Cocer Peptides fɛ 
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BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Melanotan-II Lajɛba
Melanotan-II (MT-II) ye α-melanocyte-stimulating hormone (α-MSH) analogu synthétique ye min bɛ melanocortin agoniste kulu dɔ la. MT-II tɛ kɛ dɔrɔn ka ɲɛsin farikolojidɛsɛ ma; furakɛli ɲinini siratigɛ la , a bɛ ka sɛgɛsɛgɛ walasa ka se ka baara kɛ ni a ye banaw furakɛli la i n’a fɔ cɛya gɛlɛya.
Jaa 1 Melanotan-II ka sigicogo.
Melanotan-II ka baarakɛcogo
MT-II bɛ a nɔw jira fɔlɔ a kɛtɔ ka jɛɲɔgɔnya kɛ ni melanocortin receptors (MCRs) ye. Melanokɔriti minɛbaga denbaya kɔnɔ, suguya fitinin caman bɛ yen i n’a fɔ MC1R, MC2R, MC3R, MC4R, ani MC5R. MT-II ye melanocortin receptor agoniste ye min tɛ sugandi, min bɛ se ka siri MCR caman na ani ka u baara.
Fari la, MT-II bɛ siri MC1R la melanositɛriw sanfɛ, ka adenilati siklazi baara, o bɛ dɔ fara AMP cyclique (cAMP) hakɛ kan, o la, a bɛ protein kinase A (PKA) baara. PKA bɛ microphtalmie-associé transcription facteur (MITF) baara fosforilasi fɛ. MITF ye sɛbɛnnikɛlan jɔnjɔn ye melanin dilanni na, A bɛ jamu jiracogo kɔrɔta i n’a fɔ tirosinase, tirosinase-related protein-1 (TRP-1), ani tyrosinase-related protein-2 (TRP-2), olu ye enzymes ye minnu sen bɛ melanin sɔrɔli la, o laban bɛ na ni fari ɲɛ bonya ye ani ka farikolo ɲɛjibɔ nɔ sɔrɔ.
Farikoloɲɛnajɛ la, MT-II fana bɛ nɔ bila farikoloɲɛnajɛ dɔw la. A bɛ se ka oksitosini cɛmancɛla sigida lawuli. Kɔlɔsiliw y’a jira ko MT-II pikiri kɛli joli la, o bɛ Fos jirali bila kosɛbɛ hipotalamus suprachiasmatic nucleus (SON) ani paraventricular nucleus (PVN) senfagabana belebelebaw la, o jaabi bɛ se ka dɔgɔya ni melanocortin antagonist SHU-9119 pikiri kɛli ye ka kɔn kunsɛmɛ na. Kuranko sɛbɛnw b’a jira ko MT-II pikiri kɛli joli la, o bɛ dɔ fara okisitosini senkɔniw ka marifa cicogo kan SON kɔnɔ nka a tɛ oksitosini dendɛrɛsi bɔli daminɛ SON kɔnɔ. K’a sababu kɛ ɲinini tɛmɛnenw ye minnu y’a jira ko melanocortin agonistes tali tilennen bɛ supraoptic nucléus (SON) oxytocine neurons bali, MT-II min bɛ kɛ joli la, o nɔ bɛ se ka kɛ a dɔgɔyalenba la, a bɛ se ka kɛ sababu ye ka fɛnw kɛ ka bɔ kɔkolo la, o yɔrɔ la, MT-II fana bɛ dɔ fara Fos jirali kan.
Ka fara o kan, MT-II bɛ ni baarakɛcogo dɔw ye fanga sɛnɛcogo ni funteni sɛgɛsɛgɛli la. Sogow ka kɔlɔsiliw la, MT-II pikiri kɛli kɔnɔbara la, o bɛ farikoloɲɛnajɛ/furakɛli dɔgɔyali nafama ni waati dɔɔnin bila mɔgɔ la. Nin fariganko in bɛ tunun Kit W-sh/W-sh sogow la minnu tɛ ni masɔrɔsiraw ye, o b’a jira ko farikolojidɛsɛbanakisɛw nafa ka bon MT-II sababu la. MT-II bɛ se ka masɔrɔsiraw lawuli MRGPRB2-dependant ni -independant fɛɛrɛ fila bɛɛ fɛ walasa ka histamine bɔ, o min bɛ funteni dɔgɔyali lase histamine H 1 sɔrɔyɔrɔw fɛ, barisa pirilamine kɛlɛbaga sugandilen walima H 1 minɛbagaw bɔli bɛ o funteni dɔgɔyali nɔ dɔgɔya kosɛbɛ.
Melanotan-II nɔ minnu bɛ sɔrɔ a la
Jɔrɔ min bɛ fari ɲɛjibɔ la
MT-II nɔ kɛrɛnkɛrɛnnen dɔ ye ka fari ɲɛkisɛw caya, o kɔrɔ ye ka fari ɲɛci nɔ sɔrɔ. Baarakɛlaw ka hakilinaw b’a jira ko mɔgɔ minnu y’a ɲini ka ɲɛgɛnw kɛ ni MT-II ye, olu bɛɛ lajɛlen bɛ se ka fari dibi jira. O b’a jira ko MT-II ka yɛrɛmahɔrɔnya hakɛ dɔ bɛ farikolo ɲɛjibɔ la, a tɛ tali kɛ pewu fiɲɛbɔli la min bɛ wele ko ultraviolet walasa ka melanojeni masin daminɛ.Kalan dɔw la, kɔlɔsili minnu kɛra baganw ka misaliw la ani selilɛriw ka sɛgɛsɛgɛliw la in vitro, olu y’a jira ko MT-II bɛ melanositɛriw lawuli k’a ɲɛsin a yɛrɛ ma, ka anzimuw bɔli wuli ka taa a fɛ minnu bɛ tali kɛ melanin dilanni na, o bɛ melanin ni dibi kɛli sabati fari kulɛri. O nɔ in bɛ se ka kɛ fɛɛrɛ wɛrɛ ye mɔgɔ minnu bɛ ɲɛda ɲɛgɛn ɲini, k’a sɔrɔ u haminanko ye farikolo tiɲɛni ye min bɛ sɔrɔ UV fɛ.
A nɔ minnu bɛ sɔrɔ Neurobehavior (Sɔgɔsɔgɔninjɛ kɛcogo) la
Senfagabana nɔfɛkow siratigɛ la, MT-II bɛ wale caman jira. Kalan minnu kɛra ni zebra jɛgɛ ye i n’a fɔ misali, a jirala ko hali dumuni minnu bɛ kɛ ni tulumafɛnw ye (HF) waati kunkurunnin kɔnɔ (minnu bɛ mɛn zebra jɛgɛ ka ɲɛnamaya kɔnɔ 1% ɲɔgɔn dɔrɔn, walima dɔgɔkun saba) o bɛ se ka kɛ sababu ye ka dɔnniya hakili dɔgɔya, ka jɔrɔnanko hakɛ caya, ani ka ɲinini kɛcogo dɔgɔya zebɛrɛ jɛgɛ la. MT-II bɛ se ka nin ko jugu ninnu kɔsegin minnu bɛ sɔrɔ dumuni tuluma caman fɛ, ka zebra jɛgɛ ka dɔnniya hakilijagabɔ, a ka jɔrɔnanko ani a ka ɲinini kɛcogo segin a hakɛ la min ni dumuni nafama kulu ta bɛ tali kɛ ɲɔgɔn na.
Sɛgɛsɛgɛliw la minnu ɲɛsinnen bɛ autizmu ma, ni baara kɛra ni denba ka farikolo tangalan baarakɛcogo (MIA) sogo misali ye walasa ka autizmu ladege, MIA sogo cɛmanw bɛ autizmu ɲɔgɔnna jogo jira, i n’a fɔ sigidamɔgɔw ka kɛwalew taamasiɲɛw dɔgɔyali, kan kumaɲɔgɔnya dɔgɔyali, ani segin-ka-bɔnyew caya. Tile wolonwula MT-II furakɛli kɔfɛ, sigida taamacogo jiralanw MIA sogo cɛmanw na, olu ɲɛnabɔra, ka sɔrɔ sigida taamacogo jiralanw C57 sogow la minnu ka ɲɛnamaya kɛcogo bɛnnen don, olu ma fɛn caman jira MT-II furakɛli kɔfɛ. O b’a jira ko MT-II bɛ se ka furakɛli kɛ ka ɲɛsin autizmu ɲɔgɔnna kɛcogo dɛsɛw ɲɛnabɔli ma, ka sira kura di autizmu furakɛli ɲininiw ma.
Jaa 2 MIA sogo cɛkɔrɔbaw ye dɔ fara okisitosini minɛcogo jirali kan ɲɛda ɲɛfɛla la.
A bɛ nɔ bila fanga sɛnɛcogo la ani funteni hakɛ labɛnni na
MT-II fana bɛ nɔba bila fanga sɛnɛcogo la ani funteni hakɛ labɛnni na. Sogow ka kɛlɛli la, soso minnu ka pituitaire adenylate cyclase-activating peptide (PACAP) dɛsɛ bɛ olu la, olu ye MT-II kɛ u la pikiri kɛli fɛ u lamini na don o don dɔgɔkun saba tugu-tugulen kɔnɔ nɛnɛ ladamuni waati. Jateminɛw y’a jira ko MT-II bɛ se ka sosow ka funteni sɔrɔli seko tiɲɛnen segin a yɔrɔ dɔ la. Norepinephrine ka farikoloɲɛnajɛ hakɛ sumani fɛ, a jirala ko soso minnu furakɛra ni MT-II ye, olu ka funteni sɔrɔli seko yɔrɔ dɔ seginna. Ka fara o kan, MT-II furakɛli ye tulumafɛnw baaracogo nɔgɔlenw latilen adɛrɛnerji lawulili kɔrɔ, o b’a jira ko MT-II bɛ se ka nɔ bila funteni sɔrɔli la tulumafɛnw na, a kɛtɔ ka hinɛ farikoloɲɛnajɛw labɛn, o la, a jɔyɔrɔ bɛ fanga farikoloɲɛnajɛ balansi sabatili la.
MT-II bɛ se ka farigan dɔgɔya sosow la ni a ye masɔrɔsiraw baara ani ka histamine bɔ. O wale in bɛ MT-II jɔyɔrɔ jira funteni hakɛ labɛnni fɛɛrɛw la.
A bɛ se ka nɔ minnu bila bangekɔlɔsi fɛɛrɛw la
MT-II fana bɛ se ka nɔ bila bangekɔlɔsi fɛɛrɛw la. A sɛgɛsɛgɛra cɛyabana furakɛli kama, o min bɛ tali kɛ a ka wuli-wuli nɔw la bangekɔlɔsi fɛɛrɛw la.
Melanotan-II (Melanotan-II) kɛcogo
Aplikasi minnu bɛ kɛ cɛɲa baara la
Cɛɲi baara la, MT-II bɛ kɛ fɔlɔ i n’a fɔ farikolojidɛsɛ fura. Ni nege bɛ ka bonya ka ɲɛsin fari kɛnɛman, nɛgɛma ma ani haminankow fari tiɲɛni minnu bɛ se ka sɔrɔ laadala tile fɛ (i n’a fɔ tilejeni ani fari kansɛri farati bonya), MT-II ye mɔgɔw hakili sama i n’a fɔ fura min b’a fɔ ko a bɛ se ka ɲɛgɛnɛ kɛ k’a sɔrɔ a ma a jigi da tile kan. Nka, ikomi a ma sɔn fanga baaradaw fɛ i n’a fɔ FDA, wa a tɛ lakana ni nafa sɛgɛsɛgɛlibaw kɛ, a kɛcogo cɛɲi sugu la, o bɛ to yɔrɔ jɛlen na. Jamana ni mara dɔw la, MT-II feereli min tɛ sariya kɔnɔ ɛntɛrinɛti kan walasa ka ɲɛgɛnw kɛ, o bɛ kɛ tuma dɔw la.
A kɛcogo furakɛli ɲininiw na
Furakɛcogo ɲinini siratigɛ la, MT-II tali sinsinnen bɛ fɔlɔ a furakɛli kɛcogo kan bana suguya caman na. Hakilila-jɔ-banaw siratigɛ la, MT-II y’a jira ko a bɛ se ka farikolo-ɲɛnajɛ-taamacogo juguw ɲɛnabɔ minnu bɛ sɔrɔ dumuni tuluma dunni fɛ zebɛrɛ jɛgɛw la ani kɛwale dɛsɛ minnu bɛ i n’a fɔ autizmu MIA sogo cɛmanw na, o bɛ ɲinini sira kura di hakiliɲagami banaw furakɛli kan minnu bɛ tali kɛ ɲɔgɔn na.
Fanga sɛnɛcogo sɛgɛsɛgɛliw la ani bana minnu bɛ tali kɛ funteni hakɛ la, MT-II ka kisi nɔ min bɛ funteni sɔrɔli la sosow la minnu tɛ PACAP sɔrɔ, o b’a jira ko a nafa bɛ se ka kɛ farikoloɲɛnajɛ banaw furakɛli la i n’a fɔ fasa. Sɛgɛsɛgɛli wɛrɛw kɛli MT-II ka ɲɛnabɔli fɛɛrɛw kan fanga falenfalen taamasiɲɛw siraw kan, o bɛ se ka kɛ sababu ye ka furakɛli fɛɛrɛ kuraw labɛn farikoloɲɛnajɛ banaw kama. Kalan minnu kɛra MT-II ka funteni dɔgɔyali sababuw kan, olu fana bɛ se ka dɔ fara an ka faamuyali kan farikolo funteni taabolow kan, ka kɛ hakilinata jusigilan ye banaw furakɛli la minnu bɛ tali kɛ funteni kunbɛncogo jugumanw na.
Bangekɔlɔsi banaw siratigɛ la, ɲinini minnu kɛra MT-II tali kan cɛya furakɛli la, hali n’a bɛ a daminɛ na hali bi, olu bɛ fɛɛrɛ kura di cɛw ka cɛnimusoya furakɛli la.
Kuncɛli
Melanotan-II, i n’a fɔ α-melanocyte-stimulating hormone analogique synthétique, a bɛ ni ɲɛnamaya baara caman ye minnu bɛ fari ɲɛ jɛyali, farikoloɲɛnajɛ kɛcogo, fanga sɛnɛcogo, funteni hakɛ labɛnni, ani bangekɔlɔsi fɛɛrɛw. Fari ɲɛ jɛyali siratigɛ la, a bɛ se ka fari dibi bila, ka sira di min bɛ se ka kɛ fari ɲɛci ye. Furakɛcogo ɲinini siratigɛ la, MT-II bɛ baarakɛcogo caman jira. Sɛgɛsɛgɛli minnu kɛra hakiliɲagami banaw kan, fanga sɛnɛcogo ani bana minnu bɛ sɔrɔ funteni hakɛ la, ani bangekɔlɔsi fɛɛrɛw la, olu bɛ sira kura di nin bana ninnu furakɛli ma.
Sosow (Sɔrɔyɔrɔw).
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Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
