Sermorelin miligaramu 5

▎ Sermorelin (Sɛrmɔrilini) ka jɔcogo

▎ Sermorelin ka ɲininiw

Sermorelin ye mun ye?

Sermorelin ye farikolojidɛsɛ fura ye min bɛ kɛ ka bonya hormone releasing factor (GHRF) kɛ. A baara koloma ye ka siri bonya hormone (GHRH) minɛbagaw la minnu bɛ ɲɛgɛnɛsira ɲɛfɛla la, ka selilɛri kɔnɔ taamasiɲɛw siraw baara (i n’a fɔ cAMP/PKA sira), ka endogène growth hormone (GH) dilanni n’a bɔli lawuli, ani o cogo la ka denmisɛnw ka bonya ni u ka yiriwali sabati. A bɛ kɛ ka caya ka ɲɛsin bonya hormone fɔlɔ dɛsɛ furakɛli ma (denmisɛnw ka bonya damatɛmɛni min bɛ sɔrɔ ɲɛgɛnɛsira baarakɛbaliya fɛ). Ni a ye GH bɔli segin a cogo kɔrɔ la, a bɛ se ka mɔgɔ janya bonya ani ka farikoloɲɛnajɛ kɛcogo ɲɛ. A tɛ i n’a fɔ hadamaden ka bonya hormone recombinant, min bɛ GH kɔkanna fara ɲɔgɔn kan k’a ɲɛsin a yɛrɛ ma, Sermorelin bɛ a jigi da ɲɛgɛnɛsira yɛrɛ ka bɔli seko kan, wa a bɛnnen don banabagatɔw ma minnu ka ɲɛgɛnɛsira bɛ baara kɛ cogo bɛnnen na nka GHRH tɛ se ka kɛ.

Sermorelin ka ɲininiw kɛcogo ye mun ye?

Sermorelin ka ɲininiw kɛcogo bɔra bonya hormone jɔyɔrɔba la hadamaden ka bonya ni a yiriwali la. Bonya hormone fɔlɔ dɛsɛ bɛ se ka kɛ sababu ye ka denmisɛnw ka bonya damatɛmɛ ani ka nɔ bila u janya laban na. O la, furakɛli fɛɛrɛ ɲumanw sɔrɔli kɛra barokun nafama ye tuma bɛɛ furakɛli ɲininiw na. Hali ni hadamaden ka bonya hormone recombinant bɛ kɛ kabini san caman, wa a kɛra sababu ye ka dɔ fara kosɛbɛ denmisɛn minnu ka bonya hormone dɛsɛ bɛ u la, olu janya laban na, ni furakɛli ɲininiw juguyara, mɔgɔw bɛ ka furakɛli suguya caman fana ɲini ani furakɛlicogo ɲumanw. O hukumu kɔnɔ, Sermorelin, n’o ye hadamaden ka bonya hormone (hormone) bɔli ye min dilannen don, o bɔra kɛnɛ kan. Ni a ye bonya hormone bɔli lawuli, a ye jigiya kura lase bonya hormone dɛsɛ furakɛli ma ani ka denmisɛnw ka bonya ni u ka yiriwali sabati.

Fɛɛrɛ min bɛ Kɛ ni wale ye

Semorelin ka fɛɛrɛ kɛrɛnkɛrɛnnen ye mun ye ka ɲɛsin bonya hormone fɔlɔ dɛsɛ furakɛli ma?

Semorelin ka wale in jusigilan

I n’a fɔ bonya hormone (banakisɛfagalan) bɔlifɛn, Sermorelin bɛ a nɔw jira kosɛbɛ ni a sirili ye farikolojɔlan kɛrɛnkɛrɛnnenw na. A bɛ bonya hormone bɔlifɛn min bɛ sɔrɔ a yɛrɛ la, o ka baara ladege hadamaden farikolo la, ka ɲɛgɛnɛsira ɲɛfɛla bila ka bonya hormone bɔ. O kɛcogo in ni bonya fura wɛrɛw ta bɛ tali kɛ ɲɔgɔn na, i n’a fɔ bonya hormone releasing peptides (GHRPs).

Ka bonya hormone bɔli lawuli

Hypothalamuse-pituitaire axis jɔyɔrɔ min bɛ ɲɛnabɔli la: 

Sermorelin ye hadamaden ka bonya hormone (banakisɛfagalan) bɔli ye min dilannen don. Ni ko bɛnnen don, bonya hormone bɔli hadamaden farikolo la, o bɛ labɛn kosɛbɛ ni hypothalamic-pituitary axis ye. Hypothalamus bɛ bonya hormone releasing hormone (GHRH) bɔ, o min bɛ ɲɛgɛnɛsira ɲɛfɛla bila ka bonya hormone (GH) dilan ani ka a bɔ. Sermorelin bɛ GHRH ka baara ladege, a bɛ siri fɛn kɛrɛnkɛrɛnnenw na minnu bɛ hypothalamus kɔnɔ, ka pituitaire gland (pituitaire gland) bila ka bonya hormone bɔ.

Siginiden sira baarakɛcogo : . 

A sirilen kɔ a minɛbaga la, Sermorelin bɛ selilu kɔnɔ taamasiɲɛw sira baara. O bɛ se ka kɛ anzimu ka waleyaw ye minnu bɛ tugu ɲɔgɔn na ani cidenw ka sigida filanan, o laban bɛ na ni dɔ farali ye bonya hormone (banakisɛfagalan) sɔrɔli ni a bɔli kan. Misali la, a bɛ se ka adenilati siklazi baara, ka dɔ fara cAMP hakɛ kan selilu kɔnɔ, ka sɔrɔ ka poroteyini kinase A baara, ka bonya hormone jamu sɛbɛnni ni a bamanankan na.

A bɛ nɔ minnu bila bonya hormones (hormones) dɛsɛ la

Ka bonya ni yiriwali sabati: 

Denmisɛn minnu ka bonya hormone fɔlɔ dɛsɛ bɛ u la, a ka ca a la u bɛ bonya dɔɔni dɔɔni ani u janya ka surun. Sermorelin bɛ bonya hormone dɛsɛ kunbɛn farikolo la ni a bɛ bonya hormone bɔli lawuli. Bonya hormone bɛ se ka baara kɛ kolo, farikolo ani farikolo yɔrɔ wɛrɛw la k’a ɲɛsin u ma, ka farikolokisɛw caya ani ka u faranfasi, o la, a bɛ bonya ni u yiriwali sabati. Bonya hormone fana bɛ se ka farikolo yɔrɔw lawuli i n’a fɔ sugunɛ walasa u ka inisɔndiya ɲɔgɔnna bonyalan-1 (IGF-1) dilan, ani IGF-1 bɛ bonya sabatili nɔ bila ka taa a fɛ.

Farikoloɲɛnajɛ baarakɛcogo ɲɛnabɔli: 

Bonya hormone dɛsɛ tɛ nɔ bila bonya ni yiriwali dɔrɔn na, nka a bɛ se ka kɛ sababu ye fana ka farikoloɲɛnajɛ gɛlɛyaw lase mɔgɔ ma. Semɔrilini furakɛli bɛ se ka farikoloɲɛnajɛ baara ɲɛ, i n’a fɔ ka farikolojɔli dumuniw sɔrɔli caya, ka tulumafɛnw tiɲɛni sabati, ani ka sukaro baara caya. O farikoloɲɛnajɛ caman yeli bɛ dɛmɛ ka farikolo ka farikoloɲɛnajɛ kɛcogo ɲuman sabati ani ka banabagatɔw ka ɲɛnamaya kɛcogo ɲɛ.

Janya-SDS caman ɲɔgɔnna ye denmisɛnniw na minnu bɛ ni ɲɔgɔn cɛ banaw ye minnu furakɛra ni biologikiw ye.

Soso:PubMed ^{[1] Ɲɛjirali dɔw.}

Semorelin baarakɛcogo ye mun ye?

Bonya furaw dɛsɛ furakɛli: 

Bonya hormone fɔlɔ dɛsɛ bɛ se ka kɛ sababu ye ka denmisɛnw ka bonya ni u ka yiriwali bila kɔfɛ ani ka nɔ bila u janya laban na. Adamadenw ka bonya hormone recombinant bɛ kɛ kɛnɛyaso la kabini san caman, wa a kɛra sababu ye ka dɔ fara kosɛbɛ denmisɛnniw janya laban kan, minnu ka bonya hormone dɛsɛ bɛ u la. I n’a fɔ bonya hormone bɔlifɛn, Semorelin fana jɔyɔrɔ ka bon bonya hormone dɛsɛ furakɛli la.

Sermorelin bɛ denmisɛnw ka bonya ni u ka yiriwali sabati ni a bɛ ɲɛgɛnɛsira lawuli walasa ka bonya hormone bɔ. A bɛ se ka farikolo ka bonya hormones bɔcogo ladege, ka dɔ fara bonya hormones hakɛ kan, ani o cogo la ka kolo bonya ni farikolo yiriwali sabati. Ni an y’a suma ni hadamaden ka bonya hormone recombinant ye, nafa kɛrɛnkɛrɛnnen dɔw bɛ Semorelin na. Misali la, a bɛ se ka kɛ a muɲuni ni a lakanani ka fisa, o bɛ dɔ bɔ kɔlɔlɔ dɔw la minnu bɛ se ka sɔrɔ.

Sermorelin furakɛli nɔ jumɛn bɛ denmisɛnniw na minnu ka bana basigilenw walima u ka jamu suguya tɛ kelen ye?

Bana basigilen bɛ denmisɛn minnu na

Denmisɛn minnu bɛ ni ɲɔgɔndɛmɛbana basigilenw ye: 

Denmisɛn minnu bɛ ni funu basigilenw ye (CTD), i n’a fɔ denmisɛnninw ka ɲɛgɛnɛsiralabanaw ni denmisɛnninw ka jolidɛsɛbana (JIA), ka a sababu kɛ farikolo funu tilennen ye ani glucocorticoïde furakɛli, a ka ca a la, bonya hakɛ damatɛmɛni bɛ kɛ. Sisan furakɛli minnu bɛ kɛ, olu bɛ baara kɛ kosɛbɛ ni fɛnɲɛnamafagalanw ye i n’a fɔ tumor necrosis factor-α blockers (etanercept, adalimumab, golimumab) ani interleukin-6 receptor blockers (tocilizumab), olu bɛ se ka denmisɛnw ka bonya teliya dɔɔni dɔɔni ani ka u kɛ cogo la, ni u bɛ funu bali ani ka glucocorticoïdes hakɛ dɔgɔya don o don. Nka sisan, sɛgɛsɛgɛli si ma kɛ Sermorelin kɛcogo n’a furakɛli nɔ kan o denmisɛn suguw la ^{[1] .}.

Sɔgɔsɔgɔninjɛ basigilen bɛ denmisɛn minnu na: 

Sɔgɔsɔgɔninjɛ basigilen ka teli denmisɛn cɛmanw na, a ka ca togodaw la ka tɛmɛ dugubaw kan, wa danfara jɛlen tɛ u si hakɛ walima waatiw la. Denmisɛn minnu si tɛ san 3 bɔ, bana basigilenw bɛ minnu na, fogonfogonlabanaw bangenenw ka teli ka sɔrɔ, ka sɔrɔ farikolo tangacogo fɔlɔ banaw ka ca denmisɛnniw na minnu si bɛ san 3 la ka tɛmɛ o kan. Banakisɛfagalanw, kɛrɛnkɛrɛnnenya la, banakisɛfagalanw ka banakisɛfagalanw, olu de ye a sababuba ye san hakɛ bɛɛ la ^{[2] .}.

Semorelin ka fɛɛrɛ kɛrɛnkɛrɛnnen ye mun ye denmisɛnw ka bonya damatɛmɛni furakɛli la min bɛ sɔrɔ bonya hormone fɔlɔ dɛsɛ fɛ?

Ka bonya hormone bɔli lawuli:

Sermorelin ye hadamaden ka bonya hormone (banakisɛfagalan) bɔli ye min dilannen don. Bonya ɔrimɔni bɔli fɛnw bɛ se ka siri bonya hormone bɔli fɛnw minɛbagaw la ɲɛgɛnɛsira ɲɛfɛla la, ka ɲɛgɛnɛsiralabanaw bila ka bonya ɔrimɔni dilan ani ka a bɔ O cogo la, Semɔrilini bɛ se ka dɔ fara bonya hormone hakɛ kan farikolo la, o bɛ denmisɛnw ka bonya sabati.

Ni a kɛra cogo bɛnnen na, bonya hormone bɔli bɛ ɲɛnabɔ fɛn caman fɛ, i n’a fɔ bonya hormone releasing hormone (GHRH), somatostatin, neurotransmetteurs, a ɲɔgɔnnaw I n’a fɔ exgenous growth hormone releasing factor, Semorelin bɛ se ka GHRH ka baara ladege ani ka bonya hormone bɔli sabati.

Ka nɔ bila bonya hormone-insuline ɲɔgɔnna bonya factor axis la:

Ni bonya hormone bɔli cayara, a bɛ baara kɛ farikolo yɔrɔw kan i n’a fɔ sugunɛ ani ka inisɔndiya-like growth factor (IGF) dilanni n’a bɔli lawuli. IGF ye bonya ɲɛnabɔlan nafama ye min bɛ se ka selilɛriw caya, ka danfara don u ni ɲɔgɔn cɛ, ani ka farikolojɔli dumuniw dilan, o jɔyɔrɔ ka bon denmisɛnw ka bonya ni u ka yiriwali la

Sermorelin bɛ IGF sɔrɔli ni a bɔli sabati cogo la min tɛ ɲɛ, a kɛtɔ ka bonya hormone bɔli lawuli, o la, a bɛ bonya sabatili nɔ bonya ka taa a fɛ. IGF bɛ se ka siri IGF minɛbagaw la farikolokisɛw laɲinitaw kan, ka jiginɛ taamasiɲɛw siraw baara, ka seliluw falenni ni sukarodunbana sabati.

A bɛ nɔ bila kolo falenni na:

Bonya hormone ni IGF bɛ nɔba bila kolo falenni na. U bɛ se ka kolosinsinnanw caya ni u danfara sabati, ka dɔ fara kolo janya ni koloci kan[3]. Semɔrilini bɛ denmisɛnw ka bonya damatɛmɛ furakɛ min bɛ sɔrɔ bonya hormone fɔlɔ dɛsɛ fɛ, a kɛtɔ ka dɔ fara bonya hormone ni IGF hakɛ kan, o bɛ kolo bonya ni yiriwali sabati.

Ka fara o kan, bonya hormone fana bɛ se ka fɛnɲɛnamafagalanw ka sukarodunbana labɛn i n’a fɔ kalisiyɔmu ni fosiporozɛni, ka kolotugudaw jɔcogo ni u baaracogo ɲuman sabati. Semɔrilini bɛ se ka kolo falenni sabati ka taa a fɛ ni a bɛ nɔ bila o farikoloɲɛnajɛ kɛcogo ninnu na.

A bɛ se ka kɛ farikolo ni tuluma sukarodunbana na:

Bonya hormone ni IGF tɛ nɔ bila kolo bonya dɔrɔn na, nka u bɛ nɔ bila farikolo ni tuluma sukarodunbana fana na. Bonya hormone bɛ se ka farikolojɔli dumuniw sɔrɔli sabati, ka farikolo fanga bonya, ani o waati kelen na ka tulu dalajɛli dɔgɔya[3]. Semɔrilini furakɛli bɛ se ka denmisɛnw farikolo ni tulumafɛnw ka sukarodunbana ɲɛ ni a bɛ dɔ fara u ka bonya hormone hakɛ kan, ka farikolo bonya ni u ka yiriwali sabati.

Ka fara o kan, bonya hormone fana bɛ se ka fanga sukarodunbana labɛn, ka dɔ fara farikoloɲɛnajɛ basigilen kan, ani ka dɔ fara fanga ta kan. O bɛ dɛmɛ don ka denmisɛnw girinya ni u farikolo labɛncogo ɲuman sabati ani ka u ka bonya kɛnɛya sabati.

Sermorelin baarakɛcogo minnu bɛ tali kɛ o la, olu ye mun ye?

A bɛ kɛ ka denmisɛnw ka bonya damatɛmɛ furakɛli la:

I n’a fɔ bonya hormone lase factor synthétique analogue, Semorelin bɛ endogène growth hormone bɔli sabati cogo la min tɛ ɲɛsin a ma, a kɛtɔ ka GHRH minɛbagaw baara minnu bɛ ɲɛgɛnɛsira ɲɛfɛla la, o bɛ denmisɛn minnu ka bonya hormone fɔlɔ dɛsɛ, olu janya bonya ni u ka farikoloɲɛnajɛ baara ɲɛ kosɛbɛ. A nafa bɛ furakɛli sugandilen dɔ di banabagatɔw ma minnu ka ɲɛgɛnɛsira bɛ baara kɛ cogo bɛnnen na nka GHRH tɛ u la, ka u yɛrɛ tanga faratiw ma minnu bɛ sɔrɔ farikolo tangalanw walima farikoloɲɛnajɛ gɛlɛyaw la minnu bɛ se ka na ni kɛnɛyaji ye min bɛ bɔ kɛnɛyaso la. Nafa bɛ semɔrilini na, o ye ka a jigi da a yɛrɛ ka bɔli kan, ka dɔ bɔ ɔrimɔni nɔ na, ​​ani ka surunya farikolo labɛncogo la.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ ^{[4] .}.

Dɔnniya gafe sɛbɛnbaga

Simon TJ ye ɲininikɛla ye min ni tɔnba tɔgɔba caman cɛsirilen don. Olu ye Zoetis Vet Med Regulatory Affairs, Akili Interact Labs, University of California Davis, Univ Calif, Dept Psychiat & Behav Sci, UC Davis MIND Inst, California State University Sacramento, MIND Inst, UCDHS, Denmisɛnw ka dɔgɔtɔrɔso Filadɛlifi, NIH jamana ka dɔrɔguko baarada (NIDA), Emory Iniwɛrisite, Georgia Institute of Technology, ani Merck & Company. O jɛkuluw ni ɲɔgɔn cɛ jɛɲɔgɔnya suguya caman b’a ka kalanko ni ɲinini dɔnniyaba jira.

A ka ɲininiw ɲɛsinnen bɛ kalansen suguya caman ma i n’a fɔ Neurosciences & Neurology, Psychiatry, Psychology, Genetics & Heredity, ani Gastroenterology & Hepatology. A ka baara minnu kɛra o ko ninnu na, olu b’a ka dɔnniya jugu ni a ka dɛmɛba jira furakɛli dɔnniya ɲɛtaa la ani kɛnɛyako taabolo ɲɛtaa la. Simon TJ tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [4].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Swidrowska J, Zygmunt A, Biernacka-Zielinska M, ani a ɲɔgɔnnaw. Biologique furakɛli nɔ min bɛ denmisɛnniw ka bonya la minnu ka bana basigilenw bɛ u la[J]. Reumatologia (Warsaw), 2015,53(1):14-20.DOI:10.5114/reum.2015.50552. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[2] Sijie Y, Jiangfeng O. Denmisɛn minnu bɛ ni sɔgɔsɔgɔninjɛ basigilen ye, olu ka bana 102 ka kɛnɛyaso sɛgɛsɛgɛli[J]. Bi furakɛli ni kɛnɛya gafe, 2019,35(12):1800-1803. 155FDI97duNJbDlT0BpqFrBjyXEORr9zmNdi7f9n51M5zS6v3ccNYGDIl_c rUXos6V5MhYjUzV8NZaxoHVQnVZoB_FvN7hrZq7OLXrt_tDSd0mmMfeiuHoDq37r6raVNjZXCwj4IV5TxOlYAFg7GmsIw1HpJNE6VF_CEHjw=&Uniplatform=NZKPT&kan=CHS.

[3] Li Ming ye baara kɛ. Bonya-hormone-releasing factor min bɛ kɛ ka bonya hormone dɛsɛ furakɛ [J]. Sinuwa furakɛlikɛla, 1999(06): 333. https://kns.cnki.net/kcms2/article/abstrait?v=bEegF8awJvyCUvydH2XgdIGr7pLvLM2eL7wOoSCfKs3gR77cpaEUGORQnJJ3l4BU_yyyXCohkE2UjpJI2ZKu5t_bAgmBg XMK5MRJMpt4ieJiS55PZv6llMK0foTlnsaYu1ETWfpCauLwyWWEtc7W5R4v1Ow5FMn0MdHZPR3wOfU_zWBMuCi3_GjoxcjsSOCn1Yii66eto=&Uniplateforme=NZKPT&kan=CHS

[4] Simon T J. Denmisɛnw ka hakililata cogoyaw minnu bɛ ni jamu ye[J]. Denmisɛnw ni funankɛninw ka hakiliɲagami dɔgɔtɔrɔsow Ameriki Woroduguyanfan fɛ, 2007,16(3):599.DOI:10.1016/j.chc.2007.03.002.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.