1kits (10Vials) .
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▎ Nukae nye Pancragen?
Pancragen nye tetrapeptide bioregulator si me amino acid ƒe ɖoɖo si nye Lys-Glu-Asp-Trp (KEDW) le.
▎ Pancragen ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PepDraw |
Nusiwo kplɔ wo nɔewo ɖo: Lys-Glu-Asp-Trp (KEDW) . Molekyulãwo ƒe Mɔfiame: C 26H 36N 6O9 Molekyulã ƒe Kpekpeme: 576.65g/mol PubChem ƒe CID: 68452887 |
▎ Pancragen Ŋuti Numekuku
Nukae nye Pancragen ƒe numekuku?
Tsitsi Kple Dɔlélewo Ŋuti Numekuku Dodo Ðe Ŋgɔ: Dzɔdzɔmeŋutinunyalawo ɖoe kplikpaa be yewoake ɖe nusiwo kple mɔnu siwo ate ŋu ade nu tsitsi ƒe ɖoɖoa me eye woana dɔléle siwo do ƒome kplii ƒe dzesiwo nanyo ɖe edzi la ŋu. Le tsitsi ƒe mɔnu ŋuti numekuku me la, wokpɔe be dɔgboa ƒe dɔwɔwɔ ƒe ɖiɖi wɔa akpa vevi aɖe le ame tsitsiwo ƒe dɔléle geɖe ƒe dzɔdzɔ kple woƒe dzɔdzɔ me, si na numekulawo lé fɔ ɖe nusiwo wɔa dɔ siwo ate ŋu aɖɔ dɔgboa ƒe dɔwɔwɔ ɖo ŋu.
Peptide-nuwo Didi: Peptide-nuawo wɔa dɔ vevi vovovowo le ŋutilã me eye wole dedie vie eye woƒe nugbegblẽ le ame ŋu ʋɛ aɖewo koe. Numekulawo do molecule siwo ate ŋu aɖɔ dɔgboa ƒe dɔwɔwɔ ɖo le peptide-nu gbogbo aɖewo dome kpɔ. To dzɔdzɔme kple nuwɔwɔ ƒe peptide gbogbo aɖewo ŋuti numekuku me la, wokpɔe be peptide aɖewo siwo ƒe amino acid ƒe ɖoɖo tɔxɛwo ate ŋu akpɔ ŋusẽ ɖe dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi le ɖoɖowɔwɔ me.
Pancragen ƒe Kekeɖenuŋu: Le dodokpɔ kple dodokpɔ vovovowo megbe la, numekulawo ke ɖe tetrapeptide Pancragen ŋu, si me amino acid ƒe ɖoɖo si nye Lys-Glu-Asp-Trp le. Numekuku bubuwo ɖee fia be Pancragen ɖe ŋusẽkpɔɖeamedzi nyuiwo fia ɖe dɔgboa ƒe lãmenugbagbeviwo ŋu le lãmenugbagbeviwo dodokpɔ kple lãwo ƒe kpɔɖeŋuwo me, abe dɔgbo ƒe lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ kple insulin kple glucagon ƒe dodo dzi kpɔkpɔ ene, si ɖo gɔmeɖoanyi na eƒe dɔdamɔnu ŋuti numekuku kple eŋudɔwɔwɔ emegbe.
Nukae nye Pancragen ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋusẽkpɔɖeamedzi ɖe Dɔgboa ƒe Lãmenugbagbeviwo ƒe Vovototodedeameme Dzi
Vovototodedeameme Nuwo Ƒe Ðeɖefia ƒe Ʋuʋu: Ne dɔgboa me lãmenugbagbeviwo le tsitsim la, woƒe vovototodedeameme ƒe dzesiwo ƒe ɖeɖefia dzi ɖena kpɔtɔna. Pancragen ateŋu aʋã vovototodedeamemenuwo ƒe ɖeɖefia le dɔgboa ƒe lãmenugbagbeviwo me, si me vovototodedeamemenuwo ƒe ɖeɖefia le acinar lãmenugbagbeviwo (Pdx1, Ptfla) kple ƒukpo lãmenugbagbeviwo me hã le. Wokpɔa ŋusẽkpɔɖeamedzi sia le 'sɔhɛ' kple 'ame tsitsi' dekɔnuwo siaa me [1] . Dɔwɔwɔ sia si doa ŋusẽ ame kpena ɖe ame ŋu be dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie nanɔ anyi. Vevietɔ le tsitsime la, ate ŋu ado lãmenugbagbeviwo ƒe vovototodedeameme ɖe ŋgɔ, si ana dɔgboa ƒe dɔwɔwɔ bliboa nanyo ɖe edzi.
Mɔnu siwo tsia suklidɔ nu kple esiwo tsi tre ɖe dɔdzẽ ŋu: Vovototo si le dɔgboa ƒe acinar lãmenugbagbeviwo kple ƒukpo lãmenugbagbeviwo ƒe vovototo si Pancragen hena vɛ ate ŋu anye mɔnu siwo dzi wòtona tsia suklidɔ kple dɔdzẽ nu la dometɔ ɖeka. To dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ me la, Pancragen ate ŋu aɖɔ dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo, si ana woate ŋu aɖɔ sukli ƒe agbɔsɔsɔ le ʋu me ɖo nyuie wu, eye ate ŋu aɖe dɔdzẽ ƒe ŋuɖoɖo hã dzi akpɔtɔ [1] . Nuŋɔŋlɔ ƒe nuwɔna wɔa akpa vevi aɖe le ɖoɖowɔwɔ me le dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme me, eye Pancragen tɔa ŋku nuŋɔŋlɔ ƒe nuwɔna siawo le atikeŋutinunya me, si wɔe be wònye dɔwɔnu nyui aɖe na lãmenugbagbeviwo ƒe dɔwɔwɔ kple dɔgbo ƒe dɔléle dada [1]..
2. Ŋusẽkpɔɖeamedzi ɖe Dɔgbo ƒe Dɔwɔna Siwo Le Boso Tsitsiwo Me
Glucose ƒe asitɔtrɔ le wo ŋu ƒe nyonyo: Le boso tsitsiwo gome la, le sukli ƒe agbɔsɔsɔ si woɖo ɖi nana vɔ megbe, ne wotsɔe sɔ kple boso viwo la, sukli ƒe 'bu' ƒe agbɔsɔsɔ le boso tsitsiwo me le ʋɛ wu, eye insulin kple C-peptide ƒe agbɔsɔsɔ si sɔ gbɔ wu (aɖabaƒoƒo 5 kple aɖabaƒoƒo 15 le sukli dodo vɔ megbe) sɔa gbɔ wu. Pancragen (tetrapeptide Lys-Glu-Asp-Trp) (50μg na lã ɖeka gbesiagbe, dodo ɖe lãmeka me, hena ŋkeke 10) nana ateŋu adzi sukli 'bu' ƒe agbɔsɔsɔ ɖe edzi ŋutɔ le boso tsitsiwo me eye wòana plasma insulin kple C-peptide ƒe dɔwɔwɔ ɖe sukli ŋu ƒe ʋuʋu nasɔ [2] ..
Gbugbɔgaɖoanyi ƒe Ŋusẽkpɔɖeamedzi si Nɔa Anyi: Pancragen ƒe ŋusẽkpɔɖeamedzi ɖe dɔgboa ƒe dɔwɔwɔ gbugbɔgaɖoanyi dzi nɔa anyi ƒe akpa aɖe ne woɖe asi le atike la ŋu vɔ megbe. Kwasiɖa etɔ̃ le atike la dzudzɔ megbe la, ŋusẽ si Pancragen kpɔna ɖe boso tsitsiwo ƒe dɔgbo ƒe dɔwɔwɔ gbugbɔgaɖoanyi dzi la gakpɔtɔ li vaseɖe afi aɖe, si ɖee fia be Pancragen ate ŋu akpɔ ŋusẽ ɖe dɔdamɔnu dzi ɣeyiɣi didi [2] ..
3. Lãmetsiŋusẽ ƒe Dɔlélewo Ðɔɖɔɖo le Ame Tsitsiwo Me
Ʋumesukli kple Insulin ƒe Agbɔsɔsɔme Dzi Ðeɖe Akpɔtɔ: Le dɔnɔ tsitsi siwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi eve le gome la, Pancragen ate ŋu aɖe sukli ƒe agbɔsɔsɔ dzi akpɔtɔ ŋutɔ le nutsitsidɔ me kple le suklidɔ ƒe mɔɖeɖe ɖe nu ŋu dodokpɔ si wowɔna ɖaa me, eye wòaɖe insulin ƒe agbɔsɔsɔ kple insulin ƒe tsitretsitsi ƒe dzesi si le ʋumenugbagbevi dzĩ me hã dzi akpɔtɔ. Le dɔnɔ siwo womewɔ Pancragen dɔdamɔnu na o gome la, womekpɔ tɔtrɔ aɖeke le carbohydrate ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dzesi ŋu o. Esia ɖee fia be Pancragen kpɔa ŋusẽ ɖe ame tsitsiwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxiwo ɖɔɖɔɖo dzi, vevietɔ na dɔnɔ tsitsi siwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 [3]..
Insulin ƒe Tsitretsitsi ƒe Nyonyome: Tɔtɔ si le pineal melatonin wɔwɔ ƒe dɔwɔwɔ me le ame tsitsiwo me kpena ɖe insulin ƒe dɔlélenutsiŋutete ŋu. Pancragen dodo nye mɔnu si ŋugbe wodo be woatsɔ aɖɔ insulin ƒe dɔlélenutsiŋutete ɖo le ame tsitsiwo me. Le dɔnɔ tsitsiwo gome la, Pancragen peptide la kpɔa ŋusẽ bubu si ɖea suklidɔ dzi kpɔtɔna ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 dzi, vevietɔ le dɔnɔ siwo ƒe insulin ƒe dɔlélenutsiŋutete sɔ gbɔ le gɔmedzedzea me eye insulin ƒe agbɔsɔsɔ si gbɔ eme le. Le peptide dzadzraɖo ƒe ŋusẽkpɔɖeamedzi te la, Homa insulin ƒe tsitretsitsi ƒe dzesi dzi ɖena kpɔtɔna [4]..
Nukae nye Pancragen ƒe dɔwɔwɔ?
1. Ŋusẽkpɔɖeamedzi si Tsi Tre Ðe Tsitsi Ŋu
Ne amewo le tsitsim la, dɔgboa me lãmenugbagbeviwo ƒe dɔwɔwɔ dzi ɖena kpɔtɔna vivivi. Pancragen ate ŋu aʋã vovototodedeameme ƒe nu vovovowo ƒe ɖeɖefia le dɔgboa ƒe lãmenugbagbeviwo me, ana lãmenugbagbeviwo nawɔ dɔ nyuie wu, eye wòana dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nanyo ɖe edzi, si ana dɔgboa ƒe tsitsi nahe ɖe megbe vaseɖe afi aɖe. Tsitsi hea dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi ɖena kpɔtɔna eye wònaa lãmenugbagbeviwo ƒe dɔwɔwɔ abe lãmenugbagbeviwo ƒe dɔwɔwɔ ene ƒe afɔkua dzina ɖe edzi. Pancragen ate ŋu ahe dɔgboa ƒe lãmenugbagbeviwo ƒe tsitsi ɖe megbe to vovototodedeameme ƒe nusiwo woɖena fiana le dɔgboa ƒe lãmenugbagbeviwo me dodo ɖe ŋgɔ me. Le kpɔɖeŋu me, le lãwo dodokpɔ aɖewo me la, Pancragen ate ŋu ana dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nanyo ɖe edzi le lã tsitsiwo me eye wòahe dɔgboa ƒe tsitsi ɖe megbe [4]..
2. Kpekpeɖeŋunana Dɔgboa ƒe Lãmenugbagbeviwo ƒe Vovototodedeameme
Pancragen ate ŋu awɔ nu kple DNA ƒe ɖoɖo siwo le dɔgboa ƒe lãmenugbagbeviwo me, akpɔ ŋusẽ ɖe domenyiŋusẽfianu ƒe ɖeɖefia dzi, eye wòato esia me ado dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme ɖe ŋgɔ, si ana dɔgboa ƒe wɔwɔme kple dɔwɔwɔ si sɔ la nanɔ anyi. Dɔwɔwɔ ƒe mɔnu sia ɖee fia be Pancragen ate ŋu adze dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme ƒe dzesimɔ gɔme to domenyiŋusẽfianu tɔxɛwo ƒe ɖeɖefia dzi kpɔkpɔ me. Le kpɔɖeŋu me, numekukuwo ɖee fia be Pancragen ate ŋu aʋã vovototodedeameme ƒe nu vevi aɖewo ƒe ɖeɖefia le dɔgboa ƒe lãmenugbagbeviwo me [1] . Nusiwo wotsɔna ŋlɔa nu wɔa akpa vevi aɖe le dɔgboa ƒe lãmenugbagbeviwo ƒe vovototodedeameme me. Woate ŋu aɖɔ dɔgboa ƒe lãmenugbagbeviwo ƒe tsitsi kple dɔwɔwɔ ɖo eye woalé dɔgboa ƒe ŋutilã ƒe dɔwɔwɔ si sɔ la me ɖe asi.
3. Insulin kple Glucagon ƒe Ʋuʋu ƒe Ðoɖowɔwɔ
Le numekukuwo me la, Pancragen ɖee fia be ekpɔa ŋusẽ ɖe dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi, si kpena ɖe ame ŋu wòɖɔa insulin kple suklidɔ ƒe dodo ɖo eye wònana sukli si le ʋu me la nada asɔ. Insulin kple sukli nye lãmetsi vevi siwo ana sukli ƒe agbɔsɔsɔ le ʋu me naɖɔ ɖo, eye woƒe dodo ƒe dadasɔ le vevie ŋutɔ be sukli ƒe agbɔsɔsɔ si le ʋu me nali ke. Pancragen ate ŋu aɖɔ insulin kple glucagon ƒe dodo ɖo to ŋusẽkpɔkpɔ ɖe dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi me. Le kpɔɖeŋu me, le lãwo dodokpɔ me la, Pancragen ate ŋu aɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ eye wòaɖɔ insulin kple C-peptide ƒe agbɔsɔsɔ ɖo [5] . Esia ɖee fia be Pancragen ate ŋu ana sukli ƒe asitɔtrɔ nanyo ɖe edzi eye wòana sukli si le ʋu me nada asɔ to dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me.
4. Ʋumesukli ƒe Dadasɔ Dodo Ðe Ŋgɔ
Insulin ƒe Tsitretsitsi ƒe Nyonyome: Akpa si Pancragen ate ŋu awɔ le sukli ƒe agbɔsɔsɔ si le ʋu me dzi kpɔkpɔ me. Ate ŋu aɖe sukli si le ʋu me le nutsitsidɔ me dzi akpɔtɔ, aɖe insulin ƒe agbɔsɔsɔ kple insulin ƒe dɔlélenutsiŋutete ƒe dzesi dzi akpɔtɔ, eye wòato esia me akpɔ ŋusẽ nyui ɖe insulin ƒe dɔlélenutsiŋutete ƒe nyonyo dzi. Insulin ƒe dɔlélenutsiŋutete nye dɔléle vevi siwo hea lãmenugbagbeviwo ƒe dɔwɔwɔ ƒomevi 2 vɛ dometɔ ɖeka, eye insulin ƒe dɔlélenutsiŋutete ƒe nyonyome ate ŋu axe mɔ ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ nu nyuie ahadae. Pancragen ate ŋu aɖɔ lãmenugbagbeviwo ƒe sukli ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ ɖo, aɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ, eye wòaɖe insulin ƒe dodo dzi akpɔtɔ, si ana insulin ƒe dɔlélenutsiŋutete nanyo ɖe edzi. Le kpɔɖeŋu me, le lãwo ƒe kpɔɖeŋu ŋuti numekuku aɖewo me la, Pancragen ate ŋu aɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ eye wòana insulin ƒe dɔlélenutsiŋutete nanyo ɖe edzi [2, 4]..
Sukli ƒe Dɔwɔnawo Dzi Kpɔkpɔ: Ate ŋu aɖɔ lãmenugbagbeviwo ƒe sukli ƒe xɔxɔ kple eŋudɔwɔwɔ ɖo to ŋusẽkpɔkpɔ ɖe enzyme vevi siwo le sukli ƒe asitɔtrɔ me dzi, si akpe ɖe eŋu be sukli ƒe agbɔsɔsɔ le ʋu me nali ke, si le vevie ŋutɔ le mɔxexe ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo abe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle ene nu ahawɔ wo ŋudɔ nyuie wu. Glucose ƒe asitɔtrɔ nye nu vevi aɖe si ana amegbetɔ ƒe ŋutilã ƒe ŋutilã ƒe dɔwɔwɔ nyuie nalé ɖe te. Sukli ƒe asitɔtrɔ le lãme na ame ƒe ɖoɖowɔwɔ ate ŋu axe mɔ ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ abe lãmenugbagbeviwo ƒe dɔwɔwɔ ene nu nyuie ahada wo. Pancragen ate ŋu aɖɔ lãmenugbagbeviwo ƒe sukli ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ ɖo to ŋusẽkpɔkpɔ ɖe enzyme vevi siwo le sukli ƒe asitɔtrɔ me, abe sukli tsɔtsɔ yi teƒe bubuwo kple hexokinase ene, dzi be sukli ƒe agbɔsɔsɔ si le ʋu me nali ke. Le kpɔɖeŋu me, le dodokpɔ aɖewo siwo wowɔna le lãwo ŋu me la, Pancragen ate ŋu aɖɔ sukli ƒe asitɔtrɔ ɖo eye wòana sukli ƒe agbɔsɔsɔ le ʋu me nanyo ɖe edzi [2, 4]..
5. Kpekpeɖeŋunana Endocrine Dɔwɔwɔ
Lãmetsiŋusẽ ƒe Dadasɔ: Pancragen ƒe ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpena ɖe lãmetsiŋusẽ ƒe agbɔsɔsɔ si le ŋutilãa me ƒe dadasɔ ŋu, vevietɔ insulin kple glucagon ƒe dadasɔ, si le vevie ŋutɔ na lãmenugbagbeviwo ƒe lãmesẽ bliboa. Insulin kple sukli nye lãmetsi vevi siwo ana sukli ƒe agbɔsɔsɔ le ʋu me naɖɔ ɖo, eye woƒe dodo ƒe dadasɔ le vevie ŋutɔ be sukli ƒe agbɔsɔsɔ si le ʋu me nali ke. Pancragen ate ŋu ana insulin kple glucagon nada asɔ to dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me. Le kpɔɖeŋu me, le lãwo dodokpɔ aɖewo me la, Pancragen ate ŋu aɖɔ insulin kple suklidɔ ƒe dodo ɖo eye wòana sukli ƒe agbɔsɔsɔ si le ʋu me nali ke [2, 4]..
6. Lãmetsiŋusẽ ƒe Dɔwɔnawo Dzikpɔkpɔ
Ʋumesukli Kple Insulin ƒe Agbɔsɔsɔme Dzi Kpɔkpɔ: Le numekuku aɖewo me la, Pancragen ɖee fia be eɖea suklidɔ ƒe agbɔsɔsɔ dzi kpɔtɔna le ʋu me si sɔ kple suklidɔtike siwo wozãna zi geɖe tsɔ ɖea suklidɔ dzi kpɔtɔna. Le ɣeyiɣi ma ke me la, ate ŋu aɖɔ insulin kple C-peptide ƒe agbɔsɔsɔ ɖo nyuie wu, eye wole mɔ kpɔm be ava zu atike yeye na lãmenugbagbeviwo ƒe dɔwɔwɔ. Lãmetsiŋusẽ ƒe dɔwɔwɔ nye lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle sesẽ aɖe, eye sukli ƒe agbɔsɔsɔ dzi ɖuɖu le ʋu me nye nu vevitɔ si woatsɔ ada lãmenugbagbeviwo ƒe dɔwɔwɔ. Pancragen ate ŋu aɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ eye wòaɖɔ insulin kple C-peptide ƒe agbɔsɔsɔ ɖo to dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me. Le kpɔɖeŋu me, le dodokpɔ aɖewo siwo wowɔna le lãwo ŋu me la, Pancragen ate ŋu aɖe sukli ƒe agbɔsɔsɔ le ʋu me dzi akpɔtɔ eye wòaɖɔ insulin kple C-peptide ƒe agbɔsɔsɔ ɖo, eye eƒe ŋusẽkpɔɖeamedzi sɔ kple suklidɔ ƒe atike siwo wozãna zi geɖe [2, 4, 5]..
Dɔgboa ƒe β-lãmenugbagbeviwo ƒe Dɔwɔwɔ Takpɔkpɔ: To dɔgboa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple dɔwɔwɔ nyuie wu me la, Pancragen ate ŋu akpe ɖe dɔgboa ƒe β-lãmenugbagbeviwo takpɔkpɔ ŋu eye wòana lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ŋgɔyiyi nagbɔdzɔ, si le vevie ŋutɔ na lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe mɔxexe ɖe enu kple edada. Dɔgboa ƒe β-lãmenugbagbeviwoe nye lãmenugbagbevi vevitɔ siwo ɖea insulin ɖa, eye dɔgboa ƒe β-lãmenugbagbeviwo ƒe dɔwɔwɔ takpɔkpɔ le vevie ŋutɔ na mɔxexe ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ nu kple edada. Pancragen ate ŋu akpɔ dɔgboa ƒe β-lãmenugbagbeviwo ta to dɔgbo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple dɔwɔwɔ nyuie wu me.
7. Dɔdzẽ si Nɔa Anyi Didi ƒe Atikewɔwɔ
Dɔdzẽ ƒe Ŋuɖoɖo Dzi Ðeɖe Akpɔtɔ: Dɔlékuiwutike aɖe le dɔdzẽ ŋu, si ate ŋu aɖe dɔdzẽ ƒe dɔwɔwɔ dzi akpɔtɔ eye wòaɖe dɔdzẽ si nɔa anyi didi ƒe dzesiwo dzi akpɔtɔ. Dɔdzẽ si nɔa anyi didi nye dɔgbo ƒe dɔléle si bɔ, eye dɔdzẽ ƒe ŋuɖoɖo nye dɔléle vevi siwo le dɔdzẽ si nɔa anyi didi me la dometɔ ɖeka. Pancragen ate ŋu aɖe dɔdzẽ ƒe ŋuɖoɖo dzi akpɔtɔ to dɔdzẽ ƒe nusiwo woɖena fiana dzi kpɔkpɔ me. Le kpɔɖeŋu me, le dodokpɔ aɖewo siwo wowɔ le lãwo ŋu me la, Pancragen ate ŋu aɖe dɔdzẽ ƒe dɔwɔwɔ dzi akpɔtɔ eye wòaɖe dɔdzẽ si nɔa anyi didi ƒe dzesiwo dzi akpɔtɔ.
Dɔgboa ƒe Lãmetsiwo Dzadzraɖo Dodo Ðe Ŋgɔ: Ate ŋu ado dɔgboa ƒe lãkusiwo dzadzraɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ to lãmenugbagbeviwo ƒe dzidziɖedzi kple woƒe vovototodedeameme dzi kpɔkpɔ me, si akpe ɖe dɔgboa ƒe dɔwɔwɔ ƒe nɔnɔme ŋu wòanyo ɖe edzi. Dɔgbo ƒe lãkusiwo dzadzraɖo kple wo gbugbɔgawɔ le vevie ŋutɔ na dɔgbo ƒe dɔléle si nɔa anyi didi dada. Pancragen ate ŋu ado dɔgboa ƒe lãkusiwo dzadzraɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ to lãmenugbagbeviwo ƒe dzidziɖedzi kple woƒe vovototodedeameme dzi kpɔkpɔ me. Le kpɔɖeŋu me, le lãwo dodokpɔ aɖewo me la, Pancragen ate ŋu ado dɔgboa ƒe lãkusiwo dzadzraɖo kple wo gbugbɔgawɔ ɖe ŋgɔ eye wòana dɔgboa ƒe dɔwɔwɔ nanyo ɖe edzi.
Le nyataƒoƒo me la, Pancragen wɔa akpa vevi aɖe le dɔwɔwɔ ɖe tsitsi ŋu, dɔgboa ƒe dɔwɔwɔ dzi kpɔkpɔ, ʋumesukli ƒe dadasɔ dodo ɖe ŋgɔ, kpekpeɖeŋu nana lãmenugbagbeviwo ƒe dɔwɔwɔ, kpakple le lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ kple dɔgbo ƒe dɔléle si nɔa anyi didi dada me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Khavinson VK nye numekula xɔŋkɔ aɖe si do ƒome geɖe le dɔwɔƒe xɔŋkɔ geɖewo me. Esiawo dometɔ aɖewoe nye Russiatɔwo ƒe Dzɔdzɔmeŋutinunya Suku, St Petersburg ƒe Nu Gbagbewo ƒe Ðoɖowɔwɔ Kple Ame Tsitsiwo Ŋuti Nusrɔ̃ƒe, Dzieheɣetoɖoƒe Dukɔa ƒe Atikewɔwɔ Yunivɛsiti si wotsɔ ŋkɔ na II Mechnikov, Pavlov Dzɔdzɔmeŋutinunya Suku, Russiatɔwo ƒe Atikeŋutinunya Suku, kple Peter St. Petersburg Gãtɔ ƒe Mɔ̃ɖaŋununya Yunivɛsiti, kpakple bubuawo.
Eƒe numekuku ƒe didiwo ku ɖe akpa vovovowo abe Numekuku & Dodokpɔ Atikewɔwɔ, Ame Tsitsiwo & Ame Tsitsiwo Ŋuti Nunya, Nu gbagbewo ƒe Dzɔdzɔmeŋusẽŋununya & Molecular Biology, Endocrinology & Metabolism, kple Neurosciences & Neurology. Le eƒe agbemeŋkekewo katã me la, ewɔ akpa vevi aɖe le go siawo me, eye wòdo nugbagbewo ƒe dɔwɔwɔ vovovowo kple atikewɔwɔ ƒe nɔnɔmewo gɔmesese ɖe ŋgɔ.
▎ Nyayɔyɔ Siwo Sɔ
[1] Khavinson V. K., Durnova A. O., Polyakova V. O., kple ame bubuwo. Dɔ si pancragen wɔna ɖe pancreatic cells ƒe vovototodedeameme dzi le woƒe tsitsi me[J]. Bulletin of dodokpɔ nugbagbeŋutinunya kple atikewɔwɔ, 2013, 154 (4): 501-504.DOI: 10.1007 / s10517-013-1987-6.
[2] Goncharova ND, Ivanova LG, Oganian T É, kple ame bubuwo. Ŋusẽ si tetrapeptide pancragen kpɔna ɖe dɔgboa ƒe dɔwɔwɔ le lãmenugbagbeviwo me le boso tsitsiwo me[J]. Ŋgɔyiyi le Amegãkukuŋutinunya me, 2014,27 (4): 662-667. https://pubmed.ncbi.nlm.nih.gov/25946840/ ƒe lãmesẽnyawo gbɔ kpɔkpɔ.
[3] Korkushko O. V., Khavinson V. K., Shatilo V. B., kple ame bubuwo. Mɔkpɔkpɔ siwo li be woazã pancragen hena lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe kuxiwo ɖɔɖɔɖo le ame tsitsiwo me[J]. Bulletin of dodokpɔ nugbagbeŋutinunya kple atikewɔwɔ, 2011, 151 (4): 454-456.DOI: 10.1007 / s10517-011-1354-4.
[4] Korkushko O, Shatilo V, Havinson W, kple ame bubuwo. Pancragen peptide ƒe dɔwɔwɔ nyuie le dɔnɔ tsitsi siwo ŋu metabolism mellitus ƒomevi 2 le ŋu[J]. Kuxi siwo le lãmenugbagbeviwo ƒe dɔléle ŋu, 2010,33:5-10.DOI:10.21856/j-PEP.2010.3.01.
[5] Goncharova N. D., Ivanova L. G., Oganyan T. E., kple ame bubuwo. Suklidɔ ƒe mɔɖeɖe ɖe nu ŋu ƒe gbegblẽ ɖɔɖɔɖo to tetrapeptide (Pancragen) zazã me le rhesus boso tsitsiwo me[J]. Ŋgɔyiyi le Amegãkukuŋutinunya me, 2015,28 (3): 579-585. https://pubmed.ncbi.nlm.nih.gov/28509500/ ƒe lãmesẽnyawo gbɔ kpɔkpɔ.
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.