Teriparatidi miligaramu 750

▎ Teriparatid (Teriparatid) ka sigicogo

▎ Teriparatid ɲininiw

Teriparatid kɔrɔ ye mun ye?

Teriparatid ye hadamaden ka paratayiroyi ɔrimɔni (PTH) ɲɔgɔnna ye min bɛ kɛ ni hadamaden paratayiroyi ɔrimɔni asidi aminiyɔmu 34 fɔlɔw ye. A bɛ kolotugudaw labɛn ni paratayiroyidi hormone endogène ka farikoloɲɛnajɛ walew ladege ye. Teriparatid ye fura fɔlɔ ye min dilannen don ni anaboliki ye, min dabɔra koloci jugumanba kama. A jɔcogo bɛ ɲɔgɔndɛmɛba jira ni PTH kɔnɔna na, o bɛ kɛ sababu ye ka PTH minɛbaga baarakɛli kɛ ka kolotugudaw ka farikoloɲɛnajɛ baara sɛmɛntiya.

Teriparatid ka wale kɛcogo ye mun ye?

A nɔ minnu bɛ kolotugudaw la:

A bɛ kolotugudaw caya sabati : Teriparatidi bɛ kolotugudaw ɲɛbila selilɛriw caya, ka dɔ fara kolotugudaw hakɛ kan. Baganw ka sɛgɛsɛgɛliw la, teriparatidi tali waati ni waati, o ye mesɛnkimi jirisunw caya teliya kosɛbɛ minnu bɛ se ka danfara don u ni ɲɔgɔn cɛ ka kɛ kolotugudaw ye kolotugudaw la. O kɛra sababu ye ka selilu caman kɛ ka danfara don u ni ɲɔgɔn cɛ ka kɛ kolotugudaw kɔgɔlenw ye, o kɛra sababu ye ka selilu caman di kolo dilancogo ma. In vitro cellule culture experiments y’a jira ko osteoblast precursor cellules tilali hakɛ Teriparatid furakɛli kulu la, o tun ka ca kosɛbɛ ka tɛmɛ control group kan, o b’a jira ko Teriparatid bɛ osteoblast precursor cellules caya sabati k’a ɲɛsin u yɛrɛ ma ^[1,.

Kolotugudaw ka baara caya : Teriparatid tɛ dɔ fara kolotugudaw hakɛ kan dɔrɔn, nka a bɛ dɔ fara u ka baara kan fana. A bɛ jeninida minnu bɛ tali kɛ kolotugudaw labɛnni na kolotugudaw la, olu jiracogo kɔrɔta, i n’a fɔ minnu bɛ kolajɛ suguya fɔlɔ ni kolotugudaw kofɔ, olu minnu bɛ dɔ fara kosɛbɛ jiracogo hakɛ kan kosɛbɛ. Kolazɛni suguya fɔlɔ, n’o ye kolotuguda yɔrɔ fɔlɔ ye, o bɛ kɛ sababu ye ka kolotuguda karamɔgɔya barikama dilan ni dɔ farali ye ɲɔgɔn kan. Osteocalcine jɔyɔrɔ ka bon kolotugudaw la, a kɛtɔ ka kalisiyɔmu ionw bilali sabati matiriyali kɔnɔ, o la, a bɛ kolotugudaw caya. O fɛɛrɛw sababu fɛ, kolotugudaw bɛ kolotugudaw labɛn ani k’u bɔ kɛnɛ kan ka ɲɛ, o bɛ kolo kura sɔrɔli nɔgɔya ^[2,3]..

Kolotugudaw ka apoptose balili : Ni farikolo cogoya bɛnnen don, kolotugudaw bɛ apoptose kɛ kolo dilanni baara kɛrɛnkɛrɛnnenw kɛlen kɔ. Teriparatid bɛ o apoptose kɛcogo in bali, ka kolotugudaw si janya. Teriparatid bɛ selilɛri taamasiɲɛw siraw baara minnu bɛ tali kɛ ɲɔgɔn na, i n’a fɔ PI3K/Akt sira. Ni baara kɛra, o sira in bɛ apoptose ni farikolojɔli dumuniw jirali bali, o bɛ kɛ sababu ye ka kolotugudaw dɛmɛ u ka kolo dilanni baara sabati ani ka kolo dilanni taabolo ni sabatili sabati ^[1,.

A nɔ minnu bɛ kolotugudaw la: Teriparatid ka nɔ minnu bɛ kolotugudaw la, olu ka gɛlɛn. Ni a tali bɛ kɛ tuma ni tuma, a bɛ nɔ bila kolotugudaw la ni fɛɛrɛw ye minnu tɛ ɲɛ. A bɛ kolotugudaw (OPG) bɔli sabati kolotugudaw la, o ye sitokini ye min bɛ siri ni ɲɔgɔndan ye ni nukilila facteur κB ligandi (RANKL) ka receptor activateur ye. RANKL ye kolotugudaw danfara ni u baarakɛcogo ɲɛnabɔbaga jɔnjɔn ye. Ni OPG sirilen don RANKL la, RANKL tɛ se ka siri RANK minɛbaga la kolotugudaw ɲɛfɛla selilɛriw sanfɛ, o bɛ kolotugudaw danfara ni u kɔgɔli bali ani ka kolo seginni dɔgɔya. Kolocibanabagatɔw la, ni koloci bɛ tɛmɛ a jɔli kan min bɛ na ni kolo bɔli ye, teriparatide bɛ koloci baara dɔgɔya o fɛɛrɛ in sababu fɛ. O bɛ balansi segin kɔsegin ni a dilanni cɛ, ka kolo sɔrɔli sabati ^[2,3]..

Jaa 1 Baarakɛyɔrɔw koloci furakɛli fɔlɔw la. Teriparatid, o ye parathyroïde hormone yɔrɔ ye min bɛ fara ɲɔgɔn kan, o bɛ dilancogo lawuli ni kolotugudaw baara caya ye ani ka dɔgɔya, a bɛ kolotugudaw sɔrɔli bali^kolo .

Modulation des voies de signalisation de la métabolisme de la bone:

Wnt/β-Catenin taamasiɲɛw sira : Wnt/β-catenin taamasiɲɛw sira jɔyɔrɔ ka bon kolo yiriwali ni kolo ka homeostasis sabatili la. Teriparatid bɛ o sira in baara, ka β-catenin dalajɛli ni nukilila jiginni sabati selilu kɔnɔ. Nukilila β-catenin bɛ siri ni sɛbɛnnikɛlanw ye minnu bɛ tali kɛ ɲɔgɔn na, ka kolo dilancogo ni ɲɔgɔn cɛ jamu sɛbɛnni daminɛ ani ka koloci kɛrɛnkɛrɛnnen Runx2 jirali bonya. Runx2 bɛ kolotugudaw danfara ni u baara ɲɛnabɔ ka taa a fɛ, o bɛ kolo dilancogo sabati. Nin sira in baarakɛli fana bɛ kolotugudaw danfara bali ka taa farikolojɔlifɛnw na, o bɛ kolotugudaw ka mesenchymal stem cells danfaraba sabati ka taa kolotugudaw bɔnsɔn fan fɛ, o bɛ dɔ fara kolo girinya kan ^[1,.

PTH/PTHrP minɛbaga taamasiɲɛw sira : Teriparatid, n’o ye paratayiroyidi ɔrimɔni (PTH) bɔɲɔgɔnko ye, o bɛ a nɔw jira fɔlɔ ni a sirili ye PTH/PTHrP minɛbaga la. Ni a sirilen don, Teriparatid bɛ jiginɛ taamasiɲɛw siraw baara i n’a fɔ cAMP/PKA sira ani PLC/PKC sira. O siraw baarakɛli bɛ kolotugudaw ni kolotugudaw baara ɲɛnabɔ, o bɛ kolotugudaw sɔrɔli sabati. cAMP/PKA sira bɛ kolotugudaw ni ɲɔgɔn cɛ jamu jirali bonya ni sɛbɛnnikɛlan ka baara kɛcogo sɛmɛntiya ye, ka sɔrɔ PLC/PKC sira bɛ nɔ bila sitokolola labɛnni kura ni selilɛriw ka lamagacogo la, o bɛ nɔ bila kolotugudaw ka jiginni ni u ka baara la ^[2,.

Teriparatid (Teriparatid) baarakɛcogo ye mun ye?

Koloci furakɛli

Kɔnɔbara basigilen kɔfɛ koloci : Teriparatidi ye farikolojidɛsɛ fura fɔlɔ ye min dabɔra ka musow furakɛ minnu bɛ kalolabɔ kɔfɛ, koloci jugumanba bɛ minnu na. Ni a bɛ kolo jɔli lawuli, a bɛ dɔ fara kolo girinya kan, o la, a bɛ dɔ bɔ kolo karilen na. Muso minnu bɛ kalolabɔ kɔfɛ, don o don teriparatidi tali bɛ dɔ fara kolotugudaw hakɛ kan, o bɛ dɔ bɔ kɔkolo karili farati la ni 65% ye ani kɔkolo karilenw tɛ minnu na ni 53% ye ni i ye a suma ni furakisɛ ta ye. Banabagatɔ kelen-kelen bɛɛ ka kunnafoniw sɛgɛsɛgɛli meta-sɛgɛsɛgɛli y’a jira ko kɔkolo kari farati dɔgɔyara 56% ni i ye a suma ni kɔrɔsilikɛlaw ye. Ka fara o kan, ni i ye a suma ni risedronate ye, Teriparatid ye kɔkolo ni kɛnɛyaso kari kura farati dɔgɔya ni 56% ni 52% ye, koloci jugumanba bɛ muso minnu na ^[3,6,.

Cɛw ka koloci: A dagalen don fana cɛw ka koloci furakɛli la. Quattrocchi E ni a ɲɔgɔnnaw. y’a jira ko cɛ kolocibanabagatɔw la, Teriparatid (pikiri 20μg ani 40μg don o don) ye dɔ fara jateminɛ na min bɛ kɛ kɔkolo kolotugudaw la: 5,9% 20μg kulu la ani 9,0% 40μg kulu la (u fila bɛɛ P < 0,001). Senkɔni kɔ la, koloci hakɛ cayara ni 1,5% ye 20μg kulu la (P = 0,021) ani ni 0,9% ye 40μg kulu la (P < 0,001 ⁾.

Glucocorticoïde-associé Osteoporosis : Teriparatid bɛ kɛ fana ka glucocorticoïde sɔrɔlen koloci furakɛ cɛw ni musomanw na minnu karilen don, o bɛ o banabagatɔw dɛmɛ ka kolo girinya caya ani ka kolo bɔnɛni ni kari farati dɔgɔya min bɛ sɔrɔ glucocorticoïde tali ^fɛ.

Kari kɛnɛya dɛmɛni : Karilen banabagatɔw fɛ, ka dɔ fara kolo bɔli kan waati dɔɔnin kɔnɔ kariyɔrɔ la, o nafa ka bon kosɛbɛ dilancogo la, jɔyɔrɔ min bɛ se ka kɛ teriparatide fɛ. A sɛgɛsɛgɛra baganw ka misaliw ni banabagatɔw bɛɛ la i n’a fɔ a bɛ se ka kɛ sababu ye ka kari kɛnɛya sabati. Hali ni ɲinini wɛrɛw ka kan ka kɛ, ɲinini minnu bɛ sen na, olu b’a jira ko a bɛ se ka kari kɛnɛya sabati ^{[3] .}.

Ɲɛgɛnɛsiraw kolo seginni : Kalan minnu bɛ tali kɛ o la, olu y’a jira ko Teriparatid bɛ se ka kɛ ɲɛgɛnɛsira kolo labɛnni na cogoyaw la i n’a fɔ dawolo koloci, ɲinw dawoloci basigilen, ɲinw doncogo koloci, ani ɲinw labɛnni ɲinw lamagacogo, yɔrɔ minnu na a bɛ ɲinw dilanni sabati. Nka, hadamadenw ka kɛnɛyako sɛgɛsɛgɛli wɛrɛw ka kan ka kɛ walasa k’a kɛcogo n’a nɔ juguw tiɲɛ da kɔnɔ kolo bana suguya caman na ^{[9] .}.

Kɔnɔmaya ni sinji dili koloci : Banabagatɔ minnu ka koloci bɛ sɔrɔ kɔnɔmaya ni sinji dili fɛ (PLO), furakɛli ni Teriparatid (20μg/day) ye ka fara kalisiyɔmu ni witamini D kan, o kɛra sababu ye ka kɔkolo kolotugudaw hakɛ caya kosɛbɛ kalo 12 ni kalo 24 kɔnɔ ni i ye a suma ni kalisiyɔmu ni witamini D dɔrɔn ye. Kalo 12 la, kɔkolo kolosinsinnanw hakɛ cayalenba hakɛ cayalenba kɛra 20,9 ± 11,9% ye teriparatidi kulu la ni 6,2 ± 4,8% ye kɔrɔsili kulu la (P < 0,001). Kalo 24 na, kɔkolo kolosinsinnanw hakɛ cayalenba kɛra 32,9 ± 13,4% ye banabagatɔ 7 la minnu furakɛra ni Teriparatid ye ani 12,2 ± 4,2% ye banabagatɔ 6 la minnu furakɛra ni kɔrɔsili ye (P = 0,001). Kɛnɛyaso kari kura si ma kɛ furakɛli senfɛ ^{[10] .}.

A kɛcogo kɛrɛnkɛrɛnnenw : Teriparatidi kofɔra ko kɛlenw na kolotugudaw kɛrɛnkɛrɛnnenw kan, i n’a fɔ koloci min bɛ sɔrɔ farikolojidɛsɛ fɛ (ABD) ni jolidɛsɛ ye. Muso min si bɛ san 51 na, n’a bɛ diyalizi kɛ, o ye jolidɛsɛ sɔrɔ paratayiroyidi bɔli kɔfɛ, o min sɛgɛsɛgɛra kolotuguda fɛ ko ABD. Teriparatid furakɛli kalo 12 kɔfɛ, joli la kalisiyɔmu hakɛ bɛ kɛ cogo la, o bɛ kɛ sababu ye ka Teriparatid ka jolidɛsɛ furakɛ min bɛ sɔrɔ ABD fɛ, o ye ko fɔlɔ ye min sɛbɛnnen don ^[11]..

Kuncɛli

Teriparatidi bɛ se ka kɛ koloci jugumanba la min ka kari farati ka bon. A jiralen don banabagatɔw la minnu ka koloci caman bɛ u la, minnu kolotugudaw ka dɔgɔn kosɛbɛ, ani minnu ka jaabi danmadɔ bɛ koloci furakɛlicogo kɔrɔw la.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Susan V. Bukata ye ɲininikɛla ye Rochester Iniwɛrisite ka furakɛli ni ɲinw furakɛli kalanso la, a ka baara ɲɛsinnen bɛ kolotugudaw ni farikolo banaw ma. A ye sɛbɛn caman sɛbɛn ɲɔgɔn fɛ minnu sinsinnen bɛ kolotugudaw furakɛli kan, kolo karilenw kɛnɛyali, ani farikolojidɛsɛ furaw tali kɛnɛyaso la i n’a fɔ teriparatidi kolotugudaw furakɛli la. A ka baara kɛra sababu ye ka furakɛli fɛɛrɛw faamuya walasa ka kolo dilancogo n’a lasegincogo sabati. Susan V. Bukata tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [1].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Bukata S. V., Puzas J. E., ani mɔgɔ wɛrɛw. Teriparatide tali kolotugudaw la. Sisan koloci kunnafoniw san 2010; 8(1): 28-33.DOI: 10.1007/s11914-010-0006-3.. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[2] Hasegawa T, Miyamoto Y, Yamamoto T, Amizuka N. [Teriparatide ka baara kɛcogo anaboliki kolocibanabagatɔw la]. Nihon Yakurigaku Zasshi ka san 2019; 153(1): 16-21.DOI: 10,1254/fpj.153,16.

[3] Marin F, Ma YL, ani a ɲɔgɔnnaw. Kolotugudaw ka kari ani kolotugudaw ka banaw: A kɛcogo, a jateminɛcogo ani a furakɛcogo. A bɛ sɔrɔ: Takahashi H. E., Burr D. B., Yamamoto N., eds. Teriparatid (Teriparatid) bɛ sɔrɔ. Singapuri: Springer Singapuri; 2022: 339-359.DOI: 10.1007/978-981-16-5613-2_22. Bamako, Mali.

[4] Hanley D, Adachi J, Bell A, Brown V. Denosumab: A kɛcogo ani kɛnɛyaso kɔlɔlɔw. Duniya kɔnɔ kɛnɛyaso baarakɛcogo gafe 2012; 66.DOI: 10.1111/ijcp.12022. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[5] Kim S. Paratayiroyidi ɔrimɔni kɛcogo ni a nafa koloci la. Kore dɔgɔtɔrɔso jɛkulu ka gafe 2022; 65: 361-365.DOI: 10,5124/jkma.2022.65.6.361.

[6] Stroup JS, Kane MP, Abu-Baker A. Teriparatidi koloci furakɛli la. Ameriki ka kɛnɛyako furakɛli gafe : Ajhp : Ameriki kɛnɛyako furakɛli jɛkulu ka gafe ofisiyali 2008; 65 6: 532-539. Ɲɛjirali dɔw. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[7] Quattrocchi E, Kourlas H. Teriparatid: seginnkanni. Dɔgɔtɔrɔso furakɛli 2004; 26 6: 841-854. Bamako, Mali. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[8] Minisola S, Cipriani C, Grotta G. D., ani mɔgɔ wɛrɛw. Kunnafoni kura minnu bɛ teriparatidi lakanani ni a nafa kan koloci furakɛli la. Furakɛcogo ɲɛtaa farikolo ni kolotugudaw banaw na 2019;DOI: 10.1177/1759720X19877994.

[9] Agnihotri R, Gaur S. Teriparatid tali ka ɲɛsin kolotugudaw labɛnni ma: Seginkanni kɛcogo sigilen. Journal of International Society of Preventive and Community Dentistry san 2021; 11(6): 639-643.DOI: 10.4103/jispcd.JISPCD_169_21. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[10] Lampropoulou-Adamidou K, Trovas G, Triantafyllopoulos I. K., ani mɔgɔ wɛrɛw. Teriparatidi furakɛli banabagatɔw la minnu koloci bɛ sɔrɔ kɔnɔmaya ni sinji dili fɛ. Tissue calcifié International 2021; 109(5): 554-562.DOI: 10.1007/s00223-021-00871-y. Bamako, Mali.

[11] Peugh J, Khalil A, Chan M. R., Hansen K. E., ani mɔgɔw ye baara kɛ ni u ye. Teriparatid furakɛli ka ɲɛsin jolidɛsɛ furakɛli ma min bɛ tali kɛ kolobana jugumanba la. Jbmr Plus 2019 sàn; 3(7): e10176.DOI: 10.1002/jbm4.10176.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, olu BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.