SS31 30 mg

▎ SS-31 Qauv

Source: PubChem

Sequence: RXKF Molecular Formula: C 32H 49N 9O5 Molecular Luj: 639.8g/mol CAS Nr .: 736992-21-5 PubChem CID: 11764719 Synonyms: Elamipretide

▎ SS-31 Kev Tshawb Fawb

Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm SS-31?

SS-31 yog ib qho opioid peptide muab los ntawm pheromone peptide. Nws tau pib pom thaum lub sijhawm kev tshawb fawb txog kev siv tshuab ntawm pheromone peptide, uas nthuav tawm cov teebmeem analgesic muaj zog thiab zoo heev cell membrane permeability, ua rau kev txheeb xyuas ntawm mitochondrial-targeted antioxidant peptide SS-311. Nws qhov kev tshawb fawb keeb kwm yav dhau los kuj tseem cuam tshuam nrog kev tshawb fawb txog cov kab mob cuam tshuam nrog mitochondrial dysfunction. Raws li 'powerhouse' ntawm tes, mitochondrial dysfunction yog txuam nrog rau qhov pib thiab kev loj hlob ntawm ntau yam kab mob, xws li ischemia-reperfusion raug mob, neurodegenerative kab mob, plawv tsis ua hauj lwm, thiab nqaij laus, tag nrho cov uas muaj feem xyuam rau oxidative kev nyuaj siab tshwm sim los ntawm ntau dawb radical ntau lawm. SS-31 zoo alleviates oxidative kev nyuaj siab thiab tiv thaiv mitochondrial muaj nuj nqi.

Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm SS-31?

Regulating membrane nto electrostatic zog: 

SS-31 cuam tshuam nrog mitochondrial daim nyias nyias, hloov cov khoom electrostatic ntawm daim nyias nyias los cuam tshuam rau kev faib cov ions thiab cov proteins yooj yim ntawm daim nyias nyias. Cov kev tshawb fawb tau pom tias SS-31 tuaj yeem hloov pauv qhov kev faib tawm ntawm cov cations sib txawv hauv thaj tsam daim nyias nyias, yog li txo lub zog ntawm mitochondrial calcium kev nyuaj siab thiab tswj mitochondrial membrane stability ^[1,2].

Kev cuam tshuam lipid kev npaj: 

Cov peptide no tuaj yeem ua rau muaj kev hloov pauv hloov hauv lipid kev npaj. Txawm hais tias nws tsis cuam tshuam qhov kev ruaj ntseg ntawm cov bilayer ntawm qhov sib txuam siab, nws tuaj yeem cuam tshuam ncaj qha rau mitochondrial membrane-txog physiological txheej txheem, xws li membrane protein muaj nuj nqi thiab daim nyias nyias fluidity, yog li ua rau muaj txiaj ntsig zoo ntawm kev ua haujlwm mitochondrial ^[1,2].

Inhibition ntawm inflammatory teb: 

Hauv cov kev tshawb fawb ntsig txog sepsis, SS-31 tau pom tias txo qis cov kab mob xws li interleukin-6 (IL-6), interleukin-1β (IL-1β), thiab qog necrosis factor -α (TNF-α), yog li txo qhov kev puas tsuaj los ntawm inflammatory teb rau cov ntaub so ntswg thiab lub cev ^[3].

Txo oxidative kev nyuaj siab: 

SS-31 tuaj yeem txhim kho kev ua haujlwm ntawm cov enzymes antioxidant xws li superoxide dismutase (SOD) thiab glutathione peroxidase, txo cov qib ntawm oxidative khoom xws li malondialdehyde (MDA), thiab txo qis kev tsim cov pa oxygen reactive (ROS), yog li txo cov oxidative kev nyuaj siab vim kev puas tsuaj rau cov hlwb thiab cov ntaub so ntswg thiab tiv thaiv lub cev ua haujlwm ntawm lub cev ^. .

Regulating mitochondrial dynamics: 

Hauv cov kev tshawb fawb ntawm sepsis-associated encephalopathy, SS-31 tuaj yeem cuam tshuam qhov kev ua haujlwm ntau dhau ntawm mitochondrial fission-related proteins xws li dynamin-related protein 1 (Drp1), txo cov mitochondrial fission ntau dhau, tswj cov mitochondrial morphology thiab kev ua haujlwm, thiab ua haujlwm zoo ^. .

Daim duab 1. Kev sib txuam thiab cov tshuaj tiv thaiv antioxidant ntawm Szeto-Schiller-31 (SS-31) ^[5].

Source: MDPI

Dab tsi yog cov haujlwm thiab kev siv ntawm SS-31?

Muaj nuj nqi

Cellular tiv thaiv teebmeem: 

Hauv hydrogen peroxide (H₂O₂) induced oxidative stress damage model of ARPE-19 cells, SS-31 tuaj yeem ua kom cov cell ciaj sia taus, txo cov ntsiab lus ntawm intracellular ROS, tswj cov mitochondrial membrane muaj peev xwm, thiab txo qis cell tuag, qhia txog kev tiv thaiv tseem ceeb ntawm cov hlwb puas los ntawm oxidative kev nyuaj siab.

Kev txhim kho ntawm lub cev ua haujlwm  

Lub plawv: Hauv cov qauv tsiaj ntawm myocardial ischemia-reperfusion raug mob, pretreatment nrog SS-31 ua ntej reperfusion txo qis myocardial infarct loj, nrog rau kev ua tau zoo cuam tshuam nrog qhov hnyav ntawm myocardial ischemia; Thaum lub sij hawm ischemic lub sij hawm, SS-31 txo qhov tsis muaj qhov chaw nyob rau hauv lub hypoperfused myocardial cheeb tsam thiab txhim kho qhov tshwm sim thiab qhov hnyav ntawm arrhythmias. Nyob rau hauv sepsis-induced myocardial dysfunction, SS-31 tuaj yeem rov qab kho myocardial morphological puas, inhibit inflammatory teb, txhim kho myocardial zog tsis txaus, tswj mitochondrial membrane muaj peev xwm, thiab tiv thaiv lub plawv los ntawm kev puas tsuaj ^[3].

Lub ntsws: SS-31 tuaj yeem txo qis cov exudation thiab edema nyob rau hauv lub ntsws cov ntaub so ntswg, txo lub ntsws histology qhab nia, tswj inflammatory yam tseem ceeb thiab oxidative kev nyuaj siab cov cim qhia, thiab txhim kho mob ntsws mob.

Lub paj hlwb: Kev txhaj tshuaj intraperitoneal tsis tu ncua ntawm SS-31 tuaj yeem txhim kho kev txawj ntse thiab kev ciaj sia nyob hauv cov nas, txo qis hippocampal o, ROS ntau lawm, thiab mitochondrial hyperdivision. Hauv cov qauv nas laus, SS-31 kev kho mob ua rau muaj kev hloov pauv hauv microvascular proteome ntawm cerebral cortex, cuam tshuam rau kev nthuav qhia ntawm mitochondrial-related proteins, thiab muaj qee yam ameliorative cuam tshuam rau cov hnub nyoog ntsig txog microvascular hloov hauv lub hlwb ^[4,6].

Daim ntawv thov

Cov kab mob plawv: 

Muab nws cov kev tiv thaiv los tiv thaiv myocardial ischemia-reperfusion raug mob thiab sepsis-induced myocardial dysfunction, SS-31 tuav lub peev xwm daim ntawv thov tus nqi hauv kev tiv thaiv thiab kho cov kab mob plawv, nrog lub peev xwm los tsim los ua cov tshuaj kho tshiab rau cov mob xws li myocardial infarction thiab cardiovascular sepsis-induce3 ^..

Cov Kab Mob Pulmonary: 

Rau cov mob ntsws mob hnyav tshwm sim los ntawm sepsis, SS-31 tuaj yeem ua tus kws kho mob zoo los ntawm kev txo qhov mob thiab oxidative kev nyuaj siab, yog li txhim kho lub ntsws ua haujlwm thiab muab kev kho mob tshiab rau cov neeg mob mob ntsws.

Cov kab mob neurological: 

Nyob rau hauv sepsis-associated encephalopathy thiab hnub nyoog-txog cov kab mob paj hlwb, SS-31 tau qhia lub peev xwm los txhim kho kev txawj ntse, qhia nws lub peev xwm rau kev loj hlob hauv kev kho cov kab mob neurological xws li Alzheimer's disease thiab post-sepsis cognitive impairment ^[4,6].

Atherosclerosis: 

Vim nws txoj kev kho mob ntawm ApoE gene-knockout atherosclerotic nas, SS-31 muaj peev xwm siv tau rau hauv kev kho mob ntawm cov kab mob atherosclerotic los ntawm kev txo qis oxidative kev nyuaj siab thiab qeeb cov kab mob.

Xaus

Hauv cov ntsiab lus, SS-31 yog mitochondrial-targeted antioxidant peptide uas tswj cov membrane nto electrostatic zog, inhibits o, txo oxidative kev nyuaj siab, thiab txhim kho mitochondrial dynamics. Nws tiv thaiv kab mob xws li lub plawv, ntsws, thiab lub hlwb, alleviates ischemia-reperfusion raug mob thiab sepsis-txog kev puas tsuaj, qeeb cellular aging, thiab muaj qee yam kev kho mob hauv kev tiv thaiv thiab kho mob plawv, paj hlwb, thiab lwm yam kab mob, nrog rau atherosclerosis.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Broome, Sophie C koom nrog Australian Catholic University thiab University of Auckland. Nws txoj kev tshawb fawb nthuav dav ntau yam kev qhuab qhia, suav nrog Kev Tshawb Fawb Kev Ua Si, Physiology, Khoom noj khoom haus & Dietetics, Biochemistry & Molecular Biology, thiab Neurosciences & Neurology. Nws tshawb xyuas qhov cuam tshuam ntawm kev tawm dag zog ntawm lub cev kev ua haujlwm thiab kev noj qab haus huv, tshuaj xyuas cov lus teb ntawm lub cev thiab kev hloov pauv rau lub cev ua si. Broome kuj tshawb txog kev sib raug zoo ntawm kev noj haus thiab kev noj qab haus huv, thiab kev siv biochemistry thiab molecular biology hauv kev tawm dag zog. Nws txoj hauj lwm hauv neurosciences thiab neurology ntxiv rau peb txoj kev nkag siab ntawm lub paj hlwb lub luag haujlwm thiab cov teeb meem cuam tshuam, muab qhov muaj txiaj ntsig theoretical thiab cov tswv yim pom zoo rau kev ua kis las thiab kev tshawb fawb txog kev noj qab haus huv. Broome, Sophie C tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [5].

▎ Cov Lus Qhia Tseem Ceeb

[1] Mitchell W, Ng EA, Tamucci JD, et al. Lub mitochondria-targeted peptide SS-31 khi lipid bilayers thiab modulates nto electrostatics raws li ib feem tseem ceeb ntawm nws mechanism ntawm kev ua [J]. Phau ntawv Journal of Biological Chemistry, 2020,295(21):7452-7469.DOI:10.1074/jbc.RA119.012094.

[2] Mitchell W, Ng EA, Tamucci JD, et al. Molecular Mechanism of Action of Mitochondrial Therapeutic SS-31 (Elamipretide): Membrane Interactions thiab Effects on Surface Electrostatics [J]. Biorxiv, 2019. DOI: 10.1101/735001.

[3] Li Y., Yang W, Sun X, et al. SS31 Ameliorates Sepsis-Induced Heart Injury los ntawm Inhibiting Oxidative Stress thiab Inflamation [J]. Kab mob, 2019,42(6):2170-2180.DOI:10.1007/s10753-019-01081-3.

[4] Zhong L, Ren X, Ai Y, et al. SS-31 Txhim kho kev paub txog kev ua haujlwm hauv Sepsis-Associated Encephalopathy los ntawm Inhibiting the Drp1-NLRP3 Inflammasome Activation[J]. Neuromolecular Medicine, 2023,25(2):230-241. DOI: 10.1007/s12017-022-08730-1.

[5] Broome SC, Woodhead JST, Zoo Siab T L. Mitochondria-Targeted Antioxidants thiab Skeletal Muscle Function[J]. Antioxidants, 2018,7(8},ARTICLE-NUMBER ={107).DOI:10.3390/antiox7080107.

[6] Rutkai I, Seman A, Chandra P, et al. Cov txiaj ntsig zoo ntawm SS-31 ntawm kev laus nas cerebral microvasculature [J]. Physiology, 2023,38.DOI:10.1152/physiol.2023.38.S1.5734232.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.