By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
1. Okwu mmalite
N'oge mmega ahụ, ike ọgwụgwụ na-egbochikarị mmelite nke ntachi obi mgbatị ahụ. Ịrụ ọrụ nkịtị nke ụzọ metabolism ume dị oke mkpa maka ịnọgide na-enwe ike mmega ahụ. Dị ka ihe nwere ike imezi ihe, ọrụ Vilon na-arụ n'ime ụzọ metabolism ike ejirila nwayọọ nwayọọ dọta uche.
Ọgụgụ 1 A na-ahazi metabolism ike site na ụzọ akara nke nwere AMPK na ihe ndị metụtara ala ya.
2. Mmekọrịta dị n'etiti Ụzọ Metabolism Energy na mmega ahụ ike na ntachi obi.
(1) Nchịkọta nke Ụzọ Metabolism Energy
N'oge mmega ahụ, ike nke anụ ahụ na-adabere na metabolism nke carbohydrates, abụba, na protein. Metabolism nke carbohydrate na-arụ ọrụ dị mkpa n'ime mgbatị ahụ ogologo oge, na-enye ume site na glycolysis na ụzọ ikuku oxidation. Metabolism nke abụba na-arụ ọrụ dị ka isi iyi ike na-adịgide adịgide, na-enyere aka ichekwa oke nchekwa carbohydrate. Protein na-enyekwa aka n'akụkụ ume n'oge mmega ahụ ogologo ntachi obi, na-aza ihe dịka 10% nke mkpokọta ATP.
(2) Mmekọrịta dị n'etiti mmega ahụ ike ọgwụgwụ na ike metabolism
Mmega ahụ ogologo oge nwere ike iduga n'ịba ụba nke metabolism ike, dị ka mbelata ọkwa glucose ọbara na mbelata glycogen, yana mkpokọta nke ngwaahịa metabolic dị ka lactic acid na amonia ọbara. Mgbanwe ndị a nwere ike ịkpalite ike ọgwụgwụ ma belata ntachi obi.
Ọrụ nchịkwa nke Vilon na okporo ụzọ Metabolism Energy
(1) Iwu Vilon nke Carbohydrate Metabolism
Njikọ Glycogen na ndakpọ: Vilon nwere ike imetụta njikọ glycogen na ndakpọ site na ịhazi ọrụ nke enzymes isi dị ka glycogen synthase (GS) na glycogen phosphorylase. Tupu mgbatị ahụ, Vilon na-akwalite njikọ glycogen, na-abawanye ụba nke glycogen; N'oge mmega ahụ, Vilon nwere ike ịhazi n'ụzọ ziri ezi na ọnụego ndakpọ glycogen iji hụ na ọkọnọ glucose ọbara kwụsiri ike. N'ime nnwale òké, ụmụ oke e ji Vilon emeso ya gosipụtara mgbanwe ezi uche dị na ya na ọdịnaya glycogen na uru ahụ na imeju tupu na mgbe emechara mgbatị ahụ, na-edobe ike ka mma n'oge mmega ahụ.
Glycolysis na aerobic oxidation: Vilon nwere ike imetụta ọrụ nke enzymes isi na ụzọ glycolytic, dị ka phosphofructokinase (PFK), na-achịkwa ọnụego glycolysis. Vilon nwekwara ike sonye n'ịhazi ọrụ nke enzymes metụtara tricarboxylic acid okirikiri na aerobic oxidation, dị ka citrate synthase (CS), na-ebuli aerobic oxidation nke carbohydrates maka mmepụta ume na imeziwanye ike itinye n'ọrụ.
(2) Iwu nke Fat Metabolism site na Vilon
Mkpokọta fatty acid na mbufe: Vilon nwere ike ịkwalite mkpokọta abụba abụba na anụ ahụ adipose site na ịhazi ọrụ nke enzymes dị ka lipase hormone-sensitive (HSL). Vilon nwekwara ike imetụta nkwupụta nke ndị na-ebugharị fatty acid (FATP), na-eme ngwa ngwa ibufe fatty acids gaa na mkpụrụ ndụ akwara yana inyekwu mkpụrụ maka mmepụta ike oxidative muscle.
β-Oxidation: N'ime mkpụrụ ndụ akwara, Vilon nwere ike ịhazi ọrụ nke enzymes isi dị ka carnitine palmitoyltransferase (CPT), na-akwalite β-oxidation nke fatty acids, na-eme ka arụmọrụ nke abụba oxidation dị mma maka mmepụta ume, na-ebelata oriri carbohydrate, wee si otú ahụ na-agbatị ntachi obi.
(3) Iwu nke Protein Metabolism site na Vilon
Ọ bụ ezie na ndị na-edozi ahụ na-aza maka ntakịrị ume ike n'oge mmega ahụ, Vilon nwere ike ịhazi ụzọ mgbaàmà ndị metụtara ya iji belata mmebi protein, si otú a na-ejigide uru ahụ na ọrụ. Vilon nwere ike igbochi ọrụ nke usoro ubiquitin-proteasome, na-ebelata mmebi nke protein muscle, nke na-enyere aka ịnọgide na-enwe mgbagwoju anya ma na-ebelata ike ọgwụgwụ.
Ọrụ Vilon n'ịhazi Ụzọ Metabolism Ike Maka Nkwụsị Ike Ike Ike na Mmelite Mmelite Ntachi Obi
(1) Mmetụta mgbochi ike ọgwụgwụ
Na-egbu oge ike ọgwụgwụ: Site n'ịhazi ụzọ metabolism ike, Vilon nwere ike ịnọgide na-enye ike dị ka glucose ọbara na glycogen kwụsiri ike, belata mkpokọta nke ngwaahịa metabolic, wee si otú a na-egbu oge mmalite nke ike ọgwụgwụ. N'ime nnwale ụmụ anụmanụ, anụmanụ ndị e ji Vilon agwọ ọrịa gosipụtara nnukwu ike ọgwụgwụ na-egbu oge n'oge mmega ahụ ogologo oge.
Mbelata ike ọgwụgwụ: Ndị mmadụ na-emeso Vilon gosipụtara ọkwa dị ala nke ihe nrịbama biochemical metụtara ike ọgwụgwụ dị ka lactate na ọbara urea nitrogen (BUN) n'ọbara ha mgbe emechara mgbatị ahụ, na-egosi na Vilon nwere ike belata oke ike ọgwụgwụ nke mmega ahụ na-ebute ma mee ka mgbake ngwa ngwa.
(2) Ime ka mmega ahụ dịkwuo elu
Ogologo oge mmega ahụ agbatịkwuru: N'ihi usoro kachasị mma nke Vilon nke ụzọ metabolism ike, ahụ nwere ike iji ihe ike eme ihe nke ọma, si otú a na-agbatị ogologo oge mgbatị ahụ. Ọtụtụ ọmụmụ egosila na anụmanụ ndị a na-elekọta Vilon gosipụtara ogologo oge mgbatị ahụ mụbara nke ukwuu n'oge mmega ahụ na-agwụ ike.
Mmega ahụ siri ike: Vilon ọ bụghị naanị na-agbatị oge mmega ahụ kamakwa ọ na-eme ka mmega ahụ siri ike ruo n'ókè ụfọdụ. Nke a nwere ike ịbụ n'ihi na Vilon na-emeziwanye ike metabolism, na-eme ka akwara nwee ike nweta ume zuru oke n'oge mmega ahụ dị elu iji nọgide na-arụ ọrụ mkpirisi ahụ.
Mmechi
Vilon na-arụ ọrụ dị oke mkpa na nguzogide ike ọgwụgwụ na mmega ahụ nke mmega ahụ site na nhazi usoro nke carbohydrate, abụba na protein metabolism n'ime ụzọ metabolic ike. Ọ nwere ike igbu oge mmalite nke ike ọgwụgwụ, belata oke ike ọgwụgwụ, ebe ọ na-agbatị oge mgbatị ahụ ma na-eme ka mgbatị ahụ dịkwuo elu.
Isi mmalite
[1] Zhao R, Wu R, Jin J, et al. Ụzọ nrịbama na-achịkwa site na ihe ndị na-arụ ọrụ sitere n'okike na ọgụ megide ike ọgwụgwụ-ntụleghachi[J]. Ihu ihu na Pharmacology, 2023, Mpịakọta 14 - 2023.DOI:10.3389/fphar.2023.1269878.
[2] Lee M, Hsu Y, Shen S, et al. Ntụle na-arụ ọrụ nke mgbochi ike ọgwụgwụ na mmega ahụ mmega ahụ na-esote mgbakwunye mgbagwoju anya vitamin B n'ime ụmụ mmadụ dị mma, nnwale kpuru ìsì abụọ na-enweghị usoro[J]. Akwụkwọ akụkọ mba ụwa nke sayensị ahụike, 2023,20:1272-1281.
[3] Zhong H, Shi J, Zhang J, et al. Mgbakwunye Peptide Turtle dị nro na-agbanwe ike metabolism na nrụgide Oxidative, na-eme ka ntachi obi na-emega ahụ dịkwuo mma, ma na-ebelata ike ọgwụgwụ anụ ahụ na oke [J]. Nri, 2022,11 (4).DOI:10.3390/nri11040600.
[4] Huang J, Tagawa T, Ma S, et al. Black Ginger (Kaempferia parviflora) Na-ewepụta ikike ntachi obi na-eme ka ike dị mma site na imeziwanye ike metabolism na ntinye mkpụrụ n'ime ụmụ oke[J]. Nri, 2022,14(18).DOI:10.3390/nu14183845.
[5] Alghannam AF, Ghaith MM, Alhussain M H. Regulation of Energy Substrate Metabolism in Endurance Exercise[J]. Akwụkwọ akụkọ International nke nyocha gburugburu ebe obibi na ahụike ọha, 2021,18 (9) .DOI: 10.3390/ijerph18094963.
[6] Xu X, Ding Y, Yang Y, et al. β-glucan Salecan na-eme ka mmega ahụ dịkwuo mma ma na-egosiputa mmetụta ike ọgwụgwụ site n'ịchịkwa ike metabolism na nrụgide Oxidative na ụmụ oke [J]. Nri nri, 2018,10 (7).DOI:10.3390/nu10070858.
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