|
1 ngwa (10 Vials)
| Ọnụọgụ: | |
|---|---|
▎ Ọdịdị Sermorelin
Isi mmalite: PubChem |
Usoro: YADAXFXNSYRKVLGQLSARKLLQDXMSR Ụdị mkpụrụ ndụ: C 149H 246N 44O 42S Ibu ibu: 3357.9 g/mol Nọmba CAS: 86168-78-7 PubChem CID: 16129620 Ụdị okwu: Sermorelin (INN) ;CHEBI: 9118 |
▎ Nnyocha Sermorelin
Kedu ihe bụ Sermorelin?
Sermorelin bụ analọg sịntetik nke ihe na-ewepụta homonụ uto (GHRF). Isi ọrụ ya bụ ijikọ na ndị na-anabata hormone na-ewepụta hormone (GHRH) na pituitary gland, mee ka ụzọ mgbaàmà intracellular (dị ka ụzọ cAMP/PKA), kpalie njikọ na ntọhapụ nke hormone uto endogenous (GH), ma si otú ahụ kwalite uto na mmepe ụmụaka. A na-ejikarị ya na-agwọ ụkọ homonụ nke na-eto eto (mbelata uto ụmụaka na-akpata site na ọrụ pituitary ezughi oke). Site na iweghachi ihe nzuzo GH, ọ nwere ike melite ọganihu dị elu na ọrụ metabolic. N'adịghị ka recombinant hormone uto mmadụ, nke na-agbakwunye GH exogenous ozugbo, Sermorelin na-adabere na ikike nzuzo nke gland pituitary ma dabara maka ndị ọrịa nwere ọrụ pituitary nkịtị mana ezughị ezu GHRH.
Kedu ihe ndabere nyocha nke Sermorelin?
Nchọpụta nyocha nke Sermorelin sitere na ọrụ dị mkpa nke hormone na-eto eto na uto na mmepe mmadụ. Enweghị ụkọ homonụ na-eto eto nke mbụ nwere ike ibute mbelata uto na ụmụaka ma na-emetụta ịdị elu ikpeazụ ha. Ya mere, ịchọta ụzọ ọgwụgwọ dị irè na-abụkarị isiokwu dị mkpa na nyocha ahụike. Ọ bụ ezie na a na-eji hormone na-eto eto recombinant eme ihe ruo ọtụtụ afọ ma mee ka mmụba dị ukwuu na njedebe ikpeazụ nke ụmụaka nwere ụkọ hormone na-eto eto, na nyocha ahụike miri emi, ndị mmadụ na-achọkwa nhọrọ ọgwụgwọ ọzọ na usoro ọgwụgwọ kachasị mma. N'ime ihe ndabere a, Sermorelin, dị ka ihe na-ewepụta homonụ na-eto eto mmadụ, pụtara. Site n'ịkwalite ntọhapụ nke hormone na-eto eto, ọ ewetawo olileanya ọhụrụ maka ọgwụgwọ ụkọ hormone na-eto eto ma kwalite uto na mmepe ụmụaka.
Usoro nke Omume
Kedu usoro a kapịrị ọnụ nke Semorelin n'ịgwọ ụkọ homonụ na-eto eto?
Ndabere nke omume Semorelin
Dị ka ihe na-ewepụta homonụ na-eto eto, Sermorelin na-egosipụtakarị mmetụta ya site na ijikọta ndị na-anabata ya. Ọ na-eṅomi ọrụ nke ihe na-ewepụta homonụ uto na-apụta n'ime ahụ mmadụ ma na-akpali gland pituitary nke dị n'ihu iwepụta homonụ na-eto eto. Usoro a na-eme dị ka ihe na-akpali akpali nke hormone uto, dị ka peptides na-ewepụta hormone na-eto eto (GHRPs).
Na-akpali ntọhapụ nke ibu hormone
Ọrụ nchịkwa nke hypothalamic-pituitary axis:
Sermorelin bụ ihe na-ewepụta homonụ uto mmadụ. N'ọnọdụ nkịtị, a na-achịkwa nzuzo nke homonụ na-eto eto na ahụ mmadụ site na axis hypothalamic-pituitary. Hypothalamus na-ezobe homonụ nke na-ewepụta homonụ na-eto eto (GHRH), nke na-akpali gland pituitary nke dị n'ihu iji mepụta ma zoo homonụ uto (GH). Sermorelin na-eṅomi omume nke GHRH, na-ejikọta ya na ndị na-anabata ya na hypothalamus, ma na-akwalite gland pituitary iji wepụta hormone na-eto eto.
Mgbalite ụzọ mgbama :
Mgbe ejikọtara ya na onye na-anabata ya, Sermorelin na-eme ka ụzọ mgbaàmà intracellular rụọ ọrụ. Nke a nwere ike ịgụnye mmeghachi omume enzymatic nke abụọ na usoro ozi nke abụọ, n'ikpeazụ na-eduga n'ịba ụba na njikọ na ntọhapụ nke hormone na-eto eto. Dịka ọmụmaatụ, ọ nwere ike mee ka adenylate cyclase rụọ ọrụ, mụbaa ọkwa cAMP intracellular, wee mee ka protein kinase A rụọ ọrụ, na-akwalite nsụgharị na nsụgharị nke mkpụrụ ndụ hormone uto.
Mmetụta na erughi homonụ nke uto
Na-akwalite uto na mmepe:
Ụmụaka nwere ụkọ homonụ na-eto eto na-egosipụtakarị uto dị nwayọ na mkpụmkpụ. Sermorelin na-akwụ ụgwọ maka ụkọ hormone uto n'ime ahụ site n'ịkwalite ntọhapụ nke hormone ibu. Hormone na-eto eto nwere ike na-arụ ọrụ ozugbo na ọkpụkpụ, mọzụlụ, na anụ ahụ ndị ọzọ, na-akwalite mmụba cell na ọdịiche, ma si otú ahụ na-akwalite uto na mmepe. Hormone na-eto eto nwekwara ike ịkpali akụkụ ndị dị ka imeju iji mepụta insulin-dị ka ihe na-eto eto-1 (IGF-1), na IGF-1 na-arụkwa ọrụ na-akwalite uto.
Melite ọrụ metabolic:
Enweghị ụkọ homonụ na-eto eto abụghị naanị na-emetụta uto na mmepe kamakwa ọ nwekwara ike ibute nsogbu metabolic. Ọgwụ Semorelin nwere ike imeziwanye ọrụ metabolic, dị ka ịba ụba protein njikọ, na-akwalite ndakpọ abụba, na ịkwalite ojiji glucose. Mgbanwe metabolic ndị a na-enyere aka ịnọgide na-arụ ọrụ physiological nkịtị nke ahụ ma melite ogo ndụ nke ndị ọrịa.
Ọdịiche dị elu-SDS n'ime ụmụaka nwere ọrịa anụ ahụ jikọtara ya na ihe ndị na-ahụ maka ndụ ndụ.
Isi mmalite: PubMed [1]
Kedu ihe bụ ngwa nke Semorelin?
Ọgwụgwọ ụkọ homonụ nke uto:
Enweghị ụkọ homonụ na-eto eto nwere ike iduga n'oge uto na mmepe ụmụaka ma na-emetụta ịdị elu ikpeazụ ha. A na-eji homonụ na-eto mmadụ recombinant eme ihe n'ụlọ ọgwụ ruo ọtụtụ afọ ma mee ka mmụba dị ukwuu n'ogo ikpeazụ nke ụmụaka nwere ụkọ hormone uto. Dị ka ihe na-ewepụta hormone na-eto eto, Semorelin na-arụkwa ọrụ dị mkpa n'ịgwọ ụkọ hormone uto.
Sermorelin na-akwalite uto na mmepe nke ụmụaka site na-akpali akpali pituitary gland na-ezobe hormone ibu. Ọ nwere ike na-eṅomi usoro ntọhapụ nke homonụ na-eto eke nke anụ ahụ, na-amụba ọkwa hormone na-eto eto, wee si otú ahụ kwalite uto ọkpụkpụ na mmepe anụ ahụ. E jiri ya tụnyere homonụ na-eto mmadụ recombinant, Semorelin nwere ụfọdụ uru pụrụ iche. Dịka ọmụmaatụ, ọ nwere ike ịnwe nnabata na nchekwa ka mma, na-ebelata mmetụta ụfọdụ nwere ike ime.
Gịnị bụ ọgwụgwọ ọgwụgwọ Sermorelin na ụmụaka nwere ụdị ọrịa na-adịghị ala ala dị iche iche ma ọ bụ ọrịa mkpụrụ ndụ ihe nketa?
Ụmụaka nwere ọrịa na-adịghị ala ala
Ụmụaka nwere ọrịa njikọ anụ ahụ na-adịghị ala ala:
Maka ụmụaka nwere ọrịa anụ ahụ na-egbu egbu na-adịghị ala ala (CTD), dị ka spondyloarthropathy na-eto eto na ọrịa ogbu na nkwonkwo nke ụmụaka (JIA), n'ihi nrịanrịa nke usoro musculoskeletal kpọmkwem na ọgwụgwọ glucocorticoid, nkwụsị nke uto na-emekarị. Ọgwụgwọ ugbu a na-ejikarị ihe ndị dị ndụ dị ka tumor necrosis factor-α blockers (etanercept, adalimumab, golimumab) na interleukin-6 receptor blockers (tocilizumab), nke nwere ike jiri nwayọọ nwayọọ mee ka ọnụ ọgụgụ ụmụaka dịkwuo elu site na igbochi mbufụt na ibelata dose nke glucocorticoids kwa ụbọchị. Agbanyeghị, enwebeghị ọmụmụ ihe ugbu a na ntinye na ọgwụgwọ ọgwụgwọ Sermorelin na ụmụaka dị otú ahụ [1].
Ụmụaka nwere oyi baa na-adịghị ala ala:
Ọrịa oyi na-adịghị ala ala na-adịkarị na ụmụ nwoke, na-emekarị n'ime ime obodo karịa n'obodo mepere emepe, ọ dịghịkwa afọ ma ọ bụ ihe dị iche n'oge. N'ime ụmụaka ndị na-erubeghị afọ 3 nwere ọrịa ndị na-akpata ọrịa, ọrịa tracheobronchopulmonary na-eto eto na-emekarị, ebe ọrịa ọrịa immunodeficiency bụ isi na-adịkarị na ụmụaka dị afọ 3 na karịa. Ọrịa nje bacteria, ọkachasị nje nje nje gram-adịghị mma, bụ isi ihe na-akpatara ndị ọgbọ niile [2].
Kedu usoro a kapịrị ọnụ nke Semorelin n'ịgwọ mbelata uto n'ime ụmụaka nke ụkọ homonụ na-eto eto kpatara?
Na-akpali mwepụta nke hormone ibu:
Sermorelin bụ ihe na-ewepụta homonụ uto mmadụ. Ihe na-ewepụta homonụ na-eto eto nwere ike jikọta na hormone na-ewepụta ihe na-anabata ndị na-anabata ya na gland pituitary nke dị n'ihu, na-akpali sel pituitary iji mepụta ma hapụ homonụ uto[3]. N'ụzọ dị otú a, Semorelin nwere ike ịbawanye ọkwa nke hormone na-eto eto n'ime ahụ, si otú ahụ na-akwalite uto ụmụaka.
N'okpuru ọnọdụ nkịtị, a na-achịkwa ihe nzuzo nke hormone na-eto eto site na ihe dị iche iche, gụnyere hormone nke na-ewepụta hormone (GHRH), somatostatin, neurotransmitters, wdg. Dị ka ihe na-emepụta ihe na-emepụta hormone na-eto eto, Semorelin nwere ike iṅomi omume nke GHRH ma kwalite mmepụta nke hormone nke uto.
Na-emetụta axis ibu hormone-insulin dị ka ihe na-akpata uto:
Mgbe nzuzo nke hormone na-eto eto na-abawanye, ọ na-arụ ọrụ na anụ ahụ dị ka imeju ma na-akpali njikọ na nzuzo nke insulin-like growth factor (IGF). IGF bụ ihe dị mkpa na-achịkwa usoro uto nke nwere ike ịkwalite mmụba cell, ọdịiche, na njikọ protein, na-ekere òkè dị mkpa na uto na mmepe ụmụaka[3].
Sermorelin na-akwalite njikọ na ntọhapụ nke IGF n'ụzọ na-apụtaghị ìhè site na-akpali mmepụta nke hormone nke na-eto eto, si otú a na-eme ka ọganihu na-eto eto dịkwuo elu. IGF nwere ike jikọta ndị na-anabata IGF na mkpụrụ ndụ ebumnuche, mee ka ụzọ mgbama dị ala, ma kwalite uto cell na metabolism.
Mmetụta na uto ọkpụkpụ:
Hormone uto na IGF nwere mmetụta dị mkpa na uto ọkpụkpụ. Ha nwere ike ịkwalite mmụba na ọdịiche nke chondrocytes, na-abawanye ogologo ọkpụkpụ na ọkpụkpụ ọkpụkpụ [3]. Semorelin na-agwọ mbelata uto n'ime ụmụaka ndị kpatara ụkọ homonụ na-eto eto site na ịbawanye ọkwa nke hormone uto na IGF, na-akwalite uto na mmepe ọkpụkpụ.
Na mgbakwunye, hormone na-eto eto nwekwara ike ịhazi metabolism nke mineral dị ka calcium na phosphorus, na-ejigide usoro na ọrụ ọkpụkpụ. Semorelin nwere ike ịkwalite uto ọkpụkpụ site na imetụta usoro metabolic ndị a.
Mmetụta na metabolism abụba na muscle:
Hormone uto na IGF ọ bụghị naanị na-emetụta uto ọkpụkpụ kamakwa ọ na-enwe mmetụta na akwara na abụba metabolism. Hormone na-eto eto nwere ike ịkwalite njikọ protein, mụbaa oke ahụ, ma n'otu oge ahụ belata mkpokọta abụba[3]. Ọgwụgwọ Semorelin nwere ike melite akwara na abụba metabolism nke ụmụaka site n'ịbawanye ọkwa nke hormone uto, na-akwalite uto anụ ahụ na mmepe.
Na mgbakwunye, homonụ nke na-eto eto nwekwara ike ịhazi metabolism ike, mee ka ọnụọgụ basal metabolic na-abawanye, ma nwekwuo ike oriri. Nke a na-enyere aka ịnọgide na-enwe ịdị arọ nkịtị na nhazi ahụ nke ụmụaka ma na-akwalite uto dị mma.
Kedu ihe ndị metụtara Sermorelin?
A na-eji maka ọgwụgwọ nkwụsị nke uto na ụmụaka:
Dị ka ihe analog sịntetik nke ihe na-ewepụta homonụ uto, Semorelin na-akwalite nzuzo nke homonụ uto endogenous site na ịgbalite ndị na-anabata GHRH na gland pituitary anterior, na-eme ka uto dị elu na ọrụ metabolic nke ụmụaka nwere ụkọ homonụ nke mbụ. Ihe ọ pụtara bụ ịnye nhọrọ ọgwụgwọ yana usoro nhazi usoro ọmụmụ maka ndị ọrịa nwere ọrụ pituitary nkịtị mana ezughị ezu GHRH, na-ezere ihe egwu nke mmeghachi omume antibody ma ọ bụ nsogbu metabolic nke enwere ike bute site na ọgwụgwọ nnọchi homonụ uto na-apụ apụ. Semorelin nwere uru nke ịdabere na nzuzo nke onwe ya, na-ebelata mmetụta hormonal, na ịbịaru nso na usoro nhazi usoro ahụ.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ ndị Cocer Peptides na-enyocha, dezie ma chịkọta ya [4].
Onye ode akwụkwọ akụkọ sayensị
Simon TJ bụ onye nyocha nwere njikọ na ọtụtụ ụlọ ọrụ ama ama. Ndị a gụnyere Zoetis Vet Med Regulatory Affairs, Akili Interact Labs, University of California Davis, Univ Calif, Dept Psychiat & Behav Sci, UC Davis MIND Inst, California State University Sacramento, MIND Inst, UCDHS, Hospitallọ ọgwụ ụmụaka nke Philadelphia, NIH National Institute on Drug Abuse (NIDA), Ụlọ ọrụ Emory, Georgia Merck Institute na Technology Institute, Georgia Merck Institute. Njikọ ụlọ ọrụ dị iche iche dị otú ahụ na-egosipụta nnukwu agụmakwụkwọ ya na nyocha nyocha ya.
Ọchịchọ nyocha ya gbasara ụdị isiokwu dị iche iche dị ka Neurosciences & Neurology, Psychiatry, Psychology, Genetics & Heredity, na Gastroenterology & Hepatology. Ọrụ ya na mpaghara ndị a na-egosipụta ihe ọmụma dị omimi ya na ntinye aka dị ukwuu n'ịkwalite sayensị ahụike na ịkwalite omume nlekọta ahụike. Edepụtara Simon TJ na ntụaka nke ntụaka [4].
