5-Amino-1MQ 10mg

▎ 5-Amino-1MQ Tsarin

▎ 5-Amino-1MQ Bincike

Menene asalin bincike na 5-Amino-1MQ?

Tare da ci gaba da karuwa a cikin abubuwan da ke faruwa a duniya na cututtuka na rayuwa irin su kiba da ciwon sukari, gano maƙasudi da magungunan da za su iya daidaita tsarin makamashi yadda ya kamata da inganta cututtuka na rayuwa ya zama muhimmin bincike na bincike. Nicotinamide N-methyltransferase (NNMT), babban enzyme na rayuwa, yana taka muhimmiyar rawa a cikin makamashi homeostasis. Yawan wuce gona da iri yana haifar da batutuwa kamar tara mai da juriya na insulin, yin tsarin NNMT ya zama maƙasudin warkewa don cututtukan da ke da alaƙa.

A kan wannan bayanan, 5-Amino-1MQ ya fito azaman takamaiman mai hana NNMT. Ta hanyar murkushe ayyukan NNMT, yana rage ƙarancin nicotinamide methylation, yana maido da matakan NAD + na intracellular kuma yana daidaita hanyoyin sigina masu alaƙa, ta haka inganta haɓakar lipid metabolism da haɓaka haɓakar insulin. 5-Amino-1-methylquinolinium ya fito a matsayin babban maƙasudin bincike don bincika sabbin dabarun warkewa game da rikice-rikice na rayuwa, yana haifar da bincike na asali akan hanyoyin sa.

Menene tasirin 5-Amino-1-methylquinolinium ke aiwatarwa akan metabolism na adipocyte?

Tasiri akan Adipogenesis

Hana Adipogenesis: Adipogenesis yana nufin tsari inda preadipocytes ke bambanta cikin adipocytes balagagge kuma suna tara lipids yayin ci gaban adipocyte. Bincike ya nuna cewa methylquinolinium scaffolds dauke da farko amine masu maye gurbin suna nuna babban tasiri ga duka masu wucewa da kuma jigilar jigilar kayayyaki, yayin da analogues na su suna nuna aikin hanawa na musamman akan nicotinamide N-methyltransferase (NNMT) ^[1] . Masu hanawa na NNMT suna hana adipogenesis a cikin adipocytes, suna haifar da hasashe cewa 5-Amino-1-methylquinolinium, idan yana da irin wannan aikin hanawa na NNMT, yana da yuwuwar rage adipogenesis ta hanyar hana NNMT. Alal misali, a cikin gwaje-gwajen adipocyte na al'ada, masu hana NNMT suna rage matakan 1-methylnicotinamide (1-MNA), ƙara yawan nicotinamide adenine dinucleotide (NAD⁺) da S- (5'-adenosyl) -L-methionine (SAM), da hana adipogenesis a cikin ƙwayoyin mai ^..

Tasirin maganganun jinsin da ke da alaƙa da adipogenesis: Adipogenesis an tsara shi ta hanyar jerin abubuwan da aka rubuta da kuma kwayoyin halitta, irin su peroxisome proliferator-activated receptor-gamma (PPAR-γ) da CCAT / haɓaka haɓakar furotin (C / EBP). Abubuwan da ake samu na Methylquinoline ba makawa suna yin tasiri ga lipogenesis ta hanyar tasirin maganganun waɗannan mahimman kwayoyin halitta.

Hoto 1 Zaɓaɓɓu da ƙananan ƙwayoyin ƙwayoyin ƙwayoyin cuta na nicotinamide N-methyltransferase suna jujjuya kiba mai kitse da ke haifar da kiba a cikin mice.

Source: ScienceDirect ^[1]

Tasiri kan Metabolism na Lipid

Tsarin sunadaran da ke da hannu cikin haɓakar lipid da lalata: metabolism na lipid ya ƙunshi matakai kamar haɓakar lipid, ajiya, da lalata. A cikin nazarin cututtukan cututtukan hanta mai haɗe-haɗe (MAFLD), Donglingcao yana daidaita ayyukan mai karɓar mai haɓaka mai haɓakawa-a (PPAR-α), sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), da acetyl-CoA carboxylase (ACC). 5-Amino-1-methylquinolinium na iya yin tasiri akan metabolism na lipid a cikin adipocytes ta hanyar irin wannan tsari, wato ta hanyar daidaita maganganun waɗannan mahimman sunadaran da ke da hannu wajen haɗakarwar lipid da lalata. Alal misali, idan 5-Amino-1-methylquinolinium zai iya daidaita maganganun PPAR-α, yana iya inganta haɓakar acid acid oxidation kuma ya rage tarin lipid a cikin adipocytes. Sabanin haka, idan ya shafi maganganun SREBP-1c, FAS, da sauransu, zai iya rinjayar tsarin tsarin hadakar acid.

Canza matakan metabolite na cikin salula don tasiri metabolism na lipid: Matakan metabolite na ciki suna taka muhimmiyar rawa wajen daidaita metabolism na lipid. Kamar yadda aka ambata a baya, masu hanawa na NNMT na iya canza matakan intracellular na metabolites irin su 1-MNA, NAD⁺, da SAM, ta haka yana tasiri metabolism na adipocyte ^[1] . Idan 5-Amino-1-methylquinolinium yana samar da irin wannan tasiri akan waɗannan matakan metabolite, zai daidaita metabolism na lipid a kaikaice. A matsayin mahimmin coenzyme na intracellular wanda ke da hannu cikin hanyoyin rayuwa da yawa, sauye-sauye a cikin matakan NAD⁺ na iya yin tasiri kan ayyukan da ke da alaƙa da lipid metabolism kamar fatty acid oxidation da sake zagayowar acid tricarboxylic.

Tasiri kan Metabolism na Makamashi

Tasiri akan Ayyukan Mitochondrial: Tsarin makamashi a cikin adipocytes yana da alaƙa da aikin mitochondrial. Nazarin ya nuna cewa a ƙarƙashin in vitro simulated a tsaye yanayin shimfidawa, ayyukan mitochondrial a cikin adipocytes yana ƙaruwa, haɓaka lipogenesis da haɓaka metabolism na salula ^[2] . Magungunan Methylquinolinium na iya canza ayyukan mitochondrial ta hanyar tasiri hanyoyin rayuwa masu alaƙa da mitochondrial ko bayanin furotin. Idan 5-Amino-1-methylquinolinium ya hana wasu mahimman sunadaran mitochondrial ko tafiyar matakai na rayuwa, yana iya rage ayyukan mitochondrial kuma rage kashe kuzari a cikin adipocytes. Akasin haka, yana iya haɓaka metabolism na makamashi. Misali, ta hanyar shafar ayyukan sarkar numfashi na mitochondrial, zai iya daidaita samar da ATP, ta yadda zai rinjayi yanayin makamashi da kuma tsarin rayuwa na adipocytes.

Gudanar da ma'aunin makamashi na adipocyte: Adipocytes ba wai kawai adana makamashi ba amma kuma suna shiga cikin tsarin ma'auni na makamashi. Tasirin 5-Amino-1-methylquinolinium akan metabolism na adipocyte na iya bayyana a ƙarshe a cikin ƙa'idodin daidaiton makamashi. Idan yana hana lipogenesis kuma yana haɓaka lipolysis, yana iya rage ajiyar makamashi da haɓaka sakin kuzari a cikin adipocytes. Sabanin haka, idan yana inganta lipogenesis kuma yana hana lipolysis, zai iya haifar da tarin makamashi mai yawa a cikin adipocytes, rushe ma'aunin makamashi-mahimmin mahimmanci a cikin haɓakar kiba da cututtukan da ke da alaƙa.

Tasiri akan Ayyukan Adpocyte Endocrine

Tasirin siginar adipokine: Kamar yadda gabobin endocrin, adipocytes ke ɓoye adipokines da yawa kamar leptin da adiponectin, waɗanda ke taka muhimmiyar rawa a cikin tsarin metabolism ^[3] . Wasu magunguna ko abubuwa na iya yin tasiri ga fitar da adipocyte na waɗannan adipokines. Duk da yake babu wata shaida ta kai tsaye game da tasirin 5-Amino-1-methylquinolinium akan ɓoyewar adipokine, tasirinsa gaba ɗaya akan metabolism na adipocyte yana nuna yuwuwar tsarin kai tsaye na sirrin adipokine. Idan 5-Amino-1-methylquinolinium ya canza matsayin makamashi na adipocyte ko metabolism na lipid, yana iya sake mayar da martani-daidaita fitar da leptin. A matsayin kwayar siginar siginar da ke nuna shagunan kitse, canje-canje a cikin siginar leptin suna tasiri ga ci da haɓakar kuzari.

Tasirin Sirrin Cytokine mai ƙumburi: Yanayin kumburin ƙwayar ƙwayar cuta yana da alaƙa da alaƙa da metabolism na adipocyte. Adipocytes na iya ɓoye cytokines masu kumburi daban-daban, irin su interleukin-1β (IL-1β), interleukin-6 (IL-6), da ƙari necrosis factor-α (TNF-α) (Michalczyk K). A cikin jihohin da ke da kiba, haɓakar kumburin nama na adipose yana haifar da haɓakar ɓoye waɗannan abubuwan kumburi, daga baya yana shafar metabolism na tsarin da kuma ji na insulin. 5-Amino-1-methylquinolinium, idan yana iya daidaita tsarin metabolism na adipocyte, na iya canza ɓoyewar cytokine, ta haka yana rinjayar microenvironment mai kumburi na ƙwayar adipose da kuma rinjayar matsalolin da ke da alaka da kiba. Ƙimar sa don hana ɓoyewar cytokine zai iya taimakawa wajen rage juriya na insulin da inganta yanayin rayuwa.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

Harshini Neelakantan masanin kimiyyar harhada magunguna ne kuma jagorar bincike tare da gogewa mai yawa a cikin haɓakar ƙwayar cuta ta asali don cututtukan rayuwa, ƙwayoyin cuta, da cututtukan musculoskeletal. A halin yanzu tana aiki a matsayin Babban Darakta na Bincike & Ci gaba a Ridgeline Therapeutics, tana mai da hankali kan fassarar ƙananan ƙwayoyin cuta daga ingantaccen bugun-zuwa jagora zuwa aikace-aikacen asibiti. Kwarewarta ta mamaye ilimin harhada magunguna na vivo, ƙirar cuta, da ƙwayoyin cuta, kuma a baya ta yi aiki a Reshen Likita na Jami'ar Texas. Harshini Neelakantan an jera shi cikin ma'anar ambaton [1].

▎ Abubuwan da suka dace

[1] Neelakantan H, Vance V, Wetzel MD, et al. Zaɓuɓɓuka da membrane-permeable ƙananan ƙwayoyin ƙwayoyin cuta na nicotinamide N-methyltransferase suna jujjuya kiba mai kiba mai haifar da kiba a cikin mice. Magungunan Magungunan Halittu 2018; 147: 141-152.DOI: 10.1016/j.bcp.2017.11.007.

[2] Mor-Yossef ML, Kislev N, Lustig M, Pomeraniec L, Benayahu D. Biomechanical stimulation effects on the metabolism of adipocyte. Jaridar Salon Halitta 2020; 235(11): 8702-8713.DOI: 10.1002/jcp.29714.

[3] Michalczyk K, Niklas N, Rychlicka M, Cymbaluk-Płoska A. Tasirin Abubuwan da ke Aiki Na Halittar Halittu da Tushen Adipose Ya Fada akan Ciwon daji na Endometrial. Bincike 2021; 11(3).DOI: 10.3390/diagnostics11030494.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.