▎ Binciken Pancragen
Menene asalin bincike na Pancragen?
Ƙaddamar da Ciwon tsufa da Bincike na Cututtuka: Masana kimiyya sun himmatu wajen gano abubuwa da hanyoyin da za su iya shiga cikin tsarin tsufa da kuma inganta alamun cututtuka masu alaƙa. A cikin binciken tsarin tsufa, an gano cewa raguwar aikin pancreatic yana taka muhimmiyar rawa wajen faruwa da ci gaban cututtukan geriatric da yawa, wanda ya sa masu bincike suka mayar da hankali kan sinadarai masu bioactive waɗanda zasu iya daidaita aikin pancreatic.
Binciken Abubuwan Peptide: Abubuwan Peptide suna da ayyuka iri-iri masu mahimmanci na ilimin lissafi a cikin jiki kuma suna da lafiya tare da ƴan illa. Masu bincike sun bincika kwayoyin halitta tare da yuwuwar daidaita aikin pancreatic tsakanin abubuwa masu yawa peptide. Ta hanyar nazarin adadi mai yawa na peptides na halitta da na roba, an gano cewa wasu peptides tare da takamaiman jerin amino acid na iya samun tasiri na tsari akan aikin ƙwayoyin pancreatic.
Gano Pancragen: Bayan jerin gwaje-gwaje da gwaje-gwaje, masu bincike sun gano Pancragen tetrapeptide, tare da jerin amino acid na Lys-Glu-Asp-Trp. Ƙarin bincike ya nuna cewa Pancragen ya nuna sakamako mai kyau a kan ƙwayoyin pancreatic a cikin gwaje-gwajen tantanin halitta da nau'in dabba, irin su inganta bambancin kwayar halitta na pancreatic da daidaita ƙwayar insulin da glucagon, wanda ya kafa harsashin bincike na asibiti na gaba da aikace-aikace.
Menene tsarin aikin Pancragen?
1. Tasiri akan Bambancin Kwayoyin Pancreatic
Ƙarfafa Bayanin Abubuwan Bambance-Bambance: Yayin da ƙwayoyin pancreatic suka tsufa, bayyanar alamun bambancin su yana raguwa. Pancragen na iya tayar da bayyanar cututtuka na bambance-bambance a cikin ƙwayoyin pancreatic, ciki har da ƙarfafa maganganun abubuwan ban sha'awa a cikin ƙwayoyin acinar (Pdx1, Ptfla) da sel tsibirin. Ana lura da wannan tasiri a duka al'adun 'matasa' da 'tsofaffin' al'adun [1] . Wannan sakamako mai ban sha'awa yana taimakawa kula da aikin al'ada na ƙwayoyin pancreatic. Musamman a lokacin tsarin tsufa, yana iya haɓaka bambance-bambancen tantanin halitta, don haka haɓaka aikin gaba ɗaya na pancreas.
Magungunan rigakafin ciwon sukari da hanyoyin hana kumburi: Bambance-bambancen ƙwayoyin acinar pancreatic da ƙwayoyin tsibiri da Pancragen ya jawo na iya zama ɗaya daga cikin hanyoyin maganin ciwon sukari da cututtukan kumburi. Ta hanyar haɓaka bambance-bambancen ƙwayoyin pancreatic, Pancragen na iya daidaita aikin ƙwayoyin pancreatic, yana ba su damar daidaita matakan glucose na jini, kuma yana iya rage amsawar kumburi [1] . Abubuwan rubuce-rubucen suna taka muhimmiyar rawa wajen daidaitawa a cikin bambance-bambancen ƙwayoyin pancreatic, kuma Pancragen ya yi niyya ga waɗannan abubuwan rubutun ta hanyar magunguna, yana mai da shi ingantaccen kayan aiki don maganin metabolism da pancreatitis [1].
2. Tasiri kan Aikin Endocrine na Pancreas a cikin Tsofaffi Birai
Inganta Metabolism na Glucose: A cikin tsofaffin birai, bayan gudanar da daidaitaccen adadin glucose, idan aka kwatanta da samarin birai, adadin glucose 'bacewar' a cikin tsofaffin birai ya ragu, kuma matakan insulin da C-peptide (minti 5 da mintuna 15 bayan allurar glucose) sun fi girma. Gudanar da Pancragen (tetrapeptide Lys-Glu-Asp-Trp) (50μg kowace dabba kowace rana, allurar intramuscular, na tsawon kwanaki 10) na iya haɓaka ƙimar glucose 'bacewar' a cikin tsofaffin birai da daidaita yanayin motsin insulin na plasma da amsawar C-peptide ga glucose [2]..
Tasirin Maidowa Mai Dorewa: Tasirin Pancragen akan maido da aikin pancreatic yana ci gaba da kasancewa a wani bangare bayan an cire maganin. Makonni uku bayan dakatar da maganin, tasirin Pancragen akan maido da aikin pancreatic na tsofaffin birai har yanzu yana riƙe da wani ɗan lokaci, yana nuna cewa Pancragen na iya samun tasirin warkewa na dogon lokaci [2].
3. Gyaran Ciwon Jiki A Cikin Tsofaffi
Rage Glucose na Jini da Matsayin Insulin: A cikin tsofaffi marasa lafiya da ke da nau'in metabolism na nau'in 2, Pancragen na iya rage matakan glucose sosai yayin azumi da kuma daidaitaccen gwajin haƙuri na glucose, kuma yana rage yawan ƙwayar insulin da ƙididdigar juriya na insulin a cikin plasma. Ga marasa lafiya waɗanda ba su karɓi maganin Pancragen ba, ba a sami canje-canje a cikin ma'aunin metabolism na carbohydrate ba. Wannan yana nuna cewa Pancragen yana da tasirin gyarawa akan rikice-rikice na rayuwa na tsofaffi, musamman ga tsofaffi marasa lafiya tare da nau'in 2 metabolism [3]..
Inganta Resistance Insulin: Rashin aikin samar da melatonin na pineal a cikin tsofaffi yana ba da gudummawa ga haɓaka juriya na insulin. Gudanar da Pancragen hanya ce mai ban sha'awa don gyara juriya na insulin a cikin tsofaffi. A cikin tsofaffi marasa lafiya, peptide Pancragen yana da ƙarin tasirin hypoglycemic akan nau'in 2 na metabolism, musamman a cikin marasa lafiya da ke da babban juriya na insulin na farko da hyperinsulinemia. A ƙarƙashin tasirin shirye-shiryen peptide, ƙimar juriya na insulin Homa yana raguwa [4].
Menene aikace-aikacen Pancragen?
1. Tasirin hana tsufa
Yayin da mutane ke tsufa, aikin sel pancreatic yana raguwa a hankali. Pancragen na iya tayar da bayyanar cututtuka daban-daban na bambance-bambance a cikin sel na pancreatic, haɓaka ayyukan sel, da haɓaka aikin ƙwayoyin pancreatic, don haka jinkirta tsarin tsufa na pancreas zuwa wani ɗan lokaci. Tsufa yana haifar da raguwar aikin sel na pancreatic kuma yana ƙara haɗarin cututtukan rayuwa kamar metabolism. Pancragen na iya jinkirta tsarin tsufa na ƙwayoyin pancreatic ta hanyar ƙarfafa maganganun bambance-bambance a cikin ƙwayoyin pancreatic. Misali, a wasu gwaje-gwajen dabba, Pancragen na iya inganta aikin ƙwayoyin pancreatic a cikin dabbobin da suka tsufa da jinkirta tsarin tsufa na pancreas [4].
2. Taimakawa Bambance-bambancen Kwayoyin Pancreatic
Pancragen na iya yin hulɗa tare da jerin DNA a cikin ƙwayoyin pancreatic, yana rinjayar maganganun kwayoyin halitta, don haka yana inganta bambancin ƙwayoyin pancreatic, kiyaye tsarin al'ada da aikin pancreas. Wannan tsarin aikin yana nuna cewa Pancragen na iya fara hanyar siginar siginar bambance-bambancen cell na pancreatic ta hanyar daidaita maganganun takamaiman kwayoyin halitta. Alal misali, binciken ya gano cewa Pancragen na iya tayar da maganganun wasu mahimman abubuwan bambance-bambance a cikin ƙwayoyin pancreatic [1] . Abubuwan da aka rubuta suna taka muhimmiyar rawa a cikin tsarin bambance-bambancen ƙwayoyin pancreatic. Suna iya tsara haɓakawa da aikin ƙwayoyin pancreatic kuma su kula da aikin al'ada na physiological na pancreas.
3. Gudanar da Insulin da Glucagon
A cikin bincike, Pancragen ya nuna sakamako mai goyan baya akan aikin endocrin na pancreas, yana taimakawa wajen daidaita fitar da insulin da glucagon da kuma kula da ma'aunin glucose na jini. Insulin da glucagon sune muhimman abubuwan da ake amfani da su don daidaita matakan glucose na jini, kuma ma'aunin sigar su yana da mahimmanci don kiyaye matakan glucose na jini. Pancragen na iya daidaita fitowar insulin da glucagon ta hanyar shafar aikin ƙwayoyin pancreatic. Misali, a cikin gwaje-gwajen dabba, Pancragen na iya rage matakan glucose na jini kuma ya daidaita matakan insulin da C-peptide [5] . Wannan yana nuna cewa Pancragen na iya inganta metabolism na glucose kuma ya kula da ma'aunin glucose na jini ta hanyar daidaita aikin endocrine na pancreas.
4. Haɓaka Ma'aunin Glucose na Jini
Inganta Juriya na Insulin: Pancragen yana da yuwuwar rawa wajen daidaita matakan glucose na jini. Yana iya rage matakan glucose na jini mai azumi, rage yawan tattarawar insulin da ma'aunin juriya na insulin, don haka yana da tasiri mai kyau akan inganta juriya na insulin. Juriya na insulin shine ɗayan mahimman pathogenesis na nau'in metabolism na nau'in 2, kuma haɓaka juriya na insulin na iya hanawa da magance metabolism yadda yakamata. Pancragen na iya tsara yadda ake ɗauka da amfani da glucose ta sel, rage matakan glucose na jini, da rage ƙwayar insulin, ta haka inganta juriya na insulin. Misali, a wasu nazarin samfurin dabba, Pancragen na iya rage matakan glucose na jini kuma ya inganta juriya na insulin [2, 4]..
Gudanar da Metabolism na Glucose: Yana iya daidaita haɓakawa da amfani da glucose ta hanyar sel ta hanyar tasirin enzymes masu mahimmanci a cikin metabolism na glucose, yana taimakawa wajen kiyaye matakan glucose na jini, wanda ke da mahimmanci don hanawa da haɓaka rikice-rikice na rayuwa kamar ciwon suga. Metabolism na glucose shine muhimmin tsari don kiyaye ayyukan al'ada na ilimin lissafi na jikin mutum. Daidaita metabolism na glucose na iya hanawa da kuma bi da cututtukan da ke rayuwa kamar metabolism. Pancragen na iya tsara ɗauka da amfani da glucose ta sel ta hanyar shafar mahimman enzymes a cikin metabolism na glucose, kamar masu jigilar glucose da hexokinase, don kiyaye matakan glucose na jini. Misali, a cikin wasu gwaje-gwajen dabba, Pancragen na iya daidaita glucose metabolism da inganta matakan glucose na jini [2, 4].
5. Taimakawa Ayyukan Endocrine
Kula da Ma'auni na Hormone: Sakamakon tsari na Pancragen akan aikin endocrin na pancreas yana taimakawa wajen kiyaye daidaiton matakan hormone a cikin jiki, musamman ma'auni tsakanin insulin da glucagon, wanda ke da mahimmanci ga lafiyar lafiyar jiki gaba ɗaya. Insulin da glucagon sune muhimman abubuwan da ake amfani da su don daidaita matakan glucose na jini, kuma ma'aunin sigar su yana da mahimmanci don kiyaye matakan glucose na jini. Pancragen na iya kiyaye ma'auni tsakanin insulin da glucagon ta hanyar daidaita aikin ƙwayoyin pancreatic. Misali, a cikin wasu gwaje-gwajen dabba, Pancragen na iya daidaita sigar insulin da glucagon da kiyaye matakan glucose na jini [2, 4]..
6. Gudanar da Metabolism
Daidaita Glucose na Jini da Matsayin Insulin: A wasu binciken, Pancragen ya nuna tasirin rage matakan glucose na jini kwatankwacin na magungunan hypoglycemic da aka saba amfani da su. A lokaci guda, yana iya daidaita matakan insulin da C-peptide yadda ya kamata, kuma ana sa ran ya zama sabon magani na metabolism. Metabolism cuta ce mai tsanani na rayuwa, kuma sarrafa matakan glucose na jini shine mabuɗin jiyya na metabolism. Pancragen na iya rage matakan glucose na jini kuma ya daidaita matakan insulin da C-peptide ta hanyar daidaita aikin endocrine na pancreas. Misali, a wasu gwaje-gwajen dabba, Pancragen na iya rage matakan glucose na jini kuma ya daidaita matakan insulin da C-peptide, tare da sakamako mai kama da na magungunan hypoglycemic da aka saba amfani da su [2, 4, 5]..
Kare Ayyukan β-cell na Pancreatic: Ta hanyar inganta aiki da aiki na ƙwayoyin pancreatic, Pancragen na iya taimakawa wajen kare β-cell na pancreatic kuma yana rage jinkirin ci gaban metabolism, wanda yake da mahimmanci ga rigakafi da magani na metabolism. Kwayoyin β-sel na pancreatic sune manyan ƙwayoyin da ke ɓoye insulin, kuma kare aikin β-cell na pancreatic yana da mahimmanci don rigakafi da magani na metabolism. Pancragen na iya kare ƙwayoyin β-sel na pancreatic ta hanyar haɓaka aiki da ayyukan ƙwayoyin pancreatic.
7. Maganin Cutar Kanjamau
Rage martani mai kumburi: Pancragen yana da wani sakamako mai hana kumburi, wanda zai iya rage kumburin kumburin ƙwayar cuta kuma ya sauƙaƙa alamun alamun pancreatitis na yau da kullun. Cutar sankara na yau da kullun cuta ce ta pancreatic na yau da kullun, kuma martanin kumburi yana ɗaya daga cikin mahimman abubuwan cututtukan cututtukan ƙwayar cuta na pancreatitis na yau da kullun. Pancragen na iya rage tasirin kumburin ƙwayar cuta ta hanyar daidaita maganganun abubuwan kumburi. Alal misali, a wasu gwaje-gwajen dabba, Pancragen na iya rage amsawar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.
Inganta Gyaran Nama na Pancreatic: Yana iya inganta gyare-gyare da sake farfadowa na ƙwayar pancreatic ta hanyar daidaita yaduwar kwayar halitta da bambance-bambance, yana taimakawa wajen inganta yanayin aiki na pancreas. Gyarawa da farfadowa na nama na pancreatic suna da mahimmanci don maganin ciwon daji na kullum. Pancragen na iya inganta gyaran gyare-gyare da farfadowa na ƙwayar pancreatic ta hanyar daidaita yaduwar kwayar halitta da bambanta. Alal misali, a wasu gwaje-gwajen dabba, Pancragen na iya inganta gyare-gyare da farfadowa na ƙwayar pancreatic da inganta yanayin aiki na pancreas.
A ƙarshe, Pancragen yana taka muhimmiyar rawa wajen aiwatar da tasirin tsufa, daidaita ayyukan pancreatic, haɓaka ma'auni na glucose na jini, tallafawa aikin endocrine, da kuma kula da metabolism da kuma kula da pancreatitis na yau da kullun.
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Mawallafin Jaridar Kimiyya
Khavinson VK fitaccen mai bincike ne wanda ke da alaƙa da alaƙa a cikin manyan manyan cibiyoyi da yawa. Waɗannan sun haɗa da Cibiyar Kimiyya ta Rasha, Cibiyar Nazarin Halittu ta St Petersburg da Gerontology, Jami'ar Kiwon Lafiya ta Arewa maso Yamma mai suna II Mechnikov, Cibiyar Nazarin Kiwon Lafiya ta Pavlov, Kwalejin Kimiyyar Kiwon Lafiya ta Rasha, da Peter the Great St. Petersburg Polytechnic University, da sauransu.
Bukatun bincikensa sun mamaye fannoni daban-daban kamar Bincike & Magungunan Gwaji, Geriatrics & Gerontology, Biochemistry & Molecular Biology, Endocrinology & Metabolism, da Neurosciences & Neurology. A duk tsawon aikinsa, ya ba da gudummawa mai mahimmanci ga waɗannan fannoni, yana haɓaka fahimtar hanyoyin nazarin halittu daban-daban da yanayin kiwon lafiya.
