Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
1. Intangiriro
Mugihe c'imyitozo ngororamubiri, umunaniro ukunze kugabanya iterambere ryo kwihanganira imyitozo. Imikorere isanzwe yinzira ya metabolism inzira ningirakamaro mugukomeza ubushobozi bwimyitozo. Nkikintu gishobora kugenzurwa, uruhare rwa Vilon mumihanda ya metabolism yingufu zagiye zikurura abantu buhoro buhoro.
Igicapo 1 Metabolism yingufu igengwa ninzira yerekana inzira igizwe na AMPK nibintu bifitanye isano nayo.
2. Isano iri hagati yingufu za Diyabete Yingufu no Gukoresha Umunaniro no Kwihangana
(1) Incamake yinzira ya Diyabete yingufu
Mugihe cy'imyitozo ngororamubiri, imbaraga z'umubiri zishingiye cyane cyane kuri metabolisme ya karubone, amavuta, na proteyine. Carbohydrate metabolism igira uruhare runini mu myitozo yo kwihangana igihe kirekire, itanga ingufu binyuze muri glycolysis n'inzira ya okiside ya aerobic. Metabolism yibinure ikora nkisoko irambye yingufu, ifasha kubika ibigega bike bya karubone. Poroteyine nazo zitanga igice cyingufu mugihe cyimyitozo yo kwihangana igihe kirekire, bingana hafi 10% yumusaruro wose wa ATP.
(2) Isano iri hagati y'imyitozo ngororamubiri na Diyabete y'ingufu
Imyitozo ngororangingo igihe kirekire irashobora gutuma habaho ubusumbane bw’ingufu za metabolisme, urugero nko kugabanuka kwamaraso glucose yamaraso no kugabanya ububiko bwa glycogene, bikajyana no kwegeranya ibicuruzwa biva mu mahanga nka acide lactique na ammonia yamaraso. Izi mpinduka zirashobora gukurura umunaniro wimyitozo no kugabanya kwihangana kwimyitozo.
Uruhare rwo kugenzura Vilon muburyo bw'ingufu za Diyabete
(1) Amabwiriza ya Vilon ya Diyabete ya Carbohydrate
Glycogene synthesis hamwe no gusenyuka: Vilon irashobora guhindura synthesis ya glycogene no gusenyuka muguhindura ibikorwa byimisemburo yingenzi nka synthase ya glycogene (GS) na fosifori ya glycogene. Mbere yo gukora siporo, Vilon iteza imbere synthesis ya glycogene, ikongera ububiko bwa glycogene; mugihe cy'imyitozo ngororamubiri, Vilon irashobora kugena neza igipimo cyo kugabanuka kwa glycogene kugirango glucose itangwe neza. Mu bushakashatsi bwimbeba, imbeba zavuwe na Vilon zagaragaje impinduka zifatika mubintu bya glycogene mumitsi ndetse numwijima mbere na nyuma yimyitozo ngororamubiri, bikomeza kubungabunga ingufu mugihe cyimyitozo ngororamubiri.
Glycolysis na okiside ya aerobic: Vilon irashobora guhindura imikorere yimisemburo yingenzi munzira ya glycolitike, nka fosifofructokinase (PFK), igenga igipimo cya glycolise. Vilon irashobora kandi kugira uruhare mugutunganya ibikorwa byimisemburo ijyanye na acide ya tricarboxylique muri okiside ya aerobic, nka citrate synthase (CS), guhindura okiside ya aerobic ya karubone ya hydrata kugirango itange ingufu kandi inoze gukoresha ingufu.
(2) Amabwiriza ya Diyabete yibinure na Vilon
Gukusanya aside irike no gutwara: Vilon irashobora guteza imbere ubukangurambaga bwa aside irike muri tipusi ya adipose muguhuza ibikorwa byimisemburo nka lipase yangiza imisemburo (HSL). Vilon irashobora kandi kugira ingaruka kumagambo yabatwara aside irike (FATP), kwihutisha ubwikorezi bwa aside irike mungirangingo yimitsi no gutanga insimburangingo nyinshi kugirango itange ingufu za okiside.
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(3) Amabwiriza ya Diyabete ya poroteyine na Vilon
Nubwo poroteyine zigira uruhare runini mu gutanga ingufu mu gihe cy'imyitozo ngororamubiri, Vilon irashobora kugena inzira zerekana ibimenyetso bifitanye isano no kugabanya iyangirika rya poroteyine, bityo igakomeza imitsi n'imikorere. Vilon irashobora guhagarika ibikorwa bya sisitemu ya ubiquitin-proteasome, igabanya iyangirika rya poroteyine yimitsi, ifasha kugumana imitsi no kugabanya umunaniro wimyitozo ngororamubiri.
Uruhare rwa Vilon mugutunganya inzira ya Diyabete yingufu zo kurwanya umunaniro no gukora imyitozo yo kwihangana
(1) Ingaruka zo Kurwanya umunaniro
Gutinda Umunaniro Gutangira: Mugutegeka inzira ya metabolisme yingufu, Vilon irashobora gukomeza gutanga ibintu bihamye byingufu zingufu nka glucose yamaraso na glycogene, kugabanya ikwirakwizwa ryibicuruzwa biva mu mahanga, bityo bigatinda gutangira umunaniro. Mu bushakashatsi bw’inyamaswa, inyamaswa zavuwe na Vilon zagaragaje gutinda cyane gutangira umunaniro mugihe imyitozo myinshi.
Kugabanya ubukana bw'umunaniro: Abantu bavuwe na Vilon bagaragaje urugero rwo hasi rw'ibimenyetso bya biohimiki bifitanye isano n'umunaniro nka lactate na maraso urea azote (BUN) mu maraso yabo nyuma y'imyitozo ngororamubiri, byerekana ko Vilon ishobora kugabanya ubukana bw'umunaniro uterwa na siporo kandi bikoroha gukira vuba.
(2) Kongera imbaraga zo kwihangana
Igihe kinini cyimyitozo ngororamubiri: Bitewe nuburyo bwiza bwa Vilon bwo kuyobora inzira ya metabolism yingufu, umubiri urashobora gukoresha insimburangingo zingufu neza, bityo bikongerera igihe imyitozo. Ubushakashatsi bwinshi bwerekanye ko inyamaswa zayobowe na Vilon zagaragaje cyane igihe cyimyitozo ngororamubiri mugihe cyimyitozo ngororamubiri.
Imyitozo ngororamubiri yongerewe imbaraga: Vilon ntabwo yongerera igihe imyitozo gusa ahubwo inongera imbaraga zimyitozo kurwego runaka. Ibi birashobora kuba kubera ko Vilon itezimbere imbaraga za metabolisme, bigatuma imitsi ibona ingufu zihagije mugihe cyimyitozo ngororamubiri ikomeza imikorere yo kugabanya imitsi.
Umwanzuro
Vilon igira uruhare runini mukurwanya umunaniro no kongera imbaraga zo kwihangana binyuze mumabwiriza yayo menshi agenga karubone, ibinure, na protein metabolism mumihanda ya metabolike. Irashobora gutinza gutangira umunaniro, kugabanya ubukana bwumunaniro, mugihe wongereye imyitozo no kongera imbaraga zimyitozo ngororamubiri.
Inkomoko
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Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
