Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
1. Ŋgɔdonya
Le kamedede me la, zi geɖe la, ɖeɖiteameŋu nana be kamedede ƒe dzidodo ƒe nyonyo dzi ɖena kpɔtɔna. Ŋusẽ ƒe asitɔtrɔ ƒe mɔnuwo ƒe dɔwɔwɔ nyuie le vevie ŋutɔ be woalé kamedede ƒe ŋutete me ɖe asi. Abe nusi ate ŋu awɔ ɖoɖo ɖe eŋu ene la, akpa si Vilon wɔna le ŋusẽ ƒe asitɔtrɔ ƒe mɔnuwo me he amewo ƒe susu vivivi.
Figure 1 Wokpɔa ŋusẽ ƒe asitɔtrɔ to dzesimɔ si me AMPK kple eƒe nusiwo do ƒome kple eƒe anyime le dzi.
2. Ƒomedodo si le Ŋusẽ ƒe Tɔtrɔyimɔ̃wo Kple Kamedede ƒe Ðeɖiteameŋu Kple Dzidodo Dome
(1) Ŋusẽ ƒe Tɔtrɔ ƒe Mɔnuwo Ŋuti Nyatakaka Kpuie
Le kamedede me la, ŋusẽ si ŋutilãa nana la nɔa te ɖe carbohydrates, ami, kple protein ƒe asitɔtrɔ le lãmenugbagbeviwo me dzi koŋ. Carbohydrate ƒe asitɔtrɔ wɔa akpa vevi aɖe le dzidodo ƒe kamedede didi me, si naa ŋusẽ to glycolysis kple aerobic oxidation mɔwo dzi. Ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu nyea ŋusẽtsoƒe si nɔa anyi ɖaa, si kpena ɖe ame ŋu be carbohydrate si mesɔ gbɔ o la nanɔ anyi. Proteinwo hã naa ŋusẽ ƒe akpa aɖe le dzidodo ƒe kamedede didi me, eye wònyea ATP ƒe wɔwɔme bliboa ƒe 10% lɔƒo.
(2) Ƒomedodo Si Le Kamedede ƒe Ðeɖiteameŋu Kple Ŋusẽ ƒe Tɔtrɔyimɔ̃ Dome
Kamedede didi ate ŋu ana ŋusẽ ƒe asitɔtrɔ le lãme na ame ƒe dadasɔ, abe sukli ƒe agbɔsɔsɔ si dzi ɖena kpɔtɔna le ʋu me kple glycogen ƒe agbɔsɔsɔ si dzi ɖe kpɔtɔ ene, si kpe ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa aɖewo abe lactic acid kple ʋu me amonia ƒe ƒuƒoƒo ŋu. Tɔtrɔ siawo ate ŋu ahe kamedede ƒe ɖeɖiteameŋu vɛ eye wòaɖe kamedede ƒe dzidodo dzi akpɔtɔ.
Vilon ƒe Dɔwɔwɔ le Ðoɖowɔwɔ me le Ŋusẽ ƒe Tɔtrɔyimɔ̃wo Me
(1) Vilon ƒe Carbohydrate ƒe Dɔwɔnawo Ŋuti Ðoɖowɔwɔ
Glycogen ƒe wɔwɔme kple eƒe gbagbã: Vilon ate ŋu akpɔ ŋusẽ ɖe glycogen ƒe wɔwɔme kple eƒe gbagbã dzi to enzyme veviwo abe glycogen synthase (GS) kple glycogen phosphorylase ƒe dɔwɔwɔ dzi kpɔkpɔ me. Hafi Vilon nade kame la, edoa glycogen ƒe wɔwɔ ɖe ŋgɔ, si wɔnɛ be glycogen ƒe agbɔsɔsɔ si le eme dzina ɖe edzi; le kamedede me la, Vilon ate ŋu aɖɔ glycogen ƒe gbagbã ƒe agbɔsɔsɔme ɖo wòasɔ be wòakpɔ egbɔ be sukli si le ʋu me la li ke. Le sisiblisiwo ƒe dodokpɔwo me la, sisiblisi siwo wotsɔ Vilon da dɔe la ɖe tɔtrɔ siwo sɔ wu fia le glycogen ƒe agbɔsɔsɔ si le lãmekawo kple aklã me do ŋgɔ na kamedede kple le kamedede megbe, si na ŋusẽ si hiã le kamedede me la nɔ anyi nyuie wu.
Glycolysis kple aerobic oxidation: Vilon ate ŋu akpɔ ŋusẽ ɖe enzyme vevi siwo le glycolytic mɔa me, abe phosphofructokinase (PFK) ene, ƒe dɔwɔwɔ dzi, si ana glycolysis ƒe agbɔsɔsɔme nanɔ anyi. Vilon ate ŋu akpɔ gome le enzyme siwo do ƒome kple tricarboxylic acid ƒe tsatsam le aerobic oxidation me ƒe dɔwɔwɔ dzi kpɔkpɔ me, abe citrate synthase (CS) ene, ana carbohydrates ƒe aerobic oxidation nanyo ɖe edzi hena ŋusẽ wɔwɔ kple ŋusẽzazã nyuie wu.
(2) Vilon ƒe Ami ƒe Dɔwɔnawo Ŋuti Ðoɖowɔwɔ
Ami ƒe ʋuʋu kple etsɔtsɔ yi teƒe bubuwo: Vilon ate ŋu ado ami ƒe ʋuʋu ɖe ŋgɔ le ami me to enzymewo abe hormone-sensitive lipase (HSL) ƒe dɔwɔwɔ dzi kpɔkpɔ me. Vilon ate ŋu akpɔ ŋusẽ ɖe amitsɔlawo (FATP) ƒe ɖeɖefia hã dzi, si ana ami ƒe tsɔtsɔ yi lãmekawo me kabakaba eye wòana nu geɖe wu nasu lãmekawo ƒe oxidative ŋusẽ wɔwɔ.
β-Oxidation: Le lãmekawo me la, Vilon ate ŋu aɖɔ enzyme veviwo abe carnitine palmitoyltransferase (CPT) ƒe dɔwɔwɔ ɖo, ado ami ƒe β-oxidation ɖe ŋgɔ, ana ami ƒe oxidation ƒe dɔwɔwɔ nanyo ɖe edzi hena ŋusẽ wɔwɔ, aɖe carbohydrate zazã dzi akpɔtɔ, eye wòato esia me ana kamedede ƒe dzidodo nadidi ɖe edzi.
(3) Vilon ƒe Protein ƒe Tɔtrɔyimɔ̃ ƒe Ðoɖowɔwɔ
Togbɔ be proteinwoe naa ŋusẽ ƒe akpa sue aɖe ko le kamedede me hã la, Vilon ate ŋu aɖɔ dzesimɔ siwo do ƒome kplii ɖo be wòaɖe protein ƒe gbegblẽ dzi akpɔtɔ, si ana lãmekawo ƒe lolome kple dɔwɔwɔ nanɔ anyi. Vilon ate ŋu axe mɔ ɖe ubiquitin-proteasome ƒe ɖoɖoa ƒe dɔwɔwɔ nu, si aɖe lãmekawo me protein ƒe gbegblẽ dzi akpɔtɔ, si kpena ɖe lãmekawo ƒe ʋuʋu ŋu eye wòɖea kamedede ƒe ɖeɖiteameŋu dzi kpɔtɔna.
Vilon ƒe Akpa si wòwɔna le Ŋusẽ ƒe Tɔtrɔyimɔ̃wo Dzikpɔkpɔ me hena Ðeɖiteameŋu ƒe Tsitretsitsi Kple Kamedede ƒe Dzidodo ƒe Nyonyome
(1) Ŋusẽkpɔɖeamedzi si Tsi Tre Ðe Ðeɖiteameŋu Ŋu
Ðeɖiteameŋu ƒe Gɔmedzedze Hehehe Ðe Eme: To ŋusẽ ƒe asitɔtrɔ ƒe mɔnuwo dzi kpɔkpɔ me la, Vilon ate ŋu alé ŋusẽnu siwo le ʋu me abe ʋumesukli kple glycogen ene ƒe agbɔsɔsɔ si li ke me ɖe asi, aɖe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa aɖewo ƒe ƒuƒoƒo dzi akpɔtɔ, eye wòato esia me ahe ɖeɖiteameŋu ƒe gɔmedzedze ɖe megbe. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, lã siwo wotsɔ Vilon da dɔe la ɖe ɖeɖiteameŋu ƒe gɔmedzedze si tsi megbe ŋutɔ fia le kamedede didi me.
Ðeɖiteameŋu ƒe sesẽ dzi ɖeɖe kpɔtɔ: Ame ɖekaɖeka siwo wotsɔ Vilon da dɔe la ɖe nugbagbeŋusẽ ƒe dzesi siwo do ƒome kple ɖeɖiteameŋu abe lactate kple ʋu me urea nitrogen (BUN) ƒe agbɔsɔsɔ si bɔbɔ ɖe anyi wu fia le woƒe ʋu me le kamedede megbe, si ɖee fia be Vilon ate ŋu aɖe ɖeɖiteameŋu si kamedede hena vɛ ƒe sesẽ dzi akpɔtɔ eye wòana woahaya kabakaba.
(2) Kamedede ƒe dzidodo dzi ɖeɖe kpɔtɔ
Kamedede ƒe ɣeyiɣi didi: Le Vilon ƒe ŋusẽ ƒe asitɔtrɔ ƒe mɔnuwo dzi kpɔkpɔ nyuie ta la, ŋutilãa ate ŋu azã ŋusẽ ƒe gɔmeɖoanyiwo nyuie wu, si ana kamedede ƒe ɣeyiɣi didi nadidi ɖe edzi. Numekuku geɖe ɖee fia be lã siwo wodo Vilon na la ɖe kamedede ƒe ɣeyiɣi didi si dzi ɖe edzi ŋutɔ fia le kamedede blibo me.
Kamedede ƒe sesẽme si dzi ɖe edzi: Menye ɖeko Vilon naa kamedede ƒe ɣeyiɣi didi ɖe edzi ko o, ke enaa kamedede ƒe sesẽme hã dzina ɖe edzi vaseɖe afi aɖe. Esia ate ŋu atso esi Vilon naa ŋusẽ ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu nyona ɖe edzi, si wɔnɛ be lãmekawo te ŋu kpɔa ŋusẽ si sɔ le kamedede sesẽ me be woalé lãmekawo ƒe tete ƒe dɔwɔwɔ me ɖe asi.
Nyanuwuwuw
Vilon wɔa akpa vevi aɖe le ɖeɖiteameŋu ƒe tsitretsitsi kple kamedede ƒe dzidodo dzi ɖeɖe kpɔtɔ me to eƒe ɖoɖowɔwɔ ɖe carbohydrate, ami, kple protein ƒe asitɔtrɔ le ŋusẽ ƒe asitɔtrɔ ƒe mɔnuwo me ŋu le mɔ vovovowo nu me. Ate ŋu ahe ɖeɖiteameŋu ƒe gɔmedzedze ɖe megbe, aɖe ɖeɖiteameŋu ƒe sesẽ dzi akpɔtɔ, evɔ wòana kamedede ƒe ɣeyiɣi didi nadidi ɖe edzi eye wòana kamedede ƒe ŋusẽ nanyo ɖe edzi.
Dzɔtsoƒewo
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[4] Huang J, Tagawa T, Ma S, kple ame bubuwo. Black Ginger (Kaempferia parviflora) Extract Doa Dzidodo Ŋutete Ðe Dzi To Ŋusẽ ƒe Tɔtrɔ Kple Substrate Zazã ƒe Nyonyome le Mice me[J]. Nunyiamewo, 2022, 14 (18).DOI: 10.3390 / nu14183845.
[5] Alghannam AF, Ghaith MM, Alhussain M H. Ŋusẽ ƒe Substrate Metabolism ƒe ɖoɖowɔwɔ le Dzidodo ƒe Kamedede me[J]. Dukɔwo Dome Nyadzɔdzɔgbalẽ si Ku Ðe Nutome Ŋuti Numekuku Kple Dukɔa ƒe Lãmesẽnyawo Ŋu, 2021,18 (9).DOI:10.3390/ijerph18094963.
[6] Xu X, Ding Y, Yang Y, kple ame bubuwo. β-glucan Salecan Na Kamedede ƒe Dɔwɔwɔ nyona ɖe edzi eye wòɖea ɖeɖiteameŋu ƒe ŋusẽkpɔɖeamedziwo fiana to ŋusẽ ƒe asitɔtrɔ kple oxidative nuteɖeamedzi dzi kpɔkpɔ le Mice me[J]. Nunyiamewo, 2018, 10 (7).DOI: 10.3390 / nu10070858.
Adzɔnu si li na numekuku zazã ɖeɖeko:
