Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
1. Taw qhia
Thaum qoj ib ce, qaug zog feem ntau txwv kev txhim kho ntawm kev tawm dag zog. Kev ua haujlwm ib txwm muaj ntawm lub zog metabolism hauv txoj hauv kev yog qhov tseem ceeb rau kev tswj kom muaj peev xwm tawm dag zog. Raws li kev tswj hwm muaj peev xwm, lub luag haujlwm ntawm Vilon hauv lub zog metabolism hauv txoj hauv kev tau maj mam nyiam mloog.
Daim duab 1 Lub zog metabolism yog tswj hwm los ntawm txoj kev taw qhia uas muaj AMPK thiab nws cov ntsiab lus hauv qab.
2. Kev sib raug zoo ntawm Lub Zog Metabolism Pathways thiab Exercise Fatigue thiab Endurance
(1) Txheej txheem cej luam ntawm Zog Metabolism Pathways
Thaum lub sij hawm ib ce, lub cev lub zog muab feem ntau nyob rau hauv lub metabolism ntawm carbohydrates, rog, thiab proteins. Carbohydrate metabolism plays lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntev ntev, muab lub zog los ntawm glycolysis thiab aerobic oxidation txoj hauv kev. Cov roj metabolism ua haujlwm ua lub zog ruaj khov, pab khaws cia cov carbohydrates tsawg. Proteins kuj tseem pab txhawb ib feem ntawm lub zog thaum lub sij hawm ua haujlwm ntev, suav txog kwv yees li 10% ntawm tag nrho cov khoom ATP.
(2) Kev sib raug zoo ntawm kev tawm dag zog qaug zog thiab lub zog Metabolism
Kev tawm dag zog ntev tuaj yeem ua rau lub zog metabolism tsis txaus, xws li txo cov ntshav qabzib thiab txo qis glycogen reserves, nrog rau cov khoom sib txuam ntawm cov khoom noj metabolic xws li lactic acid thiab ntshav ammonia. Cov kev hloov no tuaj yeem ua rau muaj kev qaug zog thiab txo qis kev tawm dag zog.
Txoj Cai Tswjfwm ntawm Vilon hauv Zog Metabolism Pathways
(1) Vilon's Regulation of Carbohydrate Metabolism
Glycogen synthesis thiab tawg: Vilon tuaj yeem cuam tshuam glycogen synthesis thiab kev puas tsuaj los ntawm kev tswj hwm cov haujlwm ntawm cov enzymes tseem ceeb xws li glycogen synthase (GS) thiab glycogen phosphorylase. Ua ntej kev tawm dag zog, Vilon txhawb nqa glycogen synthesis, nce glycogen reserves; Thaum lub sijhawm ua haujlwm, Vilon tuaj yeem tsim nyog tswj tus nqi ntawm glycogen tawg kom ntseeg tau cov ntshav qabzib ruaj khov. Hauv kev sim nas, nas kho nrog Vilon nthuav tawm ntau qhov kev hloov pauv ntawm cov ntsiab lus glycogen hauv cov leeg thiab daim siab ua ntej thiab tom qab kev tawm dag zog, kev tswj hwm lub zog kom zoo thaum lub sijhawm ua haujlwm.
Glycolysis thiab aerobic oxidation: Vilon tuaj yeem cuam tshuam cov haujlwm ntawm cov enzymes tseem ceeb hauv txoj kev glycolytic, xws li phosphofructokinase (PFK), tswj tus nqi ntawm glycolysis. Vilon kuj tseem tuaj yeem koom nrog hauv kev tswj hwm cov haujlwm ntawm cov enzymes ntsig txog lub voj voog tricarboxylic acid hauv aerobic oxidation, xws li citrate synthase (CS), optimizing aerobic oxidation ntawm carbohydrates rau lub zog tsim thiab txhim kho kev siv hluav taws xob.
(2) Kev Tswj Fat Metabolism los ntawm Vilon
Fatty acid mobilization thiab thauj: Vilon tuaj yeem txhawb nqa fatty acid mobilization hauv cov ntaub so ntswg adipose los ntawm kev tswj cov enzymes xws li hormone-rhiab heev lipase (HSL). Vilon kuj tseem tuaj yeem cuam tshuam rau kev nthuav qhia ntawm fatty acid transporters (FATP), ua kom ceev cov roj fatty acids mus rau cov leeg hlwb thiab muab ntau cov substrates rau cov leeg nqaij oxidative zog.
β-Oxidation: Hauv cov leeg nqaij, Vilon tuaj yeem tswj hwm cov haujlwm ntawm cov enzymes tseem ceeb xws li carnitine palmitoyltransferase (CPT), txhawb nqa β-oxidation ntawm fatty acids, txhim kho kev ua haujlwm ntawm cov roj oxidation rau lub zog tsim khoom, txo cov carbohydrate noj, thiab yog li ncua kev tawm dag zog.
(3) Kev tswj hwm ntawm Protein Metabolism los ntawm Vilon
Txawm hais tias cov proteins suav nrog qee qhov me me ntawm cov khoom siv hluav taws xob thaum lub sijhawm ua haujlwm, Vilon tuaj yeem tswj hwm txoj hauv kev cuam tshuam los txo cov protein degradation, yog li tswj cov leeg nqaij thiab ua haujlwm. Vilon tuaj yeem cuam tshuam cov kev ua ntawm ubiquitin-proteasome system, txo cov leeg nqaij protein degradation, uas pab tswj cov leeg nqaij contractility thiab alleviate ce qaug zog.
Vilon Lub luag haujlwm hauv Kev Tswj Xyuas Lub Zog Metabolism Txoj hauv kev rau Kev Fatigue Resistance thiab Exercise Endurance Txhim Kho
(1) Los tiv thaiv qaug zog
Kev ncua sij hawm qaug zog: Los ntawm kev tswj hwm lub zog metabolism hauv txoj hauv kev, Vilon tuaj yeem tswj cov khoom siv hluav taws xob ruaj khov xws li cov ntshav qabzib thiab glycogen, txo qis cov khoom lag luam metabolic, thiab yog li ncua qhov pib qaug zog. Hauv kev sim tsiaj, tsiaj kho nrog Vilon nthuav tawm qhov pib qeeb ntawm kev qaug zog thaum lub sijhawm ua haujlwm ntev.
Txo kev qaug zog hnyav: Cov tib neeg kho nrog Vilon tau nthuav tawm qis qis ntawm kev qaug zog txog biochemical cim xws li lactate thiab ntshav urea nitrogen (BUN) hauv lawv cov ntshav tom qab kev tawm dag zog, qhia tias Vilon tuaj yeem txo qhov hnyav ntawm kev tawm dag zog ua rau qaug zog thiab pab kom rov zoo dua.
(2) Txhim khu kev tawm dag zog
Kev siv sijhawm ntev ntev: Vim Vilon txoj kev tswj hwm ntawm lub zog metabolism hauv txoj hauv kev, lub cev tuaj yeem siv lub zog substrates tau zoo dua, yog li ncua sijhawm ua haujlwm. Ntau qhov kev tshawb fawb tau pom tias cov tsiaj uas tau tswj hwm Vilon tau nthuav tawm qhov kev tawm dag zog ntau ntxiv thaum lub sijhawm ua haujlwm hnyav.
Kev siv zog ua kom muaj zog: Vilon tsis tsuas yog ncua kev tawm dag zog tab sis kuj tseem txhim kho kev siv zog rau qee qhov. Qhov no yuav yog vim Vilon txhim kho cov metabolism hauv lub zog, ua rau cov leeg kom tau txais lub zog txaus thaum lub zog siv zog los tswj cov leeg nqaij ua haujlwm.
Xaus
Vilon plays lub luag haujlwm tseem ceeb hauv kev qaug zog thiab kev ua kom muaj zog tiv thaiv los ntawm nws txoj kev tswj hwm ntau yam ntawm cov carbohydrates, rog, thiab cov protein metabolism hauv lub zog metabolic. Nws tuaj yeem ncua qhov pib ntawm kev qaug zog, txo qis qaug zog, thaum ncua kev tawm dag zog lub sijhawm thiab txhim kho kev siv zog.
Qhov chaw
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Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
