Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
1. Intangiriro
Mugihe cy'imyitozo ngororamubiri, umunaniro ukunze kugabanya iterambere ryo kwihangana. Imikorere isanzwe yinzira ya metabolism inzira ningirakamaro mugukomeza ubushobozi bwimyitozo. Nkikintu gishobora kugenzurwa, uruhare rwa Vilon mumihanda ya metabolism yingufu zagiye zikurura abantu buhoro buhoro.
Igicapo 1 Metabolism yingufu igengwa ninzira yerekana inzira igizwe na AMPK nibintu bifitanye isano nayo.
2. Isano iri hagati yingufu za Metabolism Inzira no Gukoresha Umunaniro no Kwihangana
(1) Incamake yinzira zingufu za Metabolism Inzira
Mugihe cy'imyitozo ngororamubiri, imbaraga z'umubiri zishingiye cyane cyane kuri metabolisme ya karubone, amavuta, na proteyine. Carbohydrate metabolism igira uruhare runini mu myitozo yo kwihangana igihe kirekire, itanga ingufu binyuze muri glycolysis n'inzira ya okiside ya aerobic. Metabolism yibinure ikora nkisoko irambye yingufu, ifasha kubika ibigega bike bya karubone. Poroteyine nazo zitanga igice cyingufu mugihe cyimyitozo yo kwihangana igihe kirekire, bingana hafi 10% yumusaruro wose wa ATP.
(2) Isano iri hagati y'imyitozo ngororamubiri na Metabolism y'ingufu
Imyitozo ngororangingo igihe kirekire irashobora gutuma habaho ubusumbane bw’ingufu za metabolisme, nko kugabanuka kwa glucose yamaraso no kugabanya ububiko bwa glycogene, bikajyana no kwegeranya ibicuruzwa biva mu mahanga nka acide lactique na ammonia yamaraso. Izi mpinduka zirashobora gukurura umunaniro wimyitozo no kugabanya kwihangana kwimyitozo.
Uruhare rwo kugenzura Vilon munzira zingufu za Metabolism
(1) Amabwiriza ya Vilon ya Carbohydrate Metabolism
Glycogene synthesis hamwe no gusenyuka: Vilon irashobora kugira uruhare muri synthesis ya glycogene no gusenyuka muguhuza ibikorwa byimisemburo yingenzi nka synthase ya glycogene (GS) na fosifori ya glycogene. Mbere yo gukora siporo, Vilon iteza imbere synthesis ya glycogene, ikongera ububiko bwa glycogene; mugihe cy'imyitozo ngororamubiri, Vilon irashobora kugena neza igipimo cyo kugabanuka kwa glycogene kugirango glucose itangwe neza. Mu bushakashatsi bwimbeba, imbeba zavuwe na Vilon zagaragaje impinduka zifatika mubintu bya glycogene mumitsi ndetse numwijima mbere na nyuma yimyitozo ngororamubiri, bikomeza kubungabunga ingufu mugihe cyimyitozo ngororamubiri.
Glycolysis na okiside ya aerobic: Vilon irashobora guhindura imikorere yimisemburo yingenzi munzira ya glycolitike, nka fosifofructokinase (PFK), igenga igipimo cya glycolise. Vilon irashobora kandi kugira uruhare mukugenzura ibikorwa byimisemburo ijyanye na acide ya tricarboxylique muri okiside ya aerobic, nka citrate synthase (CS), guhindura okiside ya aerobic ya karubone ya hydrata kugirango itange ingufu no kunoza ikoreshwa ryingufu.
(2) Amabwiriza ya Metabolism yibinure na Vilon
Gukusanya aside irike no gutwara: Vilon irashobora guteza imbere ubukangurambaga bwa aside irike mumyanya ya adipose muguhuza ibikorwa byimisemburo nka lipase yangiza imisemburo (HSL). Vilon irashobora kandi kugira ingaruka kumagambo yabatwara aside irike (FATP), kwihutisha ubwikorezi bwa aside irike mungirangingo yimitsi no gutanga insimburangingo nyinshi kugirango ingufu za okiside zitanga imitsi.
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(3) Amabwiriza ya Protein Metabolism na Vilon
Nubwo poroteyine zifite uruhare runini mu gutanga ingufu mu gihe cy'imyitozo ngororamubiri, Vilon irashobora kugena inzira zerekana ibimenyetso bifitanye isano no kugabanya iyangirika rya poroteyine, bityo bikomeza imitsi n'imikorere. Vilon irashobora guhagarika ibikorwa bya sisitemu ya ubiquitin-proteasome, igabanya iyangirika rya poroteyine yimitsi, ifasha kugumana imitsi no kugabanya umunaniro wimyitozo ngororamubiri.
Uruhare rwa Vilon muguhuza ingufu za Metabolism Inzira zo Kurwanya Umunaniro no Gukora Kwihangana Kwihangana
(1) Ingaruka zo Kurwanya umunaniro
Gutinda Umunaniro Gutangira: Mu kugenzura inzira za metabolisme yingufu, Vilon irashobora gukomeza gutanga ibintu bihamye byingufu zingufu nka glucose yamaraso na glycogene, bikagabanya ikwirakwizwa ryibicuruzwa biva mu mahanga, bityo bikadindiza gutangira umunaniro. Mu bushakashatsi bw’inyamaswa, inyamaswa zavuwe na Vilon zagaragaje gutinda cyane gutangira umunaniro mugihe imyitozo myinshi.
Kugabanya ubukana bwumunaniro: Abantu bavuwe na Vilon bagaragaje urwego rwo hasi rwibimenyetso bifitanye isano na biohimiki yumunaniro nka lactate na maraso urea azote (BUN) mumaraso yabo nyuma yimyitozo ngororamubiri, byerekana ko Vilon ishobora kugabanya ubukana bwumunaniro uterwa na siporo kandi bikoroha gukira vuba.
(2) Kongera imbaraga zo kwihangana
Igihe kinini cyimyitozo ngororamubiri: Bitewe na Vilon uburyo bwiza bwo kugenzura ingufu za metabolisme yingufu, umubiri urashobora gukoresha ingufu zingirakamaro, bityo bikongerera igihe imyitozo. Ubushakashatsi bwinshi bwerekanye ko inyamaswa zayobowe na Vilon zagaragaje cyane igihe cyimyitozo ngororamubiri mugihe cyimyitozo ngororamubiri.
Imyitozo ngororamubiri yongerewe imbaraga: Vilon ntabwo yongerera igihe imyitozo gusa ahubwo inongera imbaraga zimyitozo kurwego runaka. Ibi birashobora kuba kubera ko Vilon itezimbere imbaraga za metabolisme, igafasha imitsi kubona ingufu zihagije mugihe cyimyitozo ngororamubiri ikomeza imikorere yo kugabanya imitsi.
Umwanzuro
Vilon igira uruhare runini mukurwanya umunaniro no kongera imbaraga zo kwihangana binyuze mumabwiriza yayo menshi agenga karubone, ibinure, na protein metabolism mumihanda ya metabolike. Irashobora gutinza gutangira umunaniro, kugabanya ubukana bwumunaniro, mugihe wongereye imyitozo no kongera imbaraga zimyitozo ngororamubiri.
Inkomoko
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Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
