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▎ PT 141 Jateminɛ kɛcogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: Ac-Nle-cyclo(DHFRWK)-OH Formula molekilɛri: C 50H 68N 14O10 Molecules girinya: 1025,2g/mol CAS nimɔrɔ: 189691-06-3 PubChem ka CID: 9941379. Bamako, Mali Kɔrɔɲɔgɔnmaw: Bremelanotide |
▎ PT 141 Sɛgɛsɛgɛli
PT 141 ka ɲininiw kɛcogo ye mun ye?
PT 141 ye pepitiri sintetiki analozi ye ani melanocortin minɛbagaw ka agoniste ye, kɛrɛnkɛrɛnnenya la MC3R ni MC4R, olu bɛ sɔrɔ kosɛbɛ farikolo cɛmancɛ la [1] .PT 141 sɔrɔli ye jigiya kura lase cɛnimusoya furakɛli ma. Kalan fɔlɔ minnu kɛra a kan, olu y’a jira ko PT 141 tali sosow ni fɛnɲɛnama minnu tɛ hadamadenw ye, o bɛ na ni cɛya wuli ye. A tali kɔfɛ sigida la sosow la, sɔgɔsɔgɔninjɛ minnu bɛ hipotalamus kɔnɔ, olu baarakɛli jirala ni c-Fos farikolo tangacogo caya ye. Senfagabana minnu bɛ cɛmancɛ farikolo yɔrɔ kelen na, olu tun bɛna pseudorabies banakisɛ ta min pikirilen don soso cɛya kɔnɔ [1] .PT 141 bɛ se ka cɛnimusoya furakɛ. Kɔlɔsiliw y’a jira ko PT 141 dilen kɔfɛ cɛw ni banabagatɔw la minnu ka cɛya ka ɲi, cɛya jiginni baara cayara teliya la ani ka kɛɲɛ ni a tata hakɛ ye. Nin jaabi ninnu b’a jira ko PT 141 bɛ se ka kɛ cɛnimusoya fura kura ye [1] ..
PT 141 bɛ baara kɛ ni fɛɛrɛ jumɛn ye melanocortin minɛbagaw kan?
PT 141 (Bremelanotide) bɛ baara kɛ ni fɛɛrɛ kɛrɛnkɛrɛnnen min ye melanocortin minɛbagaw kan, o ka gɛlɛn kosɛbɛ, wa nin ye a kɛcogo ɲɛfɔcogo caman ye:
Melanokɔriti minɛcogo bɛ kɛ ni melanokɔrini pepitiriw ye, minɛyɔrɔ kɛrɛnkɛrɛnnenw, farikolojɔli dumuniw dɛmɛnanw, ani kɔnɔnatumuw kɛlɛbagaw. Melanokɔrini pepitiriw ye pepitiri ɔrimɔni misɛnninw ye minnu sɛgɛsɛgɛra farikolo ni bana suguya caman na. Sisan, melanokɔrini sɔrɔyɔrɔ suguya duuru dɔnna, minnu bɛ jɛnsɛn cɛmancɛ-farikolo-yɔrɔw la ani farikolo-yɔrɔ dɔw la. A ka c’a la, melanocortin minɛbagaw minnu bɛ G poroteyini ni ɲɔgɔn cɛ, olu bɛ taamasiɲɛw ci adenylate cyclase ni jiginɛ taamasiɲɛ sira wɛrɛw fɛ. Ka kɛɲɛ ni ligandi ye, melanocortin minɛbaga ka surface expression, receptor minɛni waati, a ni ɲɔgɔn cɛ farikolojɔlifɛnw, selilɛri suguya, ani fɛn wɛrɛw, taamasiɲɛw siraw ka gɛlɛn ani u bɛ pleiotropic. Hali ni melanocortin minɛbaga duuru bɛɛ bɛ fara Gs kan, tuma dɔw la u bɛ se ka fara Gq walima Gi fana kan [2]..
PT 141 sirili melanokɔrini sɔrɔyɔrɔw la:
PT 141 ye pepitiri analozi ye. I n’a fɔ melanocortin minɛbaga agoniste, a bɛ se ka siri cɛmancɛ melanocortin minɛbagaw la. PT 141, i n’a fɔ α-melanocyte-stimulating hormone ka pepitiri sintetiki analozi, o ye melanocortin minɛbagaw ka agoniste ye MC3R ni MC4R sen bɛ minnu na, olu bɛ jira kosɛbɛ farikolo cɛmancɛ lafana .
A nɔ minnu bɛ sɔrɔ wulu musomanw na:
Sogo musomanw na, PT 141 bɛ furusiri kɛcogo ɲɛnatɔmɔ k’a sɔrɔ a ma nɔ bila lordosis, rhythm walima cɛnimusoya kɛcogo wɛrɛw la. PT 141 tɛ kɛ sababu ye ka farikoloɲɛnajɛ kɛ farikolo la, wa a tɛ nɔ bila cɛnimusoya sara faamuyali la. O b’a jira ko melanocortin central system nafa ka bon muso ka cɛnimusoya nege labɛnni na. Furakɛcogo sugandilen nɔ min bɛ musomanninw ka cɛnimusoya nege kɛcogo la, o ma deli ka fɔ fɔlɔ, o fana b’a to PT 141 bɛ se ka kɛ fura fɔlɔ ye min dɔnna, min bɛ se ka musomanninw ka cɛnimusoya negebanaw furakɛ.
A nɔ minnu bɛ sɔrɔ sosow ni fɛnɲɛnamaw la minnu tɛ hadamadenw ye : PT 141 tali sosow ni fɛnɲɛnama minnu tɛ hadamadenw ye, o bɛ na ni cɛya wuli ye. PT 141 tali farikolo la, o bɛ senfagabana baara kɛ sosow ka hypothalamus kɔnɔ, o bɛ jira ni c-Fos farikolo tangacogo caya ye. Senfagabana minnu bɛ hipotalamus yɔrɔ kelen na, olu bɛna pseudorabies banakisɛ ta min pikirilen don soso cɛya kɔnɔbara la [3] ..
A nɔ minnu bɛ hadamaden cɛw la:
PT 141 tali cɛw la minnu ka kɛnɛ ani cɛyabana bɛ minnu na, o bɛ na ni cɛya kɛcogo caya ye joona ani ka kɛɲɛ ni a tata hakɛ ye. Jateminɛw y’a jira ko PT 141 bɛna kɛ cɛnimusoya fura kura ye [3] ..
A nɔ minnu bɛ hadamaden musow la : Cɛnimusoko juguya bɛ muso minnu na ka kɔn kalolabɔ ɲɛ, Bremelanotide (o kɔrɔ ye ko PT 141) pikiri kelen kɛlen kɔ nugu la, muso caman ye cɛnimusoya nege hakɛ danmadɔ walima hakɛ caman fɔ. Ni an y’a suma ni furakisɛ ta ye, jaabi ɲumanw sɔrɔli cogoya jɛlen tun bɛ yen ka ɲɛsin cɛya ni musoya wulicogo dusukunnataw ma Bremelanotide furakɛli kɔfɛ. Muso minnu y’a ɲini ka cɛnimusoya kɛ lɛri 24 kɔnɔ furakɛli kɔfɛ, muso minnu wasalen don kosɛbɛ cɛnimusoya nege hakɛ la Bremelanotide tali kɔfɛ ni i ye olu suma ni furakisɛ ta ye. Nka, Bremelanotide tali kɔfɛ, fɛn caman ma yeli kɛ musoya jolilabanaw la ni u bɛ porno wideyow lajɛ [4]..
Kuncɛli la, i n’a fɔ melanokɔriti minɛbaga agoniste, PT 141, n’a sirilen don melanokɔriti minɛbagaw la, o bɛ farikoloɲɛnajɛ nɔ suguya caman lase baganw ka misaliw ni hadamadenw ma, kɛrɛnkɛrɛnnenya la, a jɔyɔrɔ ka bon cɛnimusoya baara labɛnni na.
PT-141 tata hakɛ ni a jaabi nɔ minnu bɛ cɛnimusoya kɛcogo la joli-sira-funu-yɔrɔw la. (Sanfɛ) A bɛ nɔ minnu bila ɲininiw na musow la minnu primed ni ɔrimɔni ni porojɛsitɛri (EP) walima ɔrimɔni dɔrɔn (E dɔrɔn). Sɛgɛsɛgɛli minnu kɛra kɔfɛ, olu y’a jira ko garamu 100 ni garamu 200/kg fila bɛɛ ye dɔ fara ɲininiw hakɛ kan kosɛbɛ ni i ye a suma ni kɔgɔ furakɛli kɛlenw ye (P hakɛw <0,05). (Cɛmancɛ) A bɛ nɔ minnu bila taamacogo la musow la minnu primed ni EP walima E dɔrɔn ye. (Jiginni) A bɛ nɔ minnu bila lordosis quotients la musow la minnu primed ni EP walima E dɔrɔn ye. Donanw ye kɔrɔ SEM ye. *, P <0,05 ka bɔ kɔrɔsili la.
Soso:PubMed [3] Ɲɛjirali dɔw.
PT 141 nafa kɛrɛnkɛrɛnnen jumɛnw bɛ se ka sɔrɔ cɛw ka cɛnimusoya nege dɔgɔyali ni cɛya gɛlɛyaw la?
Cɛya baarakɛcogo ɲɛnabɔli:
Kalan caman y’a jira ko PT 141 bɛ furakɛli nɔ dɔ lase cɛw ka cɛya gɛlɛya ma. Misali la, kɛnɛyaso sɛgɛsɛgɛli dɔw la, a jirala ko a bɛ se ka cɛya wuli [5] (Shadiack AM, 2007). Fase IIb ka sɛgɛsɛgɛli dɔ la, sukarodunbanabagatɔ cɛmanw kan, cɛyabana bɛ minnu na, banabagatɔw bilala ka furakisɛ ta walima ka PT 141 hakɛ danfaralenw ta (IIEF), ni danfara jɛlen don ni a ni furakisɛ kulu ta kɛra ɲɔgɔn fɛ [5]. .
PT 141 bɛ cɛya baara ɲɛ ka taa a fɛ cogo min na, o bɛ se ka kɛ a jɔyɔrɔ ye i n’a fɔ melanocortinergic fura, a bɛ siri melanocortine minɛbagaw la cɛmancɛ farikolo la, kɛrɛnkɛrɛnnenya la hypothalamus la. O sirili bɛ se ka senfagabana siraw labɛn minnu bɛ tali kɛ cɛya la, o bɛ cɛya wulicogo sabati [5] . .
Muɲuli ɲuman ni lakana:
Ka kɛɲɛ ni Bremelanotide ka kɛnɛyako dɔnniya ye, melanocortin agoniste (i n’a fɔ Bremelanotide) tali bɛ muɲu kosɛbɛ [6] . A tɛ tali kɛ tansiyɔn jiginni na min kɔlɔsira ni fosifodiɛsitɛrisi-5 inhibiteurs ye sisan minnu bɛ kɛ ka cɛya bana furakɛ.
Kɛnɛyaso nɔfɛkow sɛgɛsɛgɛliw:
Jateminɛ kɛli cɛ kɛnɛmanw na ani banabagatɔ minnu cɛya tɛ u la:
Farikolo jukɔrɔla tali kɔfɛ cɛ kɛnɛmanw na ani banabagatɔ minnu ka cɛya tɛ baara la (ED) minnu y’a jira ko jaabi bɛrɛ tɛ Viagra la, hɛpɛpɛpɛtidi melanokɔrini cyclique analogique PT 141 jateminɛna [7] (Rosen RC, 2004). A tata hakɛ minnu bɛ bɔ miligaramu 0,3 la ka se miligaramu 10 ma, olu kɛra cɛ kɛnɛmanw na, wa a tata hakɛ minnu ka ca ni miligaramu 1,0 ye, olu ye cɛya jaabi di jateminɛ na. ED banabagatɔw ye furakisɛ ta, miligaramu 4 walima 6 PT 141, crossover design kɔnɔ cɛnimusoya lawulili ɲɛnama (VSS) ɲɛkɔrɔ. A tata hakɛ fila bɛɛ la, cɛya jaabi min bɛ sɔrɔ PT 141 fɛ, o tun ye jateminɛ nafama ye. PT 141 tun farati tɛ a la, wa a tun muɲulen don kosɛbɛ nin kalan fila bɛɛ la. Banabagatɔ minnu ma jaabi ɲuman sɔrɔ PDE5 balilanw na, PT 141 ka cɛya se, a muɲuni, ani a se ka cɛya wuli kosɛbɛ, o b’a jira ko PT 141 bɛ se ka furakɛli suguya wɛrɛ di ED ma banabagatɔ caman na minnu bɛ se ka kɛ.
Sildenafili faralen ɲɔgɔn kan, o nɔ:
Cɛyabanabagatɔ tan ni kɔnɔntɔn minnu y’u yɛrɛ jira ko u ye Viagra walima Levitra jaabi di, olu ye sildenafili miligaramu 25 di u ma ani PT 141 miligaramu 7,5 nugu la, sildenafili miligaramu 25 ni furakisɛ fiyɛli nugu la, ani furakisɛ furakisɛw ni furakisɛ fiyɛli nugu la, ka kɛɲɛ ni ɲɔgɔndan kɛcogo ye min kɛra ni mɔgɔw ye [8] (Diamond LE, 2005). Cɛya jaabi min bɛ sɔrɔ cɛnimusoya kɛcogo ɲɛnama fila la miniti 30 kɔnɔ, o jateminɛna RigiScan fɛ. Jateminɛw y’a jira ko cɛya jaabi min bɛ sɔrɔ PT 141 ni sildenafili faralen ɲɔgɔn kan, o ka bon kosɛbɛ ka tɛmɛ sildenafili dɔrɔn kan. O faralen ɲɔgɔn kan, farati tɛ a la, wa a tun bɛ muɲu kosɛbɛ, k’a sɔrɔ a ma kɛ sababu ye ka kɔlɔlɔ kuraw lase mɔgɔ ma walima ka dɔ fara kɔlɔlɔw caya walima u juguya kan. Kuncɛli ye ko PT 141 ni fosfodiɛsitɛri 5 balilanw faralen ɲɔgɔn kan nugu la, o bɛ se ka kɛ furakɛli sugandilen ye banabagatɔw ma minnu tɛ se ka furakɛ walima minnu tɛ se ka muɲu kosɛbɛ furakɛli kelen tali hakɛ caman na.
PT 141 tali nafa ka bon kosɛbɛ fan caman na, kɛrɛnkɛrɛnnenya la, a bɛ jigiya kura lase banabagatɔ caman ma cɛnimusoya kɛnɛyako siratigɛ la. Muso minnu ma se ka kɔnɔmaya dabila, ni cɛnimusoya nege jugumanba sɔrɔlenw ni u ka cɛnimusoya nege jugumanba (HSDD) bɛ u la, PT 141 ye ɲɛtaa ba ye. Fɔlɔ, o banabagatɔ suguw tun bɛ to ka hakili degun muɲu cɛnimusoya nege dɔgɔyali fɛ u ka don o don ɲɛnamaya kɔnɔ, o min tun bɛ nɔba bila u dusukunnataw cogoya la ani u ni u furuɲɔgɔnw cɛsira gɛlɛnw na. PT 141 bɔli ye nin ko in Changé. Ni a bɛ siraw labɛn hakili la minnu bɛ cɛnimusoya jaabi la, o bɛ banabagatɔw ka cɛnimusoya nege ɲɛ kosɛbɛ. Kɛnɛyaso ɲininiw kunnafoniw b’a jira ko Bremelanotide tali kɔfɛ, danfara jɛlen bɛ muso ka cɛnimusoya baarakɛcogo jiralan - nege yɔrɔ (FSFI-D) ni muso ka cɛnimusoya degun sɛgɛsɛgɛli - nege/wuli/ɲɛnabɔli (FSDS-DAO) fɛn 13nan yeli caman na, k’a ta kalan daminɛ na fo ka se kalan laban ma (EOS).
O b’a nɔ ɲumanw jira cogo la min bɛ banabagatɔw ka cɛnimusoya nege bonya ani ka degun minnu bɛ tali kɛ o la, olu nɔgɔyali la, ka HSDD musow ka ɲɛnamaya kɛcogo ɲɛ kosɛbɛ, ka kɔn kalolabɔ ɲɛ, ani k’u dɛmɛ u ka se ka u yɛrɛ da u yɛrɛ la kokura ani ka ɲɛnamaya nisɔndiya sɔrɔ.
Ka fara o kan, PT 141 fana bɛ nɔ ɲuman jira cɛw ka cɛnimusoya baarakɛbaliya la. Cɛw ka cɛnimusoya nege dɔgɔyali ɲɛnabɔli siratigɛ la, banabagatɔ caman y’a jira ko dɔ farala kosɛbɛ a tali kɔfɛ, u sera ka cɛnimusoya nege sɔrɔ kokura. Wa ka ɲɛsin cɛya gɛlɛyaw ma, banabagatɔ dɔw ka cɛya kɛcogo ɲɛnabɔra fo ka se hakɛ dɔ ma u tali kɔfɛ, o bɛ cɛya wulicogo nɔ bonya, o b’a to u bɛ se ka cɛnimusoya kɛcogo dafa ka ɲɛ cɛnimusoya ɲɛnamaya kɔnɔ ani k’u ka cɛnimusoya kɛcogo ɲɛ.
Siga t’a la, o bɛ farikolo ni hakili doni lajɔ cɛ kulu la min tɔɔrɔla cɛnimusoya fɛ kabini waati jan, ka hakiliɲagami dilan min bɛ sɔrɔ cɛnimusoya baarakɛcogo gɛlɛyaw fɛ, wa a bɛ dɛmɛ fana ka denbaya ka jɛɲɔgɔnyaw bɛn ɲɔgɔn na ani ka sabati.
Ni an bɛ furakɛli ɲininiw lajɛba la, PT 141 tali bɛ dalilu nafamaw di minnu bɛ se ka kɛ sababu ye ka fɛɛrɛw sɛgɛsɛgɛ kosɛbɛ minnu ɲɛsinnen bɛ hadamadenw ka cɛnimusoya kɛnɛya ma.
A ka baarakɛcogo ɲinini taabolo ye ɲininikɛlaw bila ka sɛgɛsɛgɛli kuncɛlenw kɛ hakili la, minnu ɲɛsinnen bɛ cɛnimusoya jaabi ma, melanokɔrini minɛbagaw, a ɲɔgɔnnaw, ka ɲinini jɔnjɔnw ɲɛtaa sabati cɛnimusoya kɛnɛyako siratigɛ la, ka jusigilan sigi furakɛli fɛɛrɛ caman ni fura caman labɛnni na cɛnimusoya baarakɛbaliya kama, ka furakɛli nafolo nafa ka taa a fɛ, ani ka sennateliya sabati ka taa ɲɛ furakɛli kama cɛnimusoya gɛlɛyaw gɛlɛyaw kunbɛnni na.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Scientific Journal sɛbɛnbaga Pfaus JG kalanden danbetigi min bɛ tali kɛ baarada tɔgɔba caman na, i n’a fɔ Charles Iniwɛrisite Prague, Tcheki jamana hakili kɛnɛya baarada, Universidad Veracruzana, Concordia Iniwɛrisite Kanada, Rockefeller Iniwɛrisite, ani British Columbia Iniwɛrisite. A ka ɲininiw bɛ tali kɛ dɔnniya caman na, kɛrɛnkɛrɛnnenya la, u sinsinnen bɛ Taamacogo dɔnniyaw kan, hakili ni hakiliɲagami dɔnniyaw, hakilijagabɔ, Endocrinology & Metabolism, ani Urology & Nephrology kan.
Taamacogo dɔnniya siratigɛ la, Pfaus bɛ kɛwale gɛlɛnw n’u kɔnɔkow sɛgɛsɛgɛ. A ka baara min kɛra Neurosciences & Neurology la, o bɛ sɛgɛsɛgɛli kɛ farikoloɲɛnajɛw jɔcogo n’a baarakɛcogo kan, ka dɛmɛ don hakiliɲagami banaw ni hakililata taabolo faamuyali la. Psychology kɔnɔ, a ka ɲininiw bɛ se ka kɛwalew ni hakili taabolo sɛgɛsɛgɛ, ka hakilinaw di hadamadenw ka kɛwalew ni hakili kɛnɛya kan. Endocrinology & Metabolism kɔnɔ, a bɛ ɔrimɔni sigicogo ni farikoloɲɛnajɛ taabolo sɛgɛsɛgɛ, o bɛ se ka kɛ sababu ye ka o ɲɛnamaya baara ninnu ni kɛwalew cɛsiri. A ka baara min kɛra Urology & Nephrology la, o bɛ se ka sinsin sugunɛ ni sugunɛ farikolo ni banako siratigɛ la, n’a sɔrɔla a bɛ se ka o sigida ninnu bɛ ɲɔgɔn sɔrɔ cogo min na ni farikolo baara ni kɛwale wɛrɛw ye.
A ka baara kɔnɔna bɛɛ la, n’a sɔrɔla James G. Pfaus ye sɛbɛn caman bɔ, wa a ye dɛmɛba lase dɔnniya jɛkulu ma, ka danfara don dɔnniya siraw danfaralenw ni ɲɔgɔn cɛ ani ka ɲininiw sabati dɔnniyaw ni ɲɔgɔn cɛ. A ka baara tɛ dan nin kalan ninnu faamuyali hakilila la dɔrɔn, nka a bɛ nɔ ɲuman bila kɛnɛyako ni furakɛli fɛɛrɛw yiriwali fana na. Pfaus JG tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [3].
