By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
1. Gabatarwa
A lokacin motsa jiki, gajiya sau da yawa yana iyakance haɓaka juriya na motsa jiki. Aiki na yau da kullun na hanyoyin metabolism kuzari yana da mahimmanci don kiyaye ƙarfin motsa jiki. A matsayin mai yuwuwar tsarin tsari, rawar Vilon a cikin hanyoyin samar da makamashi na makamashi ya jawo hankali a hankali.
Hoto na 1 ana sarrafa metabolism na makamashi ta hanyar sigina da ta ƙunshi AMPK da abubuwan da suka danganci ƙasa.
2. Dangantakar Tsakanin Hanyoyi Metabolism Makamashi da Motsa Gaji da Juriya
(1) Bayanin Hanyoyi na Metabolism Makamashi
A lokacin motsa jiki, samar da kuzarin jiki da farko ya dogara ne akan metabolism na carbohydrates, fats, da sunadarai. Carbohydrate metabolism yana taka muhimmiyar rawa a cikin motsa jiki na tsayin daka, samar da makamashi ta hanyar glycolysis da hanyoyin iskar oxygenation. Fat metabolism yana aiki azaman tushen kuzari mai ɗorewa, yana taimakawa adana iyakanceccen tanadin carbohydrate. Sunadaran kuma suna ba da gudummawar wani yanki na kuzari yayin aikin juriya na tsayin daka, wanda ke lissafin kusan kashi 10% na yawan samar da ATP.
(2) Dangantaka Tsakanin Motsa Jiki da Tattalin Arziki na Makamashi
Tsawon aikin motsa jiki na iya haifar da rashin daidaituwa na metabolism na makamashi, kamar rage matakan glucose na jini da rage ajiyar glycogen, tare da tarin abubuwan da ke haifar da rayuwa kamar lactic acid da ammonia na jini. Wadannan canje-canje na iya haifar da gajiyar motsa jiki da kuma rage juriyar motsa jiki.
Matsayin Gudanarwa na Vilon a Hanyoyi Metabolism Makamashi
(1) Dokokin Vilon na Carbohydrate Metabolism
Haɗin Glycogen da rushewa: Vilon na iya yin tasiri akan haɗin glycogen da raguwa ta hanyar daidaita ayyukan mahimman enzymes kamar glycogen synthase (GS) da glycogen phosphorylase. Kafin motsa jiki, Vilon yana inganta haɓakar glycogen, yana haɓaka ajiyar glycogen; A lokacin motsa jiki, Vilon na iya daidaita yawan raguwar glycogen yadda ya kamata don tabbatar da kwanciyar hankali na glucose na jini. A cikin gwaje-gwajen linzamin kwamfuta, berayen da aka yi wa Vilon sun nuna ƙarin canje-canje masu ma'ana a cikin abun ciki na glycogen a cikin tsokoki da hanta kafin da bayan motsa jiki, mafi kyawun kiyaye buƙatun kuzari yayin motsa jiki.
Glycolysis da aerobic oxidation: Vilon na iya yin tasiri ga ayyukan enzymes masu mahimmanci a cikin hanyar glycolytic, irin su phosphofructokinase (PFK), yana daidaita yawan glycolysis. Hakanan Vilon na iya shiga cikin daidaita ayyukan enzymes masu alaƙa da zagayowar tricarboxylic acid a cikin iskar oxygen na iska, irin su citrate synthase (CS), haɓaka iskar oxygen na aerobic na carbohydrates don samar da kuzari da haɓaka ingantaccen amfani da makamashi.
(2) Dokokin Fat Metabolism ta Vilon
Fatty acid tattarawa da sufuri: Vilon na iya inganta haɓakar fatty acid a cikin adipose nama ta hanyar daidaita ayyukan enzymes kamar lipase mai jin daɗin hormone (HSL). Vilon kuma na iya yin tasiri ga maganganun masu jigilar fatty acid (FATP), yana haɓaka jigilar fatty acid zuwa ƙwayoyin tsoka da kuma samar da ƙarin abubuwan da ke samar da makamashin iskar oxygen na tsoka.
β-Oxidation: A cikin ƙwayoyin tsoka, Vilon na iya daidaita ayyukan enzymes masu mahimmanci irin su carnitine palmitoyltransferase (CPT), inganta β-oxidation na fatty acids, inganta haɓakar haɓakar ƙwayar mai don samar da makamashi, rage yawan amfani da carbohydrate, kuma ta haka ne ya kara ƙarfin motsa jiki.
(3) Ka'idar Rarraba Protein Metabolism ta Vilon
Ko da yake sunadaran suna lissafin ƙarancin ƙarancin kuzarin samar da makamashi yayin motsa jiki, Vilon na iya daidaita hanyoyin siginar da ke da alaƙa don rage lalata furotin, don haka kiyaye ƙwayar tsoka da aiki. Vilon na iya hana aikin tsarin ubiquitin-proteasome, rage lalata furotin na tsoka, wanda ke taimakawa wajen kula da ƙwayar tsoka da kuma rage gajiyar motsa jiki.
Matsayin Vilon a Gudanar da Hanyoyi Metabolism Makamashi don Juriya ga Gaji da Inganta Jimiri.
(1) Maganganun Gajiya
Jinkirta Gajiwar Farko: Ta hanyar daidaita hanyoyin samar da makamashi, Vilon na iya kiyaye kwanciyar hankali na abubuwan makamashi kamar glucose na jini da glycogen, rage tarin abubuwan da ke haifar da rayuwa, kuma ta haka ne ya jinkirta fara gajiya. A cikin gwaje-gwajen dabba, dabbobin da aka yi musu magani tare da Vilon sun nuna jinkirin jinkirin gajiya a lokacin motsa jiki mai tsawo.
Rage tsananin gajiya: Mutanen da aka yi wa Vilon sun nuna ƙananan matakan alamomin biochemical masu alaƙa irin su lactate da jini na urea nitrogen (BUN) a cikin jininsu bayan motsa jiki, wanda ke nuna cewa Vilon na iya rage tsananin gajiyar motsa jiki da kuma sauƙaƙe saurin dawowa.
(2) Inganta juriyar motsa jiki
Tsawon lokacin motsa jiki: Saboda ingantaccen tsarin Vilon na hanyoyin samar da makamashi, jiki na iya yin amfani da abubuwan samar da makamashi cikin inganci, ta haka zai tsawaita tsawon lokacin motsa jiki. Yawancin karatu sun nuna cewa dabbobin da ake gudanar da su na Vilon sun nuna matukar yawan lokacin motsa jiki yayin motsa jiki.
Ingantattun ƙarfin motsa jiki: Vilon ba kawai yana tsawaita lokacin motsa jiki ba amma yana haɓaka ƙarfin motsa jiki zuwa ɗan lokaci. Wannan yana iya zama saboda Vilon yana inganta haɓakar makamashi, yana ba da damar tsokoki don samun isasshen makamashi a lokacin motsa jiki mai tsanani don kula da aikin ƙwayar tsoka.
Kammalawa
Vilon yana taka muhimmiyar rawa a cikin juriya ga gajiya da haɓaka juriya ta motsa jiki ta hanyar tsarin sa mai yawa na carbohydrate, mai da furotin metabolism a cikin hanyoyin rayuwa na makamashi. Yana iya jinkirta fara gajiya, rage tsananin gajiya, yayin da yake tsawaita lokacin motsa jiki da haɓaka ƙarfin motsa jiki.
Sources
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Samfura akwai don amfani da bincike kawai:
