Ghrp-6 miligaramu 10

▎ GHRP-6  ka baarakɛcogo

▎ GHRP-6  Sɛgɛsɛgɛli

GHRP-6 ka ɲininiw kɛcogo ye mun ye?

Sɛgɛsɛgɛli minnu kɛra GHRP-6 kan, olu bɔra sɛgɛsɛgɛli kunbabaw la minnu kɛra bonya hormone (GH) ka ɲɛnabɔli fɛɛrɛw kan. Kalan fɔlɔw y’a jira ko, ka tɛmɛ bonya hormone-releasing hormone (GHRH) kan, sira wɛrɛw bɛ farikolo la minnu bɛ GH bɔli ɲɛnabɔ, o la, recepteurs minnu bɛ se ka GH bɔli sabati kɛrɛnkɛrɛnnenya la (o kɔrɔ ye ko growth hormone secretagogue receptor, GHSR). Walasa ka nin sariyasun in ɲɛfɔ ka taa a fɛ ani ka baarakɛminɛnw dɔn walasa ka se ka don tigitigi GH bɔli la, ɲininikɛlaw y’a daminɛ ka fɛnɲɛnamafagalanw labɛn minnu bɛ GHSR laɲini. GHRP-6 bɔra nin hakilinata-jɛkulu in na i n’a fɔ hɛkɛsipɛtidi min dabɔra ka GHSR sira baara, k’a jɔyɔrɔ ɲɛfɔ GH dilanni n’a bɔli labɛnni na.

O waati kelen na, kɛnɛyaso ni ɲininiw ɲininiw GH modulasiyɔn baarakɛminɛnw na, olu ye GHRP-6 kalanw bila senkan. Faan dɔ fɛ, bana minnu bɛ i n’a fɔ bonya hormone dɛsɛ, olu bɛ GH labɛncogo ɲumanw de wajibiya ni fɛɛrɛ kɛrɛnkɛrɛnnenw ye walasa ka laadala fɛɛrɛw fara ɲɔgɔn kan. Faan wɛrɛ fɛ, ɲininikɛlaw minnu bɛ baara dɔw la i n’a fɔ farikoloɲɛnajɛ, farikolo kɛnɛya, ani farikolo yɔrɔw dilancogo, olu y’a ɲini ka farikoloɲɛnajɛ taabolo minnu bɛ tali kɛ ɲɔgɔn na, olu sɛgɛsɛgɛ, u kɛtɔ ka GH-IGF-1 aksidan sɛmɛntiya. I n’a fɔ fɛnɲɛnamafagalan min bɛ se ka GHSR baara tigitigi ani ka GH bɔli ɲɛnabɔ, GHRP-6 kɛra baarakɛminɛn nafamaba ye walasa ka aksidan baarakɛcogo n’a kɛcogo sɛgɛsɛgɛ yɔrɔw la minnu bɛ tali kɛ ɲɔgɔn na, o la, a ye sɛgɛsɛgɛliw kɛ a farikolo-ɲɛnajɛ-cogo n’a baarakɛcogo kan.

GHRP-6 ka baarakɛcogo ye mun ye?

Bonya hormone bɔli ɲɛnabɔli

Laadalata farikolojidɛsɛ furaw tali tɛ : GHRP-6 bɛ se ka bonya hormone (GH) bɔ kɛrɛnkɛrɛnnenya la ka kɛɲɛ ni hypothalamus growth hormone-releasing hormone (GHRH) ni somatostatin ye. O b’a jira ko a bɛ sira dɔ baara min ni klasiki hipotalamu ɲɛnabɔli sira tɛ kelen ye walasa ka GH bɔli lawuli. Misali la, baganw ka misali dɔw la minnu kɛra k’a lajɛ ani mɔgɔ fasalenw na, GHRP-6 bɛ GH bɔli se barikama jira min tɛ bali ni GHRH hipotalamu ni somatostatin ɲɛnabɔli fɛɛrɛ kɔrɔw ^ye.

Baarakɛɲɔgɔnya ni GHRH ye : GHRP-6 ni GHRH bɛ baara kɛ ni fɛn minɛbaga danfaralenw ye, ka jɛɲɔgɔnya nɔ jira. Kɔlɔsiliw y’a jira ko dumuni kɔfɛ, GH bɔli farikolokisɛw bɛ GHRH jaabi dɔgɔyali jira waati dɔ kɔnɔ; o waati kɔnɔ, GHRP-6 bɛ GHRH ka GH bɔli fanga bonya. GHRP-6 min bɛ kɛ joli la, o bɛ GH bɔli lawuli cogo la min bɛ bɔ a tata hakɛ la. Ni a ni GHRH farala ɲɔgɔn kan, sani dumuni ka kɛ ani dumuni kɔfɛ, GHRP-6 bɛ GH bɔli caman bila ɲɔgɔn na. O nɔ faralen ɲɔgɔn kan, o fana tiɲɛna GH selilɛriw la minnu falen don. Ka fara o kan, GHRP-6 bɛ baara kɛ hipotalamus kan walasa ka GHRH bɔli lawuli, o la, a bɛ GH bɔli sabati cogo la min tɛ ɲɛ ^{[2] .}.

A nɔ minnu bɛ sɔrɔ otofaji ni apoptose la

Otofaji yiriwali : [D-Lys3]-GHRP-6, n’o ye GHRP-6 suguya dɔ ye, o jatera ko a ye bonya hormone-releasing hormone receptor (GHSR) kɛlɛbaga ye min bɛ sugandi kosɛbɛ. Kɔlɔsiliw y’a jira ko a bɛ otofaji taamasiɲɛw bonya farikolo la min bɛ kɛ ka ɲɛ ani farikolo yɔrɔ min tiɲɛna doxorubicine fɛ, o bɛ jira ni bɛkilini-1 farikolojɔli dumuni caya ye ani LC3 II ni LC3 I hakɛ cayalenba. O b’a jira ko GHRP-6 ni ɲɔgɔn cɛ fɛn wɛrɛw jɔyɔrɔ ka bon farikolo selilɛriw ka homeostasis sabatili la ani ka joginda jaabi ni otofaji (otofaji) sabatili ye walasa ka selilɛriw yɔrɔ tiɲɛnenw jɛya, o bɛ selilɛriw ka farikoloɲɛnajɛ kɛcogo ɲuman nɔgɔya ani ka baarakɛcogo ɲuman ^sɔrɔ.

Apoptose balili : [D-Lys3]-GHRP-6 fana ye dɔkisirubisini ka apoptose baarakɛcogo dɔgɔya farikolokisɛw la, ni farikolo yɔrɔ dɔw ma ye farikolo yɔrɔ furakɛlenw na. O waati kelen na, dɔkisisini ye mikorofiyɛriw cɛmancɛ nukilisi caya, o tun tɛ farikolo yɔrɔw la minnu furakɛra ni [D-Lys3]-GHRP-6 ye, o b’a jira ko a bɛ se ka mɔgɔ tanga dɔkisisini tiɲɛni ma. O bɛ farikolokisɛw farikolo cogoya ɲuman mara ni apoptose (apoptose) labɛnni ye ^{[3] .}.

Fibrose-related jeninida jiracogo ɲɛnabɔli

Pro-Fibrotic Genes jirali dɔgɔyali : Modeliw la i n’a fɔ sugunɛbilenni ani fari joginda kɛnɛyali, GHRP-6 bɛ fiɲɛbana kɛlɛli seko jira. Molecules (molecules) ta fan fɛ, a bɛ dɔ bɔ pro-fibrotic genes TGFB1 ni CTGF ka transkripsiyɔn jirali la. TGFB1 ni CTGF jɔyɔrɔ ka bon kosɛbɛ fiɲɛbana na; u jiracogo dɔgɔyali bɛ dɛmɛ ka farikolo kɔkanna matiriyali furakisɛw dalajɛ kojugu bali, o bɛ fiɲɛbana juguya nɔgɔya ^{[4] .}.

Fibɔrɔsi kɛlɛli jɛnɛya jirali daminɛni : GHRP-6 bɛ PPARG ni MMP-13 jeninida jirali bila ɲɔgɔn na. PPARG bɛ a sen don farikolo tulumafɛnw danfara ni u farikoloɲɛnajɛ labɛnni na ka sɔrɔ a bɛ balili nɔ jira funu ni fiɲɛ bilali la; MMP-13 bɛ farikolo kɔkanna matiriyali yɔrɔw tiɲɛ, ka dɛmɛ don farikolo yɔrɔw jɔcogo ni u baaracogo ɲuman sabatili la. Ni dɔ farala jamu fila bɛɛ jirali kan, o bɛ fiɲɛbana banakisɛw dalajɛcogo bali ^{[4] .}.

Kɔnɔnatumuw tangacogo

Degun taamasiɲɛw cili balili : Ji su jisuma degun (WRS)-induite kɔnɔbara basigilen jogincogo misali la, GHRP-6 bɛ mɔgɔ tanga. WRS bɛ taamasiɲɛw ci ka bɔ fari lawulili la vagus nerve fɛ ka taa central nervous system fɛ, o bɛ na ni kɔnɔbara basigilen jogin ye. GHRP-6 bɛ o tiɲɛni in bali, a ka ca a la a bɛ degun taamasiɲɛw cili bali, o la a bɛ dɔ bɔ vagus nerve stimulation jugu la kɔnɔbara la ani ka ɲɛgɛnɛsira joginni bali ^, .

Kɔnɔbara asidi bɔli ɲɛnabɔli ani fɛn wɛrɛw : WRS bɛ kɔnɔbara asidi bɔli caya, k’a sɔrɔ GHRP-6 bɛ se ka asidi bɔli segin a cogo kɔrɔ la, o bɛ kɔnɔbara asidi tiɲɛni nɔgɔya ɲɛgɛnɛsira la. Ka fara o kan, GHRP-6 bɛ se ka kɔnɔbara tangacogo juguw kɛ kɔnɔbara la, a kɛtɔ ka nɔ bila joli la renin, endothélin-1, tromboxane B2, ani kɔnɔbara funteni sɔgɔsɔgɔninjɛ furakisɛ 70 la joli la, o la, a bɛ kɔnɔbara tanga cogo la min tɛ ɲɛ ani ka a dafalen ni a baarakɛcogo ɲuman ^mara.

Jaa 1 Dusukun tantanni fɛnɲɛnamafagalanw sɛgɛsɛgɛli minnu bɛ danfara jira RR cɛmancɛw cɛmancɛ la, RR cɛmancɛw ni ɲɔgɔn cɛ danfara minnu bɛ bɔ cogoya la, ani RR cɛmancɛw danfara minnu bɛ tugu ɲɔgɔn kɔ kuluw danfaralenw ^na.

GHRP-6 baarakɛcogo ye mun ye?

Fibɔrɔsi kɛlɛli nɔw

Sugunɛbilenni : Sugunɛbilenni misaliw la, minnu kɛra sosow la, GHRP-6 tali kunbɛncogo ni furakɛlicogo fila bɛɛ ye nafa caman jira. A ye fiɲɛbanakisɛw dɔgɔya ni 75% ni kɔ ye, ka jurukisɛw girinya dɔgɔya ani ka ɲɛgɛnɛsiralabanaw hakɛ dɔgɔya fo ka se 60% ma, ka sɔrɔ fana a bɛ sugunɛ lakanani nɔba jira. Molecules ta fan fɛ, GHRP-6 ye dɔ bɔ pro-fibrotique jɛnɛya TGFB1 ni CTGF ka transkripsiyɔn jirali la k’a sɔrɔ a bɛ PPARG ni MMP-13 jamu jirali bila sen kan — jɛnɛya minnu nafa ka bon kosɛbɛ banaw dalajɛli taabolo balili ^la.

Farikolojidɛsɛ : Joginda nɔgɔman dɔ la, GHRP-6 ye joginda datuguli teliya ani ka funu doncogo dɔgɔya. Laɲɔ ka sɔgɔsɔgɔninjɛ cayalenba modɛli la, pepitiri ye keloid sɔrɔli bali joginda furakɛlenw 90% ni kɔ la, o b’a jira ko -6 nafa bɛ se ka kɛ farikolojidɛsɛbanaw kunbɛnni ni u furakɛli la^GHRP .

Kɔrɔya-hormone (banakisɛfagalan) bɔli lawulili

A nɔ minnu bɛ farikolo la: GHRP-6 tali jolisira fɛ, o bɛ bonya hormone (GH) bɔli lawuli cogo la min bɛ bɔ a tata hakɛ la. Dumuni kɔfɛ, GH selilɛriw ka jaabi bɛ dɔgɔya ka ɲɛsin bonya hormone-releasing hormone (GHRH) ma waati dɔɔni. Nka, GHRP-6 ni GHRH tali ɲɔgɔn fɛ, o bɛ kɛ sababu ye ka GH bɔli caman kɛ ka kɔn balo ɲɛ ani balo kɔfɛ, ni nɔ kelenw bɛ ye GH selilɛriw la minnu falen don. Ka fara o kan, GHRP-6 bɛ baara kɛ hipotalamus kan walasa ka GHRH bɔli lawuli ^[6]..

Bana kɛrɛnkɛrɛnnenw nɔfɛkow : Sogo minnu bɛ glucocorticoïde furakɛli kuntaalajan ta, GHRP-6 bɛ GH bɔli lawuli nka a tɛ se ka GH balili kɔsegin glucocorticoïde fɛ. Banabagatɔ minnu ka glucocorticoïde tɛmɛnen don u kɔnɔ walima u kɔkan, minnu ka hypercortisolemia endogène bɛ u la, olu ye GH jaabiw dɔgɔyali jira GHRP-6 ni GHRH fila bɛɛ la, k’a sɔrɔ GHRP-6 jaabi fɛɛrɛ bɛ i n’a fɔ a maralen bɛ banabagatɔw la minnu ka glucocorticoïde tɛmɛnen kɔfɛ ^[7,.

Banakisɛfagalanw tali nɔfɛkow : Tilapiya la, GHRP-6 bɛ jɛgɛ kɛrɛnkɛrɛnnenw banakisɛ saba (Oreochromicins I, II, ani III) ni granzyme ka sɛbɛnni hakɛ wuli ka taa a fɛ cogo la min bɛ bɔ farikolo yɔrɔw la, Pseudomonas aeruginosa banakisɛ cogoya mana kɛ min o min ye. A bɛ dɔ fara joli la banakisɛfagalanw ka baara kan (lizozimu ni antiprotéase baara), ka tilapia gill mucus ni serum talenw ka banakisɛfagalanw baara fanga bonya in vitro Pseudomonas aeruginosa kan ani ka banakisɛw doni dɔgɔya in vivo banakisɛ sɔrɔlen kɔfɛ. O b’a jira ko GHRP-6 bɛ layidu ta i fɔ furakɛli fɛɛrɛ wɛrɛ jiko la walasa ka teleost jɛgɛw farikolo tangacogo lawuli banakisɛw ma minnu bɛ se ka sababu sɔrɔ ^n’a .

Dusukun lakanani seko : Pepitiri minnu bɛ bonya hormones (GHRPs) bɔ, olu bɛ bonya hormone bɔli ni jiginɛw ka baara lawuli, ni u ni ɲɔgɔn cɛ minɛyɔrɔw bɛ jɛnsɛn kosɛbɛ dusukun ni jolisiraw bɛɛ la. Kalan fɔlɔw y’a jira ko GHRP dilannenw ye layidu talenw ye dusukun ni selilɛri lakanani na. Olu cɛma, GHRP-6 — hali ni dɔgɔtɔrɔsow bɛ kɛ tuma dɔw la ani tuma dɔw la — a bɛ se ka kɛnɛyaso yiriwali jɛlen sɔrɔ ka da a ka fɛɛrɛ caman kan dusukun tantanni ^na.

Kuncɛli

I n’a fɔ hɛkɛsipɛtidi bonya ɔrimɔni sintetiki, GHRP-6 bɛ GH-IGF-1 aksidan labɛn fɔlɔ ni GHSR sirili kɛrɛnkɛrɛnnen ye, o bɛ nafa caman jira farikolo baarakɛcogo caman sɛgɛsɛgɛli la ani bana ɲinini na. GHRP-6 tɛ GH bɔli dɔrɔn laɲini walasa ka nɔ bila farikoloɲɛnajɛ balansi ni farikolo yɔrɔw falenni ɲɛnabɔli la, nka a bɛ nɔ jira fana fiɲɛbana kɛlɛli la (sugunɛ, fari), dusukun lakanani (ka dusukun tantanni bali, ka dusukun baara ɲɛ), ani farikolo tangacogo la. A bɛ kɛ fana ɲininikɛlan nafamaba ye walasa ka GHSR baarakɛcogo ni GH labɛnni fɛɛrɛw ɲɛfɔ.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

L. Hernández ye ɲininikɛla ye ɲɛnamaya dɔnniyaw la, a bɛ kalanko baara kɛ inivɛrisitew la walima ɲininikɛyɔrɔw la. A ka dɔnniya nafaw bɛ yɔrɔw la minnu ɲɛsinnen bɛ baganw ka kɛnɛyako ni molekiyɔmuw ka ɲɛnamayako ma, k’a sen don kosɛbɛ dɔnniyaw ni diɲɛ jɛkafɔw la. I n’a fɔ sɛbɛn caman sɛbɛnbaga minnu lajɛra ɲɔgɔn fɛ, L. Hernández ye dɛmɛ don dɔnniya yiriwali la o baara in na, wa a bɛ a ka jɔyɔrɔ dɔn dɔnniya jɛkulu kɔnɔ. L. Hernández tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [9].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Micic D, Mallo F, Peino R, ani a ɲɔgɔnnaw. Bonya hormone bɔli ɲɛnabɔli ni bonya hormone bɔli hexapeptide (GHRP-6) ye. J Denmisɛnw ka dɔgɔtɔrɔ Endocrinol 1993; 6(3-4): Ɲɛjirali 283-289.

[2] McMahon C. D., Chapin L. T., Radcliff R. P., Lookingland K. J., Tucker H. A., ani mɔgɔw ye baara kɛ ni u ye. GH-releasing peptide-6 bɛ se sɔrɔ somatotropes ka refractoriness kan GHRH la balo kɔfɛ. Journal of Endocrinologie 2001 sàn; 170(1): 235-241.DOI: 10.1677/joe.0.1700235. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[3] Yu A. P., Pei X. M., Sin T. K., ani a ɲɔgɔnnaw. [D-Lys3]-GHRP-6 bɛ farikolojɔli fɛɛrɛw jira kolotugudaw la. Molecules ani 

Selulɛriw ka Endocrinologie 2015; 401: 155-164.DOI: 10.1016/j.mce.2014.09.031. Bamako, Mali.

[4] Mendoza-Mari Y, Fernández Mayola M, Vázquez-Blomquist D, ani a ɲɔgɔnnaw. GHRP-6, o ye mɔgɔ kura ye min bɛ se ka fiɲɛbanaw kunbɛn ani ka u furakɛ. Biotecnologia Aplicada ka gafe 2017; 34: 2501-2504. Ɲɛjirali dɔw.

[5] Guo S, Gao Q, Jiao Q, Hao W, Gao X, Cao JM, ani mɔgɔw ye baara kɛ ni u ye. Kɔnɔbara basigilen tiɲɛni ji su ji la: a kɛcogo ni a kunbɛncogo ni GHRP-6 ye. Diɲɛ kɔnɔbara basigilen gafe 2012; 18(24): 3145-3155.DOI: 10.3748/wjg.v18.i24.3145. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[6] McMahon C. D., Chapin L. T., Radcliff R. P., Lookingland K. J., Tucker H. A., ani mɔgɔw ye baara kɛ ni u ye. GH-releasing peptide-6 bɛ se sɔrɔ somatotropes ka refractoriness kan GHRH la balo kɔfɛ. Journal of Endocrinologie 2001 sàn; 170(1): 235-241. Ɲɛjirali dɔw.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Sɔrɔ&db=pubmed&dopt=Abstract&list_uids=11431156&ɲininkali_hl=1.

[7] Voltz D. M., Piering A. W., Magestro M., Giustina A., Wehrenberg W. B., ani mɔgɔw ye baara kɛ ni u ye. GHRP-6 ni GHRH nɔ min bɛ GH bɔli la sosow la glucocorticoïde furakɛli kuntaalajan kɔfɛ. Ɲɛnamaya dɔnniyaw 1995; 56(7): 491-497.DOI: 10.1016/0024-3205(94)00478-b. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[8] Borges M. H., DiNinno F. B., Lengyel A. M., ani mɔgɔw ye baara kɛ ni u ye. Pepitiri min bɛ bonya hormone bɔ (GHRP-6) ani hormone min bɛ GH bɔ, olu nɔ tɛ kelen ye GH bɔli la kɔnɔnatumu ni kɛnɛma hypercortisolisme la. Kɛnɛyaso ka Endocrinologie 1997; 46(6): 713-718.DOI: 10.1046/j.1365-2265.1997.1981008.x. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[9] Hernández L, Camacho H, Nuñez-Robainas A, ani a ɲɔgɔnnaw. Bonya hormone secretagogue peptide-6 bɛ oreochromicins sɛbɛnni ni banakisɛfagalanw baara bonya tilapia (Oreochromis sp.) la. Jɛgɛw ni jɛgɛkɛnɛw farikolo tangacogo 2021; 119: 508-515.DOI: 10.1016/j.fsi.2021.08.011. Bamako, Mali.

[10] Berlanga-Acosta J, Nieto GEG, Pez-Mola ELO, Nez LISH, ani mɔgɔw ye baara kɛ ni u ye. Bonya hormone releasing peptide-6 (GHRP-6) ani a ni o ɲɔgɔnna secretagogue synthétique peptide wɛrɛw: Furakɛcogo seko minɛni furakɛli magow ɲɛnabɔbaliw la. Furakɛcogo molekilɛri jɛlen 2016; 3: 616-623. Ɲɛjirali dɔw. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.