Research Ubushakashatsi bwa Cerebrolysin
Ni ubuhe bushakashatsi bwakozwe na Cerebrolysin?
Fondation Early Research: Mu ntangiriro z'ikinyejana cya 20, abahanga batangiye kwita ku ngaruka z'ibintu bimwe na bimwe bidasanzwe mu bwonko ku ngirabuzimafatizo. Muri kiriya gihe, byari bizwi ko mu bwonko hari ibintu bitandukanye bikoresha bioaktique, byagize uruhare runini mu mikurire, iterambere, gusana, no gufata neza ingirabuzimafatizo.
Ubu bushakashatsi bwambere bwashizeho urufatiro rwubushakashatsi bwubushakashatsi bwakurikiyeho ndetse niterambere rya cerebrolysine, bituma abashakashatsi bagerageza gukuramo no gutandukanya ibice bioaktique biva mubice byubwonko kugirango bavure indwara zifata imitsi.
Iterambere rya tekinoroji yo gukuramo: Hamwe niterambere ryikomeza ryibinyabuzima na tekinoroji ya biyolojiya y’ibinyabuzima, abashakashatsi bafite uburyo buhanitse bwo kuvana no kweza ibintu bioaktique biva mu bwonko.
Kuva mu myaka ya za 1960 kugeza mu myaka ya za 70, amatsinda amwe y’ubushakashatsi yakuye neza imvange zivanze mu ngingo z’ubwonko bw’inyamaswa nkubwonko bwingurube, zirimo aside amine zitandukanye, peptide, nibindi bikoresho bioaktike. Ibikururwa byerekanaga ingaruka zimirire nuburinzi kuri selile nervice mubushakashatsi bwinyamaswa kandi bishobora guteza imbere gukura no gusana ingirabuzimafatizo.
Ubushakashatsi ku miterere nuburyo bukoreshwa: Nyuma yimyaka yubushakashatsi, habonetse gusobanukirwa byimbitse imiterere nuburyo bwibikorwa bya cerebrolysin. Byagaragaye ko cerebrolysine irimo ibinyabuzima bitandukanye bya neurotransmitter, ibintu bya neurotrophique, hamwe na peptide ya bioactive. Ibi bice birashobora kurenga inzitizi yubwonko bwamaraso hanyuma bikinjira mubice byubwonko, bigakora kuri selile nervice, bigatera metabolism ya selile nervice, synthesis protein, hamwe no kurekura neurotransmitter, bityo bikazamura imikorere yingirabuzimafatizo kandi bikagira uruhare mukurinda no kwishura ingirabuzimafatizo zangiritse.
Ubushakashatsi bwibikorwa bya Clinical: Bishingiye ku ngaruka nziza zabyo mu bushakashatsi bw’inyamaswa, cerebrolysin yagiye ikoreshwa mubushakashatsi bwamavuriro. Ku ikubitiro, yakoreshejwe cyane cyane mu kuvura indwara zimwe na zimwe zifata ubwonko bwa sisitemu y'imitsi, nk'indwara ya Alzheimer, indwara ya Parkinson, n'indwara ziterwa n'imitsi iterwa n'ihungabana ry'ubwonko, indwara zifata ubwonko, n'ibindi.
Ni ubuhe buryo bwo gukora bwa Cerebrolysin?
1. Ifite ingaruka za neuroprotective
Kugabanya ibyangiritse kuri Hypoxic: Muri moderi ya vitro, nka moderi ya selile PC12 ivurwa na cobalt chloride (CoCl2), Cerebrolysin yerekana ingaruka za neuroprotective [1] . By'umwihariko, ikomeza diameter ya selile PC12 itandukanijwe nyuma yo kuvura CoCl2, igabanya kugabanuka kwa selile; igabanya ibikorwa bya pro-apoptotic Caspase muri selile PC12 itandukanijwe na stress ya CoCl2; igarura ibikorwa bya metabolike ya selile PC12 itandukanijwe kandi itandukanye yangijwe na CoCl2; kandi icyarimwe bigabanya urwego rwa superoxide rwagaragaye nyuma ya CoCl2. Uburyo bwibikorwa bushobora kuba binyuze mukwongera fosifora ya GSK3β, bityo bikabuza ibikorwa bya GSK3β. Ibi birashobora kugira akamaro kindwara ya Alzheimer, kubera ko ibikorwa bya GSK3β bifitanye isano no gukora amyloide β.
Uruhare muri Ischemic Stroke: Ku barwayi bafite ikibazo cyubwonko, Cerebrolysin irashobora kugira uruhare mu bwonko binyuze mu nzira nyinshi. Mu bigeragezo byambere by’amavuriro, iyo wiga ku baturage batewe n'ubwonko bworoheje, bitewe n’ubusanzwe abantu bamenyekana neza, hashobora kubaho ingaruka cyangwa igisenge, bigatuma nta tandukaniro rigaragara riri hagati y’amatsinda y’ubuvuzi [2] . Nyamara, isesengura ryitsinda ry’abarwayi barwaye cyane ryerekanye ko Cerebrolysin yagize uruhare runini mu kongera gukira, kandi n’ubunini bw’ingaruka zayo bwiyongereye n'uburemere bw'ubwonko. Byongeye kandi, Cerebrolysin irashobora guhuzwa neza hamwe nubuvuzi bwa trombolique. Ntabwo igira ingaruka gusa mu bwonko ahubwo ifite n'ubushobozi bwo gukira imitsi kandi ikerekana imikorere ku barwayi bafite ubwonko bukabije kandi bukabije [2, 3].
2. Nkumukozi wo gusana imitsi
Guteza imbere itumanaho hagati ya selile Nerv: Cerebrolysin nuruvange rwa proteine ruvanze na aside irimo aside amine yubusa 85% hamwe na 15% bioaktike nkeya-ifite uburemere buke bwa aminide acide, harimo na neuropeptide ifite uburemere buke [4, 5] . Ubu bwonko bukora ubwonko bushobora kwinjira mu nzitizi yubwonko bwamaraso kandi bugakoreshwa na neuron mugushyikirana.
Ingaruka ku ihungabana rya Neurodevelopmental: Muri neuropsychiatrie y’abana, Cerebrolysin ifatwa nkikintu cyitwa peptidergic gifite uburyo bwinshi bwo gukora kandi bukora nk'umukozi wo gusana imitsi. Mu ndwara ziterwa n'iterambere (PDD) zirimo na autism na syndrome ya Asperger, uburyo bushya bwo kuvura hamwe na Cerebrolysin yatewe inshinge nk'ibice nyamukuru bivura byerekanaga ko ibiranga autistic abarwayi bose bavuwe byateye imbere kandi bikagabanuka ku buryo bugaragara, kandi ibintu nyamukuru biranga autistic biranga abarwayi bamwe na bamwe byarazimye burundu nta ngaruka mbi [5].
3. Ingaruka zo kuvura kuri spasme nyuma yubwonko
Kunoza ibipimo bifitanye isano na spasme: Binyuze mu bushakashatsi bwakozwe n’umurwayi w’imyaka 56 ufite ubwonko budakira, Cerebrolysin yatewe inshinge mu gihimba cya spastique ku gipimo cya mL 10 ku munsi mu minsi 30. Nyuma yo kuvurwa, ibipimo bifitanye isano na spasme nkikizamini cya Manual Test (MMT) cyazamutseho 70%, naho igipimo cya Ashworth cyahinduwe (MAS) cyaragabanutseho amanota 2 [6] . Umurwayi yavuze kandi ingaruka nziza kumutima no kubitera imbaraga.
4. Ingaruka ku gukomeretsa umwijima
Kunoza ibipimo byerekana ibikomere byumwijima: Ku barwayi bafite indwara zidakira, kuvura ibintu byangiza ubuzima biragoye. Ku barwayi ba stroke bavuwe na Cerebrolysin, niba hari kwiyongera kwa aminotransferase (AST) na / cyangwa alanine aminotransferase (ALT), ubushakashatsi ku mavuriro bwerekanye ko Cerebrolysin ishobora kuzamura urwego rwa AST rw’abarwayi benshi bafite ibibazo by’umwijima [7].
Guhindura Kubuza Neurogenezi: Muburyo bwimbeba yindwara yumwijima idafite inzoga (NAFLD), mugusuzuma ibyavuye mumyitwarire namateka, byagaragaye ko Cerebrolysin ishobora guhindura imyitwarire imeze nkigihagararo ariko ikananirwa kunoza imitekerereze yigihe gito cyangwa gutabara ikwirakwizwa rya selile muri hippocampus nyuma yo gufata MCD ibiryo [7].
Ni ubuhe buryo bukoreshwa na Cerebrolysin?
Gusaba muri Neuropsychiatrie y'abana:
Guteza Imbere Utugingo ngengabuzima: Mu 1949, umuhanga Gerhart Harrer wo muri kaminuza ya Innsbruck muri Otirishiya yatangaje ko Cerebrolysin, amavuta ya poroteyine akorwa na hydrolysis ya enzymatique yo mu bwonko, ashobora gutera ingirabuzimafatizo. Cerebrolysin ni ivangwa rya poroteyine ishingiye ku mavuta igizwe na 85% ya amine acide yubusa na 15% bioaktike nkeya-ifite uburemere buke bwa aminide acide, harimo na neuropeptide ifite uburemere buke. Izi neuropeptide zirimo ubwonko bukomoka mu bwonko bukomoka mu bwonko, glial selile umurongo ukomoka kuri neurotrophique, ibintu bikura imitsi, hamwe na ciliary neurotrophique [4].
Uburyo bwa Multimodal Mechanism of Action: Cerebrolysin ifatwa nkibintu bya peptide hamwe nuburyo bwinshi bwibikorwa. Ubwonko bukora ubwonko burimo burashobora kwinjira mu nzitizi yubwonko bwamaraso kandi bugakoreshwa na neuron mugushyikirana. Umutekano wacyo, kwihanganira, no gukora neza washyizweho mubushakashatsi bwubushakashatsi no mu mavuriro. Cerebrolysin ifitanye isano nigihe kinini cyo kuvura idirishya kandi irashobora gukoreshwa nka neuroprotective na neurotrophique, ifasha gutinda gutera imbere kwindwara zubwonko [4].
Porogaramu mu Kuvura Indwara:
Ingaruka ku barwayi bafite uburemere butandukanye: Mu kuvura indwara y’imitsi, ibizamini byo kwa muganga hakiri kare byakorewe cyane cyane ku baturage bafite ibibazo by’ubwonko bworoheje, bakunze kugira ibimenyetso byiza. Ariko, kubera iri hitamo, hashobora kubaho ingaruka cyangwa igisenge mubikorwa byo gukira kubibazo byoroheje, bikagorana kwerekana inyungu zigaragara hagati yitsinda rivura. Ibinyuranye, isesengura ryitsinda ry’abarwayi barwaye cyane ryerekanye ko Cerebrolysin yagize ingaruka nziza mu kuzamura gukira. Ukurikije ibisubizo byubushakashatsi bwinshi, biragaragara ko ubunini bwingaruka za Cerebrolysin bwiyongera hamwe nuburemere bwubwonko [2].
Gukoresha hamwe hamwe nubuvuzi bwa Thrombolytike: Ubundi bushakashatsi bwagenzuwe bwerekanye ko Cerebrolysin ishobora guhuzwa neza hamwe nubuvuzi bwa trombolique. Vuba aha, Cerebrolysin ntiyageragejwe gusa ku ngaruka zayo zifata ubwonko gusa ahubwo inagaragaza ubushobozi bwayo bwo gukira imitsi kandi yerekanye ingaruka ku barwayi bafite ubwonko bukabije kandi bukabije [2].
Ingaruka ku Kugarura Imikorere: Cerebrolysin yerekanye inyungu kubarwayi bafite ikibazo cyubwonko bukabije kandi bukabije. Iyo ikoreshejwe ifatanije na neurorehabilitation ugereranije na neurorehabilitation yonyine, igira ingaruka rusange muburyo bwo gukira kwimikorere. Ibi bitanga icyerekezo cyibishushanyo mbonera byubushakashatsi mugihe kizaza.
Porogaramu mu Kuvura Ischemic Acute:
Ingaruka ku rupfu n’ibintu bibi: Ibimenyetso byujuje ubuziranenge byerekana ko Cerebrolysin ishobora kugira ingaruka nke mu gukumira impfu zose cyangwa umubare rusange w’ibintu bibi byakorewe mu bwonko bukabije. Muri icyo gihe, ibimenyetso bifite ireme kandi byerekana ko ikoreshwa rya Cerebrolysin rishobora kongera kubaho ibintu bibi bidahitana abantu [8] . By'umwihariko, mu itsinda rifite igipimo cya 30 mL mu minsi 10 (ikigereranyo cya cumulative ya 300 mL), kwiyongera kw'ibintu bikomeye bidahitana abantu byabaye bibi cyane [8].
Ingaruka ku bindi bipimo: Nta na kimwe mu bigeragezo byashyizwe ahagaragara cyerekanye ingaruka mbi zasobanuwe nk'urupfu cyangwa guterwa nyuma yigihe cyo gukurikirana, gupfa hakiri kare (mu byumweru bibiri nyuma yo gutangira ubwonko), igihe cyo gusubira mu bushobozi bw'akazi, n'ubuzima bwiza n'ibindi bipimo. Ikigeragezo kimwe gusa cyerekanye neza impamvu zitera urupfu, harimo n'indwara y'ubwonko, kunanirwa k'umutima, embolisme y'ibihaha, na pnewoniya, n'ibindi, ariko nta tandukaniro rito ryagabanijwe hagati y'itsinda rya Cerebrolysin n'itsinda rya placebo [8].
Porogaramu mu Kuvura Ubumuga bwo Kumenya:
Kunoza imikorere yubwenge no gutinza iterambere: Ubumuga bwo kutamenya nikimwe mubibazo byingenzi mubuvuzi bugezweho. Kugeza ubu, ku isi hari abantu barenga miliyoni 55 barwaye umutwe. Indwara yo guta umutwe ni imwe mu mpamvu nyamukuru zitera ubumuga no kwishingikiriza ku bageze mu za bukuru ku isi. Abarwayi benshi bafite ubumuga bworoheje bwo kumenya bafite ibyago byinshi byo kwandura indwara yo guta umutwe ugereranije na bagenzi babo. Bitewe n'ingaruka za COVID-19, umubare w'abarwayi bafite ubumuga bwo kutamenya nawo wariyongereye. Cerebrolysin ni ibiyobyabwenge bidashobora kunoza imikorere yubwenge gusa ahubwo binadindiza iterambere ryabyo [9].
Gusaba abarwayi bafite ikibazo cyumutimanama nyuma yubwonko:
Kunoza urwego rwimitekerereze: Ubushakashatsi bwisubireho bwerekanye ko Cerebrolysin ishobora kuzamura urwego rwimitekerereze yabarwayi mumitekerereze mike nyuma yubwonko. Muri ubu bushakashatsi, ubushakashatsi bwakozwe ku barwayi bafite ubwenge buke nyuma y’ubushakashatsi bwakozwe na ischemic na / cyangwa hemorhagie, kandi abo barwayi basuzumwe hakurikijwe ivugururwa rya Coma Recovery Scale (CRS-R). Abarwayi bose bahawe ubuvuzi bwuzuye burimo kuvura umubiri no kuvura akazi. Abarwayi bavuwe na Cerebrolysin bagereranijwe n'abatahawe imiti ya Cerebrolysin. Ibisubizo byerekanye ko nyuma yo guhindura ibintu bitera urujijo, itsinda ryivura Cerebrolysin ryagize iterambere ryinshi mumanota CRS-R, cyane cyane mumoteri yo mumunwa no kubyutsa [10].
Gusaba abarwayi bafite ibikomere byumwijima:
Ingaruka zo kuvura abarwayi bafite ibikomere byumwijima: Ku barwayi bafite indwara zidakira, kuvura ibintu bikaze byangiza ubuzima ni ikibazo kuko abaganga bakeneye gutekereza ku ngaruka z’imiti myinshi. Ku bijyanye na Cerebrolysin, nk'inyongera ya Sonic Hedgehog yerekana inzira imwe mu miti mike yemewe yo kuvura indwara ya neurotrophique ivura abarwayi ba stroke, hari impungenge z'uko gukora cyane inzira ya Hedgehog bishobora kwihutisha iterambere ry’indwara z’umwijima zidafite inzoga (NAFLD) kuri cirrhose. Byagaragaye ko Cerebrolysin yazamuye urwego rwa aspinate aminotransferase (AST) y’abarwayi benshi bafite ibibazo by’umwijima bafite ikibazo cy’umwijima. Mu bushakashatsi bwakozwe, Cerebrolysin yashoboye guhindura imyitwarire isa n’amaganya mu buryo bw’imbeba y’indwara y’umwijima idafite inzoga ariko ntiyahinduye neza igihe gito cyangwa ngo akize ikwirakwizwa ry’uturemangingo muri hippocampus nyuma yo gufata ibiryo bya MCD [7].
Mu gusoza, Cerebrolysin irashobora guteza imbere gusana no kuvugurura ingirangingo z'imitsi, igenga uburinganire bwa neurotransmitter kugira ngo iteze imbere ibimenyetso, itange intungamubiri ku ngirabuzimafatizo kandi yongere kwihanganira kwangirika, kandi inateze imbere imikurire. Mubuvuzi, cerebrolysin ikoreshwa cyane mukuvura indwara zinyuranye zifata imitsi nka ihahamuka ryubwonko hamwe na sequelae yindwara zifata ubwonko, zishobora kuzamura ibimenyetso byabarwayi nubuzima bwabo. Muri icyo gihe, nigikoresho cyingenzi mubushakashatsi bwubwonko, bufasha gusobanukirwa byimbitse kumikorere ya physiologique yingirabuzimafatizo hamwe nuburyo bwo guteza imbere no gusana sisitemu yimitsi, bitanga ibitekerezo nibitekerezo byo guteza imbere imiti mishya ya neuroprotective no gusana imiti, kandi ifite akamaro kanini mubijyanye no kuvura indwara zifata ubwonko nubushakashatsi bwa neuroscience.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Ziganshina LE numushakashatsi ufatanije ninzego nyinshi zizwi. Muri byo harimo Ishuri Rikuru ry’Ubuvuzi ry’Uburusiya rikomeza amashuri y’umwuga (RMANPO), Kaminuza y’Ubucuti y’Abarusiya, Kaminuza ya Leta y’Ubuvuzi ya Kazan, Ishuri Rikuru ry’Ubuvuzi ry’Uburusiya ry’Uburezi bw’umwuga, Minisiteri y’ubuzima y’Uburusiya, Cochrane Uburusiya, kaminuza nkuru ya Kazan, Minisiteri y’ubuzima ya Repubulika ya Tatarstan, Ishuri rikuru ry’ubuvuzi rya Kazan, na SV Kurashov Med Inst. Guhuza ibigo byerekana amateka akomeye mubumenyi bwubuvuzi nubuzima.
Inyungu zubushakashatsi bwe zikubiye mubyiciro bitandukanye. Afite ubuhanga muri rusange & Imbere mu Gihugu, Pharmacology & Farumasi, Ubuzima rusange, Ibidukikije & Ubuzima bw'akazi, Neurosciences & Neurology, n'Ubushakashatsi & Medicine Experimental Medicine. Ibikorwa bye muri izi nzego byerekana ubumenyi n’intererano mu guteza imbere ubumenyi bw’ubuvuzi n’ubuvuzi. Ziganshina LE yanditse murutonde rwibisobanuro [8].
