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▎ CJC1295 Enweghị usoro DAC
Isi mmalite: PubChem |
Usoro: YADAXFXQSYRKVLAQLSARKLLQDXLSR Ụdị mkpụrụ ndụ: C 152H 252N 44O42 Arọ molekụla: 3367.9g/mol Nọmba CAS: 446262-90-4 PubChem CID: 91976842 |
▎ CJC1295 Enweghị nyocha DAC
Kedu ihe ndabere nyocha nke CJC1295 enweghị DAC?
A na-eji hormone na-ewepụta hormone na-eto eto (GHRH) na ọgwụgwọ iji mee ka mmepụta nke hormone na-eto eto (GH) dịkwuo elu, ma ọ nwere njedebe dị ukwuu, ya bụ, obere oge ọrụ ya [1] . Nke a na-egbochi ngwa ụlọ ọgwụ GHRH zuru ebe niile ma kpalie ndị nyocha ka ha chọọ ụzọ ọzọ na-eme ogologo oge. CJC1295 enweghị DAC bụ ọgwụ peptide dabere na amino acid 30. Ọ nwere ike kpalie pituitary gland ịhapụ hormone uto (GH). Ọgwụ peptide a dị iche na ọgwụ peptide ọdịnala. Ọpụrụiche ya dabere na ọnụnọ nke otu maleimide propionic acid na-emeghachi omume, nke nwere ike jikọta ya na thiols efu n'elu protein protein. Ozugbo ejikọtara ya na protein plasma, oge ọrụ CJC1295 enweghị DAC n'ime ọbara na-agbatịkwu ogologo oge. E jiri ya tụnyere ọgwụ peptide na-adịghị ejikọta, ọgwụ peptide ndị ahụ na-adịghị agwụ agwụ ga-apụ ngwa ngwa n'ahụ, ebe agbụ CJC1295 enweghị DAC nwere ike ịnọgide na-arụ ọrụ n'ime ọbara ruo ogologo oge. Usoro njikọ a na-eme CJC1295 enweghị DAC ọgwụ nwere mmetụta pụrụ iche.
Kedu usoro nke CJC1295 enweghị DAC?
Na-akpali akpali nke pituitary gland iji wepụta hormone na-eto eto: ọgwụ a nwere ike ime ka pituitary gland hapụ hormone na-eto eto (GH). Mgbe CJC1295 ọ dịghị DAC na-abanye n'ime ahụ, ọ na-arụ ọrụ na pituitary gland site na usoro a kapịrị ọnụ, na-eme ka mkpụrụ ndụ pituitary dịkwuo elu na nzuzo nke GH. Kpọmkwem, ọ nwere ike jikọta ya na ndị na-anabata ya kpọmkwem n'elu sel pituitary, na-amalite usoro ụzọ ntụgharị mgbaàmà, n'ikpeazụ na-eduga n'ịbawanye njikọ na ntọhapụ nke GH [1, 2]..
Ejikọ na protein protein plasma: CJC1295 enweghị DAC nwere njirimara pụrụ iche, ya bụ, enwere otu mmeghachi omume na nhazi ya, nke nwere ike jikọta ya na thiols efu n'elu protein protein. Njikọ a nke ukwuu na-agbatịkwu oge nke ọgwụ na-anọgide na-arụ ọrụ n'ime ọbara. E jiri ya tụnyere ọgwụ peptide na-ejikọtaghị ọnụ, agbụ CJC1295 enweghị DAC nwere ogologo ndụ ọkara ndụ [2] . Ụfọdụ nnyocha egosila na CJC-1295 na-ejikọta otu maleimide na-arụ ọrụ na C-terminus, na-enye ya ohere ijikọ na protein protein plasma dị ka serum albumin. Ozugbo ejikọtara ya, ọ nwere ike ịkwalite mmepụta GH n'ime mmadụ ihe karịrị ụbọchị isii ka otu nchịkwa gasịrị (Timms M, 2019, a).
Ịbawanye ihe nzuzo nke hormone na-eto eto: Mgbe otu ịgbanye CJC1295 enweghị DAC, ọ ga-eduga na mmụba na-adabere na dose na mkpokọta plasma GH. Mmụba a nwere ike ịdịru ụbọchị 6 ma ọ bụ karịa, yana mmụba nke 2 ruo ugboro 10 [2-4] . N'ime ọmụmụ ihe, mgbe ndị okenye nwere ahụike natara ọgwụ mgbochi subcutaneous nke CJC-1295, enwere mmụba na-aga n'ihu na-adabere na dose na ọkwa GH. Atụmatụ ọkara ndụ nke CJC-1295 bụ 5.8 - 8.1 ụbọchị (Teichman SL, 2006). Na ụmụ oke GHRH knockout (GHRHKO), ihe ndị yiri ya ka egosiri. Nlekọta kwa ụbọchị nke CJC1295 nwere ike idowe nhazi ahụ na uto nkịtị [5].
Na-emetụta ihe nzuzo nke insulin-dị ka ihe na-eto eto I: CJC1295 enweghị DAC ga-emetụtakwa nzuzo nke insulin-like growth factor I (IGF-I). Nkezi plasma IGF-I ntinye uche ga-abawanye n'ụzọ dabere na dose, yana mmụba nke 1.5 ruo ugboro 3, na ogologo oge bụ 9 - 11 ụbọchị [2-4] . Mgbe ọtụtụ nchịkwa nke CJC1295 enweghị DAC dose, nkezi ọkwa IGF-I ka dị elu karịa ọkwa ntọala ruo ụbọchị 28 (Teichman SL, 2006). Na ụmụ oke GHRHKO, CJC1295 mekwara ka mmụba na mkpokọta pituitary RNA na GH mRNA, na-egosi mmụba nke mkpụrụ ndụ nzuzo na-eto eto [5].
Usoro mwepu nke Plasma nke CJC-1295 mgbe otu ntụtụ sc gasịrị. Egosiri bụ ọkara SD ọkara ndụ.
Isi mmalite: PubMed [1]
Kedu ihe dị iche na usoro ọgwụgwọ nke CJC1295 enweghị DAC maka ndị ọrịa nwere ụkọ hormone na-eto eto nke afọ dị iche iche?
Ụmụaka na-arịa ọrịa: Ụmụaka nọ n'oge dị oke egwu nke uto na uto, hormone na-eto eto na-ekerekwa òkè dị mkpa na uto na mmepe nke ọkpụkpụ, mọzụlụ, na akụkụ ahụ ha. Enweghị ụkọ homonụ na-eto eto nwere ike ibute nsogbu ndị dị ka uto ngwa ngwa, mkpụmkpụ mkpụmkpụ, na igbu oge ọkpụkpụ n'ime ụmụaka.
CJC1295 ọ dịghị DAC na-akwalite uto na mmepe nke ụmụaka site na-akpali pituitary gland na-ezobe hormone ibu. Ọ nwere ike ịbawanye ọnụọgụ nzuzo na ogologo oge nke hormone na-eto eto, na-ebuli ọkwa nke hormone na-eto eto na insulin-dị ka ihe na-eto eto - I (IGF-I) na serum [3] . IGF-I bụ isi ogbugbo nke omume nke hormone ibu. Ọ nwere ike ịkwalite mgbasa nke cell, ọdịiche, na njikọ protein, ma nwee ọrụ dị mkpa na uto na mmepe nke ọkpụkpụ, mọzụlụ, na akụkụ ahụ. CJC1295 enweghị DAC nwekwara ike ịkwalite mmụba nke ihe ngosi metabolism nke ọkpụkpụ dị ka osteocalcin na alkaline phosphatase, nke na-enyere aka maka uto na ịnweta ọkpụkpụ. Na mgbakwunye, CJC1295 enweghị DAC enweghị mmetụta doro anya na ọrụ thyroid ma nwee ọkwa nchekwa dị elu.
Ndị ọrịa okenye:
Ndị ọrịa toro eto nwere ụkọ homonụ na-eto eto nwere ike ịnwe nsogbu dị ka mbelata ahụ ike, ịba ụba abụba, ike anụ ahụ mbelata, ihe ize ndụ nke ọrịa obi, na ọkpụkpụ ọkpụkpụ. E jiri ya tụnyere ụmụaka na-arịa ọrịa, ọganihu na mmepe nke ndị ọrịa toro eto ka emechara nke ọma, na nlekọta nke ọgwụgwọ bụ imeziwanye ọrụ metabolic na ndụ ndụ. Usoro ọgwụgwọ nke CJC1295 ọ dịghị DAC na ndị ọrịa toro eto bụ karịsịa iji meziwanye ike anụ ahụ, belata oke abụba, melite ọrụ obi, igbu oge ịka nká, na igbochi osteoporosis site n'ịba ụba nke hormone na-eto eto na IGF-I. Nnyocha egosiwo na CJC1295 ọ dịghị DAC nwere ike ịbawanye ụbara ahụ nke ndị okenye toro eto, belata oke abụba subcutaneous, meziwanye mmetụta insulin, ma belata ihe ize ndụ nke ọrịa obi. Na mgbakwunye, CJC1295 ọ dịghị DAC nwekwara ike ịkwalite uto na ịnweta ọkpụkpụ, na-abawanye njupụta ọkpụkpụ, ma gbochie osteoporosis [3, 5].
Ndị ọrịa agadi:
Site na mmụba nke afọ, ihe nzuzo nke hormone na-eto eto na ahụ mmadụ na-eji nwayọọ nwayọọ na-ebelata, na-eduga ná nsogbu ndị dị ka mbelata ahụ ike, ụbara abụba, ọkpụkpụ ọkpụkpụ, na mbelata ihe mgbochi. Ndị agadi nwere ụkọ homonụ na-eto eto nwere nnukwu ihe ize ndụ nke ọrịa, ọgwụgwọ ahụ na-esikwa ike karị. Usoro ọgwụgwọ nke CJC1295 enweghị DAC na ndị ọrịa agadi yiri nke ahụ na ndị ọrịa toro eto, mana ọ dị mkpa ka edozi usoro ọgwụgwọ nke ọma na mmeghachi omume ọjọọ kwesịrị ileba anya. N'ihi mbelata nke ọrụ anụ ahụ nke ndị ọrịa meworo agadi na ike adịghị ike nke metabolize na excretion ọgwụ, ọ dị mkpa ka ibelata dose nke ọgwụ ahụ iji zere mkpokọta ọgwụ na omume nke mmeghachi omume ọjọọ.
Nnyocha metụtara ya
Kedu nsonaazụ CJC1295 enweghị DAC?
Na-akwalite mmepụta nke hormone nke uto:
Dị ka ihe analog nke hormone na-ewepụta hormone na-eto eto (GHRH), CJC1295 ọ dịghị DAC nwere ike jikọta na GHRH ndị na-anabata ya na ụbụrụ pituitary nke dị n'ihu ma kpalie njikọ na nzuzo nke hormone uto site na mkpụrụ ndụ hormone uto. Hormone na-eto eto dị oke mkpa maka uto na mmepe nke ahụ, metabolism, na nhazi anụ ahụ. N'ime nnyocha ụfọdụ, mgbe ejiri CJC1295 enweghị DAC, enwere ike ịhụ mmụba nke ọkwa hormone na-eto eto n'ime ọbara, nke na-enyere aka ịkwalite uto na nrụzi nke anụ ahụ dị ka ọkpụkpụ na akwara.
Mbelata nke metabolism:
Hormone uto na-arụ ọrụ dị mkpa na nhazi nke metabolism. CJC1295 enweghị DAC na-emetụta usoro metabolic na-apụtaghị ìhè site n'ịkwalite secretion nke hormone uto. Ọ nwere ike ịkwalite mgbaka abụba, na-eme ka abụba na-eme ka ọ bụrụ isi iyi ike, nke na-enyere aka belata nchekwa nke abụba n'ime ahụ ma melite nkesa abụba anụ ahụ. N'otu oge ahụ, ọ nwekwara ike ịkwalite njikọ protein, mụbaa ntinye nke protein n'ime anụ ahụ akwara, nke na-enyere aka imeziwanye ahụ ike na ike, na ịkwalite ikike mgbatị ahụ na ntachi obi. Na mgbakwunye, CJC1295 enweghị DAC nwekwara mmetụta ụfọdụ na metabolism glucose, ma nwee ike ịbawanye mmetụta insulin, nke na-enyere aka idobe ọkwa glucose ọbara nkịtị.
Na-akwalite nrụzi na mmeghari anụ ahụ:
Hormone na-eto eto na-arụ ọrụ dị mkpa na nrụzi na imeghari anụ ahụ mebiri emebi. CJC1295 ọ dịghị DAC na-akwalite mmepụta nke hormone na-eto eto, nke na-eme ka cell gbasaa na ọdịiche dị iche iche, na-eme ka ọnya na-agwọ ọrịa ngwa ngwa, ma na-akwalite mmezi nke anụ ahụ mebiri emebi. N'ime ụfọdụ nnwale anụmanụ na ọmụmụ ụlọ ọgwụ, a chọpụtala na ọ na-enye aka maka ọgwụgwọ mgbaji, nrụzi mmerụ ahụ, na ọgwụgwọ anụ ahụ, wdg, ma nwee ihe ọ pụtara maka imeziwanye ikike mgbake ahụ na iweghachi ọrụ nke anụ ahụ mebiri emebi.
Kedu mpaghara ngwa nke CJC1295 enweghị DAC?
Ọgwụgwọ ụkọ homonụ nke uto:
Maka ndị ọrịa nwere ụkọ hormone na-eto eto, CJC-1295 na-enweghị DAC nwere ike ime ka mmepụta nke hormone na-eto eto, si otú ahụ na-akwalite uto na mmepe nke ahụ. Ọ nwere ike ịnye nhọrọ ọgwụgwọ ọhụrụ maka ndị ọrịa na-enwechaghị nzaghachi maka ọgwụgwọ homonụ uto ọdịnala [3].
Usoro ọgwụgwọ ọrịa metabolic:
Hormone uto na-arụ ọrụ dị mkpa n'ịhazi usoro metabolic nke anụ ahụ. CJC-1295 na-enweghị DAC nwere ike melite nguzogide insulin, mezie abụba metabolism, wdg site n'ịba ụba nke homonụ na-eto eto, ma nwee ike ịnwe ụfọdụ ikike ọgwụgwọ maka ọrịa metabolic dị ka ọrịa shuga na oke ibu [3]..
Ntughari akpụkpọ ahụ:
Hormone na-eto eto nwere ike ịkwalite njikọ nke collagen, mee ka akpụkpọ ahụ dịkwuo mma, ma belata wrinkles. CJC-1295 na-enweghị DAC nwere ike nweta mmụba anụ ahụ site na-akpali mmepụta nke hormone uto [6].
Imelite ọrụ anụ ahụ:
Site na mmụba nke afọ, ọrụ dị iche iche nke ahụ ga-eji nwayọọ nwayọọ daa. Hormone na-eto eto nwere ike ịbawanye ike anụ ahụ, melite njupụta ọkpụkpụ, na ịkwalite mgbochi, wdg. CJC-1295 Enweghị DAC nwere ike inye aka igbu oge usoro ịka nká ma melite ogo ndụ ndị agadi [3]..
Na-abawanye ike akwara:
Hormone na-eto eto nwere ike ịkwalite njikọ protein ma mee ka uru ahụ dịkwuo elu. Maka ndị na-eme egwuregwu na ndị na-anụ ọkụ n'obi, CJC-1295 na-enweghị DAC nwere ike inye aka melite ike na ntachi obi [6].
Na-akwalite mgbake mmega ahụ:
Mgbe mgbatị ahụ dị elu, ahụ chọrọ oge iji gbakee. Hormone na-eto eto nwere ike ime ngwa ngwa nrụzi anụ ahụ mebiri emebi ma belata nzaghachi mkpali. CJC-1295 Enweghị DAC nwere ike inye aka belata oge mgbake mgbe mgbatị ahụ gasịrị ma melite arụmọrụ mmega ahụ [3].
mgbochi ịka nká:
Site na nlebara anya na-abawanye na mgbochi ịka nká, CJC1295 ọ dịghị DAC na-ewerekwa ụfọdụ ndị nwere ikike nke mgbochi ịka nká. Hormone na-eto eto na IGF-I na-arụ ọrụ dị mkpa n'ịkwado ọrụ physiological nkịtị nke anụ ahụ na nrụzi anụ ahụ. Ya mere, ihe a nwere ike inwe mmetụta na usoro ịka nká site na ịhazi ihe ndị a [3].
Dị ka ihe analog nke hormone na-ewepụta hormone na-eto eto, CJC1295 enweghị DAC nwere mmetụta dị ukwuu. Ọ nwere ike kpalie pituitary gland wepụta homonụ nke na-eto eto, na-achịkwa nzuzo nke insulin-dị ka ihe na-eto eto, ma si otú ahụ na-emetụta uto na metabolism nke ahụ. N'ime nchọpụta sayensị, ọ na-enye enyemaka dị mkpa maka ịchọpụta usoro ọrụ nke hormone na-eto eto ma na-akwalite ọganihu nke echiche ndị dị mkpa. N'ime ngwa ụlọ ọgwụ, maka ndị ọrịa nwere ụkọ hormone na-eto eto, a na-atụ anya na ọ ga-akpali mmepụta nke hormone uto endogenous ma melite uto na mmepe na ọrịa metabolic. Ọ na-egosikwa ikike ịchịkwa ọkwa hormone na ịlụso mgbanwe ịka nká ọgụ na nchọpụta mgbochi ịka nká. N'ozuzu, ọ dị oke mkpa na nyocha sayensị na mpaghara ahụike, na-eweta ohere ọhụrụ maka nchọpụta metụtara ya na ọgwụgwọ ọrịa.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Teichman SL bụ ọkachamara nwere ahụmahụ bara ụba na mmetụta na ngalaba ọgwụ na mmepe ọgwụ. O nwere mmekọrịta chiri anya na ọtụtụ ụlọ ọrụ na ụlọ ọrụ a ma ama, gụnyere Organisation Concentr Analges Inc, Teichman Drug Dev Consulting, Wroclaw Medical University, BEAT Biotherapeut Corp, Corthera Inc na ụlọ ọrụ mmekọ Corthera, Chiasma, ARYx Therapeut Inc, wdg Na mgbakwunye, ọ na-ejikọta ya na ụlọ ọrụ agụmakwụkwọ dị ka Ụlọ Ọgwụ nke Athens na Ụlọ Ọgwụ E, nke Ụlọ Akwụkwọ Ọgwụ nke Athens na-egosi na Ụlọ Ọgwụ E. ndabere miri emi na nyocha ahụike na omume ụlọ ọgwụ. Ọkachamara ya na-ekpuchi ọtụtụ akụkụ dị ka usoro obi na akwara obi, ọgwụ ime n'ozuzu na omume izugbe, injinia, endocrinology na metabolism, na pharmacology and pharmacy, ọkachasị na mmezu dị ịrịba ama na ntinye aka na mmepe ọgwụ na biotherapy. Edepụtara Teichman SL na ntụaka ntụaka [1].
