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Ym Imiterere ya Thymosine Alpha-1
Inkomoko: PubChem |
Urukurikirane: SDAAVDTSSEITTKDLKEKKEVVEEAEN Inzira ya molekulari: C 129H 215N 33O.55 Uburemere bwa molekuline: 3108.3 g / mol Numero ya CAS: 62304-98-7 CIDCID CID: 16130571 Synonyme: Thymalfasin ； Zadaxin |
Ym Thymosin Alpha-1 Ubushakashatsi
Thymosin Alpha-1 ni iki?
Thymosine Alpha-1 ni polypeptide igizwe na aside amine 28. Mubisanzwe bibaho muri thymus kandi bigira uruhare runini mugukura no gutandukanya ingirabuzimafatizo za T.
Ni ubuhe bushakashatsi bwakozwe na Thymosin Alpha-1?
Thymosine Alpha-1 ni bioactive polypeptide yitaruye kandi isukurwa mu gice cya thymosine 5, igizwe na acide 28 amine. Tymus ni urugingo rukomeye rwa sisitemu yumubiri, itanga ibintu bitandukanye bigenga imikorere yumubiri, kandi thymosine nimwe murimwe. Hamwe nubushakashatsi bwimbitse bwimikorere ya thymus, abantu bamenye buhoro buhoro ko ibice bikora birimo bishobora kugira agaciro kokuvura indwara zitandukanye.
Nubuhe buryo bwo gukora bwa Thymosin Alpha-1?
Gukingira indwara:
Thymosine Alpha-1 nigisubizo cyibinyabuzima gishobora gukora selile zitandukanye mumikorere yumubiri. Igenga cyane cyane imikorere yubudahangarwa mu kongera itandukaniro no gukura kwingirangingo za T (Sjogren MH, 2004; Mao L, 2023). By'umwihariko, Thymosine Alpha-1 irashobora kugira ingaruka kuri thymocytes itera itandukaniro cyangwa ikayihindura ingirabuzimafatizo za T.
Uburyo bwo kurwanya inflammatory:
Mu kuvura umusonga COVID-19, Thymosin Alpha-1 yihutisha gukira umusonga binyuze mu buryo bwo kurwanya inflammatory. Irashobora kugabanya igisubizo kibabaza, igateza imbere kugabanya ibimenyetso bifitanye isano na COVID-19 nk'umusonga n'umunaniro, koroshya kwinjiza exudate, no kwihutisha gukira umusonga wa COVID-19 (Wang Z, 2023).
Nigute Thymalfasin itera apoptose ya selile yibibyimba mukuvura kanseri?
Kongera ibikorwa bya selile immunite:
Thymalfasin ni thémopeptide ya syntetique hamwe nibikorwa byinshi byongera ubudahangarwa bw'umubiri. Irashobora kongera imbaraga zo kwica ingirabuzimafatizo z'umubiri ku ngirabuzimafatizo, bityo bigatuma mu buryo butaziguye apoptose ya selile y'ibibyimba. Kurugero, muri microen ibidukikije yibibyimba, Thymalfasin irashobora guteza imbere gutandukanya no gukura kwingirangingo za T no kuzamura ibikorwa bya selile T. Nkigice cyingenzi cyimikorere yumubiri, T selile irashobora kumenya no gutera selile yibibyimba, bigatera apoptose yingirabuzimafatizo yibibyimba irekura ibintu bya cytotoxique nubundi buryo.
Kugena igisubizo cyumudugudu:
Nka immunopotentiator, Thymalfasin irashobora kugenga ubudahangarwa bw'umubiri kandi igatera apoptose ya selile yibibyimba. Irashobora kongera ubudahangarwa bwa Th1. Th1 selile isohora cyane cytokine nka IFN-γ, ishobora gukora muburyo butaziguye kanseri yibibyimba kandi igatera apoptose. Byongeye kandi, Thymalfasin irashobora kandi kugenzura imikorere yizindi selile zumubiri, nko kongera ibikorwa bya selile NK. Ingirabuzimafatizo za NK zirashobora kwica mu buryo butaziguye ingirabuzimafatizo kandi zikanatera apoptose ya selile yibibyimba mu gusohora cytokine n'ubundi buryo [1].
Kunoza immunosuppression mugihe cyo kuvura ibibyimba:
Mugihe cyo kuvura ibibyimba, abarwayi bakunze guhura na immunosuppression, bizagira ingaruka kumikorere yo kuvura ibibyimba. Thymalfasin irashobora kunoza ubudahangarwa bw'umubiri butangwa mugihe cyo kuvura ibibyimba, bikongerera ubushobozi sisitemu yumubiri kwibasira ingirabuzimafatizo, bityo bigatera apoptose ya selile yibibyimba. Kurugero, mugihe cya chimiotherapie cyangwa radiotherapi, sisitemu yumubiri wumurwayi izangirika kurwego runaka. Thymalfasine irashobora guteza imbere gukira no gukwirakwira kwingirangingo z'umubiri, kunoza imikorere yubudahangarwa bw'umubiri, no kongera ingaruka zo kwica ingirabuzimafatizo.
Thymosine alpha 1 ifite ibikorwa byinshi byibinyabuzima.
Inkomoko: Byatangajwe [6]
Ni ubuhe buryo bukoreshwa na Thymalfasin?
Indwara ziterwa na virusi:
Bitewe n'ingaruka zayo zo gukingira indwara, Thymosin Alpha-1 ikoreshwa kenshi mu kuvura indwara zanduye. Kurugero, mugihe cyicyorezo cya COVID-19, cyerekanye imikorere myiza yubuvuzi mu kuvura umusonga COVID-19. Ubushakashatsi bwerekana ko Thymosin Alpha-1 ishobora gukumira indwara zanduye COVID-19 zanduye umusonga ukabije binyuze mu buryo butandukanye bwo kongera ubudahangarwa no kwirinda indwara [2] . By'umwihariko, ku barwayi bavuwe na Thymosin Alpha-1, ibitaro byaragabanutse ku buryo bugaragara, umubare w'abatabazi ku bimenyetso bifitanye isano n'umusonga (nk'umuriro n'umunaniro) wari hejuru cyane ugereranyije n'itsinda rishinzwe kugenzura, kandi agace ko gusohora umuriro na CT nako kari hasi cyane ugereranije n'itsinda rishinzwe kugenzura [2] . Byongeye kandi, isesengura ry’icyitegererezo cya Cox ryerekanye ko abarwayi bakoresheje Thymosin Alpha-1 n’abarwayi bakiri bato bafite umuvuduko mwinshi wo guhindura virusi ya COVID-19 [2] . Tα1 (igice cyingenzi cya Thymosin Alpha-1) yongereye umubare wa selile CD4 + T ku barwayi bafite umwuka uhumeka wa ogisijeni uhumeka neza ku buryo bwihuse kuruta ubuvuzi busanzwe, kandi ushobora kugira uruhare mu kuvura abarwayi bari mu bitaro barwaye hypoxemia na lymphopenia batewe na COVID-19 [3].
Umuti wa hepatite:
Thymosine Alpha-1 nayo igira ingaruka runaka mukuvura hepatite. Irashobora gukoreshwa nka mitiweli ya hepatite B cyangwa ifatanije na interferon α-2b mu kuvura indwara ya hepatite C. By'umwihariko, ubushakashatsi bwerekanye ko mu kuvura hepatite B, hasuzumwe ingaruka za Thymosin Alpha-1 zasuzumwe mu bigeragezo bine by’amavuriro birimo abarwayi 195. Muri bumwe mu bushakashatsi bwakozwe, abarwayi 9 kuri 17 bavuwe na Thymosin Alpha-1 barwaye virusi ya hepatite B (HBV) ADN mu mezi atandatu, ugereranije n’abarwayi 10 kuri 16 bavuwe na interferon α-2b na 4 kuri 15 bari mu itsinda rishinzwe kugenzura amateka.
Ubuvuzi bwa Adjuvant: Thymosine Alpha-1 nayo ikoreshwa cyane mukuvura kanseri. Ku barwayi bafite kanseri y'ibihaha idashobora kwangirika (NSCLC) na kanseri y'umwijima, mu buvuzi bwiyongereye, Thymosin Alpha-1 irashobora kuzamura cyane ubuzima rusange (OS) (Mao L, 2023). Ku barwayi bafite NSCLC yateye imbere cyane, Thymosin Alpha-1 irashobora kugabanya cyane lymphopenia na pneumoniya iterwa na radiotherapi na chimiotherapie, kandi hariho inzira yo kunoza OS [4].
Kongera ubudahangarwa bw'umubiri:
Ibimenyetso simusiga byerekana ko Thymosin Alpha-1 ishobora guhindura polarisiyasi ya M2 iterwa na efferocytose ya macrophage ukoresheje umurongo wa TLR7 / SHIP1, ukongerera imbaraga imiti ya kanseri, kandi ukongerera ubudahangarwa bw'umubiri kurwanya 'ibibyimba bikonje ' uhinduka 'ibibyimba bishyushye ' (Mao L, 2023). Byongeye kandi, Thymosin Alpha-1 nayo igira ingaruka zo gukingira kugabanya colitis iterwa na inhibitor immunite (ICIs) kandi ishobora kuzamura imikorere yubuvuzi bwa ICI [4] . Tα1 nk'ubuvuzi bujyanye na kanseri y'umwijima irashobora kunoza imenyekanisha ry'abarwayi bafite kanseri ntoya ya hepatocellular. Mu bushakashatsi bwisubireho, abarwayi bafite kanseri ntoya ya hepatocellular barwaye umwijima bagabanijwemo amatsinda abiri, itsinda A (resection + Tα1) nitsinda B (resection gusa). Nyuma yo gukurikiranwa hagati y’amezi 47.0, imyaka 1-, 3-, na 5 yimyaka muri rusange umubare wokubaho hamwe n’ubuzima bw’abarwayi bo mu itsinda A bwarushijeho kubaho ugereranije n’abari mu itsinda B. Isesengura ryinshi ryerekanye ko Tα1 ari ikintu cyigenga cyerekana ko abantu babaho muri rusange ndetse n’ubuzima budasubirwaho [5].
Kugarura imikorere yubudahangarwa no kongera urukingo:
Thymosine Alpha-1 irashobora gukoreshwa mu kuvura indwara zidakingiwe hamwe n’indwara mbi ndetse no kongera ibisubizo by’inkingo [4, 6] . Irashobora kugenga sisitemu yubudahangarwa no kongera imikorere ya T selile, kandi irashobora kugira akamaro kivura indwara zifite imikorere mibi yumubiri yangiritse cyangwa idakora neza nkindwara zikaze kandi zidakira, kanseri, ninkingo zititabira [4] . Ubushakashatsi bwerekanye ko muri sepsis ikabije, Thymosin Alpha-1 yerekanwe kugarura imikorere y’umubiri no gufasha kugabanya impfu z’abarwayi [4].
Kwirinda kwandura COVID-19 nibibazo ku barwayi barimo dialyse yimpyiko:
Abarwayi bafite indwara zimpyiko zanyuma (ESRD) bakira hemodialyse (HD) bafatwa nk’ibasirwa cyane n’ubwandu bwa SARS-CoV2 bitewe n’imyaka nko gusaza, umutwaro utera indwara, gukoresha ibiyobyabwenge, ndetse no gusura amavuriro ya dialyse kenshi. Ubushakashatsi bwakozwe mbere bwerekanye ko Thymosin Alpha-1, nk’umuti w’urukingo rw’ibicurane, ishobora kongera antibody y’abaturage bageze mu zabukuru (harimo n’abarwayi ba HD) ku rukingo rw’ibicurane no kugabanya indwara z’ibicurane. Mu minsi ya mbere y’icyorezo cya COVID-19, abashakashatsi batekereje ko guha abarwayi ba Thymosin Alpha-1 ku barwayi ba HD bishobora kugabanya ubwandu n’uburemere bw’indwara ya COVID-19. Kuva ku ya 1 Nyakanga 2022, abarwayi 254 ba ESRD / HD bo mu bigo bitanu bya dialyse byo mu mujyi wa Kansas, muri Leta ya Missouri bashyizwe mu bushakashatsi, muri bo abarwayi 194 bagabanijwe ku buryo butunguranye mu itsinda A (inshinge zo mu bwoko bwa 1.6mg Thymosin Alpha-1 kabiri mu cyumweru mu byumweru 8) n'itsinda B (itsinda rishinzwe kugenzura, batabonye Thymosin Alpha-1) [7].
Mu gusoza, nka polypeptide ifite ibikorwa byihariye byo gukingira indwara, Thymosin Alpha-1 yerekanye ibishoboka muburyo bwinshi mubuvuzi. Mu kuvura indwara ziterwa na virusi, igira ingaruka zikomeye ku ndwara nka hepatite B na COVID-19. Ntishobora kwihutisha kugabanya ibimenyetso gusa no kugabanya gucana ariko nanone ikabuza iterambere ryindwara no kuzamura umuvuduko w abarwayi. Ku bijyanye no kuvura ibibyimba, irashobora gutera apoptose ya selile yibibyimba binyuze munzira nyinshi, ikongera imbaraga zo kwica ingirangingo z'umubiri ku ngirabuzimafatizo z'ibibyimba, kandi igateza imbere immunosuppressive, ikerekana imikorere myiza mu kuvura kanseri zitandukanye nka kanseri y'ibihaha na kanseri y'umwijima.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Wang Z ni umushakashatsi ufite amasomo atandukanye kandi afite ubunararibonye mu bufatanye mu bigo byinshi. Inyungu zabo zubushakashatsi zirimo ibice bitandukanye nka Engineering, Spectroscopy, Chemistry, Dentistry, Oral Surgery & Medicine, na Physics. Wang Z yifatanije n’imiryango ikomeye na kaminuza zikomeye, harimo kaminuza y’ubumenyi y’ubushinwa (CAS), kaminuza ya Yunnan, kaminuza ya Peking, kaminuza y’ubuhinzi ya Hunan, kaminuza ya Shanghai Jiao Tong, n’abandi benshi. Ibikorwa byabo byerekana cyane guhanga udushya nubufatanye, cyane cyane mubice bijyanye ninganda zoroheje za optoelectronic injeniyeri, ubuvuzi, hamwe nibikoresho bya siyansi. Binyuze ku bufatanye n’ibigo nka Centre y’ubushakashatsi y’Intara ya Jiangsu ishinzwe Inganda zoroheje za Optoelectronic Engineering & Technology hamwe na kaminuza y’ubuvuzi ya gisirikare y’ingabo zirwanira mu kirere, Wang Z yagize uruhare mu iterambere ry’imyumvire ndetse no mu bikorwa bifatika mu bumenyi bwabo. Wang Z yanditse ku rutonde rwerekana [2].
