5-Amino-1MQ 10mg

▎ 5-Amino-1MQ Ọdịdị

▎ 5-Amino-1MQ Nchọpụta

Kedu ihe ndabere nyocha nke 5-Amino-1MQ?

Na-aga n'ihu na ịrị elu ụwa ọnụ ọgụgụ nke ọrịa metabolic dị ka oke ibu na ọrịa shuga, na-achọpụta ebumnuche na ọgwụ ndị nwere ike ịchịkwa metabolism ike nke ọma ma melite ọrịa metabolic aghọwo nnukwu nyocha nyocha. Nicotinamide N-methyltransferase (NNMT), isi enzyme metabolic, na-arụ ọrụ dị mkpa na homeostasis ume. Ngosipụta nke oke ya na-eduga n'okwu ndị dị ka mkpokọta abụba na nguzogide insulin, na-eme ka usoro NNMT bụrụ ebumnuche ọgwụgwọ maka ọrịa ndị metụtara ya.

N'ime ihe ndabere a, 5-Amino-1MQ apụtala dị ka onye na-egbochi NNMT kpọmkwem. Site n'igbochi ọrụ NNMT, ọ na-ebelata nicotinamide methylation na-adịghị mma, na-eweghachi ọkwa NAD + intracellular ma na-edozi ụzọ mgbaàmà ndị metụtara ya, si otú ahụ na-eme ka metabolism lipid dịkwuo elu ma na-eme ka mmetụta insulin dịkwuo elu. 5-Amino-1-methylquinolinium apụtala dị ka ebumnuche nyocha bụ isi maka ịchọpụta usoro ọgwụgwọ ọhụụ megide ọrịa metabolic, na-akpali ọmụmụ ihe gbasara usoro ya.

Kedu mmetụta 5-Amino-1-methylquinolinium na-arụ na metabolism adipocyte?

Mmetụta na Adipogenesis

Mgbochi nke Adipogenesis: Adipogenesis na-ezo aka na usoro ebe preadipocytes dị iche n'ime adipocytes tozuru okè ma na-akwakọba lipids n'oge mmepe adipocyte. Nnyocha na-egosi na methylquinolinium scaffolds na-ebu ihe ndị na-eme ka amine bụ isi na-egosipụta ikike dị elu maka njem transmembrane na-agafe agafe na nke na-arụ ọrụ, ebe analogues ha na-egosipụta ọrụ mgbochi nhọrọ nke ukwuu megide nicotinamide N-methyltransferase (NNMT) ^[1] . Ndị na-egbochi NNMT na-egbochi adipogenesis na adipocytes, na-eduga n'echiche bụ na 5-Amino-1-methylquinolinium, ma ọ bụrụ na ọ nwere ọrụ mgbochi NNMT yiri nke ahụ, nwere ike ibelata adipogenesis site na igbochi NNMT. Dịka ọmụmaatụ, na nnwale adipocyte omenala, ndị na-emechi NNMT na-ebelata ọkwa intracellular 1-methylnicotinamide (1-MNA), na-abawanye nicotinamide adenine dinucleotide intracellular (NAD⁺) na S- (5'-adenosyl) -L-methionine (SAM), na igbochi adipogenesis na mkpụrụ ndụ abụba ^[1].

Na-emetụta mkpụrụ okwu mkpụrụ ndụ nke adipogenesis: A na-achịkwa Adipogenesis site na usoro ihe odide ederede na mkpụrụ ndụ ihe nketa, dị ka peroxisome proliferator-activated receptor-gamma (PPAR-γ) na CCAT / enhancer-binding protein (C / EBP). Mwepụta nke Methylquinoline na-apụghị izere ezere na-emetụta lipogenesis site na-emetụta okwu nke mkpụrụ ndụ ihe nketa ndị a.

Ọnụọgụ 1 Nhọrọ na akpụkpọ anụ-permeable obere ihe mgbochi molecule nke nicotinamide N-methyltransferase na-atụgharị oke abụba na-eri nri na-akpata oke ibu na oke.

Isi mmalite: ScienceDirect ^[1]

Mmetụta na Lipid Metabolism

Iwu nke protein na-etinye aka na njikọ lipid na mmebi: metabolism lipid gụnyere usoro dị ka njikọ lipid, nchekwa, na mmebi. N'ime ọmụmụ nke ọrịa ọrịa imeju abụba metụtara metabolic (MAFLD), Donglingcao na-agbanwe ọrụ nke onye na-anabata ihe na-arụ ọrụ peroxisome proliferator -α (PPAR-α), sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), na acetyl-CoA carboxylase (ACC). 5-Amino-1-methylquinolinium nwere ike imetụta metabolism lipid na adipocytes site na usoro yiri nke ahụ, ya bụ site n'ịhazi okwu nke protein ndị a bụ isi na-etinye aka na njikọ lipid na mmebi. Dịka ọmụmaatụ, ọ bụrụ na 5-Amino-1-methylquinolinium nwere ike ịkwalite okwu PPAR-α, ọ nwere ike ịkwalite oxidation fatty acid ma belata mkpokọta lipid n'ime adipocytes. N'aka nke ọzọ, ọ bụrụ na ọ na-emetụta nkwupụta nke SREBP-1c, FAS, na ndị ọzọ, ọ nwere ike imetụta usoro nhazi nke fatty acid.

Na-agbanwe ọkwa metabolite intracellular na-emetụta metabolism lipid: Ọkwa metabolite intracellular na-arụ ọrụ nchịkwa dị mkpa na metabolism lipid. Dị ka e kwuru na mbụ, ndị na-emechi NNMT nwere ike gbanwee ọkwa intracellular nke metabolites dị ka 1-MNA, NAD⁺, na SAM, si otú ahụ na-emetụta adipocyte metabolism ^[1] . Ọ bụrụ na 5-Amino-1-methylquinolinium na-emepụta mmetụta yiri nke ahụ na ọkwa metabolite ndị a, ọ ga-edozi metabolism lipid n'ezoghị ọnụ. Dị ka coenzyme intracellular dị mkpa na-etinye aka na ọtụtụ ụzọ metabolic, mgbanwe na ọkwa NAD⁺ nwere ike imetụta usoro metụtara metabolism lipid dị ka fatty acid oxidation na okirikiri tricarboxylic acid.

Mmetụta na Metabolism Energy

Mmetụta na Ọrụ Mitochondrial: Metabolism ume na adipocytes nwere njikọ chiri anya na ọrụ mitochondrial. Nnyocha na-egosi na n'okpuru in vitro simulated static agbatị ọnọdụ, mitochondrial ọrụ na adipocytes na-abawanye, na-akwalite lipogenesis na accelerating cellular metabolism ^[2] . Ngwakọta methylquinolinium nwere ike gbanwee ọrụ mitochondrial site na imetụta ụzọ metabolic metụtara mitochondrial ma ọ bụ nkwupụta protein. Ọ bụrụ na 5-Amino-1-methylquinolinium na-egbochi ụfọdụ protein mitochondrial isi ma ọ bụ usoro metabolic, ọ nwere ike ibelata ọrụ mitochondrial ma belata mmefu ume na adipocytes. N'aka nke ọzọ, ọ nwere ike ịkwalite metabolism ume. Dịka ọmụmaatụ, site na imetụta ọrụ nke mitochondrial respiratory chain complexs, ọ nwere ike ịhazi mmepụta ATP, si otú ahụ na-emetụta ọnọdụ ume na usoro metabolic nke adipocytes.

Na-achịkwa nguzozi ike adipocyte: Adipocytes ọ bụghị naanị na-echekwa ume kamakwa sonye na nhazi nguzozi ike. Mmetụta nke 5-Amino-1-methylquinolinium na adipocyte metabolism nwere ike pụta ìhè n'ikpeazụ na nhazi nguzozi ike. Ọ bụrụ na ọ na-egbochi lipogenesis ma na-akwalite lipolysis, ọ nwere ike ibelata nchekwa ike ma mee ka ntọhapụ ike dị na adipocytes. N'aka nke ọzọ, ọ bụrụ na ọ na-akwalite lipogenesis ma na-egbochi lipolysis, ọ nwere ike iduga mkpokọta ume dị ukwuu n'ime adipocytes, na-akpaghasị nguzozi ike-ihe dị mkpa na mmepe nke oke ibu na nsogbu metabolic metụtara ya.

Mmetụta na ọrụ Adipocyte Endocrine

Na-emetụta secretion adipokine: Dị ka akụkụ endocrine, adipocytes na-ezobe ọtụtụ adipokines dị ka leptin na adiponectin, bụ ndị na-arụ ọrụ nchịkwa dị mkpa na usoro nhazi usoro ^[3] . Ụfọdụ ọgwụ ma ọ bụ ihe nwere ike imetụta mmepụta adipocyte nke adipokines ndị a. Ọ bụ ezie na enweghị ihe akaebe ọ bụla gbasara mmetụta 5-Amino-1-methylquinolinium na nzuzo nzuzo nke adipokine, mmetụta ya n'ozuzu ya na metabolism adipocyte na-egosi ikike na-apụtaghị ìhè nke nzuzo nzuzo adipokine. Ọ bụrụ na 5-Amino-1-methylquinolinium na-agbanwe ọnọdụ ike adipocyte ma ọ bụ metabolism lipid, ọ nwere ike nzaghachi-na-achịkwa secretion leptin. Dị ka ihe na-egosi molekul na-egosipụta ụlọ ahịa abụba, mgbanwe na nzuzo nke leptin na-emetụta agụụ na metabolism ike.

Na-emetụta secretion Cytokine na-egbu egbu: Ọnọdụ mkpali nke anụ ahụ adipose jikọtara ya na metabolism adipocyte. Adipocytes nwere ike zoo cytokines dị iche iche na-egbu egbu, dị ka interleukin-1β (IL-1β), interleukin-6 (IL-6), na tumor necrosis factor-α (TNF-α) (Michalczyk K). Na steeti ndị buru ibu, ịba ụba anụ ahụ adipose na-eduga na nzuzo dị elu nke ihe ndị a na-akpasu iwe, na-emesị metụta metabolism sistemu yana mmetụta insulin. 5-Amino-1-methylquinolinium, ma ọ bụrụ na-enwe ike ịchịkwa adipocyte metabolism, nwere ike ịgbanwe cytokine secretion, si otú imetụta mkpali microenvironment nke adipose anụ ahụ na-emetụta oke ibu metụtara metabolic nsogbu. Ike ya igbochi secretion cytokine nwere ike inye aka belata nguzogide insulin ma melite ọkwa metabolic.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Harshini Neelakantan bụ ọkà mmụta sayensị ọgwụ na onye ndu nyocha nwere ahụmịhe dị ukwuu na mmepe ọgwụ preclinical maka ọrịa metabolic, akwara ozi na akwara. Ọ na-eje ozi ugbu a dị ka onye isi nchịkwa nke nyocha na mmepe na Ridgeline Therapeutics, na-elekwasị anya na nsụgharị nke usoro ọgwụgwọ obere-molecule site na ntinye aka na-eduga na ngwa ụlọ ọgwụ. Ọkachamara ya gbasara vivo pharmacology, ụdị ọrịa, na metabolism ọgwụ, ọ na-arụbu ọrụ na Mahadum Texas Medical Branch.Harshini Neelakantan ka edepụtara na ntụaka nke ntụaka [1].

▎ Okwu ndị dị mkpa

[1] Neelakantan H, Vance V, Wetzel MD, et al. Nhọrọ na akpụkpọ anụ-permeable obere molecule inhibitors nke nicotinamide N-methyltransferase na-atụgharị oke abụba na-eri nri na-ebute oke ibu na oke. Biochemical Pharmacology 2018; 147: 141-152.DOI: 10.1016/j.bcp.2017.11.007.

[2] Mor-Yossef ML, Kislev N, Lustig M, Pomeraniec L, Benayahu D. Biomechanical mkpali mmetụta na metabolism nke adipocyte. Akwụkwọ akụkọ Cellular Physiology 2020; 235(11): 8702-8713.DOI: 10.1002/jcp.29714.

[3] Michalczyk K, Niklas N, Rychlicka M, Cymbaluk-Płoska A. Mmetụta nke ihe ndị na-arụ ọrụ ndụ nke anụ ahụ adipose zoro na ọrịa cancer endometrial. Nchọpụta nchọpụta 2021; 11(3) .DOI: 10.3390/diagnostics11030494.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.