▎ Kev Tshawb Fawb Pancragen
Kev tshawb fawb keeb kwm ntawm Pancragen yog dab tsi?
Kev Tshaj Tawm Txog Kev Laus thiab Kev Tshawb Fawb Txog Kab Mob: Cov kws tshawb fawb tau cog lus los nrhiav cov tshuaj thiab cov txheej txheem uas tuaj yeem cuam tshuam cov txheej txheem kev laus thiab txhim kho cov tsos mob ntawm cov kab mob. Hauv kev tshawb fawb txog kev laus, nws tau pom tias kev poob qis ntawm pancreatic muaj nuj nqi plays lub luag haujlwm tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm ntau yam kab mob geriatric, uas tau ua rau cov kws tshawb fawb tsom mus rau cov tshuaj bioactive uas tuaj yeem tswj hwm kev ua haujlwm ntawm pancreatic.
Kev Tshawb Fawb Cov Tshuaj Peptide: Cov tshuaj Peptide muaj ntau yam kev ua haujlwm tseem ceeb hauv lub cev thiab muaj kev nyab xeeb nrog qee qhov kev mob tshwm sim. Cov kws tshawb fawb tau tshuaj xyuas cov molecules nrog lub peev xwm los tswj kev ua haujlwm ntawm pancreatic ntawm ntau cov tshuaj peptide. Los ntawm txoj kev tshawb fawb ntawm ntau lub ntuj thiab hluavtaws peptides, nws tau pom tias qee cov peptides nrog cov amino acid tshwj xeeb ua ntu zus tuaj yeem muaj kev tswj hwm kev ua haujlwm ntawm cov hlwb pancreatic.
Kev Tshawb Fawb ntawm Pancragen: Tom qab kev sim thiab kev tshuaj ntsuam, cov kws tshawb fawb tau tshawb pom cov tetrapeptide Pancragen, nrog rau cov amino acid sib lawv liag ntawm Lys-Glu-Asp-Trp. Cov kev tshawb fawb ntxiv tau pom tias Pancragen tau nthuav tawm cov txiaj ntsig zoo ntawm cov kab mob pancreatic hauv kev sim ntawm tes thiab cov qauv tsiaj, xws li kev txhawb nqa pancreatic cell sib txawv thiab tswj kev tso tawm ntawm insulin thiab glucagon, tso lub hauv paus rau nws cov kev tshawb fawb tom ntej thiab daim ntawv thov.
Dab tsi yog qhov mechanism ntawm kev txiav txim ntawm Pancragen?
1. Qhov cuam tshuam rau Pancreatic Cell Differentiation
Txhawb Kev Tshaj Tawm Ntawm Cov Txheej Txheem Sib Txawv: Raws li lub hnub nyoog ntawm cov hlwb pancreatic, kev qhia ntawm lawv cov cim sib txawv txo. Pancragen tuaj yeem txhawb nqa qhov kev qhia ntawm qhov sib txawv hauv cov hlwb pancreatic, nrog rau kev txhawb nqa qhov kev qhia ntawm qhov sib txawv hauv cov hlwb acinar (Pdx1, Ptfla) thiab islet hlwb. Cov nyhuv no tau pom nyob rau hauv ob qho tib si ' hluas' thiab 'laus' kab lis kev cai [1] . Cov nyhuv stimulating no pab tswj kev ua haujlwm ntawm pancreatic hlwb. Tshwj xeeb tshaj yog thaum cov txheej txheem kev laus, nws tuaj yeem txhawb kev sib txawv ntawm tes, yog li txhim kho kev ua haujlwm tag nrho ntawm cov txiav.
Anti-diabetic thiab Anti-inflammatory Mechanisms: Qhov sib txawv ntawm pancreatic acinar cells thiab islet cells induced by Pancragen tej zaum yuav yog ib qho ntawm cov txheej txheem ntawm nws cov tshuaj tiv thaiv mob ntshav qab zib thiab tshuaj tiv thaiv. Los ntawm kev txhawb nqa kev sib txawv ntawm cov kab mob pancreatic, Pancragen tuaj yeem tswj hwm kev ua haujlwm ntawm pancreatic hlwb, ua kom lawv tswj tau cov ntshav qabzib zoo dua, thiab tseem tuaj yeem txo cov lus teb inflammatory [1] . Cov kev hloov pauv hloov pauv ua lub luag haujlwm tseem ceeb hauv kev sib txawv ntawm cov hlwb pancreatic, thiab Pancragen tsom rau cov kev hloov pauv ntawm cov tshuaj pharmacological, ua rau nws muaj txiaj ntsig zoo rau kev kho cov metabolism thiab mob pancreatitis [1].
2. Qhov cuam tshuam rau endocrine Function ntawm Pancreas hauv cov laus Monkeys
Txhim kho Glucose Metabolism: Hauv cov neeg laus liab, tom qab siv cov koob tshuaj ntawm cov piam thaj, piv nrog cov liab liab, cov piam thaj ' ploj lawm' hauv cov neeg laus liab yog qis dua, thiab cov qib siab ntawm insulin thiab C-peptide (5 feeb thiab 15 feeb tom qab txhaj cov piam thaj) siab dua. Kev tswj hwm ntawm Pancragen (tetrapeptide Lys-Glu-Asp-Trp) (50μg ib tus tsiaj hauv ib hnub, kev txhaj tshuaj intramuscular rau 10 hnub) tuaj yeem ua rau cov piam thaj ntau ntxiv hauv cov neeg laus liab thiab normalizes kinetics ntawm plasma insulin thiab C-peptide teb rau cov piam thaj [2].
Sustained Restoration Effect: Cov nyhuv ntawm Pancragen ntawm kev ua kom rov ua haujlwm ntawm pancreatic tseem nyob ib nrab tom qab tshem tawm cov tshuaj. Peb lub lis piam tom qab tso tseg cov tshuaj, cov txiaj ntsig ntawm Pancragen ntawm kev ua kom rov ua haujlwm ntawm pancreatic ntawm cov laus liab tseem khaws cia rau qee qhov, qhia tias Pancragen tuaj yeem muaj txiaj ntsig kho mob mus ntev [2].
3. Kho cov kab mob metabolic hauv cov neeg laus
Txo cov ntshav qabzib thiab qib insulin: Hauv cov neeg mob laus uas muaj hom 2 metabolism, Pancragen tuaj yeem txo cov piam thaj hauv cov ntshav thaum yoo mov thiab hauv cov qauv ntsuas ntshav qabzib, thiab tseem txo qis cov insulin concentration thiab insulin resistance index hauv plasma. Rau cov neeg mob uas tsis tau txais kev kho mob Pancragen, tsis muaj kev hloov pauv ntawm cov metabolism hauv carbohydrate. Qhov no qhia tau hais tias Pancragen muaj cov txiaj ntsig zoo rau cov kab mob metabolic ntawm cov neeg laus, tshwj xeeb tshaj yog rau cov neeg laus nrog hom 2 metabolism [3].
Txhim kho Insulin Resistance: Qhov teeb meem ntawm pineal melatonin ntau lawm muaj nuj nqi hauv cov neeg laus pab txhawb kev txhim kho ntawm insulin tsis kam. Kev tswj hwm ntawm Pancragen yog ib txoj hauv kev zoo los kho cov tshuaj insulin hauv cov neeg laus. Hauv cov neeg mob laus, Pancragen peptide muaj cov nyhuv hypoglycemic ntxiv rau hom 2 metabolism, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj cov tshuaj insulin siab pib thiab hyperinsulinemia. Raws li kev cuam tshuam ntawm kev npaj peptide, Homa insulin tsis kam Performance index txo qis [4].
Cov kev siv ntawm Pancragen yog dab tsi?
1. Anti-aging nyhuv
Raws li cov neeg muaj hnub nyoog, kev ua haujlwm ntawm pancreatic hlwb maj mam poob. Pancragen tuaj yeem txhawb kev nthuav tawm ntawm ntau yam sib txawv hauv cov kab mob pancreatic, txhim kho kev ua haujlwm ntawm tes, thiab txhim kho kev ua haujlwm ntawm pancreatic hlwb, yog li ncua kev laus ntawm cov txiav txiav mus rau qee yam. Kev laus ua rau poob ntawm pancreatic cell ua haujlwm thiab ua rau muaj kev pheej hmoo ntawm cov kab mob metabolic xws li cov metabolism. Pancragen tuaj yeem ncua cov txheej txheem kev laus ntawm pancreatic hlwb los ntawm kev txhawb nqa kev qhia txog kev sib txawv hauv cov hlwb pancreatic. Piv txwv li, hauv qee qhov kev sim tsiaj, Pancragen tuaj yeem txhim kho kev ua haujlwm ntawm pancreatic hlwb hauv cov tsiaj laus thiab ncua kev laus ntawm tus txiav [4].
2. Txhawb Pancreatic Cell Sib Txawv
Pancragen tuaj yeem cuam tshuam nrog DNA ua ntu zus hauv cov hlwb pancreatic, cuam tshuam cov noob qhia, thiab yog li txhawb kev sib txawv ntawm cov hlwb pancreatic, tswj cov qauv thiab kev ua haujlwm ntawm tus txiav. Cov txheej txheem ntawm kev ua haujlwm no qhia tau hais tias Pancragen tuaj yeem pib txoj kev taw qhia ntawm kev sib txawv ntawm pancreatic cell los ntawm kev tswj cov kev qhia ntawm cov noob tshwj xeeb. Piv txwv li, cov kev tshawb fawb tau pom tias Pancragen tuaj yeem txhawb kev nthuav tawm ntawm qee qhov sib txawv tseem ceeb hauv cov hlwb pancreatic [1] . Cov kev hloov pauv hloov pauv ua lub luag haujlwm tseem ceeb hauv kev sib txawv ntawm cov kab mob pancreatic. Lawv tuaj yeem tswj hwm txoj kev loj hlob thiab kev ua haujlwm ntawm pancreatic hlwb thiab tswj cov kev ua haujlwm ntawm lub cev ntawm tus txiav.
3. Kev tswj cov tshuaj insulin thiab Glucagon secretion
Hauv kev tshawb fawb, Pancragen tau qhia txog kev txhawb nqa ntawm kev ua haujlwm endocrine ntawm tus txiav, pab tswj kev tso tawm ntawm insulin thiab glucagon thiab tswj cov ntshav qabzib. Insulin thiab glucagon yog cov tshuaj hormones tseem ceeb rau kev tswj cov ntshav qabzib, thiab qhov sib npaug ntawm lawv qhov tso tawm yog qhov tseem ceeb rau kev tswj cov ntshav qabzib kom ruaj khov. Pancragen tuaj yeem tswj hwm qhov tso tawm ntawm insulin thiab glucagon los ntawm kev cuam tshuam kev ua haujlwm ntawm pancreatic hlwb. Piv txwv li, hauv kev sim tsiaj, Pancragen tuaj yeem txo cov ntshav qabzib thiab tswj cov qib ntawm insulin thiab C-peptide [5] . Qhov no qhia tau hais tias Pancragen tuaj yeem txhim kho cov piam thaj metabolism thiab tswj cov ntshav qabzib sib npaug los ntawm kev tswj hwm cov haujlwm endocrine ntawm cov txiav.
4. Txhawb cov ntshav qabzib sib npaug
Txhim kho Insulin Resistance: Pancragen muaj lub luag haujlwm tseem ceeb hauv kev tswj cov ntshav qabzib. Nws tuaj yeem txo cov ntshav qabzib sai sai, txo qis cov tshuaj insulin thiab cov tshuaj insulin tsis kam, thiab yog li muaj txiaj ntsig zoo rau kev txhim kho cov tshuaj insulin. Cov tshuaj insulin tsis kam yog ib qho ntawm cov kab mob tseem ceeb ntawm hom 2 metabolism, thiab kev txhim kho cov tshuaj insulin tuaj yeem tiv thaiv thiab kho cov metabolism. Pancragen tuaj yeem tswj hwm kev noj qab haus huv thiab kev siv cov piam thaj los ntawm cov hlwb, txo cov ntshav qabzib, thiab txo qis cov tshuaj insulin, yog li txhim kho cov tshuaj insulin. Piv txwv li, hauv qee qhov kev tshawb fawb tsiaj, Pancragen tuaj yeem txo cov ntshav qabzib thiab txhim kho insulin tsis kam [2, 4].
Regulating Glucose Metabolism: Nws tuaj yeem tswj hwm kev noj qab haus huv thiab kev siv cov piam thaj los ntawm cov hlwb los ntawm kev cuam tshuam cov enzymes tseem ceeb hauv cov piam thaj metabolism, pab tswj cov ntshav qabzib kom ruaj khov, uas yog qhov tseem ceeb rau kev tiv thaiv thiab txhim kho cov kab mob metabolic xws li metabolic syndrome. Glucose metabolism yog cov txheej txheem tseem ceeb rau kev tswj hwm lub cev kev ua haujlwm ntawm tib neeg lub cev. Kev tswj cov piam thaj metabolism tuaj yeem tiv thaiv thiab kho cov kab mob metabolic xws li cov metabolism. Pancragen tuaj yeem tswj hwm kev noj qab haus huv thiab kev siv cov piam thaj los ntawm cov hlwb los ntawm kev cuam tshuam cov enzymes tseem ceeb hauv cov piam thaj metabolism, xws li glucose transporters thiab hexokinase, kom tswj cov ntshav qabzib. Piv txwv li, hauv qee qhov kev sim tsiaj, Pancragen tuaj yeem tswj cov piam thaj metabolism thiab txhim kho cov ntshav qabzib [2, 4].
5. Txhawb kev ua haujlwm endocrine
Tuav Hormone Balance: Kev tswj hwm cov txiaj ntsig ntawm Pancragen ntawm kev ua haujlwm endocrine ntawm pancreas pab tswj qhov sib npaug ntawm cov tshuaj hormones hauv lub cev, tshwj xeeb tshaj yog qhov sib npaug ntawm insulin thiab glucagon, uas yog qhov tseem ceeb rau kev noj qab haus huv tag nrho. Insulin thiab glucagon yog cov tshuaj hormones tseem ceeb rau kev tswj cov ntshav qabzib, thiab qhov sib npaug ntawm lawv qhov tso tawm yog qhov tseem ceeb rau kev tswj cov ntshav qabzib kom ruaj khov. Pancragen tuaj yeem tswj hwm qhov sib npaug ntawm insulin thiab glucagon los ntawm kev tswj hwm kev ua haujlwm ntawm pancreatic hlwb. Piv txwv li, hauv qee qhov kev sim tsiaj, Pancragen tuaj yeem tswj hwm qhov tso tawm ntawm insulin thiab glucagon thiab tswj cov ntshav qabzib nyob ruaj khov [2, 4].
6. Kev Tswj Xyuas Metabolism
Kev tswj cov ntshav qabzib thiab qib insulin: Hauv qee qhov kev tshawb fawb, Pancragen tau qhia txog kev txo qis cov piam thaj hauv cov ntshav piv rau cov tshuaj hypoglycemic uas nquag siv. Nyob rau tib lub sijhawm, nws tuaj yeem tswj hwm cov qib ntawm insulin thiab C-peptide zoo dua, thiab xav tias yuav dhau los ua kev kho mob tshiab rau cov metabolism. Metabolism yog ib yam kab mob loj heev, thiab kev tswj cov ntshav qabzib yog tus yuam sij rau kev kho cov metabolism. Pancragen tuaj yeem txo qis cov piam thaj hauv cov ntshav thiab tswj cov qib ntawm insulin thiab C-peptide los ntawm kev tswj hwm cov haujlwm endocrine ntawm tus txiav. Piv txwv li, hauv qee qhov kev sim tsiaj, Pancragen tuaj yeem txo cov ntshav qabzib thiab tswj cov qib ntawm insulin thiab C-peptide, nrog rau cov nyhuv piv rau cov tshuaj hypoglycemic uas nquag siv [2, 4, 5].
Tiv thaiv Pancreatic β-cell Function: Los ntawm kev txhim kho kev ua haujlwm thiab kev ua haujlwm ntawm pancreatic hlwb, Pancragen tuaj yeem pab tiv thaiv pancreatic β-hlwb thiab ua kom qeeb ntawm cov metabolism, uas yog qhov tseem ceeb rau kev tiv thaiv thiab kho cov metabolism. Pancreatic β-hlwb yog cov hlwb tseem ceeb uas tso cov tshuaj insulin, thiab kev tiv thaiv kev ua haujlwm ntawm pancreatic β-hlwb yog qhov tseem ceeb rau kev tiv thaiv thiab kho cov metabolism. Pancragen tuaj yeem tiv thaiv pancreatic β-hlwb los ntawm kev txhim kho kev ua haujlwm thiab kev ua haujlwm ntawm pancreatic hlwb.
7. Kev kho mob ntawm tus mob pancreatitis
Txo Cov Kab Mob Ntshav Qab Zib: Pancragen muaj qee yam tshuaj tiv thaiv kab mob, uas tuaj yeem txo cov lus teb ntawm tus txiav thiab txo cov tsos mob ntawm tus mob pancreatitis. Cov kab mob pancreatitis ntev yog ib hom kab mob pancreatic, thiab cov lus teb inflammatory yog ib qho ntawm cov yam ntxwv tseem ceeb ntawm tus mob pancreatitis. Pancragen tuaj yeem txo qhov inflammatory teb ntawm tus txiav los ntawm kev tswj cov kev qhia ntawm inflammatory yam. Piv txwv li, hauv qee qhov kev sim tsiaj, Pancragen tuaj yeem txo cov lus teb ntawm tus txiav txiav thiab txo cov tsos mob ntawm tus mob pancreatitis.
Txhawb Pancreatic Tissue Repair: Nws tuaj yeem txhawb kev kho thiab rov tsim dua tshiab ntawm cov ntaub so ntswg pancreatic los ntawm kev tswj cov cell proliferation thiab sib txawv, pab txhim kho kev ua haujlwm ntawm lub txiav. Kev kho thiab rov tsim cov ntaub so ntswg pancreatic yog qhov tseem ceeb rau kev kho mob ntawm tus mob pancreatitis. Pancragen tuaj yeem txhawb kev kho thiab rov tsim dua tshiab ntawm cov ntaub so ntswg pancreatic los ntawm kev tswj cov cell proliferation thiab sib txawv. Piv txwv li, hauv qee qhov kev sim tsiaj, Pancragen tuaj yeem txhawb kev kho thiab rov tsim dua tshiab ntawm pancreatic nqaij thiab txhim kho kev ua haujlwm ntawm lub txiav.
Hauv kev xaus, Pancragen ua lub luag haujlwm tseem ceeb hauv kev tawm dag zog los tiv thaiv kev laus, tswj kev ua haujlwm ntawm pancreatic, txhawb cov ntshav qabzib sib npaug, txhawb kev ua haujlwm ntawm endocrine, nrog rau kev tswj hwm cov metabolism thiab kho mob pancreatitis.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Khavinson VK yog tus kws tshawb fawb tshwj xeeb nrog kev sib koom ua ke thoob plaws ntau lub tsev muaj koob npe. Cov no suav nrog Lavxias Academy ntawm Sciences, St Petersburg lub koom haum ntawm Bioregulation thiab Gerontology, North-Western State Medical University muaj npe tom qab II Mechnikov, Pavlov lub koom haum ntawm Physiology, Lavxias teb sab Academy of Medical Sciences, thiab Peter lub Great St. Petersburg Polytechnic University, thiab lwm yam.
Nws txoj kev tshawb fawb nyiam nthuav dav ntau yam xws li Kev Tshawb Fawb & Kev Tshawb Fawb Tshuaj, Geriatrics & Gerontology, Biochemistry & Molecular Biology, Endocrinology & Metabolism, thiab Neurosciences & Neurology. Thoob plaws hauv nws txoj haujlwm, nws tau ua haujlwm tseem ceeb rau cov cheeb tsam no, txhawb kev nkag siab txog ntau yam txheej txheem lom neeg thiab kev kho mob.
