Ghrp-6 10mg ƒe lãmekawo

▎ GHRP-6  ƒe Dɔwɔɖoɖo

▎ GHRP-6  Numekuku

Nukae nye numekuku si wowɔ le GHRP-6 ŋu?

Numekuku deto siwo wowɔ tso GHRP-6 ŋu dzɔ tso numekuku deto siwo wowɔ le tsitsi ƒe lãmetsi (GH) ƒe ɖoɖowɔwɔ ƒe mɔnuwo ŋu me. Numekuku gbãtɔwo ɖee fia be, le dzɔdzɔme tsitsi ƒe lãmetsiŋusẽ si ɖea lãme na ame (GHRH) godo la, mɔ bubu siwo kpɔa GH ƒe dodo dzi le ŋutilãa si, siwo dometɔ aɖewoe nye lãmenugbagbevi siwo te ŋu doa GH ƒe dodo ɖe ŋgɔ etɔxɛe (si nye tsitsi ƒe lãmetsi si dona le lãme na ame, GHSR). Be numekulawo nagake ɖe ɖoɖowɔɖi ƒe mɔnu sia ŋu geɖe wu eye woade dzesi dɔwɔnu siwo woatsɔ ade nu GH ƒe dodo me pɛpɛpɛ la, wodze atike siwo woɖo taɖodzinu na GHSR la wɔwɔ gɔme. GHRP-6 do tso nukpɔsusu ƒe ɖoɖo sia me abe hexapeptide si wowɔ be wòana GHSR mɔa nawɔ dɔ ene, si na akpa si wòwɔna le GH ƒe wɔwɔme kple eƒe dodo dzi kpɔkpɔ me me kɔ.

Le ɣeyiɣi ma ke me la, dɔdamɔnu kple numekuku ƒe didiwo le GH ƒe tɔtrɔ ƒe dɔwɔnuwo ŋu na GHRP-6 ƒe numekukuwo ʋã. Le go ɖeka me la, dɔlélewo abe tsitsime lãmetsiŋusẽ ƒe anyimanɔmanɔ ene hiã GH dzi kpɔkpɔ ƒe mɔnu siwo wɔa dɔ nyuie wu siwo me mɔnu tɔxɛwo le be woatsɔ akpe ɖe nusiwo wowɔna tso blema ke ŋu. Le go bubu me la, numekula siwo le nusiwo le abe lãmenugbagbeviwo ƒe dɔwɔwɔ, lãmekawo ƒe lãmesẽ, kple lãmenugbagbeviwo ɖɔɖɔɖo ene me di be yewoaku ŋutilã ƒe dɔwɔwɔ siwo do ƒome kplii me to asitɔtrɔ le GH-IGF-1 ƒe axis ŋu me. Abe atike si te ŋu wɔa dɔ pɛpɛpɛ le GHSR eye wòɖɔa GH ƒe dodo ɖo ene la, GHRP-6 va zu dɔwɔnu vevi aɖe si wotsɔ srɔ̃a nu tso axis ƒe dɔwɔwɔ kple eƒe dɔwɔwɔ ŋu le domenyinyi siwo do ƒome kplii me, si wɔe be wowɔ numekuku le eƒe dzɔdzɔmeŋusẽŋununya ƒe nɔnɔmewo kple dɔwɔwɔ ƒe mɔnuwo ŋu.

Nukae nye GHRP-6 ƒe dɔwɔwɔ ƒe mɔnu?

Tsitsi ƒe Lãmetsiŋusẽ ƒe Ʋuʋu ƒe Ðoɖowɔwɔ

Womeɖoa ŋu ɖe Hypothalamic Factors Deŋgɔwo Ŋu O: GHRP-6 ate ŋu aɖe tsitsi ƒe lãmetsi (GH) ɖa koŋ le eɖokui si le hypothalamic growth hormone-releasing hormone (GHRH) kple somatostatin me. Esia fia be ewɔa mɔ aɖe si to vovo tso blema hypothalamic regulatory pathway gbɔ be wòaʋã GH ƒe dodo. Le kpɔɖeŋu me ^..

Dɔwɔwɔ aduadu kple GHRH: GHRP-6 kple GHRH wɔa dɔ ɖe xɔla vovovowo dzi, eye woɖea dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi fiana. Numekukuwo ɖee fia be le nuɖuɖu megbe la, lãmenugbagbevi siwo ɖea GH ɖe go la ɖea GHRH ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ fiana hena ɣeyiɣi aɖe; le ɣeyiɣi sia me la, GHRP-6 doa ŋusẽ GH ƒe dodo si GHRH hena vɛ. GHRP-6 si wodona ɖe ʋuka me doa ŋusẽ GH ƒe dodo le mɔ si nɔa te ɖe agbɔsɔsɔme si wozã dzi. Ne wotsɔe kpe ɖe GHRH ŋu, do ŋgɔ na nuɖuɖu kple le nuɖuɖu vɔ megbe siaa la, GHRP-6 wɔa dɔ aduadu na GH ƒe dodo geɖe. Woda asi ɖe ŋusẽkpɔɖeamedzi sia si woƒo ƒu dzi le GH lãmenugbagbevi siwo wode agble me hã. Gakpe ɖe eŋu la, GHRP-6 wɔa dɔ ɖe hypothalamus dzi tsɔ doa ŋusẽ GHRH ƒe dodo, si wɔnɛ be GH ƒe dodo ɖe ŋgɔ le mɔ si mele tẽ o nu ^[2]..

Ŋusẽkpɔɖeamedzi ɖe Autophagy kple Apoptosis dzi

Autophagy Dodo Ðe Ŋgɔ: Wobua [D-Lys3]-GHRP-6, si nye GHRP-6 ƒe tɔtrɔ aɖe, be enye tsitsi ƒe lãmetsiŋusẽ si ɖea lãmetsiŋusẽ si xɔa lãmetsiŋusẽ (GHSR) ƒe mɔxenu si tiaa ame ŋutɔ. Numekukuwo ɖee fia be edoa autophagy signaling ɖe ŋgɔ le lãmeka si sɔ kple esi doxorubicin gblẽ siaa me, si dzena le beclin-1 protein ƒe agbɔsɔsɔ si dzi ɖe edzi kple LC3 II kple LC3 I ƒe xexlẽme si dzi ɖe edzi me. Esia ɖee fia be GHRP-6 ƒe vovototo siwo do ƒome kplii wɔa akpa vevi aɖe le lãmekawo ƒe lãmenugbagbeviwo ƒe homeostasis me léle ɖe asi me kple alesi wowɔa nui ɖe abi ŋu to autophagy dodo ɖe ŋgɔ be wòakɔ lãmenugbagbeviwo ƒe akpa siwo gblẽ ŋu, si wɔnɛ be lãmenugbagbeviwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie kple dɔwɔwɔ ƒe hayahaya nɔa bɔbɔe ^[3]..

Mɔxexe ɖe apoptosis nu: [D-Lys3]-GHRP-6 hã ɖe apoptosis ƒe dɔwɔwɔ si doxorubicin hena vɛ le lãmekawo me dzi kpɔtɔ, eye womekpɔ lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe tɔtrɔ aɖeke le lãmeka siwo ŋu wowɔ atike ɖo me o. Le ɣeyiɣi ma ke me la, myofibers ƒe titina nucleation ƒe dzidziɖedzi si doxorubicin hena vɛ menɔ lãmeka siwo wotsɔ [D-Lys3]-GHRP-6 da dɔe me o, si fia be eƒe ametakpɔnu tso doxorubicin ƒe nugbegblẽ me. Esia nana lãmekawo ƒe ŋutilã ƒe nɔnɔme si sɔ la nɔa anyi to apoptosis dzi kpɔkpɔ me ^[3]..

Domenyiŋusẽfianu Siwo Do Ƒome Kple Fibrosis Ƒe Dɔwɔnawo Ŋuti Ðoɖowɔwɔ

Pro-Fibrotic Genes ƒe ɖeɖefia dzi ɖe kpɔtɔ: Le kpɔɖeŋuwo abe aklã me fibrosis kple ŋutigbalẽ ƒe abi ƒe dɔyɔyɔ ene me la, GHRP-6 ɖea anti-fibrotic nɔnɔmewo fiana. Le molecule ƒe ɖoɖo nu la, eɖea pro-fibrotic domenyiŋusẽfianu TGFB1 kple CTGF ƒe nuŋɔŋlɔ ƒe ɖeɖefia dzi kpɔtɔna. TGFB1 kple CTGF wɔa akpa vevi aɖe le fibrosis me; woƒe ɖeɖefia dzi ɖeɖe kpɔtɔ kpena ɖe ame ŋu be woaxe mɔ ɖe lãmenugbagbeviwo godo ƒe matrix proteinwo ƒe ƒuƒoƒo fũ akpa nu, si wɔnɛ be fibrosis ƒe sesẽ dzi ɖena kpɔtɔna ^[4]..

Anti-Fibrotic Gene Expression ƒe Dɔwɔwɔ: GHRP-6 naa PPARG kple MMP-13 domenyiŋusẽfianu ƒe ɖeɖefia le ɣeyiɣi ɖeka me. PPARG kpɔa gome le adipocyte ƒe vovototodedeameme kple lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me esime wòɖea mɔxexeɖedɔléle nu ƒe ŋusẽkpɔɖeamedzi fiana ɖe dɔdzẽ kple fibrosis ŋu; MMP-13 gblẽa lãmenugbagbeviwo godo ƒe matriki ƒe akpawo, si kpena ɖe ame ŋu be lãmenugbagbeviwo ƒe wɔwɔme kple dɔwɔwɔ nyuie nanɔ anyi. Domenyiŋusẽfianu eveawo siaa ƒe ɖeɖefia dzi ɖe edzi nana be woate ŋu atɔ te dɔléle ƒe nuƒoƒoƒu ƒe ɖoɖo si nye fibrosis ^{[4] .}.

Mɔnu Siwo Kpɔa Dɔgbo ƒe Ʋukawo Ta

Nuteɖeamedzi ƒe Dzesiwo ƒe Mɔxexe Ðe Mɔ Nu: Le tsi me nyɔnyrɔ̃ ƒe nuteɖeamedzi (WRS)-si hena dɔgbo ƒe abixɔxɔ ƒe kpɔɖeŋu me la, GHRP-6 wɔa ametakpɔnu. WRS tsɔa dzesi siwo tso ŋutigbalẽ ƒe ʋuʋu me to vagus lãmeka dzi yia lãmeka si le titina, si wɔnɛ be dɔgboa ƒe ʋukawo xɔa abi. GHRP-6 xea mɔ na nugbegblẽ sia, anɔ eme be exea mɔ na nuteɖeamedzi ƒe dzesiwo ƒe kaka, si wɔnɛ be vagus nerve ƒe ʋuʋu gbegblẽ ɖe dɔgboa ƒe lãkusi me dzi ɖena kpɔtɔna eye wòxea mɔ na lãkusi ƒe abixɔxɔ ^[5]..

Dɔgbo me acid ƒe dodo kple nu bubuwo dzi kpɔkpɔ: WRS nana ƒodo me acid ƒe dodo dzina ɖe edzi, evɔ GHRP-6 ya ate ŋu ana acid ƒe dodo naɖo afisi wòle be wòanɔ, si ana dɔgboa ƒe acid ƒe gbegblẽ le lãkusia ŋu dzi naɖe akpɔtɔ. Tsɔ kpe ɖe eŋu la, GHRP-6 ate ŋu awɔ ametakpɔnu si mele tẽ o ɖe dɔgboa ƒe ʋukawo ŋu to ŋusẽkpɔkpɔ ɖe ʋumenugbagbevi dzĩ me renin, endothelin-1, thromboxane B2, kple dɔgbo ƒe dzoxɔxɔ ƒe ʋuʋudedi protein 70 dzi le ʋumenugbagbeviɣi me, si ana wòakpɔ dɔgboa ƒe ʋukawo ta le mɔ si mele tẽ o nu eye wòalé eƒe blibonyenye kple dɔwɔwɔ nyuie me ɖe asi ^{[5] .}.

Figure 1 Dzi ƒe tsotso ƒe tɔtrɔ ƒe numekuku siwo ɖe vovototo siwo le RR ƒe dometsotsowo ƒe mama dedie, RR dometsotso siwo sɔ kple esiwo sɔ ƒe vovototo si sɔ, kple RR dometsotso siwo kplɔ wo nɔewo ɖo ƒe vovototo siwo kplɔ wo nɔewo ɖo ƒe ke ƒe mama dedie ƒe dzogoe ene me fia le ƒuƒoƒo vovovowo me ^[5]..

Nukae nye GHRP-6 ƒe dɔwɔwɔ?

Dɔlékuiwutikewo ƒe ŋusẽkpɔɖeamedzi

Aklã me ʋu ƒe sisi: Le aklã me ʋu ƒe sisi ƒe kpɔɖeŋu siwo wowɔ le sisiblisiwo me la, GHRP-6 zazã le mɔxexeɖedɔléle nu kple atikewɔwɔ siaa me ɖee fia be ewɔa dɔ nyuie ŋutɔ. Eɖe fibrotic nodules dzi kpɔtɔ wu 75%, eɖe ka ƒe titrime kple cirrhotic nodule ƒe xexlẽme dzi kpɔtɔ va ɖo 60%, esime wògawɔ aklã takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi siwo dze ƒã hã. Le molecule ƒe ɖoɖo nu la, GHRP-6 ɖe pro-fibrotic domenyiŋusẽfianu TGFB1 kple CTGF ƒe nuŋɔŋlɔ ƒe ɖeɖefia dzi kpɔtɔ esime wònɔ PPARG kple MMP-13 domenyiŋusẽfianu ƒe ɖeɖefia hem vɛ—domenyiŋusẽfianu siwo le vevie ŋutɔ hena dɔlélewo ƒe ƒuƒoƒo ƒe dɔwɔwɔwo nu tsitsi ^[4]..

Ŋutilã ƒe fibrosis: Le abi ƒe kpɔɖeŋu si wowɔ le sisiblisi bɔbɔe me la, GHRP-6 na abi ƒe nutsotso kabakaba eye wòɖe abi ƒe gege ɖe lãme na ame dzi kpɔtɔ. Le avugbɔe ƒe abi si lolo akpa ƒe kpɔɖeŋu me la, peptide la xe mɔ na keloid ƒe wɔwɔ le abi siwo woda dɔ na ƒe 90% kple edzivɔ me, si fia be asixɔxɔ si ate ŋu anɔ GHRP-6 ŋu le mɔxexe ɖe dɔléle siwo do ƒome kple ŋutigbalẽ ƒe fibrosis nu kple wo dada me ^[4]..

Tsitsi ƒe Lãmetsiŋusẽ ƒe Ʋuʋu ƒe Ʋuʋu

Ŋusẽkpɔɖeamedzi ɖe Lãmesẽnyawo Gbɔ: GHRP-6 dodo ɖe ʋuka me doa ŋusẽ tsitsi ƒe lãmetsi (GH) ƒe dodo le mɔ si nɔa te ɖe agbɔsɔsɔme si wozã dzi. Le nuɖuɖu vɔ megbe la, GH lãmenugbagbeviwo ƒe ŋuɖoɖo ɖe tsitsimeŋusẽ si ɖea lãmetsiŋusẽ (GHRH) ŋu dzi ɖena kpɔtɔna hena ɣeyiɣi aɖe. Gake GHRP-6 kple GHRH zazã ɖekae nana GH dona ŋutɔ do ŋgɔ na nuɖuɖu nana kple emegbe siaa, eye wokpɔa ŋusẽ si sɔ le GH lãmenugbagbevi siwo wode agble me. Gakpe ɖe eŋu la, GHRP-6 wɔa dɔ ɖe hypothalamus dzi tsɔ doa ŋusẽ GHRH ƒe dodo ^[6]..

Ŋusẽkpɔɖeamedzi ɖe Dɔléle ƒe Nɔnɔme Tɔxɛwo Dzi: Le sisiblisi siwo xɔa glucocorticoid ƒe atike si nɔa anyi didi gome la, GHRP-6 doa ŋusẽ GH ƒe dodo gake mete ŋu trɔa GH ƒe nutete si glucocorticoid hena vɛ o. Le dɔnɔ siwo ŋu glucocorticoid si sɔ gbɔ wu le lãmenugbagbeviwo me alo le gota gome la, amesiwo ŋu hypercortisolemia si le lãmenugbagbeviwo me le la ɖe GH ƒe ŋuɖoɖo siwo dzi ɖe kpɔtɔ ɖe GHRP-6 kple GHRH siaa ŋu fia, gake edze abe alesi wowɔa nu ɖe ​​GHRP-6 ŋu ƒe mɔnu la ta le dɔnɔ siwo ƒe glucocorticoid si sɔ gbɔ wu le gota gome ene ^[7,8]..

Dɔlélenutsiŋutete ƒe Ŋusẽkpɔɖeamedzi: Le tilapia me la, GHRP-6 doa dɔlékui etɔ̃ siwo nye tɔmelã tɔxɛwo (Oreochromicins I, II, kple III) kple granzyme ƒe nuŋɔŋlɔ ƒe agbɔsɔsɔ ɖe dzi le mɔ si nɔa te ɖe lãmenugbagbeviwo dzi nu, eɖanye Pseudomonas aeruginosa dɔlékui ƒe nɔnɔme ka kee le o. Edoa dɔlékuiwutikewo ƒe dɔwɔwɔ ɖe ŋgɔ le ʋumenugbagbeviɣidɔ me hã (lysozyme kple antiprotease ƒe dɔwɔwɔ), si doa ŋusẽ tilapia gill mucus kple serum ƒe kpɔɖeŋuwo ƒe dɔlékuiwutike ƒe dɔwɔwɔ le vitro ɖe Pseudomonas aeruginosa ŋu eye wòɖea dɔlékuiwo ƒe agba dzi kpɔtɔna le vivo le dɔlékuiwo xɔxɔ vɔ megbe. Esia fia be ŋugbedodo le GHRP-6 ŋu be enye atikewɔmɔnu bubu le tɔmelãwo nyinyi me hena teleost tɔmelãwo ƒe dɔlélenutsiŋutete ƒe ŋusẽdodo ɖe dɔlékui siwo dia mɔnukpɔkpɔwo ŋu ^[9]..

Dzitodzito Takpɔkpɔ Ŋutete: Tsitsi ƒe lãmetsiŋusẽ ƒe peptidewo (GHRPs) doa ŋusẽ tsitsi ƒe lãmetsiwo ƒe dodo kple downstream axis ƒe dɔwɔwɔ, eye woƒe xɔla siwo do ƒome kplii la kaka ɖe dzitodzitowo katã me. Numekuku gbãtɔwo ɖee fia be GHRP siwo wowɔ la nye esiwo ŋugbe wodo be woatsɔ akpɔ dzi kple lãmenugbagbeviwo ta. Le esiawo dome la, GHRP-6—togbɔ be atikewɔƒewo dea nu nyawo me ɣeaɖewoɣi kple ɣeaɖewoɣi hã—te ŋu le dɔdamɔnu ƒe ŋgɔyiyi si wɔ ɖeka si wotu ɖe eƒe nu geɖe ƒe dɔwɔwɔ le dzitodzito me dɔléle me dzi ^{[10] .}.

Nyanuwuwuw

Abe hexapeptide tsitsi ƒe lãmetsiŋusẽ ƒe ʋuʋudedi si wowɔ ene la, GHRP-6 koŋue ɖɔa GH-IGF-1 ƒe axis ɖo to kadodo tɔxɛ kple GHSR me, si ɖea asixɔxɔ si le go geɖe me fiana le ŋutilã ƒe dɔwɔwɔ ƒe tɔtrɔ kple dɔléle ŋuti numekuku me. Menye ɖeko GHRP-6 tɔa ŋku GH ƒe dodo be wòakpɔ ŋusẽ ɖe lãmenugbagbeviwo ƒe dadasɔ kple lãmenugbagbeviwo ƒe tsitsi ƒe ɖoɖowɔwɔ dzi ko o, ke eɖea ŋusẽkpɔɖeamedziwo fiana le anti-fibrosis (aklã, ŋutigbalẽ), dzitodzito takpɔkpɔ (si xea mɔ na dzitodzito ƒe apoptosis, dzitodzito ƒe dɔwɔwɔ nyuie wu), kple dɔlélenutsiŋutete ƒe tɔtrɔ hã. Ewɔa dɔ hã abe numekukudɔwɔnu vevi aɖe ene hena GHSR ƒe dɔwɔwɔ kple GH ƒe ɖoɖowɔwɔ ƒe mɔnuwo me kɔ.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla

L. Hernández nye numekula le agbeŋutinunya me, eye wòwɔa sukudɔ le yunivɛsitiwo alo numekuƒewo. Eƒe agbalẽnyalagãwo ƒe didiwo lɔ nuto siwo ku ɖe lãwo ƒe lãmesẽ kple molecule biology ŋu ɖe eme, eye wòkpɔa gome vevie le nusɔsrɔ̃wo dome kple dukɔwo dome nuwɔwɔ aduadu me. Esi L. Hernández nye agbalẽ geɖe siwo me hatiwo to ŋlɔla ta la, ekpe asi ɖe sidzedze dodo ɖe ŋgɔ le dɔa me ŋu eye wòlé eƒe anyinɔnɔ si wonya nyuie me ɖe asi le dzɔdzɔmeŋutinunyalawo ƒe habɔbɔa me. Woŋlɔ L. Hernández ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [9].

▎ Nyayɔyɔ Siwo Sɔ

[1] Micic D, Mallo F, Peino R, kple ame bubuwo. Tsitsi ƒe lãmetsi ƒe dodo ƒe ɖoɖowɔwɔ to tsitsi ƒe lãmetsi si ɖea asi le hexapeptide (GHRP-6) dzi. J Ðeviwo ƒe Dɔlélenutsiŋutete ƒe Endocrinol 1993; 6(3-4): 283-289 ƒe axawo.

[2] McMahon C. D., Chapin L. T., Radcliff R. P., Lookingland K. J., Tucker H. A., kple ame bubuwo. Peptide-6 si ɖea GH ɖe go la ɖua somatotropes ƒe tsitretsitsi ɖe GHRH ŋu le nuɖuɖu vɔ megbe dzi. Dɔlékuiwutikewo Ŋuti Nuŋlɔɖigbalẽ 2001; 170(1): 235-241.DOI: 10.1677/joe.0.1700235.

[3] Yu A. P., Pei X. M., Sin T. K., kple ame bubuwo. [D-Lys3]-GHRP-6 ɖea pro-autophagic ŋusẽkpɔɖeamedziwo fiana ɖe ƒunukpeƒeŋusẽ dzi. Molekyulãwo kple 

Lãmenugbagbeviwo ƒe Dɔlékuiwo Ŋuti Nunya 2015; 401: 155-164.DOI: 10.1016/j.mce.2014.09.031.

[4] Mendoza-Mari Y, Fernández Mayola M, Vázquez-Blomquist D, kple ame bubuwo. GHRP-6, si nye nu yeye aɖe si woate ŋu azã atsɔ axe mɔ ɖe fibrotic dɔlélewo nu ahada wo. Nu gbagbewo ƒe mɔ̃ɖaŋununya ƒe Aplicada 2017; 34: 2501-2504 ƒe agbalẽa.

[5] Guo S, Gao Q, Jiao Q, Hao W, Gao X, Cao JM, kple ame bubuwo. Gastric mucosal damage le tsi nyɔnyrɔ̃ ƒe nuteɖeamedzi me: mɔnu kple mɔxexe ɖe enu kple GHRP-6. Xexeame ƒe Nyadzɔdzɔgbalẽ si Ku Ðe Dɔgbomeŋutinunya Ŋu 2012; 18(24): 3145-3155.DOI: 10.3748/wjg.v18.i24.3145.

[6] McMahon C. D., Chapin L. T., Radcliff R. P., Lookingland K. J., Tucker H. A., kple ame bubuwo. Peptide-6 si ɖea GH ɖe go la ɖua somatotropes ƒe tsitretsitsi ɖe GHRH ŋu le nuɖuɖu vɔ megbe dzi. Dɔlékuiwutikewo Ŋuti Nuŋlɔɖigbalẽ 2001; 170(1): 235-241 ƒe agbalẽa.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Xɔ&db=pubmed&dopt=Abstract&list_uids=11431156&biabia_hl=1.

[7] Voltz D. M., Piering A. W., Magestro M., Giustina A., Wehrenberg W. B., kple ame bubuwo. Ŋusẽ si GHRP-6 kple GHRH kpɔna ɖe GH ƒe dodo dzi le sisiblisiwo me le glucocorticoid zazã atraɖii megbe. Agbeŋutinunya 1995; 56(7): 491-497.DOI: 10.1016/0024-3205 (94) 00478-b.

[8] Borges M. H., DiNinno F. B., Lengyel A. M., kple ame bubuwo. Dɔ vovovo siwo tsitsi ƒe lãmetsi si ɖea asi le peptide (GHRP-6) kple GH-si ɖea asi le lãmetsi ŋu kpɔna ɖe GH ƒe dodo dzi le endogenous kple exogenous hypercortisolism me. Dɔdaƒe ƒe Dɔlékuiwo Ŋuti Nunya 1997; 46(6): 713-718.DOI: 10.1046/j.1365-2265.1997.1981008.x.

[9] Hernández L, Camacho H, Nuñez-Robainas A, kple ame bubuwo. Tsitsi ƒe lãmetsi si nye secretagogue peptide-6 doa oreochromicins ƒe nuŋɔŋlɔ kple dɔlékuiwutike ƒe dɔwɔwɔ ɖe ŋgɔ le tilapia (Oreochromis sp.) me. Tɔmelãwo & Ƒumelãwo ƒe Dɔlélenutsiŋutete 2021; 119: 508-515.DOI: 10.1016/j.fsi.2021.08.011.

[10] Berlanga-Acosta J, Nieto GEG, Pez-Mola ELO, Nez LISH, kple ame bubuwo. Tsitsi ƒe lãmetsi si ɖea peptide-6 (GHRP-6) kple secretagogue synthetic peptide bubu siwo do ƒome kplii: Atikewɔwɔ ƒe ŋutetewo ƒe tomenukuƒe na atikewɔwɔ ƒe nuhiahiã siwo gbɔ womekpɔ o. Molekyulãwo ƒe Atikewɔwɔ si Wotsɔ Wɔ Ðekae 2016; 3: 616-623 ƒe agbalẽa. https://api.semanticscholar.org/CorpusID: 45189287 ƒe ɣleti gbãtɔ me.

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.