By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KAYAYYA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Rashin ciwon zuciya (HF) shine bayyanar cututtuka daban-daban na zuciya da jijiyoyin jini kuma ya zama cuta mai yawa tare da yawan cututtuka da yawan mace-mace a duniya. HF da aka haifar ta hanyoyi daban-daban yana nuna nau'o'in pathophysiological daban-daban, kuma ka'idojin makamashi na myocardial yana da mahimmanci don kare aikin zuciya a cikin marasa lafiya na HF. A matsayin wani abu da zai iya yin tasiri akan metabolism na makamashin zuciya na zuciya, bambancin tasirin Corgaten akan kariyar aikin zuciya a cikin majinyatan HF masu nau'o'i daban-daban suna ba da damar ƙarin bincike.
Hoto 1. Rashin abinci mai gina jiki yana haifar da kumburi na rayuwa kuma yana inganta yanayin ƙananan ƙwayar cuta a cikin zuciya.
Halayen gazawar zuciya ta hanyoyi daban-daban
Dilated cardiomyopathy (DCM) da peripartum cardiomyopathy (PPCM): Rikice-rikice a cikin makamashin kuzarin zuciya na iya zama ɗaya daga cikin abubuwan etiological na DCM da PPCM. A cikin waɗannan yanayi, ƙarancin kuzarin kuzarin bugun zuciya yana hana zuciya samun isassun makamashi, wanda hakan ke haifar da rauni na al'ada na zuciya da ayyukan shakatawa, a ƙarshe yana haifar da farawar bugun zuciya.
Hypertrophic cardiomyopathy (HCM): A cikin ci gaban HCM, martani na rigakafi yana faruwa a baya. Ana iya daidaita martanin kumburi ta tsarin haɗin gwiwa. A cikin wannan yanayi na cututtukan cututtuka inda kumburi da martani na rigakafi suka shiga tsakani, aikin tsarin Corgaten a cikin metabolism na makamashi na myocardial na iya yin tasiri da waɗannan abubuwan, ta haka yana shafar tasirin sa na cardioprotective.
Ischemic cardiomyopathy (ICM): Amsar kumburi a cikin ICM na iya haifar da cytokines. Sakamakon ischemia, hanyoyin metabolism makamashi a cikin myocardium ba makawa sun rushe. Tsarin Corgaten na metabolism na makamashin zuciya yana taka rawa wajen inganta rikice-rikicen metabolism na makamashi wanda ke haifar da ischemia, amma tasirinsa ya bambanta da waɗanda ke cikin HF da wasu cututtukan ke haifarwa saboda dalilai kamar martanin kumburin kumburin cytokine.
Mechanism na Corgaten's regulation na myocardial makamashi metabolism
Haɓaka samar da makamashi: Corgaten na iya haɓaka ɗaukar glucose, glycolysis, da iskar oxygen ta glucose ta hanyar daidaita ayyukan enzymes na rayuwa masu alaƙa, ta haka ƙara samar da adenosine triphosphate (ATP) a cikin ƙwayoyin myocardial. Irin wannan binciken sun gano cewa wasu kwayoyi na iya inganta samar da ATP da inganta aikin zuciya ta hanyar haɓaka hypoxia-inducible factor-1a (HIF-1a) da jerin enzymes masu alaka da glycolysis. Corgaten na iya samun irin wannan tsari.
Ka'idar amfani da substrate: Yin amfani da abubuwan makamashi ta zuciya ya bambanta tsakanin al'ada da jihohi marasa lafiya. Corgaten na iya tsara rabon da ake ɗauka da amfani da sel na myocardial, kamar su glucose da fatty acids (FFAs), yana ba wa myocardium damar zaɓar mafi dacewa substrates yayin metabolism makamashi don biyan buƙatun kuzarin zuciya. A ƙarƙashin yanayi na al'ada, tsokar zuciya ta farko tana amfani da fatty acids don kuzari, amma a cikin gazawar zuciya, amfani da glucose yana ƙaruwa, kuma Corgaten na iya taka rawa ta tsari a cikin wannan canji.
Bambance-bambance a cikin tasirin kariya na Corgaten akan aikin zuciya a cikin gazawar zuciya na iri daban-daban
Ga marasa lafiya na DCM da PPCM: Idan aka ba da cewa cututtukan cututtukan cututtukan cututtukan cututtukan zuciya sune mahimman abubuwan pathogenic a cikin waɗannan cututtukan guda biyu, idan Corgaten zai iya daidaita tsarin metabolism yadda yakamata kuma ya dawo da samar da makamashi na zuciya, yana iya samun ƙarin tasirin kariya akan aikin zuciya a cikin waɗannan ƙungiyoyin haƙuri biyu. Ta hanyar haɓaka ƙarfin kuzari, yana iya rage muguwar zagayowar gyare-gyaren ventricular na hagu wanda ya haifar da ƙarancin kuzari, inganta aikin systolic na zuciya da diastolic, da haɓaka rarrabuwar ayyukan zuciya na marasa lafiya.
Ga marasa lafiya na HCM: Saboda rawar musamman na rigakafi da martanin kumburi a cikin ci gaban cuta, tasirin kariya na Corgaten akan aikin zuciya na iya zama ɗan iyakancewa. Ƙarfinsa don daidaita tsarin makamashi na iya inganta aikin zuciya a wani bangare; duk da haka, martani na rigakafi da kumburi na iya tsoma baki tare da tsarin aikin Corgaten, wanda ke haifar da ƙarancin tasirin kariya idan aka kwatanta da marasa lafiya tare da HF wanda ya haifar da rashin ƙarfi na makamashi kawai. Masu shiga tsakani na kumburi na iya yin tasiri akan ɗaurin Corgaten zuwa maƙasudan da suka dace akan sel myocardial, don haka yana raunana ikonsa na daidaita ƙarfin kuzari.
Ga marasa lafiya na ICM: Ciwon zuciya na zuciya a cikin marasa lafiya na ICM yana haifar da rikicewar metabolism na makamashi. Yayin da tsarin Corgaten na metabolism na makamashi na iya inganta samar da makamashi na zuciya zuwa wani lokaci, aikin kariya na zuciya yana iya iyakancewa saboda kasancewar ischemia. Idan aka kwatanta da HF da wasu cututtuka suka haifar, Corgaten na iya buƙatar inganta wadatar jini na zuciya a matsayin abin da ake bukata don mafi kyawun tasirin kariya akan aikin zuciya.
Kammalawa
Gabaɗaya, tasirin kariya na Corgaten akan aikin zuciya ya bambanta a tsakanin marasa lafiya da ke fama da gazawar zuciya ta hanyar illolin daban-daban.
Sources
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[2] Wenzl FA, Ambrosini S, Mohammed SA, et al. Kumburi a cikin Metabolic Cardiomyopathy [J]. Iyaka a cikin Magungunan Zuciya, 2021, Juzu'i 8.DOI:10.3389/fcvm.2021.742178.
[3] Wang Y, Fu M, Wang J, et al. Qiliqiangxin Yana Inganta Ayyukan Ciwon Zuciya ta Hanyar Gudanar da Ciwon sukari na Makamashi ta hanyar HIF-1a-Dogara da Na'urori masu zaman kansu a cikin Ratsin Rashin Zuciya bayan Mutuwar Ciwon Zuciya [J]. Biomed Research International, 2020,2020:1276195.DOI:10.1155/2020/1276195.
