Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Kunanirwa k'umutima (HF) ni uburyo bwo kwerekana indwara zitandukanye z'umutima n'imitsi kandi byabaye indwara yiganje cyane ku bantu benshi kandi bapfa ku isi. HF iterwa na etiologiya itandukanye yerekana uburyo butandukanye bwa patrophysiologique, kandi kugenzura ingufu za myocardial metabolism ningirakamaro mukurinda imikorere yumutima kubarwayi ba HF. Nkibintu bishobora guhindura imbaraga za myocardial metabolism, ingaruka zitandukanye za Corgaten mukurinda imikorere yumutima kubarwayi ba HF bafite etiologiya zitandukanye zirasaba ko hakorwa iperereza rindi.
Igicapo 1. Imirire mibi itera metabolic inflammation kandi iteza imbere urwego rwo hasi rwo gutwika mumutima.
Ibiranga kunanirwa k'umutima biterwa na etiologiya zitandukanye
Indwara ya Cardiomyopathie (DCM) na peripartum cardiomyopathie (PPCM): Ihungabana ry’ingufu za myocardial metabolism rishobora kuba imwe mu mpamvu ziterwa na DCM na PPCM. Muri ibi bihe, imbaraga zidasanzwe za myocardial metabolism zibuza umutima kubona ingufu zihagije, bityo bikabangamira imikorere isanzwe yumutima no kuruhuka, amaherezo biganisha ku gutangira kunanirwa k'umutima.
Hypertrophic cardiomyopathie (HCM): Mu iterambere rya HCM, ibisubizo byubudahangarwa bibaho hakiri kare. Ibisubizo bitwika birashobora guhuzwa na sisitemu yuzuzanya. Muri ibi bidukikije by’indwara aho gutwika no gukingira indwara bifitanye isano, uruhare rwa Corgaten mu kugenzura ingufu za myocardial metabolism rushobora guterwa nibi bintu, bityo bikagira ingaruka ku ngaruka z'umutima.
Ischemic cardiomyopathie (ICM): Igisubizo cyo gutwika muri ICM gishobora guterwa na cytokine. Bitewe na ischemia, inzira ya metabolism yingufu muri myocardium byanze bikunze ihungabana. Amabwiriza ya Corgaten agenga ingufu za myocardial metabolism agira uruhare mukuzamura ihungabana ryingufu ziterwa na ischemia, ariko ingaruka zayo ziratandukanye nizo muri HF ziterwa nizindi etiologiya bitewe nibintu nka cytokine-medrated inflammatory reaction.
Uburyo bwa Corgaten igenga ingufu za myocardial metabolism
Gutezimbere ingufu: Corgaten irashobora guteza glucose gufata, glycolysis, na okiside ya glucose muguhindura ibikorwa byimisemburo ya metabolike ifitanye isano, bityo bikongera umusaruro wa adenosine triphosphate (ATP) muri selile myocardial. Ubushakashatsi nkubu bwerekanye ko imiti imwe n'imwe ishobora guteza imbere umusaruro wa ATP no kunoza imikorere yumutima muguhuza hypoxia-inducable factor-1α (HIF-1α) hamwe nuruhererekane rwimisemburo ifitanye isano na glycolysis. Corgaten irashobora kugira uburyo busa.
Kugena imikoreshereze yubutaka: Gukoresha insimburangingo zingufu zumutima biratandukanye hagati yubuzima busanzwe nuburwayi. Corgaten irashobora kugena igipimo cyo gufata insimburangingo no gukoreshwa na selile myocardial, nka glucose na acide fatty acide (FFAs), bigatuma myocardium ihitamo insimburangingo ikwiye mugihe cyo guhinduranya ingufu zumutima. Mubihe bisanzwe, imitsi yumutima ikoresha cyane cyane aside irike yingufu, ariko mugihe umutima wananiranye, ikoreshwa rya glucose ryiyongera, kandi Corgaten irashobora kugira uruhare runini muriyi nzibacyuho.
Itandukaniro mubikorwa byo kurinda Corgaten kumikorere yumutima mugutsindwa kwumutima wa etiologiya zitandukanye
Ku barwayi ba DCM na PPCM: Urebye ko indwara ya myocardial ingufu metabolism ari ibintu by'ingenzi bitera indwara muri izi ndwara zombi, niba Corgaten ishobora kugenzura neza metabolisme y’ingufu no kugarura ingufu za myocardial, irashobora kugira ingaruka zikomeye zo kurinda imikorere yumutima muri aya matsinda yombi y’abarwayi. Mugutezimbere imbaraga za metabolisme, irashobora kugabanya inzitizi mbi yo kuvugurura amashanyarazi yibumoso iterwa no kubura ingufu, kunoza imikorere yimitsi yumutima na diastolique, no kuzamura imikorere yumutima yumurwayi.
Ku barwayi ba HCM: Bitewe n'uruhare rwihariye rw'ubudahangarwa bw'umubiri ndetse no gutwika indwara mu gutera indwara, ingaruka zo gukingira Corgaten ku mikorere y'umutima zishobora kuba nke. Ubushobozi bwayo bwo kugenzura ingufu za metabolisme zirashobora kunoza igice cyimikorere yumutima; icyakora, ibisubizo byubudahangarwa no gutwika bishobora kubangamira uburyo bwa Corgaten bwibikorwa, bikavamo ingaruka zitagaragara zo kurinda ugereranije n’abarwayi barwaye HF biterwa gusa n’ingaruka ziterwa na metabolism. Abunzi b'umuriro barashobora kugira ingaruka kuri Corgaten guhuza intego zijyanye na selile myocardial, bityo bikagabanya ubushobozi bwayo bwo kugenzura imbaraga za metabolism.
Ku barwayi ba ICM: Ischemia ya Myocardial mu barwayi ba ICM itera indwara ziterwa na metabolism. Mugihe Corgaten igenga ingufu za metabolisme yingufu zishobora guteza imbere ingufu za myocardial ku rugero runaka, imikorere yumutima yumutima irashobora no kugarukira kuberako ischemia ikomeza kubaho. Ugereranije na HF iterwa nizindi etiologiya, Corgaten irashobora gukenera kunoza itangwa ryamaraso ya myocardial nkibisabwa kugirango irusheho kugira ingaruka nziza zo kurinda imikorere yumutima.
Umwanzuro
Muri rusange, ingaruka zo kurinda Corgaten kumikorere yumutima ziratandukanye mubarwayi bafite ikibazo cyumutima uterwa na etiologiya zitandukanye.
Inkomoko
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[2] Wenzl FA, Ambrosini S, Mohammed SA, n'abandi. Gutwika muri Cardiomyopathie Metabolic [J]. Imipaka mu buvuzi bw'umutima n'imitsi, 2021, Umubumbe wa 8.DOI: 10.3389 / fcvm.2021.742178.
[3] Wang Y, Fu M, Wang J, n'abandi. Qiliqiangxin Itezimbere Imikorere Yumutima binyuze mu Kugena Metabolisme Yingufu Binyuze muri HIF-1α-Biterwa kandi nuburyo bwigenga mu mbeba zananirwa kumutima nyuma yindwara ikaze ya Myocardial [J]. Ubushakashatsi bwa Biomed International, 2020,2020: 1276195.DOI: 10.1155 / 2020/1276195.
