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1 ngwa (10 Vials)
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▎ Ọdịdị Mazdutide
Isi mmalite: PubChem |
Usoro: AEGTFTSDVSSYLEGQAAKFIAWLVKGRG Ụdị mkpụrụ ndụ: C 207H 317N 45O65 Ibu molekụla: 4476g/mol Nọmba CAS: 2259884-03-0 PubChem CID: 167312357 Ndị otu: GLXC-26803 |
▎ Nnyocha Mazdutide
Kedu ihe ndabere nyocha nke Mazdutide?
Okwu a ma ama nke oke oke ibu na ọrịa ndị metụtara ya:
Ibu ibu na oke ibu aghọọla ihe ịma aka ahụike ọha na eze zuru ụwa ọnụ. Dị ka World Obesity Atlas si kwuo, ọnụ ọgụgụ ndị buru oke ibu n'ụwa niile ruru nde 764 na 2020 ma na-atụ anya na ọ ga-arịgo 1 ijeri na 2030. Ibu nwere ike ịkpalite ọtụtụ nsogbu ahụike, dị ka ọrịa obi na akwara ozi na ụdị ọrịa shuga 2, bụ nke na-emetụta oke ndụ onye ahụ na akụrụngwa ahụike zuru ụwa ọnụ. Nke a emeela ka ndị nchọpụta chọpụta ụzọ ọgwụgwọ dị irè, karịsịa ọgwụ ọhụrụ.
Ntọala mmepe nke ọgwụ ndị dabere na incretin:
Ebe ọ bụ na e chepụtara echiche nke incretin na 1932, nchọpụta metụtara ya na-aga n'ihu na-aga n'ihu. N'afọ 1987, a chọpụtara GLP-1 dị ka onye na-ahụ maka mmepụta insulin na pancreas, na usoro ọgwụgwọ maka ụdị ọrịa shuga 2 nke dabere na incretin. N'afọ 2005, exenatide, GLP-1 receptor agonist (GLP-1RA), kwadoro maka ịzụ ahịa, na-etinye ntọala siri ike na nke bara uru maka nyocha na mmepe nke ọgwụ ndị dabeere na incretin ọhụrụ dị ka Mazdutide. Mazdutide bụ analog nke mammalian oxyntomodulin (OXM). Dị ka ọgbọ ọhụrụ abụọ agonist na-ezubere GLP-1R na GCGR, ọ nwere usoro ihe omume pụrụ iche na atụmanya sara mbara n'ịgwọ ọnwụ ibu na ọrịa ndị metụtara ya.
Kedu ihe bụ usoro nke Mazdutide?
Mmetụta agonistic na glucagon-dị ka peptide-1 (GLP-1) nnabata:
GLP-1 bụ hormone nke eriri afọ nke nwere ike ịkwalite mmepụta insulin na igbochi glucagon secretion n'ụzọ na-adabere na glucose, si otú ahụ na-ebelata ọkwa glucose ọbara [1] . Dị ka onye na-anabata GLP-1, Mazdutide na-eṅomi omume GLP-1, na-eme ka mmepụta insulin dịkwuo elu ma na-ebelata ntọhapụ glucagon, nke na-enyere aka ịhazi glucose ọbara. Ọzọkwa, GLP-1 agonists ndị na-anabata ihe nwere ike igbu oge ịpụsị afọ, mee ka satiety dịkwuo elu, ma belata oriri nri, nke bara uru maka njikwa ibu [1, 2].
Mmetụta Agonistic na ndị na-anabata glucagon:
Glucagon nwere ike ịkwalite mmebi nke glycogen imeju na gluconeogenesis, na-eduga n'ịbawanye glucose ọbara. Mazdutide, site na ịgbalite onye na-anabata glucagon, nwere ike ịhazi ọtụtụ akụkụ nke glucose metabolism, na-enweta ezigbo nhazi nke glucose ọbara. Glucagon na-akwalite lipolysis, na-enyere aka ibelata mkpokọta abụba na ibu arọ nke ahụ [1, 2].
Mmetụta nchịkwa na ọbara mgbali:
Mazdutide nwere ike ibelata ọbara mgbali systolic na diastolic. N'otu aka ahụ, ọ na-ebelata ọbara mgbali site na ịhazi glucose na lipid metabolism na imeziwanye ọrụ endothelial vaskụla; N'aka nke ọzọ, ọ nwere ike imetụta usoro nchịkwa ọbara mgbali dị ka renin-angiotensin.
Kedu usoro akọwapụtara nke Mazdutide maka ịbelata ibu?
Usoro nhazi nke glucose na metabolism:
Dị ka agonist abụọ nke glucagon-dị ka peptide-1 (GLP-1) na ndị na-anabata glucagon, otu n'ime ọtụtụ mmetụta physiological nke GLP-1 bụ ịhazi ọkwa glucose ọbara. Ọ na-akwalite mmepụta insulin, na-egbochi mmepụta nke glucagon, na-ebelata glucose ọbara [1] , na-egbu oge ịgbasa afọ, na-abawanye satiety, na-ebelata oriri. N'aka nke ọzọ, glucagon na-akwalite lipolysis na oriri ume. Ya mere, Mazdutide na-arụ ọrụ ma ndị na-anabata ya ma na-achịkwa metabolism nke glucose ọbara iji nweta oke ibu. Nnyocha e mere egosiwo na Mazdutide nwere ike ibelata ibu ahụ, ọbara mgbali elu (systolic na diastolic), mkpokọta cholesterol, triglycerides, obere lipoprotein dị ala, na ọkwa lipoprotein dị elu [3] , na-egosi na ọ nwere ike ime ka ọ dị arọ ma melite ọrịa metabolic metụtara oke ibu.
Mmetụta na agụụ na ike oriri:
Mazdutide nwere ike nweta oke ibu site na imetụta agụụ na oriri ume. N'ime ule ụfọdụ ụlọ ọgwụ, ndị sonyere nwetara mmeghachi omume nrịanrịa dị ka mbelata agụụ mgbe ejiri Mazdutide [3] . Nke a nwere ike bute ya site na omume Mazdutide kpọmkwem na tract gastrointestinal ma ọ bụ site na nhazi nke sistemu ụjọ nke etiti. N'agbanyeghị usoro a, mbelata agụụ na eriri afọ ga-ebelata oriri ume ma kwalite ọnwụ. Na mgbakwunye, Mazdutide nwere ike imetụta agụụ site na ịhazi neurotransmitters na homonụ na ụbụrụ. Dịka ọmụmaatụ, GLP-1 nwere ike ime ihe na hypothalamus iji mezie agụụ na nguzozi ike [4].
Kedu ụzọ omume akọwapụtara nke Mazdutide na-achịkwa glucose ọbara?
Ihe na-akpali mmepụta insulin:
Glucagon-dị ka peptide-1 (GLP-1) agonists na-anabata ya nwere ike kpalie mpụta insulin. Dị ka agonist abụọ nke GLP-1 na ndị na-anabata glucagon, Mazdutide nwere ike mee ka GLP-1 anabata ihe na-eme ka mkpụrụ ndụ beta sel pancreatic wepụta insulin. Insulin bụ isi homonụ maka ibelata glucose ọbara, nke nwere ike ịkwalite mkpụrụ ndụ iji bulie glucose ma belata ọkwa glucose ọbara [1]..
Mgbochi nke secretion glucagon:
N'otu oge ahụ, Mazdutide nwere ike ime ihe na onye na-anabata glucagon iji gbochie secretion glucagon. Glucagon na insulin na-emegiderịta onwe ha na nhazi nke glucose ọbara, na ibelata ihe nzuzo ya na-enyere aka iweda glucose ọbara [1]..
Usoro nke metabolism metabolism:
Mazdutide nwere ike ịhazi metabolism glucose n'ọtụtụ ọkwa iji gosipụta mmetụta hypoglycemic ya, dị ka imetụta metabolism nke glucose na imeju, akwara, na anụ ahụ adipose. N'ime imeju, ọ na-ebelata nkwụsị nke glycogen imeju na gluconeogenesis, na-ebelata mmepụta nke glucose ọbara; na akwara anụ ahụ, ọ na-akwalite nnabata na itinye n'ọrụ nke glucose; N'ime anụ ahụ adipose, ọ na-achịkwa metabolism lipid, na-ebelata ntọhapụ nke abụba abụba n'efu, ma na-emetụta glucose ọbara n'ụzọ na-apụtaghị ìhè [1, 3]..
Mmetụta na agụụ na ike oriri:
Nnyocha achọpụtala na Mazdutide nwere ike ibelata agụụ na oriri ume, ikekwe site n'ime ihe na ndị na-anabata ya na sistemụ ụjọ nke etiti yana ịhazi ụzọ mgbaàmà agụụ. Mbelata oriri nwere ike belata isi iyi nke glucose ọbara ma nyere aka ịchịkwa ọkwa glucose ọbara [3, 5]..
Gbanwee site na ntọala na ịdị arọ ahụ na gburugburu ukwu.
a. Pasent mgbanwe si baseline na bodyweight na oge. b. Gbanwee site na ntọala na ibu ahụ ka oge na-aga.
Isi mmalite: PubMed [2]
Kedu ihe bụ ngwa Mazdutide?
Ọgwụgwọ nke ụdị ọrịa shuga 2:
Nnwale 2 nke a na-achịkwaghị nke ọma, nke kpuru ìsì, ebe a na-achịkwa placebo gosiri na Mazdutide, onye agonist nke glucagon-dị ka peptide 1 (GLP-1) na ndị na-anabata glucagon kwa izu, gosipụtara ezigbo nrụpụta na nchekwa na ndị ọrịa China nwere ụdị ọrịa shuga 2 ..
Ngwa na mbelata ibu:
Nnyocha na ndị ọrịa na-arịa ọrịa shuga na ndị na-enweghị ọrịa shuga: Nyochaa nhazi usoro na meta-analysis gosiri na Mazdutide nwere ike ibelata arọ ahụ nke ndị okenye nwere ma ọ bụ na-enweghị ọrịa shuga [3] . Nnyocha ahụ gụnyere ule asaa a na-achịkwa na-enweghị usoro na ngụkọta nke ndị sonyere 680. Nsonaazụ gosiri na ma e jiri ya tụnyere placebo, Mazdutide mere ka mbelata dị ukwuu nke ịdị arọ ahụ (pụtara ọdịiche [MD] = -6.22%, 95% oge ntụkwasị obi [CI]: -8.02% na -4.41%, I⊃2; = 90.0%) (Nalisa DL, 2024). Nnyocha ndị dị n'okpuru na meta-regression chọpụtara na ndị ọrịa na-enweghị ọrịa shuga nwere oke ibu dị arọ karị, na ndị ọrịa a na-agwọ maka izu 24 nwere mbelata ịdị arọ nke ukwuu ma e jiri ya tụnyere nke a na-agwọ maka izu 12-20 [3]..
Ngwa na ndị okenye China nwere oke ibu ma ọ bụ oke ibu:
Nyocha nke etiti oge nke usoro, akụkụ abụọ (obere dose ruo 6mg na nnukwu dose 9mg), nke abụọ kpuru ìsì, ebe a na-achịkwa usoro 2 nke ndị okenye China nwere oke ibu ma ọ bụ oke ibu gosiri na Mazdutide dị nchebe ma dị irè na ọnụ ọgụgụ a n'ime oge ọgwụgwọ 24-izu, na-ebute oke ibu dị arọ na nke bara uru nke ụlọ ọgwụ [2] . N'ime ọmụmụ ihe, ndị okenye nwere oke ibu (BMI ≥ 24 kg / m²) na-esonyere hyperphagia na / ma ọ bụ ma ọ dịkarịa ala otu ọrịa na-emetụta oke ibu, ma ọ bụ ndị okenye nwere oke ibu (BMI ≥ 28 kg / m²) na-enyefeghị ya ịnata Mazdutide kwa izu na doses nke 3.5mg, matching placen. Nsonaazụ gosiri na site na ntọala ruo n'izu 24th, mgbanwe mgbanwe pasent na ịdị arọ ahụ bụ -6.7% (njehie ọkọlọtọ 0.7) na 3mg Mazdutide group, -10.4% (0.7) na 4.5mg otu, -11.3% (0.7) na 6mg otu, na 1.7) n'ime otu 0.0% E jiri ya tụnyere placebo, ọdịiche ọgwụgwọ sitere na -7.7% ruo -12.3% (p <0.0001 niile) [2].
N'ikpeazụ, dị ka onye na-eme ihe ọhụrụ na-eche ihu abụọ, site na ọtụtụ usoro dị ka ịhazi glucose ọbara, na-akwalite metabolism abụba, na igbochi agụụ, Mazdutide nwere ike imeziwanye ọkwa glucose ọbara nke ọma nke ndị ọrịa nwere ụdị ọrịa shuga 2 ma nyere ndị buru oke ibu aka ifelata. Ọ na-etinye ume ọhụrụ n'ime ọgwụgwọ ọrịa metabolic ma na-atụ anya na ọ ga-ebelata ibu zuru ụwa ọnụ nke oke ibu na ọrịa ndị metụtara ya.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Zhang B bụ ọkà mmụta tozuru oke jikọtara ya na ọtụtụ ụlọ ọrụ ama ama. Ndị a gụnyere Peking Union Medical College, Chinese Academy of Medical Sciences -Peking Union Medical College, - Japan Friendship Hospital, Guizhou Equipment Mfg Polytech, Shanghai Jiao Tong University, Universiti Utara Malaysia, Yingkou Institute of Technology, Zhejiang University, na Peking Union Medical College Hospital. Njikọ ụlọ ọrụ dị iche iche dị otú ahụ na-egosipụta nnukwu agụmakwụkwọ ya na nyocha nyocha ya.
N'ihe gbasara nyocha, Zhang B nwere ụdị isiokwu dị iche iche. Ọkachamara ya na-ekpuchi Endocrinology & Metabolism, General & Internal Medicine, Oncology, Cardiovascular System & Cardiology, na Radiology, Nuclear Medicine & Medical Imaging. Ọrụ ya na mpaghara ndị a na-egosi ihe ọmụma dị omimi ya na ntinye aka dị ukwuu n'ịkwalite sayensị ahụike na ịkwalite omume nlekọta ahụike. Edepụtara Zhang B na ntụaka ntụaka [1].
