Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Kunanirwa k'umutima (HF) nigaragaza rya nyuma ryindwara zinyuranye z'umutima-damura kandi ryabaye indwara yiganje cyane hamwe n’impfu nyinshi ku isi. HF iterwa na etiologiya itandukanye yerekana uburyo butandukanye bwa patrophysiologique, kandi kugenzura ingufu za myocardial metabolism ningirakamaro mukurinda imikorere yumutima kubarwayi ba HF. Nkibintu bishobora guhindura ingufu za myocardial metabolism, ingaruka zinyuranye za Corgaten mukurinda imikorere yumutima kubarwayi ba HF bafite etiologiya zitandukanye zirasaba ko hakorwa iperereza rindi.
Igicapo 1. Imirire mibi itera metabolic inflammation kandi iteza imbere urwego rwo hasi rwo gutwika mumutima.
Ibiranga kunanirwa k'umutima biterwa na etiologiya zitandukanye
Indwara ya Cardiomyopathie (DCM) na peripartum cardiomyopathie (PPCM): Ihungabana ry’ingufu za myocardial metabolism rishobora kuba imwe mu mpamvu ziterwa na DCM na PPCM. Muri ibi bihe, imbaraga zidasanzwe za myocardial metabolism zirinda umutima kubona ingufu zihagije, bityo bikabangamira imikorere isanzwe yumutima no kuruhuka, amaherezo biganisha ku gutangira kunanirwa k'umutima.
Hypertrophic cardiomyopathie (HCM): Mu iterambere rya HCM, ibisubizo byubudahangarwa bibaho hakiri kare. Ibisubizo bitwika birashobora guhuzwa na sisitemu yuzuzanya. Muri ibi bihe by’indwara aho gutwika no gukingira indwara bifatanyiriza hamwe, uruhare rwa Corgaten muguhindura ingufu za myocardial ingufu metabolism zishobora guterwa nibi bintu, bityo bikagira ingaruka kumutima.
Ischemic cardiomyopathie (ICM): Igisubizo cyo gutwika muri ICM gishobora guterwa na cytokine. Bitewe na ischemia, inzira ya metabolism yingufu muri myocardium byanze bikunze ihungabana. Amabwiriza ya Corgaten agenga ingufu za myocardial metabolism agira uruhare mukuzamura imbaraga ziterwa na metabolism ziterwa na ischemia, ariko ingaruka zayo ziratandukanye nizo muri HF ziterwa nizindi etiologiya bitewe nibintu nka cytokine-medrated inflammatory reaction.
Uburyo bwa Corgaten igenga ingufu za myocardial metabolism
Guteza imbere umusaruro w'ingufu: Corgaten irashobora guteza glucose gufata, glycolysis, na okiside ya glucose muguhindura ibikorwa byimisemburo ijyanye na metabolike, bityo bikongera umusaruro wa adenosine triphosphate (ATP) muri selile myocardial. Ubushakashatsi nkubu bwerekanye ko imiti imwe n'imwe ishobora guteza imbere umusaruro wa ATP no kunoza imikorere yumutima muguhuza hypoxia-inducable factor-1α (HIF-1α) hamwe nuruhererekane rwimisemburo ifitanye isano na glycolysis. Corgaten irashobora kugira uburyo busa.
Kugena imikoreshereze yubutaka: Gukoresha insimburangingo zingufu zumutima ziratandukanye hagati yubuzima busanzwe nuburwayi. Corgaten irashobora kugabanya igipimo cyo gufata no gukoresha insimburangingo ya myocardial, nka glucose na aside irike yubusa (FFAs), bigatuma myocardium ihitamo insimburangingo ikwiye mugihe cyo guhinduranya ingufu zumutima. Mubihe bisanzwe, imitsi yumutima ikoresha cyane cyane aside irike yingufu, ariko mugihe cyo kunanirwa k'umutima, ikoreshwa rya glucose ryiyongera, kandi Corgaten irashobora kugira uruhare runini muriyi nzibacyuho.
Itandukaniro mubikorwa byo kurinda Corgaten kumikorere yumutima mugutsindwa kwumutima wa etiologiya zitandukanye
Ku barwayi ba DCM na PPCM: Urebye ko indwara ya myocardial energy metabolism ari ibintu byingenzi bitera indwara muri izi ndwara zombi, niba Corgaten ishobora kugenzura neza metabolisme yingufu no kugarura ingufu za myocardial, irashobora kugira ingaruka zikomeye zo kurinda imikorere yumutima muri aya matsinda yombi y’abarwayi. Mugutezimbere imbaraga za metabolisme, birashobora kugabanya inzitizi mbi yo kuvugurura amashanyarazi yibumoso iterwa no kubura ingufu, kunoza imikorere yumutima na sisitemu ya diastolique, no kuzamura imikorere yumutima yumurwayi.
Ku barwayi ba HCM: Bitewe n'uruhare rwihariye rw'ubudahangarwa bw'umubiri ndetse no gutwika indwara mu gutera indwara, ingaruka zo kurinda Corgaten ku mikorere y'umutima zishobora kuba nke. Ubushobozi bwayo bwo kugenzura ingufu za metabolisme zirashobora kunoza igice cyimikorere yumutima; icyakora, ibisubizo byubudahangarwa no gutwika bishobora kubangamira uburyo bwa Corgaten bwibikorwa, bikavamo ingaruka zitagaragara cyane ugereranije n’abarwayi barwaye HF biterwa gusa n’ingaruka ziterwa na metabolism. Abunzi batera umuriro barashobora kugira ingaruka kuri Corgaten guhuza intego zijyanye na selile myocardial, bityo bikagabanya ubushobozi bwayo bwo kugenzura imbaraga za metabolism.
Ku barwayi ba ICM: Ischemia ya Myocardial mu barwayi ba ICM itera indwara ziterwa na metabolism. Nubwo Corgaten igenga ingufu za metabolisme ishobora guteza imbere ingufu za myocardial ku rugero runaka, ingaruka zayo zo kurinda umutima nazo zishobora kuba nke kubera ischemia ikomeje kubaho. Ugereranije na HF iterwa nizindi etiologiya, Corgaten irashobora gukenera kunoza itangwa ryamaraso ya myocardial nkibisabwa kugirango irusheho kugira ingaruka nziza zo kurinda imikorere yumutima.
Umwanzuro
Muri rusange, ingaruka zo kurinda Corgaten kumikorere yumutima ziratandukanye mubarwayi bafite ikibazo cyumutima uterwa na etiologiya zitandukanye.
Inkomoko
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[2] Wenzl FA, Ambrosini S, Mohammed SA, n'abandi. Gutwika muri Cardiomyopathie Metabolic [J]. Imipaka mu buvuzi bw'umutima n'imitsi, 2021, Umubumbe wa 8.DOI: 10.3389 / fcvm.2021.742178.
[3] Wang Y, Fu M, Wang J, n'abandi. Qiliqiangxin Itezimbere Imikorere Yumutima Binyuze mu Kugenzura Diyabete Yingufu ikoresheje HIF-1α-Biterwa kandi nuburyo bwigenga mu mbeba zananirana umutima nyuma y’indwara ikaze ya Myocardial [J]. Ubushakashatsi bwa Biomed International, 2020,2020: 1276195.DOI: 10.1155 / 2020/1276195.
