Research Ubushakashatsi bwa Pancragen
Ni ubuhe bushakashatsi bwakozwe na Pancragen?
Gutezimbere Ubusaza n'indwara Ubushakashatsi: Abahanga biyemeje gushakisha ibintu nuburyo bushobora kugira uruhare mugusaza no kunoza ibimenyetso byindwara zifitanye isano. Mu bushakashatsi bwakozwe ku buryo bwo gusaza, byagaragaye ko igabanuka ry’imikorere y’urwagashya rigira uruhare runini mu kubaho no guteza imbere indwara nyinshi z’ibihe, ibyo bikaba byaratumye abashakashatsi bibanda ku bintu bioaktike bishobora kugenga imikorere y’urwagashya.
Ubushakashatsi bwibintu bya Peptide: Ibintu bya peptide bifite ibikorwa bitandukanye byingenzi byimikorere yumubiri kandi bifite umutekano muke hamwe ningaruka nke. Abashakashatsi bapimye molekile zifite ubushobozi bwo kugenzura imikorere ya pancreatic mubintu byinshi bya peptide. Binyuze mu bushakashatsi bwakozwe ku mubare munini wa peptide karemano na sintetike, byagaragaye ko peptide zimwe na zimwe zikurikirana aside amine zishobora kugira ingaruka ku mikorere ya selile pancreatic.
Ivumburwa rya Pancragen: Nyuma yubushakashatsi bwakozwe hamwe nubushakashatsi, abashakashatsi bavumbuye tetrapeptide Pancragen, hamwe na aside amine ikurikirana ya Lys-Glu-Asp-Trp. Ubushakashatsi bwakozwe bwerekanye ko Pancragen yerekanye ingaruka nziza ku ngirabuzimafatizo ya pancreatic mu bushakashatsi bwakorewe mu ngirabuzimafatizo no ku ngero z’inyamaswa, nko guteza imbere itandukaniro ry’uturemangingo no kugenzura imisemburo ya insuline na glucagon, ishyiraho urufatiro rw’ubushakashatsi bwakorewe mu mavuriro no kuyishyira mu bikorwa.
Nubuhe buryo bwo gukora Pancragen?
1. Ingaruka ku Gutandukanya Uturemangingo twa Pancreatic
Gukangurira Kugaragaza Ibintu Bitandukanye: Mugihe ingirabuzimafatizo zisaza, imvugo yibimenyetso byayo itandukana. Pancragen irashobora gushimangira imvugo yibintu bitandukanya selile pancreatic selile, harimo no gushimangira imvugo yibintu bitandukanya selile acinar (Pdx1, Ptfla) na selile islet. Ingaruka zigaragara mumico yombi 'muto ' na 'kera ' imico [1] . Izi ngaruka zikangura zifasha kugumana imikorere isanzwe ya selile pancreatic selile. Cyane cyane mugihe cyo gusaza, irashobora guteza imbere gutandukanya selile, bityo bikazamura imikorere rusange ya pancreas.
Uburyo bwo kurwanya diyabete no kurwanya inflammatory: Itandukanyirizo rya selile pancreatic acinar selile na selile islet yatewe na Pancragen irashobora kuba imwe muburyo bwingaruka zayo zo kurwanya diyabete no kurwanya inflammatory. Mu guteza imbere itandukanyirizo ry'uturemangingo twa pancreatic, Pancragen irashobora kugenga imikorere y'uturemangingo twa pancreatic, ibafasha gutunganya neza urugero rwa glucose yamaraso, kandi ishobora no kugabanya igisubizo kibabaza [1] . Impapuro zanduza zigira uruhare runini mugutandukanya ingirabuzimafatizo, kandi Pancragen yibasira ibyo bintu byandikirwa imiti, bituma iba igikoresho cyiza cyo kuvura metabolism na pancreatite [1].
2. Ingaruka ku mikorere ya Endocrine ya Pancreas mu nguge zishaje
Kunoza Metabolisme ya Glucose: Mu nguge zishaje, nyuma yo gutanga igipimo gisanzwe cya glucose, ugereranije n’inguge zikiri nto, igipimo cya glucose 'kubura ' ku nguge zishaje kiri hasi, kandi urugero rwo hejuru rwa insuline na C-peptide (iminota 5 niminota 15 nyuma yo guterwa glucose). Ubuyobozi bwa Pancragen (tetrapeptide Lys-Glu-Asp-Trp) (50μg ku nyamaswa kumunsi, inshinge zo mu nda, muminsi 10) birashobora kongera cyane igipimo cya glucose 'kubura ' ku nguge zishaje kandi bigahindura imikorere ya plasma insuline na C-peptide kuri glucose [2].
Ingaruka Zisubiramo Zirambye: Ingaruka za Pancragen mukugarura imikorere ya pancreatic ikomeza igice nyuma yibiyobyabwenge. Nyuma y'ibyumweru bitatu nyuma yo guhagarika ibiyobyabwenge, ingaruka za Pancragen mukugarura imikorere ya pancreatic yinguge zinguge ziracyagumaho kurwego runaka, byerekana ko Pancragen ishobora kugira ingaruka zigihe kirekire zo kuvura [2].
3. Gukosora imvururu ziterwa na basaza
Kugabanya Amaraso ya Glucose na Insuline: Ku barwayi bageze mu zabukuru bafite metabolisme yo mu bwoko bwa 2, Pancragen irashobora kugabanya cyane urugero rwa glucose mugihe cyo kwiyiriza ubusa no mu kizamini gisanzwe cyo kwihanganira glucose, kandi ikanagabanya insuline yibanze hamwe na insuline irwanya insuline muri plasma. Ku barwayi batabonye imiti ya Pancragen, nta gihindutse ku cyerekezo cya metabolisme ya karubone. Ibi byerekana ko Pancragen igira ingaruka zo gukosora indwara ziterwa no guhindagurika kw'abasaza, cyane cyane ku barwayi bageze mu zabukuru bafite metabolism yo mu bwoko bwa 2 [3].
Kunoza Kurwanya Insuline: Ihungabana ryimikorere ya pineal melatonin ikora mubasaza igira uruhare mu mikurire yo kurwanya insuline. Ubuyobozi bwa Pancragen nuburyo butanga ikizere cyo gukosora insuline irwanya abasaza. Ku barwayi bageze mu zabukuru, peptide ya Pancragen igira izindi ngaruka za hypoglycemic ku bwoko bwa metabolism yo mu bwoko bwa 2, cyane cyane ku barwayi bafite insuline nyinshi zo mu bwoko bwa insuline na hyperinsulinemia. Bitewe no gutegura peptide, igipimo cyo kurwanya insuline ya Homa kigabanuka [4].
Ni ubuhe buryo bukoreshwa na Pancragen?
1. Ingaruka zo gusaza
Iyo abantu basaza, imikorere ya selile pancreatic selile igabanuka buhoro buhoro. Pancragen irashobora gushimangira imvugo yibintu bitandukanye bitandukanye mumyanya myanya myanya myanya myanya myanya myanya myanya myanya myanya myororokere, ikongera ibikorwa byimikorere, kandi igateza imbere imikorere yingirabuzimafatizo, bityo igatinda gusaza kwa pancreas kurwego runaka. Gusaza biganisha ku kugabanuka kwimikorere ya selile pancreatic selile kandi byongera ibyago byindwara ziterwa na metabolism nka metabolism. Pancragen irashobora gutinza gahunda yo gusaza kwingirangingo ziterwa no gutera imbaraga zo kwerekana imiterere itandukanye mu ngirabuzimafatizo. Kurugero, mubushakashatsi bwibikoko bimwe na bimwe, Pancragen irashobora kunoza imikorere yuturemangingo twa pancreatic mumatungo ashaje kandi igatinda gusaza kwa pancreas [4].
2. Gushyigikira Itandukaniro rya Pancreatic Cell
Pancragen irashobora gukorana na ADN ikurikirana mu ngirabuzimafatizo, bigira ingaruka ku mvugo ya gene, bityo bigateza imbere gutandukanya ingirabuzimafatizo, bikomeza imiterere n'imikorere isanzwe ya pancreas. Ubu buryo bwibikorwa bwerekana ko Pancragen ishobora gutangiza inzira yerekana inzira yo gutandukanya selile pancreatic selile igenga imiterere ya genes yihariye. Kurugero, ubushakashatsi bwerekanye ko Pancragen ishobora gutera imbaraga zo kwerekana ibintu bimwe na bimwe byingenzi bitandukanya ingirabuzimafatizo [1] . Impapuro zandikirwa zigira uruhare runini mugutandukanya ingirabuzimafatizo. Barashobora kugenzura iterambere nimikorere ya selile pancreatic selile kandi bagakomeza imikorere isanzwe ya physiologique ya pancreas.
3. Kugenga insuline na Glucagon
Mu bushakashatsi, Pancragen yerekanye ingaruka zifasha kumikorere ya endocrine yimikorere ya pancreas, ifasha kugenzura ururenda rwa insuline na glucagon no gukomeza glucose yamaraso. Insuline na glucagon ni imisemburo y'ingenzi igenga urugero rw'amaraso ya glucose, kandi kuringaniza ururenda rwabo ni ingenzi mu gukomeza urugero rwa glucose mu maraso. Pancragen irashobora kugenga ururenda rwa insuline na glucagon bigira ingaruka kumikorere ya selile pancreatic. Kurugero, mubushakashatsi bwibikoko, Pancragen irashobora kugabanya urugero rwa glucose yamaraso kandi ikagenga urugero rwa insuline na C-peptide [5] . Ibi byerekana ko Pancragen ishobora kunoza metabolisme ya glucose kandi ikagumana uburinganire bwamaraso glucose muguhindura imikorere ya endocrine ya pancreas.
4. Gutezimbere Amaraso ya Glucose
Kunoza Kurwanya Insuline: Pancragen ifite uruhare runini mugutunganya glucose yamaraso. Irashobora kugabanya umuvuduko wamaraso glucose, kugabanya insuline hamwe nigipimo cyo kurwanya insuline, bityo bikagira ingaruka nziza mukuzamura insuline. Kurwanya insuline ni kimwe mu bintu bitera indwara ya metabolism yo mu bwoko bwa 2, kandi kunoza insuline birashobora gukumira no kuvura metabolism. Pancragen irashobora kugenga gufata no gukoresha glucose ukoresheje selile, kugabanya glucose yamaraso, no kugabanya insuline, bityo bikarwanya insuline. Kurugero, mubushakashatsi bwikitegererezo bwinyamanswa, Pancragen irashobora kugabanya urugero rwa glucose yamaraso no kunoza insuline [2, 4].
Kugenga Metabolisme ya Glucose: Irashobora kugenga gufata no gukoresha glucose ningirabuzimafatizo bigira ingaruka ku misemburo yingenzi muri metabolisme ya glucose, ifasha kugumana urugero rwa glucose rwamaraso, rukaba rufite akamaro kanini mukurinda no kunoza indwara ziterwa na metabolike nka syndrome de metabolike. Glucose metabolism ninzira yingenzi yo kubungabunga imikorere isanzwe yumubiri wumuntu. Kugenga glucose metabolism birashobora gukumira no kuvura indwara ziterwa na metabolism. Pancragen irashobora kugenga gufata no gukoresha glucose ukoresheje selile bigira ingaruka kumisemburo yingenzi muri metabolisme ya glucose, nkabatwara glucose na hexokinase, kugirango glucose igabanuke. Kurugero, mubushakashatsi bwibikoko bimwe na bimwe, Pancragen irashobora kugenga glucose metabolism no kuzamura glucose yamaraso [2, 4].
5. Gushyigikira imikorere ya Endocrine
Kugumana uburinganire bwa Hormone: Ingaruka zoguhindura Pancragen kumikorere ya endocrine ya pancreas ifasha kugumana uburinganire bwimisemburo mumubiri, cyane cyane uburinganire buri hagati ya insuline na glucagon, nibyingenzi mubuzima rusange bwa metabolike. Insuline na glucagon ni imisemburo y'ingenzi igenga urugero rw'amaraso ya glucose, kandi kuringaniza ururenda rwabo ni ingenzi mu gukomeza urugero rwa glucose mu maraso. Pancragen irashobora gukomeza kuringaniza insuline na glucagon muguhindura imikorere ya selile pancreatic. Kurugero, mubushakashatsi bwibikoko bimwe na bimwe, Pancragen irashobora kugenga ururenda rwa insuline na glucagon kandi ikagumana urugero rwa glucose rwamaraso [2, 4].
6. Gucunga Metabolism
Kugenga Urwego rwa Glucose na Insuline: Mu bushakashatsi bumwe na bumwe, Pancragen yerekanye ingaruka zo kugabanya urugero rwa glucose mu maraso ugereranije n’imiti ikoreshwa cyane ya hypoglycemic. Muri icyo gihe, irashobora kugenzura neza urugero rwa insuline na C-peptide, kandi biteganijwe ko izahinduka uburyo bushya bwo kuvura metabolism. Metabolism nindwara ikomeye ya metabolike, kandi kugenzura urugero rwa glucose yamaraso nurufunguzo rwo kuvura metabolism. Pancragen irashobora kugabanya urugero rwa glucose yamaraso kandi ikagenga urugero rwa insuline na C-peptide muguhindura imikorere ya endocrine ya pancreas. Kurugero, mubushakashatsi bwibikoko bimwe na bimwe, Pancragen irashobora kugabanya urugero rwa glucose yamaraso kandi ikagenga urugero rwa insuline na C-peptide, hamwe ningaruka igereranywa niy'imiti ikoreshwa cyane ya hypoglycemic [2, 4, 5].
Kurinda Pancreatic β-selile Imikorere: Mugutezimbere imikorere nigikorwa cyingirabuzimafatizo, Pancragen irashobora gufasha kurinda pancreatic β-selile no kudindiza iterambere rya metabolism, ifite akamaro kanini mukurinda no kuvura metabolism. Pancreatic β-selile nizo selile nyamukuru zisohora insuline, kandi kurinda imikorere ya pancreatic β-selile ningirakamaro mukurinda no kuvura metabolism. Pancragen irashobora kurinda pancreatic β-selile mugutezimbere imikorere nigikorwa cya selile pancreatic.
7. Kuvura indwara ya pancreatite idakira
Kugabanya Igisubizo cya Inflammatory: Pancragen igira ingaruka zimwe na zimwe zo kurwanya inflammatory, zishobora kugabanya ingaruka ziterwa na pancreas no kugabanya ibimenyetso bya pancreatite idakira. Indwara ya pancreatite idakira ni indwara isanzwe ya pancreatic, kandi igisubizo cyo gutwika ni kimwe mu bintu by'ingenzi bitera indwara ya pancreatite idakira. Pancragen irashobora kugabanya ibisubizo byumuriro wa pancreas muguhindura imvugo yibintu bitera. Kurugero, mubushakashatsi bwibikoko bimwe na bimwe, Pancragen irashobora kugabanya ingaruka ziterwa na pancreas kandi ikagabanya ibimenyetso bya pancreatite idakira.
Guteza imbere isanwa rya pancreatic Tissue: Irashobora guteza imbere gusana no kuvugurura ingirangingo zifata pancreatic muguhuza ikwirakwizwa ryimikorere no gutandukana, bifasha kunoza imikorere yimikorere ya pancreas. Gusana no kuvugurura ingirabuzima fatizo ni ingenzi mu kuvura pancreatite idakira. Pancragen irashobora guteza imbere gusana no kuvugurura ingirangingo za pancreatic muguhuza ikwirakwizwa ry'uturemangingo no gutandukana. Kurugero, mubushakashatsi bwibikoko bimwe na bimwe, Pancragen irashobora guteza imbere gusana no kuvugurura ingirangingo za pancreatic no kunoza imikorere ya pancreas.
Mu gusoza, Pancragen igira uruhare runini mu kugira ingaruka zo kurwanya gusaza, kugenzura imikorere y’urwagashya, guteza imbere glucose y’amaraso, gushyigikira imikorere ya endocrine, ndetse no gucunga metabolism no kuvura indwara ya pancreatite idakira.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Khavinson VK numushakashatsi wamamaye ufite aho ahurira nibigo byinshi bizwi. Harimo Ishuri Rikuru ry’Ubumenyi ry’Uburusiya, Ikigo cy’ubuvuzi cya St Petersburg na Gerontologiya, Ishuri Rikuru ry’Ubuvuzi rya Leta y’Amajyaruguru y’Uburengerazuba ryitiriwe II Mechnikov, Ikigo cya Pavlov Institute of Physiology, Ishuri Rikuru ry’Ubuvuzi ry’Uburusiya, na Peter kaminuza nkuru ya St.
Ibyifuzo bye mubushakashatsi bikubiyemo ibintu byinshi nkubushakashatsi & Ubushakashatsi bwubuvuzi, Geriatrics & Gerontology, Biochemie & Molecular Biology, Endocrinology & Metabolism, na Neurosciences & Neurology. Mu mibereho ye yose, yagize uruhare runini muri utwo turere, ateza imbere imyumvire y’ibinyabuzima bitandukanye ndetse n’ubuvuzi.
