Ghrp-6 10mg

▎ GHRP-6  Tsarin

▎ GHRP-6  Bincike

Menene asalin bincike na GHRP-6?

Bincike akan GHRP-6 ya samo asali ne daga bincike mai zurfi a cikin tsarin tsarin tsarin girma hormone (GH). Nazarin farko ya nuna cewa, bayan haɓakar haɓakar hormone mai sakin hormone (GHRH), jiki yana da ƙarin hanyoyin da ke daidaita siginar GH, gami da masu karɓa waɗanda ke iya haɓaka sakin GH na musamman (watau, mai karɓar mai karɓar sakatare na hormone girma, GHSR). Don ƙara buɗe wannan hanyar ka'ida da gano kayan aikin don daidaitaccen shiga tsakani a cikin ɓoyewar GH, masu bincike sun fara haɗa mahaɗan da ke nufin GHSR. GHRP-6 ya fito daga wannan tsarin ka'idar azaman hexapeptide wanda aka ƙera don kunna hanyar GHSR, yana bayyana rawar da yake takawa wajen daidaita haɗin GH da sakin.

A halin yanzu, asibiti da buƙatun bincike don kayan aikin daidaitawa na GH sun haifar da nazarin GHRP-6. A gefe ɗaya, cututtuka kamar raunin hormone girma suna buƙatar ingantattun hanyoyin ka'idojin GH tare da na'urori na musamman don haɓaka ayyukan al'ada. A gefe guda, masu bincike a fannoni kamar metabolism, lafiyar tsoka, da gyaran nama sun nemi gano hanyoyin da suka shafi ilimin halittar jiki ta hanyar daidaita yanayin GH-IGF-1. A matsayin fili mai iya kunna GHSR daidai da daidaita siginar GH, GHRP-6 ya zama kayan aiki mai mahimmanci don nazarin aikin axis da hanyoyin a cikin yankuna masu alaƙa, ta haka ne ke motsa bincike kan kaddarorin sinadarai na physicochemical da hanyoyin aiki.

Menene tsarin aikin GHRP-6?

Ka'idojin Sirin Hormone na Girma

Rashin Dogaro da Abubuwan Halittu na Traditional Hypothalamic: GHRP-6 na iya sakin hormone girma (GH) musamman da kansa na haɓakar haɓakar hormone mai sakin hormone (GHRH) da somatostatin. Wannan yana nuna yana kunna hanyar da ta bambanta da tsarin tsarin tsarin hypothalamic na gargajiya don tada ɓoyewar GH. Misali, a cikin wasu samfuran dabbobi na gwaji da mutane masu kiba, GHRP-6 yana nuna ƙarfin sakin GH mai ƙarfi ba tare da tsangwama ba ta hanyar hypothalamic GHRH na al'ada da tsarin tsarin somatostatin ^[1].

Ayyukan Haɗin kai tare da GHRH: GHRP-6 da GHRH suna aiki akan masu karɓa daban-daban, suna nuna tasirin haɗin gwiwa. Nazarin ya nuna cewa bin abinci, sel masu ɓoye na GH na ɗan lokaci suna nuna raguwar amsawa ga GHRH; a lokacin wannan lokacin, GHRP-6 yana ƙarfafa ɓoyayyen GH wanda ke haifar da GHRH. GHRP-6 na cikin ciki yana motsa siginar GH ta hanyar dogaro da kashi. Lokacin da aka haɗe shi da GHRH, duka kafin abinci da bayan abinci, GHRP-6 yana haifar da sakin GH mai mahimmanci. Hakanan an inganta wannan tasirin haɗin gwiwa a cikin ƙwayoyin GH masu al'ada. Bugu da ƙari kuma, GHRP-6 yana aiki a kan hypothalamus don tada ƙwayar GHRH, ta haka a kaikaice inganta sakin GH ^[2].

Tasiri akan Autophagy da Apoptosis

Ƙaddamar da Autophagy: [D-Lys3] -GHRP-6, bambance-bambancen GHRP-6, ana la'akari da babban zaɓi na haɓakar hormone mai sakin hormone mai karɓar mai karɓa (GHSR). Nazarin ya nuna cewa yana haɓaka siginar autophagy a cikin duka na al'ada da tsoka mai lalacewa na doxorubicin, wanda ya bayyana ta ƙara yawan furotin beclin-1 da haɓaka LC3 II zuwa LC3 I. Wannan yana nuna cewa bambance-bambancen da ke da alaƙa na GHRP-6 suna taka muhimmiyar rawa wajen kiyaye homeostasis na ƙwayar tsoka da kuma amsawa ga rauni ta hanyar haɓaka autophagy don share abubuwan da suka lalace ta salon salula, don haka sauƙaƙe metabolism na salon salula na al'ada da dawo da aiki ^[3].

Hanawa na apoptosis: [D-Lys3] -GHRP-6 kuma ya rage aikin doxorubicin-induced apoptosis a cikin ƙwayoyin tsoka, ba tare da rashin daidaituwa na tarihin tarihi ba a cikin ƙwayar tsoka da aka kula da su. A lokaci guda, haɓakar tsakiya na tsakiya na myofibers wanda doxorubicin ya haifar ba ya nan a cikin [D-Lys3]-GHRP-6-tsokoki da aka yi wa magani, yana nuna tasirin kariya daga lalacewar doxorubicin. Wannan yana kula da yanayin yanayin physiological na al'ada na ƙwayoyin tsoka ta hanyar daidaita apoptosis ^[3].

Ƙa'idar Maganar Halittar Halittar Fibrosis

Rage Maganar Pro-Fibrotic Genes: A cikin samfura irin su fibrosis na hanta da warkar da rauni na fata, GHRP-6 yana nuna kaddarorin anti-fibrotic. A matakin kwayoyin halitta, yana rage bayanin rubutun pro-fibrotic genes TGFB1 da CTGF. TGFB1 da CTGF suna taka muhimmiyar rawa a cikin fibrosis; Ragewar maganganun su yana taimakawa hana tarin ƙwayoyin sunadaran matrix na extracellular, don haka yana rage tsananin fibrosis ^[4].

Ƙaddamar da Maganinta na Anti-Fibrotic Gene: GHRP-6 a lokaci guda yana haifar da PPARG da MMP-13 magana. PPARG yana shiga cikin daidaita yanayin adipocyte da metabolism yayin da yake nuna tasirin hanawa akan kumburi da fibrosis; MMP-13 yana ƙasƙantar da abubuwan haɗin matrix na waje, yana taimakawa wajen kiyaye tsarin nama na yau da kullun da aiki. Ƙarfafa maganganun kwayoyin halitta guda biyu yana sauƙaƙe danne tsarin tattarawar ƙwayoyin cuta na fibrosis ^[4].

Hanyoyin Kariya don Mucosa na Gastrointestinal

Toshe Siginar Matsala: A cikin yanayin damuwa na nutsewar ruwa (WRS) wanda ya haifar da raunin mucosal na ciki, GHRP-6 yana yin tasiri mai kariya. WRS tana watsa sigina daga motsa jiki ta hanyar jijiyar vagus zuwa tsarin jijiya ta tsakiya, wanda ke haifar da rauni na mucosal na ciki. GHRP-6 yana hana wannan lalacewa, mai yiyuwa ta hanyar toshe siginar danniya, don haka rage mummunan tasirin jijiya ga mucosa na ciki da kuma kawar da raunin mucosal ^[5].

Ka'idojin fitar da acid na ciki da sauran dalilai: WRS yana haifar da haɓakar ƙwayar gastrointestinal, yayin da GHRP-6 na iya mayar da siginar acid zuwa matakan al'ada, don haka rage lalacewar acid na ciki ga mucosa. Bugu da ƙari, GHRP-6 na iya yin tasirin kariya kai tsaye a kan mucosa na ciki ta hanyar rinjayar plasma renin, endothelin-1, thromboxane B2, da furotin zafi na ciki 70 a cikin plasma, ta haka a kaikaice yana kare mucosa na ciki da kuma kiyaye mutuncinsa da aikin al'ada ^[5].

Hoto 1 Binciken sauye-sauye na zuciya yana nuna bambance-bambance a cikin tsaka-tsakin tsaka-tsakin RR, daidaitattun daidaituwa na tsaka-tsakin RR na al'ada-zuwa na yau da kullun, da tushen ma'anar murabba'in bambance-bambancen tazarar RR a cikin ƙungiyoyi daban-daban ^[5].

Menene aikace-aikacen GHRP-6?

Anti-fibrotic sakamako

Fibrosis na hanta: A cikin nau'ikan bera na hanta cirrhosis, duka prophylactic da warkewar amfani da GHRP-6 sun nuna ingantaccen inganci. Ya rage fibrotic nodules da sama da 75%, rage kauri igiya da cirrhotic nodule count da har zuwa 60%, yayin da kuma exerting hepatoprotective effects. A matakin ƙwayoyin cuta, GHRP-6 ya rage bayanin rubutu na pro-fibrotic genes TGFB1 da CTGF yayin da yake haifar da PPARG da MMP-13 gene expression-genes masu mahimmanci don hana hanyoyin tara ƙwayoyin cuta ^[4].

Skin fibrosis: A cikin samfurin rauni mai sauƙi na bera, GHRP-6 ya hanzarta rufe rauni da rage kumburin kumburi. A cikin samfurin tabon hypertrophic zomo, peptide ya hana samuwar keloid a cikin sama da 90% na raunukan da aka jiyya, yana ba da shawarar yuwuwar ƙimar GHRP-6 don hanawa da magance cututtukan da ke da alaƙa da fibrosis na fata ^[4].

Ƙarfafa Sirin Hormone na Girma

Tasiri akan Ilimin Halitta na al'ada: Gudanar da ciki na GHRP-6 yana ƙarfafa haɓakar hormone girma (GH) ta hanyar dogaro da kashi. Bayan ciyarwa, martanin ƙwayoyin GH zuwa haɓakar hormone mai sakin hormone (GHH) yana raguwa na ɗan lokaci. Koyaya, haɗin gwiwar gudanarwa na GHRP-6 tare da GHRH tare da haɗin gwiwa yana haifar da ingantaccen sakin GH duka kafin da bayan ciyarwa, tare da tasirin daidai da aka gani a cikin ƙwayoyin GH masu al'ada. Bugu da ƙari kuma, GHRP-6 yana aiki akan hypothalamus don tada ƙwayar GHRH ^[6].

Tasiri akan takamaiman Jihohin Cuta: A cikin berayen da ke karɓar jiyya na glucocorticoid na yau da kullun, GHRP-6 yana ƙarfafa siginar GH amma ya kasa juyar da glucocorticoid-induced GH suppression. A cikin marasa lafiya tare da wuce haddi na endogenous ko exogenous glucocorticoid wuce haddi, waɗanda ke da hypercortisolemia endogenous sun nuna raguwar martanin GH ga GHRP-6 da GHRH, yayin da tsarin amsawa ga GHRP-6 ya bayyana a cikin marasa lafiya tare da wuce haddi na glucocorticoid ^[7,8]..

Immunomodulatory Effects: A cikin tilapia, GHRP-6 yana daidaita matakan rubutu na takamaiman ƙwayoyin bacteriocins na kifi guda uku (Oreochromicins I, II, da III) da granzyme a cikin hanyar dogaro da nama, ba tare da la'akari da matsayin kamuwa da cuta na Pseudomonas aeruginosa ba. Hakanan yana haɓaka aikin ƙwayoyin cuta na ƙwayar cuta (lysozyme da aikin antiprotease), yana haɓaka aikin in vitro antibacterial na tilapia gill mucus da samfuran jini akan Pseudomonas aeruginosa da rage nauyin ƙwayoyin cuta a cikin vivo bayan kamuwa da cuta. Wannan yana nuna GHRP-6 yana ɗaukar alƙawarin azaman madadin magani a cikin kifaye don ƙarfafa tsarin rigakafi na kifin teleost daga ƙwayoyin cuta masu yuwuwa ^[9].

Yiwuwar Kariya na zuciya: peptides masu sakin hormone girma (GHRPs) suna haɓaka haɓakar haɓakar hormone girma da ayyukan axis na ƙasa, tare da masu karɓan haɗin gwiwa da aka rarraba a ko'ina cikin tsarin jijiyoyin jini. Nazarin farko sun gano GHRPs na roba a matsayin ƴan takara masu ban sha'awa don kariyar zuciya da salon salula. Daga cikin waɗannan, GHRP-6-duk da lokuta na lokaci-lokaci da kuma sauye-sauye na asibiti-yana da damar haɓakar haɓakar asibiti bisa ga nau'o'in nau'o'in nau'in nau'i a cikin ciwon zuciya na zuciya ^[10]..

Kammalawa

A matsayin hexapeptide na haɓakar haɓakar hormone na roba, GHRP-6 da farko yana daidaita tsarin GH-IGF-1 ta hanyar ƙayyadaddun ɗauri ga GHSR, yana nuna ƙimar da yawa a cikin daidaitawar aikin physiological da bincike na cuta. GHRP-6 ba wai kawai ya yi niyya ga ɓoyewar GH ba don rinjayar ma'auni na rayuwa da tsarin girma na nama amma kuma yana nuna tasiri a cikin anti-fibrosis (hanta, fata), cardioprotection (hana apoptosis na myocardial, inganta aikin zuciya), da kuma immunomodulation. Hakanan yana aiki azaman kayan aikin bincike mai mahimmanci don haɓaka aikin GHSR da hanyoyin sarrafa GH.

Game da Marubuci

Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.

Mawallafin Jaridar Kimiyya

L. Hernández mai bincike ne a cikin ilimin kimiyyar rayuwa, yana yin aikin ilimi a jami'o'i ko cibiyoyin bincike. Bukatunsa na ilimi ya ƙunshi fannonin da suka shafi lafiyar dabbobi da ilmin halitta, tare da shiga tsakani a cikin haɗin gwiwar tsaka-tsaki da na duniya. A matsayin marubucin wallafe-wallafen da aka yi nazari da yawa, L. Hernández ya ba da gudummawa ga ci gaban ilimi a fagen kuma yana kula da kasancewar sananne a cikin al'ummar kimiyya. L. Hernández an jera shi a cikin ambaton ambaton [9].

▎ Abubuwan da suka dace

[1] Miic D, Mallo F, Peino R, et al. Ka'idojin fitar da hormone girma ta hanyar haɓakar hormone mai sakin hexapeptide (GHRP-6). J Pediatr Endocrinol 1993; 6(3-4): 283-289.

[2] McMahon CD, Chapin LT, Radcliff RP, Lookingland KJ, Tucker HA. GH-sakin peptide-6 yana shawo kan refractoriness na somatotropes zuwa GHRH bayan ciyarwa. Jaridar Endocrinology 2001; 170(1): 235-241.DOI: 10.1677/joe.0.1700235.

[3] Yu AP, Pei XM, Sin TK, et al. [D-Lys3] -GHRP-6 yana nuna tasirin pro-autophagic akan tsokar kwarangwal. Kwayoyin halitta da 

Kwayoyin Endocrinology na Cellular 2015; 401: 155-164.DOI: 10.1016/j.mce.2014.09.031.

[4] Mendoza-Mari Y, Fernández Mayola M, Vázquez-Blomquist D, et al. GHRP-6, ɗan takara na labari don rigakafi da maganin cututtukan fibrotic. Biotecnologia Appcada 2017; 34Saukewa: 2501-2504.

[5] Guo S, Gao Q, Jiao Q, Hao W, Gao X, Cao JM. Lalacewar mucosal na ciki a cikin damuwa na nutsewar ruwa: inji da rigakafin tare da GHRP-6. Jaridar Duniya na Gastroenterology 2012; 18(24): 3145-3155.DOI: 10.3748/wjg.v18.i24.3145.

[6] McMahon CD, Chapin LT, Radcliff RP, Lookingland KJ, Tucker HA. GH-sakin peptide-6 yana shawo kan refractoriness na somatotropes zuwa GHRH bayan ciyarwa. Jaridar Endocrinology 2001; 170(1): 235-241.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11431156&query_hl=1.

[7] Voltz DM, Piering AW, Magestro M, Giustina A, Wehrenberg WB. Tasirin GHRP-6 da GHRH akan ɓoyewar GH a cikin berayen bayan jiyya na glucocorticoid na yau da kullun. Kimiyyar Rayuwa 1995; 56(7): 491-497.DOI: 10.1016/0024-3205(94)00478-b.

[8] Borges MH, DiNinno FB, Lengyel AM. Daban-daban na haɓakar hormone haɓaka peptide (GHRP-6) da GH-sakin hormone akan sakin GH a cikin hypercortisolism na endogenous da exogenous. Clinical Endocrinology 1997; 46(6): 713-718.DOI: 10.1046/j.1365-2265.1997.1981008.x.

[9] Hernández L, Camacho H, Nuñez-Robainas A, et al. Growth hormone secretagogue peptide-6 yana haɓaka rubutun oreochromicins da aikin antimicrobial a cikin tilapia (Oreochromis sp.). Kifi & Shellfish Immunology 2021; 119: 508-515.DOI: 10.1016/j.fsi.2021.08.011.

[10] Berlanga-Acosta J, Nieto GEG, Pez-Mola ELO, Nez LISH. Haɓaka hormone mai sakin peptide-6 (GHRP-6) da sauran abubuwan da ke da alaƙa da peptides na sinadarai masu alaƙa: Ma'adinai na yuwuwar likita don buƙatun likita marasa cika. Haɗin Magungunan Kwayoyin Halitta 2016; 3shafi: 616-623. https://api.semanticscholar.org/CorpusID:45189287.

DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.  

Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.