Na Cocer Peptides 
hashize iminsi 22
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Thymosine Alpha-1 (Tα1) ni polypeptide yabitswe cyane igizwe na acide 28 ya amine igira uruhare runini mu kugenzura ubudahangarwa bw'umubiri mu mubiri. Yabanje kwitandukanya nibikomoka kuri thymus kandi imaze kumenyekana mubijyanye na immunodeficiency bitewe nuburyo bwihariye bwo kwirinda indwara. Kubura ubudahangarwa bivuga ibintu bidasanzwe mumikorere ya sisitemu yubudahangarwa, biganisha ku kugabanya ubushobozi bwo kurwanya indwara ziterwa na virusi no gukuraho selile zidasanzwe. Iyi ndwara irashobora guterwa nimpamvu zitandukanye, zirimo ibintu byavutse bikomoka hamwe nibintu byanduye nko kwandura, gukoresha ibiyobyabwenge, hamwe nibibyimba bibi. Abarwayi bafite ubudahangarwa bw'umubiri bahura n’ibyago byinshi byo kwandura, kandi kwandura akenshi bivamo ibihe bikomeye kandi bikagorana no kuvura.
Igishushanyo 1 Gukingira Tα1 nuburyo bukoreshwa.
Isesengura ryimbitse ryimikorere yubudahangarwa
Kugena imikurire ya T selile no gutandukana: Tα1 igira uruhare runini muguhuza imikurire no gutandukanya selile. Muri thymus, Tα1 irashobora gutuma itandukanyirizo rya selile ya thymic, igatera guhinduka kuva muri selile progenitor ikagera kuri selile T ikuze. Ubu buryo bukubiyemo gukora inzira nyinshi zerekana ibimenyetso, nko guhuza ibyakirwa byihariye hejuru ya selile T, gukora cascades ya transcellular signal transduction, no gutera impinduka mumagambo yibintu byandikirwa, bityo bikagenga imvugo ya genes zijyanye niterambere rya selile. Ingirabuzimafatizo zikuze zigira uruhare runini mu gukingira ingirabuzimafatizo muri sisitemu y’umubiri, harimo no kumenya no kwica ingirabuzimafatizo zanduye na selile. Tα1 yongerera T selile gukura no gutandukana, bityo igashyiraho imbaraga zikomeye zo kwirinda umubiri.
Gukora ingirabuzimafatizo z'umubiri zavutse: Tα1 nayo igira ingaruka zikomeye kumubiri. Macrophage, nkabanyamuryango bingenzi ba sisitemu yubudahangarwa bw'umubiri, berekana imbaraga za fagocyitike zongerewe cyane na Tα1. Tα1 ikora reseptor zisa na Toll (TLRs) hejuru ya macrophage, itangiza inzira yerekana ibimenyetso byerekana inzira itera macrophage gusohora cytokine zitandukanye, harimo na necrosis yibibyimba-α (TNF-α), interleukin-1 (IL-1), nibindi. Iyi cytokine ntabwo yongera ibikorwa byubudahangarwa bwa macrophage ubwayo ahubwo inashakisha kandi igakora izindi selile z'umubiri, bigatuma abantu benshi bakingira indwara. Tα1 kandi yongera ibikorwa bya cytotoxic yingirabuzimafatizo zica (NK), ibafasha kumenya neza no kwica selile zanduye virusi cyangwa selile yibibyimba, bityo hashyirwaho umurongo wambere wo kwirwanaho kugirango umubiri urinde umubiri.
Kugenzura imiyoboro ya cytokine: Cytokine ikora nkintumwa muri sisitemu yubudahangarwa, igenga imikoranire hagati yingirabuzimafatizo hamwe nuburemere bwibisubizo byubudahangarwa. Tα1 irashobora kugenzura neza uburinganire bwurusobe rwa cytokine. Muri immunosuppression, Tα1 iteza imbere gusohora ubwoko bwa Th1 bwa cytokine (nka interferon-γ, IFN-γ), byongera imikorere yumubiri. Mugihe cyo gukabya gukingira indwara, Tα1 irashobora kubuza umusaruro ukabije wa cytokine zimwe na zimwe zitera inflammatory (nka interleukin-6, IL-6), bikagabanya ibyangiritse biterwa no gutwika umubiri. Izi ngaruka zinyuranye zituma Tα1 ihindura byimazeyo ubukana nicyerekezo cyibisubizo byubudahangarwa ukurikije impinduka zumubiri wumubiri, bikomeza sisitemu yumubiri homeostasis.
Kwinjiza inzira zijyanye no kwihanganira ubudahangarwa bw'umubiri: Tα1 irashobora gukora inzira ya tryptophan catabolic inzira ijyanye no kwihanganira ubudahangarwa bw'umubiri muguhuza ibikorwa bya enzyme igenga immunite indoleamine 2,3-dioxygenase (IDO). IDO itera metabolisme ya tryptophan, iganisha ku kugabanuka kwa tripitofani muri microen ibidukikije ya selile, bityo bikabuza ikwirakwizwa rya selile T no gukora, bigatera kwihanganira ubudahangarwa bw'umubiri. Mubihe nkindwara ziterwa na autoimmune cyangwa reaction yo kwangwa, Tα1 ifasha guca ukubiri ningaruka mbi yo gukabya gukingira indwara ukoresheje iyi nzira, kugabanya ibyangiritse byatewe n’ubudahangarwa bw'umubiri, no guteza imbere ibidukikije bikingira umubiri.
Uruhare mu ndwara ziterwa no kubura ubudahangarwa
Indwara yo kubura ubudahangarwa bw'umubiri: Indwara yo kubura ubudahangarwa bw'umubiri iterwa n'impamvu zishingiye ku ngirabuzima fatizo zitera iterambere rituzuye cyangwa imikorere mibi y'umubiri. Ku barwayi bamwe na bamwe bafite ubudahangarwa bw'uturemangingo T, kuvura Tα1 birashobora kunoza imikorere ya T selile. Mugihe habaye ubudahangarwa bw'umubiri buvukana bujyanye na hypoplasia thymic, Tα1 iteza itandukaniro no gukura kwingirabuzimafatizo ya thymic, ikongera umubare wa selile T ikuze mumaraso ya periferique, ikongera imikorere yumubiri wa selile, kandi ikongerera umurwayi kurwanya virusi, bikagabanya inshuro nuburemere bwindwara. Nyuma yigihe cyo kuvura Tα1, igipimo cyutugingo ngengabuzima T mumubiri wumurwayi gisubira buhoro buhoro mubisanzwe, immunoglobuline iriyongera, kandi ibimenyetso byamavuriro biratera imbere cyane.
Indwara ya Immunodeficiency Syndrome (SIDA): SIDA iterwa no kwandura virusi ya immunodeficiency ya muntu (VIH), yibasira cyane cyane lymphocytes CD4 + T, bikangiza kwangiza umubiri. Tα1 igira uruhare runini mu kuvura sida. Irashobora kongera imikorere yubudahangarwa kubantu banduye virusi itera sida, ikongera umubare nigikorwa cya selile CD4 + T, kandi igasubiza igice ubushobozi bwumubiri bwo kwirinda. Ubushakashatsi bwerekanye ko iyo Tα1 yongewe kumiti igabanya ubukana bwa virusi itera SIDA (HAART), irashobora gutuma habaho kwiyongera gukabije kwimibare ya CD4 + T hamwe nibisubizo byiza byo kongera ubudahangarwa bw'umubiri. Tα1 irashobora kandi kugenga uburinganire bwa cytokine kubarwayi, kugabanya ibisubizo byumuriro, kugabanya ibyangiritse byatewe na virusi itera sida no gukingira indwara, kandi bikazamura imibereho y’abarwayi n’imibereho yabo.
Igishushanyo 2 Guhindura urwego rwa sjTREC (kopi / µ1 maraso) muri PBMCs uhereye kubarwayi biga. Utubari twibeshya twerekana 95% intera intera hamwe na P agaciro kabaruwe ukoresheje Mann - Whitney U-test.
Kubura ubudahangarwa bifitanye isano n'ibibyimba bibi: Abarwayi bafite ibibyimba bakunze kugira imikorere mibi yumubiri mugihe cyiterambere ryindwara na nyuma yo guhabwa imiti nka chimiotherapie na radiotherapi. Tα1 ifite ingaruka nziza zo gukosora muriki kibazo. Yongera umubiri wa antitumor immunité yumubiri ikora ingirabuzimafatizo nka T selile na NK, bityo bikongerera ubushobozi bwo kumenya no kwica selile. Tα1 irashobora kugabanya ingaruka zo gukingira indwara ya chimiotherapie na radiotherapi kandi igateza imbere imikorere yumubiri. Ku barwayi bafite kanseri y'ibihaha itari ntoya na kanseri y'umwijima batewe no kubagwa, gukoresha Tα1 mu kuvura bivura bishobora guteza imbere ubuzima muri rusange. Ku barwayi barwaye kanseri y'ibihaha yateye imbere, idashobora gukemurwa na kanseri y'ibihaha, Tα1 irashobora kugabanya cyane ingaruka mbi nka lymphocytopenia na pneumoniya iterwa na chimoradiotherapie, kandi hariho inzira yo kuzamura imibereho muri rusange.
Kubura indwara ziterwa no kwandura: Mu kwandura gukabije, nka sepsis ikabije, umubiri akenshi winjira muri immunosuppression, bigatuma bigora abarwayi kurwanya indwara zandura za bagiteri, kugabanya kurwanya indwara zandurira mu bitaro bya kabiri, no kongera ibyago byo kwandura virusi. Tα1 byagaragaye ko igarura imikorere yubudahangarwa no gufasha kugabanya impfu ku barwayi barwaye septi ikabije. Irabigeraho ikora ingirabuzimafatizo zikingira umubiri no kugenzura imikorere ya T selile kugirango yongere ubushobozi bwumubiri bwo gukuraho indwara ziterwa na virusi, mugihe ihindura umuyoboro wa cytokine kugirango ugabanye ibyangijwe n’ibisubizo bikabije by’umuriro, bityo bizamura umusaruro w’abarwayi.
Porogaramu yubuvuzi iriho hamwe nigihe kizaza
Ubuvuzi bukoreshwa ubu: Tα1 ikoreshwa cyane mukuvura abarwayi ba kanseri nabafite ubwandu bukabije, kandi yoherejwe byihutirwa nka immunomodulator mugihe cya syndrome ikaze yubuhumekero bukabije (SARS) na COVID-19. Mubikorwa byubuvuzi, Tα1 isanzwe itangwa hakoreshejwe inshinge zo munsi, byerekana kwihanganira, hamwe nubushakashatsi bwinshi buvuga gusa uburakari bwaho gusa aho batewe inshinge.
Kwishyira hamwe nubundi buryo bwo kuvura: Kugirango turusheho kunoza imikorere yubuvuzi, Tα1 ikoreshwa kenshi hamwe nubundi buryo bwo kuvura. Muri onkologiya, Tα1 yerekana ingaruka zikomeye zo guhuza imbaraga iyo ihujwe na chimiotherapie. Yongera ibikorwa bya antitumor yimiti ya chimiotherapie mugihe igabanya ingaruka ziterwa na immunosuppressive, bityo imibereho yabarwayi ikazamuka. Mu kuvura kanseri hamwe na inhibitori (ICIs), Tα1 nayo igira ingaruka zo guhuza imbaraga. Tα1 irashobora guhindura macrophage M2 polarisiyasi mugukoresha umurongo wa TLR7 / SHIP1, kongera ubudahangarwa bwa antitumor, no guhindura 'ibibyimba bikonje ' mo 'ibibyimba bishyushye, ' bityo bikazamura imikorere ya ICIs. Tα1 irashobora kandi kugira uruhare mukurinda kugabanya ingaruka mbi ziterwa nubudahangarwa nka colitis yatewe na ICI.
Umwanzuro
Nkubuvuzi bushya bwa peptide, Prostamax yerekana ibyiza murwego rwubuzima bwa prostate. Kuva mu buryo bwihariye bwibikorwa kugeza ku ngaruka zayo zikomeye mu kuzamura umuriro, kubungabunga imiterere y’imitsi, no kongera imikorere y’imyororokere, ndetse n'inzira zinyuranye zikoreshwa mu kuvura amavuriro, kuvura indwara, no kuvura hamwe, bigira uruhare mu kuvura no gukumira indwara za prostate.
Reba
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Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
