov haujlwm tshaj lij suav nrog ntau yam xws li kab mob plawv thiab mob plawv, kev siv tshuaj sab hauv thiab kev coj ua dav dav, engineering, endocrinology thiab metabolism, thiab chaw muag tshuaj thiab chaw muag tshuaj, tshwj xeeb tshaj yog muaj txiaj ntsig zoo thiab kev koom tes hauv kev tsim tshuaj thiab biotherapy. Teichman SL tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [1].

▎ Cov Lus Qhia Tseem Ceeb

[1] Teichman SL, Neale A, Lawrence B, et al. Ntev stimulation ntawm kev loj hlob hormone (GH) thiab insulin-zoo li kev loj hlob yam I secretion los ntawm CJC-1295, ib tug ntev-acting analog ntawm GH-tso cov tshuaj hormones, nyob rau hauv cov neeg laus noj qab nyob zoo [J]. Phau ntawv Journal of Clinical Endocrinology & Metabolism, 2006,91(3):799-805.DOI:10.1210/jc.2005-1536.

[2] Timms M, Ganio K, Steel R. Ib txoj hauv kev rau kev lees paub CJC-1295 kev tsim txom hauv equine ntshav kuaj los ntawm LC-MS/MS[J]. Kev kuaj tshuaj thiab tshuaj xyuas, 2019,11(8):1248-1257.DOI:10.1002/dta.2599.

[3] Teichman SL, Neale A, Lawrence B, et al. Ntev stimulation ntawm kev loj hlob hormone (GH) thiab insulin-zoo li kev loj hlob yam I secretion los ntawm CJC-1295, ib tug ntev-acting analog ntawm GH-tso cov tshuaj hormones, nyob rau hauv cov neeg laus noj qab nyob zoo [J]. Phau ntawv Journal of Clinical Endocrinology & Metabolism, 2006,91(3):799-805.DOI:10.1210/jc.2005-1536.

[4] Timms M, Ganio K, Forbes G, et al. Ib qho tshuaj tiv thaiv kab mob tiv thaiv kab mob polymerase rau kev kuaj pom ntawm CJC-1295 thiab lwm yam kev loj hlob-hormone-tso cov tshuaj hormones analogs hauv equine plasma [J]. Kev Ntsuas Tshuaj thiab Tshuaj Ntsuam Xyuas, 2019, 11(6): 804-812.DOI: 10.1002/dta.2554.

[5] Alba M, Fintini D, Sagazio A, et al. Kev tswj hwm ib hnub ib zaug ntawm CJC-1295, qhov ua haujlwm ntev-tso cov tshuaj hormones tso tawm (GHRH) analog, normalizes kev loj hlob hauv GHRH knockout nas [J]. American Journal of Physiology-Endocrinology thiab Metabolism, 2006,291(6):E1290-E1294.DOI:10.1152/ajpendo.00201.2006.

[6] Van Hout MC, Hearne E. Netnography ntawm Poj Niam Siv Cov Khoom Siv Hluav Taws Xob Loj Hlob CJC-1295: Pulses thiab Potions[J]. Kev Siv Tshuaj & Tsis Siv Neeg, 2016,51(1):73-84.DOI:10.3109/10826084.2015.1082595.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.