By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
1. Bayani
Tadalafil, a matsayin mai hana phosphodiesterase-5 (PDE-5), yana ba da sababbin hanyoyi don magance yanayi daban-daban da kuma inganta aikin jiki.
Hoto 1 Yana nufin canje-canje daga asali, tare da 95% tazarar amincewa (CIs), a cikin minti na 6 na tafiya a cikin mako 16 a cikin ƙungiyoyin tadalafil da placebo.
2. Illar Jini
Kayan aikin Vasodilation: A cikin jikin mutum, nitric oxide (NO) - cyclic guanosine monophosphate (cGMP) - hanyar siginar PDE5 tana taka muhimmiyar rawa wajen daidaita tsokar tsoka mai santsi. Lokacin da ƙwayoyin endothelial suka saki NO akan ƙarfafawa, NO yana kunna guanylate cyclase, yana inganta canjin guanosine triphosphate (GTP) zuwa cGMP. A matsayin manzo na biyu na intracellular, cGMP yana kunna furotin kinase G (PKG), wanda ke haifar da vasodilation na tsoka mai santsi, ƙara diamita na jijiyoyin jini, da haɓakar jini. Hanyar aikin Tadalafil shine hana ayyukan PDE5, rage lalata cGMP, don haka kiyaye matakan cGMP mafi girma a cikin sel da kuma ci gaba da tasirin vasodilator don inganta yanayin jini.
Tasirin Gadajen Gadajen Jijiyoyin Jiki daban-daban
Zagayewar huhu: A cikin ƙwayar huhu, Tadalafil ana amfani dashi sosai don magance hauhawar jini na huhu (PAH). A cikin marasa lafiya na PAH, haɓaka juriya na huhu na huhu yana haifar da ƙara yawan aiki na ventricular na dama, wanda hakan yana rinjayar aikin zuciya da tsarin tsarin jini. Tadalafil yana faɗaɗa tasoshin huhu, yana rage juriya na huhu na huhu, yana rage nauyin ventricular dama, yana inganta yanayin jini na huhu, yana ƙara yawan fitarwa na zuciya, don haka yana haɓaka haƙurin motsa jiki na marasa lafiya da ingancin rayuwa. Marasa lafiya na PAH da ke karɓar 40 MG na Tadalafil sau ɗaya kowace rana sun sami ci gaba mai mahimmanci a cikin ƙarfin motsa jiki da jinkirta haɓakar asibiti.
Systemic Circulation: In the systemic circulation, Tadalafil also exerts beneficial effects on blood vessels. Yana fadada arteries na gefe, yana rage juriya na gefe, kuma yana inganta zubar jini na gaba. Ga marasa lafiya da cututtuka na jijiyoyin jini, irin su claudication na tsaka-tsaki, Tadalafil na iya ƙara yawan samar da jini zuwa ƙananan tsokoki na hannu, rage alamun ischemia a lokacin motsa jiki, da inganta tafiyar tafiya da ƙarfin motsa jiki. Tadalafil kuma na iya haɓaka ajiyar jini na jijiyoyin jini na jijiyoyin jini kuma yana iya haɓaka bugun jini a cikin marasa lafiya da cututtukan jijiyoyin jini, kodayake ana buƙatar ƙarin bincike don tabbatar da waɗannan tasirin.
Microcirculation: Microcirculation wuri ne mai mahimmanci don musayar abu tsakanin kyallen jikin mutum da jini. Tadalafil yana inganta haɓakar jirgin ruwa na microcirculatory, yana ƙara yawan buɗewar capillaries, kuma yana haɓaka zubar jini na nama da iskar oxygen. A wasu nazarin, an gano cewa bayan jiyya na Tadalafil, microcirculatory jini ya kwarara gudu a cikin fata da tsoka kyallen takarda ya kara hanzari, yana sauƙaƙe isar da abinci mai sauƙi da kuma kawar da sharar gida, don haka yana taimakawa wajen kula da al'amuran physiological na kyallen takarda.
3. Aikace-aikace a inganta aikin jiki
Haɓaka juriyar motsa jiki
Marasa lafiya da cututtukan zuciya na haihuwa: Ga marasa lafiya da cututtukan zuciya na haihuwa, musamman waɗanda ke da aikin ventricle guda ɗaya waɗanda aka yi wa Fontan tiyata, juriyar motsa jiki bayan aiki yakan ragu. Tadalafil, ta hanyar tasirin vasodilator, yana rage juriya na huhu na huhu da juriya na tsarin jijiyoyin jini, yana inganta hemodynamics na zuciya, kuma yana ƙara yawan fitarwa na zuciya, ta haka yana samar da tsokoki tare da oxygen da abubuwan gina jiki a lokacin motsa jiki. A cikin marasa lafiya na 16 da suka yi aikin Fontan, bayan sun karbi maganin Tadalafil (da farko 10mg sau ɗaya kowace rana, sannan 10mg kowane sa'o'i 12 bayan makonni 2, don jimlar watanni 6), matsakaicin tafiya na minti 6 ya karu daga 418.75m zuwa 439.06m, kuma matsakaicin iskar oxygen (VO2 max.0) ya karu daga 418.75m zuwa 439.06m. yana nuna gagarumin ci gaba a cikin juriyar motsa jiki.
Yawan jama'a masu lafiya: Tadalafil kuma na iya samun tasiri mai kyau akan juriyar motsa jiki a cikin mutane masu lafiya. Kodayake babban binciken da aka yi a cikin mutane masu lafiya a halin yanzu yana iyakance, wasu ƙananan ƙananan nazarin sun nuna cewa Tadalafil zai iya inganta yanayin jini a lokacin motsa jiki, yana ba da damar tsokoki don samun isasshen iskar oxygen a lokacin aikin jiki, jinkirta farawa na gajiya, da kuma yiwuwar haɓaka wasan motsa jiki. A cikin wasu wasanni na jimiri, 'yan wasa sun ba da rahoton ingantaccen ta'aziyya na numfashi da haɓaka ƙarfin motsa jiki bayan amfani da Tadalafil; duk da haka, ana buƙatar ƙarin tsauraran binciken kimiyya don tabbatar da waɗannan binciken.
Inganta aikin tsoka: Ayyukan tsoka na yau da kullun ya dogara da isasshen jini da iskar oxygen. Ta hanyar inganta yanayin jini, Tadalafil na iya samar da tsokoki tare da ƙarin oxygen da abubuwan gina jiki, inganta haɓakar makamashi. Hakanan yana iya yin tasiri mai tasiri akan ƙanƙanwar tsoka da ayyukan shakatawa ta hanyar daidaita hanyoyin siginar ciki. A cikin gwaje-gwajen dabba, dabbobin da aka bi da su tare da Tadalafil sun nuna ƙarfin ƙarfin tsoka da juriya. Ga marasa lafiya da cututtukan ƙwayar cuta ko atrophy na tsoka wanda ya haifar da kwanciyar hankali na tsawon lokaci, Tadalafil na iya inganta yanayin jini na gida, inganta gyaran gyare-gyare da farfadowa, da haɓaka aikin tsoka.
Inganta aikin jiki na yau da kullun: Ga marasa lafiya da rashin ƙarfi na rashin ƙarfi (ED), Tadalafil ba kawai inganta aikin haɓaka ba amma yana da tasiri mai kyau akan aikin jiki gabaɗaya da ingancin rayuwa. Marasa lafiya na ED sukan fuskanci matsalolin tunani saboda yanayin su, wanda ke shafar sha'awar ayyukan yau da kullun da aikin jiki. Tadalafil yana inganta kwararar jini zuwa ga penile corpus cavernosum, maido da aikin gyaran kafa, yayin da yake ƙarfafa amincewar marasa lafiya, yana ba su damar yin aiki a rayuwar yau da kullum. Bugu da ƙari, ga marasa lafiya masu fama da cutar hawan jini (BPH) da ƙananan cututtuka na urinary fili (LUTS), Tadalafil na iya inganta aikin fitsari ta hanyar shakatawa da santsin tsokoki na prostate da wuyansa mafitsara, rage rashin jin daɗi na jiki wanda ya haifar da matsalolin urinary, kuma ta haka ne inganta aikin jiki na yau da kullum da kuma ingancin rayuwa.
4. Takaitawa
Tadalafil yana nuna tasiri mai mahimmanci wajen inganta yanayin jini da aikin jiki. Ko a cikin maganin cututtukan zuciya kamar hauhawar jini na huhu da cututtukan jijiyoyin jini, ko kuma haɓaka juriya na motsa jiki, inganta aikin tsoka, da haɓaka aikin yau da kullun ga marasa lafiya da cututtukan zuciya na haihuwa, yana taka muhimmiyar rawa.
Sources
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Samfura akwai don amfani da bincike kawai:
