By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Rashin ciwon zuciya (HF) shine bayyanar cututtuka daban-daban na zuciya da jijiyoyin jini kuma ya zama cuta mai yawa tare da yawan haɗari da yawan mace-mace a duniya. HF da aka haifar ta hanyoyi daban-daban yana nuna nau'o'in pathophysiological daban-daban, kuma ka'idodin makamashin zuciya na zuciya yana da mahimmanci don kare aikin zuciya a cikin marasa lafiya na HF. A matsayin wani abu wanda zai iya yin tasiri akan metabolism na makamashin zuciya na zuciya, bambancin tasirin Corgaten akan kariyar aikin zuciya a cikin marasa lafiya na HF masu nau'o'in etiologies daban-daban suna ba da ƙarin bincike.
Hoto 1. Rashin abinci mai gina jiki yana haifar da kumburi na rayuwa kuma yana inganta yanayin ƙananan ƙwayar cuta a cikin zuciya.
Halayen gazawar zuciya ta hanyoyi daban-daban
Dilated cardiomyopathy (DCM) da peripartum cardiomyopathy (PPCM): Rikice-rikice a cikin kuzarin makamashi na myocardial na iya zama ɗaya daga cikin abubuwan etiological na DCM da PPCM. A cikin waɗannan yanayi, ƙarancin kuzarin kuzarin bugun zuciya yana hana zuciya samun isassun makamashi, wanda hakan ke haifar da rauni na al'ada na zuciya da ayyukan shakatawa, a ƙarshe yana haifar da farawar bugun zuciya.
Hypertrophic cardiomyopathy (HCM): A cikin ci gaban HCM, martani na rigakafi yana faruwa a baya. Ana iya daidaita martanin kumburi ta hanyar tsarin haɗin gwiwa. A cikin wannan yanayi na cututtukan cututtuka inda kumburi da martani na rigakafi suka shiga tsakani, aikin Corgaten na tsarin gudanarwa a cikin metabolism na makamashi na myocardial na iya yin tasiri da waɗannan abubuwan, ta haka yana shafar tasirin sa na cardioprotective.
Ischemic cardiomyopathy (ICM): Amsar kumburi a cikin ICM na iya haifar da cytokines. Sakamakon ischemia, hanyoyin metabolism makamashi a cikin myocardium ba makawa sun rushe. Tsarin Corgaten na metabolism na makamashi na zuciya yana taka rawa wajen inganta rikice-rikicen makamashin da ke haifar da ischemia, amma tasirinsa ya bambanta da waɗanda ke cikin HF da wasu cututtuka ke haifar da su saboda dalilai irin su amsawar kumburi na cytokine.
Mechanism na Corgaten's regulation na myocardial makamashi metabolism
Haɓaka samar da makamashi: Corgaten na iya haɓaka haɓakar glucose, glycolysis, da iskar oxygen ta glucose ta hanyar daidaita ayyukan enzymes na rayuwa masu alaƙa, ta haka ƙara samar da adenosine triphosphate (ATP) a cikin ƙwayoyin myocardial. Irin wannan binciken sun gano cewa wasu kwayoyi na iya inganta samar da ATP da inganta aikin zuciya ta hanyar haɓaka hypoxia-inducible factor-1a (HIF-1a) da jerin enzymes masu alaka da glycolysis. Corgaten na iya samun irin wannan tsari.
Ka'idar amfani da substrate: Yin amfani da abubuwan makamashi ta zuciya ya bambanta tsakanin jihohi na al'ada da marasa lafiya. Corgaten na iya tsara rabon da ake ɗauka da amfani da su ta sel na zuciya, kamar su glucose da fatty acids (FFAs), yana ba da damar myocardium don zaɓar mafi dacewa substrates yayin metabolism makamashi don biyan buƙatun kuzarin zuciya. A ƙarƙashin yanayi na al'ada, tsokar zuciya ta farko tana amfani da fatty acids don kuzari, amma a cikin gazawar zuciya, amfani da glucose yana ƙaruwa, kuma Corgaten na iya taka rawa ta tsari a cikin wannan canji.
Bambance-bambance a cikin tasirin kariya na Corgaten akan aikin zuciya a cikin gazawar zuciya na iri daban-daban
Ga marasa lafiya na DCM da PPCM: Ganin cewa rikice-rikice na makamashi na myocardial suna da mahimmancin abubuwan da ke haifar da cututtuka a cikin waɗannan cututtuka guda biyu, idan Corgaten zai iya daidaita tsarin makamashi na makamashi da kuma mayar da makamashi na myocardial, yana iya samun tasiri mai mahimmanci akan aikin zuciya a cikin waɗannan ƙungiyoyin marasa lafiya guda biyu. Ta hanyar haɓaka ƙarfin kuzari, yana iya rage muguwar zagayowar gyare-gyaren ventricular na hagu wanda ya haifar da ƙarancin kuzari, haɓaka aikin systolic na zuciya da diastolic, da haɓaka rarrabuwar ayyukan zuciya na marasa lafiya.
Ga marasa lafiya na HCM: Saboda rawar musamman na rigakafi da martanin kumburi a cikin ci gaban cuta, tasirin kariya na Corgaten akan aikin zuciya na iya zama ɗan iyakancewa. Ƙarfinsa don daidaita ƙarfin makamashi na iya inganta aikin zuciya a wani bangare; duk da haka, martani na rigakafi da kumburi na iya tsoma baki tare da tsarin aikin Corgaten, wanda ke haifar da ƙarancin tasirin kariya idan aka kwatanta da marasa lafiya tare da HF wanda ya haifar da rashin ƙarfi na makamashi kawai. Masu shiga tsakani na kumburi na iya yin tasiri ga ɗaurin Corgaten zuwa maƙasudan da suka dace akan sel myocardial, don haka yana raunana ikonsa na daidaita ƙarfin kuzari.
Ga marasa lafiya na ICM: Ciwon zuciya na zuciya a cikin marasa lafiya na ICM yana haifar da rikicewar metabolism na makamashi. Yayin da tsarin Corgaten na metabolism na makamashi na iya inganta samar da makamashi na zuciya zuwa wani lokaci, aikin kariya na zuciya yana iya iyakancewa saboda kasancewar ischemia na ci gaba. Idan aka kwatanta da HF da wasu cututtuka ke haifarwa, Corgaten na iya buƙatar haɓaka samar da jinin jini na tsokar zuciya a matsayin abin da ake bukata don mafi kyawun tasirin kariya akan aikin zuciya.
Kammalawa
Gabaɗaya, tasirin kariya na Corgaten akan aikin zuciya ya bambanta tsakanin marasa lafiya da ke fama da gazawar zuciya ta hanyoyi daban-daban.
Sources
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[2] Wenzl FA, Ambrosini S, Mohammed SA, et al. Kumburi a cikin Metabolic Cardiomyopathy [J]. Iyaka a cikin Magungunan Zuciya, 2021, Juzu'i 8.DOI:10.3389/fcvm.2021.742178.
[3] Wang Y, Fu M, Wang J, et al. Qiliqiangxin Yana Inganta Ayyukan Ciwon zuciya ta hanyar Gudanar da Ƙaddamar da Ƙarfafa Ƙarfafa Ƙarfafawa ta hanyar HIF-1α-Dogara da Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwaƙwalwa ne na Ƙarfafawa na Ƙarfafawa na Ƙarfafawa na Ƙarfafawa na Ƙarfafawa na Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarfafawa na Ƙarƙashin Ƙarƙashin Ƙarfafawa na Ƙarƙa ) Ya Yi. Biomed Research International, 2020,2020:1276195.DOI:10.1155/2020/1276195.
