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Sermorelin 5 mg

Sermorelin yog ib qho tshuaj tiv thaiv kev loj hlob hormone-tso cov tshuaj hormones (GHRH) analog uas ua haujlwm los ntawm kev txhawb nqa lub caj pas pituitary kom secrete natural human growth hormone (GH). Nws lub luag haujlwm tseem ceeb suav nrog kev txhawb nqa kev loj hlob thiab kev loj hlob, txhim kho cov leeg nqaij, thiab txo cov rog, nrog rau kev txhawb nqa cov ntaub so ntswg kho thiab rov tsim dua tshiab. Sermorelin yog qhov tshwj xeeb tshaj yog rau kev kho cov tshuaj hormones tsis txaus thiab muaj kev nyab xeeb thiab sib npaug ntau dua rau kev kho cov tshuaj hormone hloov. Los ntawm ib txwm stimulating GH secretion los ntawm lub caj pas pituitary, nws pab tswj lub cev pulsatile tso tawm qauv, yog li txo qhov kev pheej hmoo ntawm hormonal tsis txaus. Tsis tas li ntawd, Semorelin tuaj yeem txhim kho qib zog, txhim kho kev txawj ntse, thiab pab txhawb kev hloov pauv lub cev muaj hnub nyoog.

Cov peptide yuav muab ua lyophilized hmoov kom muaj kev ruaj ntseg siab tshaj plaws.

Nqe: $ 120

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1 khoom (10Vials)

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Sermorelin Txheej txheem cej luam

Sermorelin Structure

Sermorelin Kev Tshawb Fawb

Kev Citations

▎ Sermorelin Txheej txheem cej luam

Sermorelin yog ib qho hluavtaws analogue ntawm kev loj hlob hormone-tso hormone (GHRH), exerting nws cov teebmeem los ntawm stimulating lub pituitary caj pas kom secrete lub cev lub ntuj kev loj hlob hormone (GH). Nws cov haujlwm tseem ceeb suav nrog txhawb cov leeg kev loj hlob, txhim kho lub cev muaj pes tsawg leeg, txhim kho cov metabolism, thiab txhawb kev kho cov nqaij mos thiab rov tsim dua tshiab. Tsis zoo li kev txhaj tshuaj ncaj qha ntawm cov tshuaj hormones kev loj hlob, Sermorelin tswj lub cev pulsatile tso tawm qauv ntawm GH los ntawm ntuj stimulation ntawm pituitary secretion, yog li txo qhov kev pheej hmoo ntawm hormonal imbalance thiab muab kev nyab xeeb, ntau npaum li cas rau kev kho tshuaj hormone hloov. Tsis tas li ntawd, Semorelin nthuav tawm cov txiaj ntsig tseem ceeb hauv kev txhawb nqa kev loj hlob thiab kev loj hlob, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm kev loj hlob hormone deficiency, qhov uas nws pab txhim kho cov leeg nqaij, txo cov rog, thiab txhawb kev noj qab haus huv tag nrho.

▎ Sermorelin Structure

1 - Sermorelin

Source: PubChem

Sequence: YADAXFXNSYRKVLGQLSARKLLQDXMSR

Molecular Formula: C ₁₄₉H ₂₄₆N ₄₄O ₄₂S

Molecular Luj: 3357.9 g / mol

CAS Nr .: 86168-78-7

PubChem CID: 16129620

Synonyms: Sermorelin (INN) ; CHEBI: 9118

▎ Sermorelin Kev Tshawb Fawb

Sermorelin yog dab tsi?

Sermorelin yog ib qho hluavtaws analog ntawm kev loj hlob hormone tso tawm (GHRF). Nws lub luag haujlwm tseem ceeb yog khi rau kev loj hlob hormone tso tawm cov tshuaj hormones (GHRH) receptors nyob rau hauv lub anterior pituitary caj pas, qhib lub intracellular signaling txoj kev (xws li txoj kev cAMP/PKA), txhawb lub synthesis thiab tso tawm ntawm endogenous loj hlob hormone (GH), thiab yog li txhawb kev loj hlob thiab kev loj hlob ntawm cov me nyuam. Nws yog tsuas yog siv los kho thawj qhov kev loj hlob hormone tsis txaus (kev loj hlob tsub zuj zuj hauv cov menyuam yaus los ntawm kev ua haujlwm pituitary tsis txaus). Los ntawm kev rov kho GH secretion, nws tuaj yeem txhim kho qhov siab loj hlob thiab ua haujlwm metabolic. Tsis zoo li recombinant tib neeg txoj kev loj hlob hormone, uas ncaj qha ntxiv exogenous GH, Sermorelin tso siab rau lub pituitary caj pas nws tus kheej secretion muaj peev xwm thiab yog haum rau cov neeg mob uas ib txwm pituitary muaj nuj nqi tab sis tsis txaus GHRH.

Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm Sermorelin?

Kev tshawb fawb keeb kwm ntawm Sermorelin yog los ntawm lub luag haujlwm tseem ceeb ntawm kev loj hlob hormone hauv tib neeg txoj kev loj hlob thiab kev loj hlob. Kev loj hlob hormone tsis txaus tuaj yeem ua rau kev loj hlob ntawm cov menyuam yaus thiab cuam tshuam rau lawv qhov siab kawg. Yog li ntawd, nrhiav txoj kev kho kom zoo yeej ib txwm yog lub ntsiab lus tseem ceeb hauv kev tshawb fawb kho mob. Txawm hais tias recombinant tib neeg txoj kev loj hlob hormone tau siv tau ntau xyoo thiab tau ua rau muaj kev nce ntxiv hauv qhov siab kawg ntawm cov menyuam yaus uas muaj kev loj hlob hormone tsis txaus, nrog rau kev tshawb nrhiav kev kho mob tob zuj zus, tib neeg kuj nrhiav kev kho mob ntau dua thiab kho kom zoo dua qub. Tawm tsam qhov teeb meem no, Sermorelin, uas yog ib qho hluavtaws tib neeg txoj kev loj hlob hormone tso tawm, tshwm sim. Los ntawm kev txhawb kev tso tawm ntawm kev loj hlob hormone, nws tau coj kev cia siab tshiab rau kev kho mob ntawm kev loj hlob hormone tsis txaus thiab txhawb kev loj hlob thiab kev loj hlob ntawm cov menyuam yaus.

Mechanism ntawm Action

Dab tsi yog qhov tshwj xeeb ntawm Semorelin hauv kev kho thawj qhov kev loj hlob hormone tsis txaus?

Lub hauv paus ntawm Semorelin qhov kev ua

Raws li kev loj hlob hormone tso tawm, Sermorelin feem ntau siv nws cov teebmeem los ntawm kev khi rau cov receptors tshwj xeeb. Nws ua raws li kev ua haujlwm ntawm qhov tshwm sim loj hlob hormone tso tawm hauv tib neeg lub cev thiab txhawb nqa lub caj pas pituitary anterior kom tso tawm cov tshuaj hormones loj hlob. Cov txheej txheem ntawm kev ua haujlwm no zoo ib yam li lwm yam kev loj hlob hormone stimulants, xws li kev loj hlob hormone tso tawm peptides (GHRPs).

Stimulating qhov tso tawm ntawm kev loj hlob hormone

Kev tswj lub luag haujlwm ntawm hypothalamic-pituitary axis:

Sermorelin yog ib qho hluavtaws tib neeg txoj kev loj hlob hormone tso tawm. Nyob rau hauv ib txwm muaj xwm txheej, qhov tso tawm ntawm kev loj hlob hormone hauv tib neeg lub cev yog nruj me ntsis tswj los ntawm hypothalamic-pituitary axis. Lub hypothalamus secretes loj hlob hormone tso tawm cov tshuaj hormones (GHRH), uas nkoos lub anterior pituitary caj pas rau synthesize thiab secrete loj hlob hormone (GH). Sermorelin ua raws li qhov kev txiav txim ntawm GHRH, khi rau cov receptors tshwj xeeb hauv hypothalamus, thiab txhawb nqa lub caj pas pituitary kom tso cov tshuaj hormones loj hlob.

Activation ntawm lub signaling txoj kev :

Tom qab khi rau lub receptor, Sermorelin qhib txoj hauv kev hauv lub cev. Qhov no tej zaum yuav koom nrog ntau cov tshuaj tiv thaiv enzymatic thiab lub tshuab xa xov thib ob, thaum kawg ua rau muaj kev nce hauv synthesis thiab tso tawm ntawm kev loj hlob hormone. Piv txwv li, nws tuaj yeem qhib adenylate cyclase, nce qib cAMP intracellular, thiab tom qab ntawd qhib cov protein kinase A, txhawb kev sau ntawv thiab txhais lus ntawm cov noob caj noob ces.

Cov teebmeem ntawm kev loj hlob hormone deficiency

Txhawb kev loj hlob thiab kev loj hlob:

Cov menyuam yaus uas muaj cov tshuaj hormones loj hlob tsis txaus feem ntau qhia tias kev loj hlob qeeb thiab qis qis. Sermorelin them nyiaj rau qhov tsis txaus ntawm kev loj hlob hormone hauv lub cev los ntawm kev txhawb kev tso tawm ntawm kev loj hlob hormone. Kev loj hlob hormone tuaj yeem ua ncaj qha rau cov pob txha, cov leeg, thiab lwm yam ntaub so ntswg, txhawb kev loj hlob ntawm tes thiab kev sib txawv, thiab yog li txhawb kev loj hlob thiab kev loj hlob. Kev loj hlob hormone kuj tseem tuaj yeem txhawb nqa lub cev xws li lub siab los tsim cov tshuaj insulin zoo li kev loj hlob zoo-1 (IGF-1), thiab IGF-1 ntxiv rau kev txhawb nqa kev loj hlob.

Txhim kho kev ua haujlwm metabolic:

Kev loj hlob hormone tsis txaus tsis tsuas yog cuam tshuam rau kev loj hlob thiab kev loj hlob, tab sis kuj tseem tuaj yeem ua rau cov kab mob metabolic. Semorelin kev kho mob tuaj yeem txhim kho kev ua haujlwm hauv metabolic, xws li nce protein synthesis, txhawb kev rog rog, thiab txhim kho kev siv cov piam thaj. Cov kev hloov pauv hauv metabolic no pab tswj kev ua haujlwm ntawm lub cev ntawm lub cev thiab txhim kho lub neej zoo ntawm cov neeg mob.

Qhov siab-SDS variations nyob rau hauv cov me nyuam uas muaj kab mob sib txuas kho nrog biolog ical agents.

Source: PubMed ^[1]

Dab tsi yog cov ntawv thov ntawm Semorelin?

Kev kho mob ntawm kev loj hlob hormone deficiency:

Kev loj hlob hormone tsis txaus tuaj yeem ua rau ncua kev loj hlob thiab kev loj hlob ntawm cov menyuam yaus thiab cuam tshuam rau lawv qhov siab kawg. Recombinant tib neeg txoj kev loj hlob hormone tau siv rau hauv kev kho mob rau ntau xyoo thiab tau ua rau muaj kev nce ntxiv hauv qhov siab kawg ntawm cov menyuam yaus nrog kev loj hlob hormone tsis txaus. Raws li kev loj hlob hormone tso tawm, Semorelin tseem ua lub luag haujlwm tseem ceeb hauv kev kho cov tshuaj hormones tsis txaus.

Sermorelin txhawb kev loj hlob thiab kev loj hlob ntawm cov menyuam yaus los ntawm kev txhawb nqa lub caj pas pituitary kom zais cov tshuaj hormones loj hlob. Nws tuaj yeem ua raws li lub cev kev loj hlob hormone tso tawm mechanism, nce qib ntawm cov tshuaj hormones, thiab yog li txhawb cov pob txha loj hlob thiab kev loj hlob ntawm lub cev. Piv nrog rau tib neeg txoj kev loj hlob hormone, Semorelin muaj qee qhov zoo. Piv txwv li, nws yuav muaj kev zam zoo dua thiab kev nyab xeeb, txo qee qhov kev mob tshwm sim.

Dab tsi yog qhov kev kho mob ntawm Sermorelin hauv cov menyuam yaus uas muaj ntau hom kab mob ntev lossis kab mob caj ces?

Cov menyuam yaus uas muaj kab mob ntev

Cov menyuam yaus uas muaj kab mob inflammatory kab mob sib kis:

Rau cov menyuam yaus uas muaj cov kab mob sib kis mob ntev (CTD), xws li cov menyuam yaus spondyloarthropathy thiab juvenile idiopathic mob caj dab (JIA), vim yog qhov ncaj qha musculoskeletal system o thiab kev kho mob glucocorticoid, kev loj hlob tus nqi suppression feem ntau tshwm sim. Cov kev kho mob tam sim no tsuas yog siv cov tshuaj lom neeg xws li qog nqaij hlav necrosis factor-α blockers (etanercept, adalimumab, golimumab) thiab interleukin-6 receptor blockers (tocilizumab), uas tuaj yeem maj nrawm thiab normalize qhov kev loj hlob ntawm cov menyuam yaus los ntawm inhibiting o thiab txo cov koob tshuaj txhua hnub ntawm glucocorticoids. Txawm li cas los xij, tam sim no tsis muaj kev tshawb fawb ntawm daim ntawv thov thiab kev kho mob ntawm Sermorelin hauv cov menyuam yaus ^[1].

Cov menyuam yaus uas muaj mob ntsws ntev:

Mob ntsws ntsws muaj ntau dua rau cov txiv neej cov menyuam yaus, feem ntau nyob rau hauv cov cheeb tsam nyob deb nroog dua li hauv nroog, thiab tsis muaj hnub nyoog pom tseeb lossis qhov sib txawv ntawm lub caij nyoog. Ntawm cov menyuam yaus hnub nyoog qis dua 3 xyoos nrog cov kab mob hauv lub hauv paus, congenital tracheobronchopulmonary txoj kev loj hlob malformations yog ib qho tshwm sim, thaum thawj cov kab mob tiv thaiv kab mob muaj ntau dua rau cov menyuam yaus hnub nyoog 3 xyoos thiab siab dua. Cov kab mob kab mob, tshwj xeeb tshaj yog kab mob Gram-negative kab mob, yog qhov ua rau tseem ceeb hauv txhua pab pawg hnub nyoog ^[2].

Dab tsi yog qhov tshwj xeeb ntawm Semorelin hauv kev kho kev loj hlob ntawm cov menyuam yaus uas tshwm sim los ntawm kev loj hlob hormone tsis txaus?

Stimulating kev tso tawm ntawm kev loj hlob hormone:

Sermorelin yog ib qho hluavtaws tib neeg txoj kev loj hlob hormone tso tawm. Kev loj hlob hormone tso tawm yam tuaj yeem khi rau txoj kev loj hlob hormone tso tawm cov txiaj ntsig receptors nyob rau hauv lub caj pas pituitary anterior, stimulating pituitary hlwb kom synthesize thiab tso tawm kev loj hlob hormone[3]. Ua li no, Semorelin tuaj yeem nce qib ntawm kev loj hlob hormone hauv lub cev, yog li txhawb kev loj hlob ntawm cov menyuam yaus.

Raws li ib txwm muaj, qhov tso tawm ntawm kev loj hlob hormone yog tswj los ntawm ntau yam, nrog rau kev loj hlob hormone tso tawm hormone (GHRH), somatostatin, neurotransmitters, thiab lwm yam. Raws li ib qho exogenous loj hlob hormone tso tawm, Semorelin tuaj yeem ua raws li qhov kev txiav txim ntawm GHRH thiab txhawb kev tso tawm ntawm kev loj hlob hormone.

Influencing txoj kev loj hlob hormone-insulin-zoo li kev loj hlob yam axis:

Tom qab qhov tso tawm ntawm cov tshuaj hormones loj hlob tuaj, nws ua rau cov ntaub so ntswg xws li lub siab thiab txhawb kev tsim thiab tso tawm ntawm insulin zoo li kev loj hlob zoo (IGF). IGF yog qhov tseem ceeb ntawm kev tswj hwm kev loj hlob uas tuaj yeem txhawb kev loj hlob ntawm tes, kev sib txawv, thiab kev tsim cov protein, ua lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov menyuam yaus [3].

Sermorelin indirectly txhawb lub synthesis thiab tso tawm ntawm IGF los ntawm stimulating lub secretion ntawm kev loj hlob hormone, yog li ntxiv mus pab txhawb txoj kev loj hlob ntawm cov nyhuv. IGF tuaj yeem khi rau IGF receptors ntawm lub hom phiaj ntawm lub hlwb, qhib cov kev taw qhia hauv qab, thiab txhawb kev loj hlob ntawm tes thiab cov metabolism.

Qhov cuam tshuam rau pob txha loj hlob:

Kev loj hlob hormone thiab IGF muaj feem cuam tshuam rau pob txha loj hlob. Lawv tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm chondrocytes, ua kom cov pob txha ntev thiab pob txha ceev [3]. Semorelin kho kev loj hlob ntawm cov menyuam yaus uas tshwm sim los ntawm kev loj hlob hormone tsis txaus los ntawm kev nce qib ntawm kev loj hlob hormone thiab IGF, txhawb kev loj hlob ntawm pob txha thiab kev loj hlob.

Tsis tas li ntawd, cov tshuaj hormones loj hlob tuaj yeem tswj cov metabolism hauv cov zaub mov xws li calcium thiab phosphorus, tswj cov qauv zoo thiab kev ua haujlwm ntawm cov pob txha. Semorelin tuaj yeem txhawb nqa pob txha loj hlob ntxiv los ntawm kev cuam tshuam cov txheej txheem metabolic.

Kev cuam tshuam rau cov leeg nqaij thiab rog metabolism:

Kev loj hlob hormone thiab IGF tsis tsuas yog cuam tshuam rau pob txha loj hlob tab sis kuj muaj kev cuam tshuam rau cov leeg nqaij thiab cov rog metabolism. Kev loj hlob hormone tuaj yeem txhawb kev tsim cov protein ntau, nce cov leeg nqaij, thiab tib lub sijhawm txo cov rog rog [3]. Kev kho mob Semorelin tuaj yeem txhim kho cov leeg nqaij thiab rog metabolism ntawm cov menyuam yaus los ntawm kev nce qib ntawm cov tshuaj hormones, txhawb kev loj hlob ntawm lub cev thiab kev loj hlob.

Tsis tas li ntawd, cov tshuaj hormones loj hlob tuaj yeem tswj hwm lub zog metabolism, ua kom cov metabolism hauv basal, thiab nce lub zog noj. Qhov no pab tswj qhov hnyav thiab lub cev muaj pes tsawg leeg ntawm cov menyuam yaus thiab txhawb kev loj hlob zoo.

Dab tsi yog cov ntawv thov cuam tshuam ntawm Sermorelin?

Siv rau kev kho mob ntawm kev loj hlob suppression nyob rau hauv cov me nyuam:

Raws li ib qho hluavtaws analogue ntawm kev loj hlob hormone tso tawm, Semorelin indirectly txhawb lub secretion ntawm endogenous txoj kev loj hlob hormone los ntawm activating GHRH receptors nyob rau hauv lub anterior pituitary caj pas, ho txhim kho qhov siab loj hlob thiab metabolic muaj nuj nqi ntawm cov me nyuam nrog thawj loj hlob hormone deficiency. Nws qhov tseem ceeb yog nyob rau hauv kev muab cov kev xaiv kho mob nrog rau kev tswj hwm lub cev rau cov neeg mob uas muaj lub luag haujlwm pituitary tab sis tsis txaus GHRH, zam qhov kev pheej hmoo ntawm cov tshuaj tiv thaiv kab mob lossis cov kab mob metabolic uas yuav raug coj los ntawm kev loj hlob ntawm cov tshuaj hormone hloov pauv. Semorelin muaj qhov zoo ntawm kev tso siab rau nws tus kheej tso tawm, txo cov kev cuam tshuam hormonal, thiab nyob ze rau cov kev cai ntawm lub cev.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides ^[4].

Scientific Journal Author

Simon TJ yog tus kws tshawb fawb nrog kev koom tes rau ntau lub koom haum muaj koob npe. Cov no suav nrog Zoetis Vet Med Regulatory Affairs, Akili Interact Labs, University of California Davis, Univ Calif, Dept Psychiat & Behav Sci, UC Davis MIND Inst, California State University Sacramento, MIND Inst, UCDHS, Childrens Hospital of Philadelphia, NIH National Institute on Drug Abuse (NIDA), Georgia thiab Emory University. Cov kev sib txawv ntawm cov koom haum sib txawv no qhia txog nws txoj kev kawm dav dav thiab kev tshawb fawb keeb kwm yav dhau los.

Nws txoj kev tshawb fawb nyiam nthuav dav thoob plaws ntau yam kev kawm xws li Neurosciences & Neurology, Psychiatry, Psychology, Genetics & Heredity, thiab Gastroenterology & Hepatology. Nws txoj haujlwm hauv cov haujlwm no qhia txog nws qhov kev paub tob tob thiab kev koom tes tseem ceeb rau kev nce qib kev kho mob thiab kev txhim kho kev noj qab haus huv. Simon TJ tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [4].

▎ Cov Lus Qhia Tseem Ceeb

[1] Swidrowska J, Zygmunt A, Biernaka-Zielinska M, et al. Kev cuam tshuam ntawm kev kho mob biologic ntawm kev loj hlob ntawm cov menyuam yaus uas muaj kab mob inflammatory kab mob sib kis [J]. Reumatologia (Warsaw), 2015,53(1):14-20.DOI:10.5114/reum.2015.50552.

[2] Sijie Y, Jiangfeng O. Kev tshuaj ntsuam xyuas ntawm 102 tus neeg mob cov menyuam yaus uas muaj mob ntsws[J]. Phau ntawv Journal of Modern Medicine thiab Health, 2019, 35(12): 1800-1803. https://kns.cnki.net/kcms2/article/abstract?v=bEegF8awJvx1tuc8VX9mZWsnvku8OJf3MuA155FDI97duNJbDlT0BpqFrBjyXEORr9zmNdi7f9n51MNYcGlS6v rUXos6V5MhYjUzV8NZaxoHVQnVZoB_FvN7hrZq7OLXrt_tDSd0mmMfeiuHoDq37r6raVNjZXCwj4IV5TxOlYAFg7GmsIw1HpJNE6VF_CEHjw=&uniplatform=>

[3] Li Ming. Kev loj hlob hormone-tso tawm yam khoom siv hauv kev kho mob ntawm kev loj hlob hormone deficiency [J]. Suav Pharmacist, 1999(06): 333. https://kns.cnki.net/kcms2/article/abstract?v=bEegF8awJvyCUvydH2XgdIGr7pLvLM2eL7wOoSCfKs3gR77cpaEUGORQnJJ3l4BU_yyyXCohkE2UjpJI2ZKu5t_ XMK5MRJMpt4ieJiS55PZv6llMK0foTlnsaYu1ETWfpCauLwyWWEtc7W5R4v1Ow5FMn0MdHZPR3wOfU_zWBMuCi3_GjoxcjsSOCn1YiiK66eto=&uniplatform=

[4] Simon T J. Kev paub txog yam ntxwv ntawm cov menyuam yaus uas muaj caj ces mob [J]. Child and Adolescent Psychiatric Clinics of North America, 2007,16(3):599.DOI:10.1016/j.chc.2007.03.002.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.

Yam khoom

Sermorelin 5 mg

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