By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Obi mgbawa (HF) bụ ngosipụta njedebe nke ọrịa obi dị iche iche ma bụrụkwa ọrịa juru ebe niile na ọnụ ọgụgụ ọnwụ dị elu n'ụwa niile. HF kpatara site na etiologies dị iche iche na-egosipụta usoro pathophysiological dị iche iche, na nhazi nke ike myocardial ike metabolism dị oke mkpa maka ichekwa ọrụ obi na ndị ọrịa HF. Dị ka ihe nwere ike imetụta metabolism ike myocardial, mmetụta dị iche iche nke Corgaten na nchebe ọrụ obi na ndị ọrịa HF nwere etiologies dị iche iche na-enye ohere nyocha ọzọ.
Onyonyo 1. Iri nri na-edozi ahụ na-ebuli mbufụt nke metabolic ma na-akwalite ọnọdụ mkpali dị ala na obi.
Njirimara nke nkụda obi nke etiologies dị iche iche kpatara
Dilated cardiomyopathy (DCM) na peripartum cardiomyopathy (PPCM): Ọgbaghara na myocardial ume metabolism nwere ike ịbụ otu n'ime ihe etiological nke DCM na PPCM. N'ọnọdụ ndị a, metabolism ike myocardial na-adịghị mma na-egbochi obi ịnweta ike zuru oke, si otú ahụ na-emebi mkpụkọ obi nkịtị na ọrụ ntụrụndụ nkịtị, n'ikpeazụ na-eduga ná mmalite nke nkụda mmụọ.
Hypertrophic cardiomyopathy (HCM): Na ọganihu nke HCM, nzaghachi mgbochi na-eme na mbụ. Azịza mkparị nwere ike ịgbazite site na usoro mmeju. N'ebe a na-ahụ maka ọrịa ọrịa ebe mbufụt na nzaghachi mgbochi ọrịa na-ejikọta ọnụ, ọrụ nchịkwa nke Corgaten na myocardial ume metabolism nwere ike imetụta ihe ndị a, si otú ahụ na-emetụta mmetụta ya na cardioprotective.
Ischemic cardiomyopathy (ICM): cytokines nwere ike ịkpalite mmeghachi omume mkpasu iwe na ICM. N'ihi ischemia, usoro metabolic ike na myocardium na-emebi emebi. Usoro nke Corgaten nke myocardial ume metabolism na-ekere òkè n'ịkwalite nsogbu metabolism ume nke ischemia kpatara, mana mmetụta ya dị iche na nke dị na HF nke etiologies ndị ọzọ kpatara n'ihi ihe ndị dị ka nzaghachi mkpali nke cytokine.
Usoro nke usoro Corgaten nke ike myocardial metabolism
Ịkwalite mmepụta ume: Corgaten nwere ike ịkwalite nnabata glucose, glycolysis, na glucose oxidation site na ịhazi ọrụ nke enzymes metabolic metụtara ya, si otú ahụ na-abawanye mmepụta nke adenosine triphosphate (ATP) na sel myocardial. Nnyocha ndị dị otú ahụ achọpụtala na ọgwụ ụfọdụ nwere ike ịkwalite mmepụta ATP ma melite ọrụ obi site n'ịkwalite hypoxia-inducible factor-1α (HIF-1α) na usoro nke enzymes metụtara glycolysis. Corgaten nwere ike ịnwe usoro yiri ya.
Iwu nke itinye mkpụrụ osisi: Ojiji nke mkpụrụ ike sitere na obi dị iche n'etiti steeti nkịtị na nke ọrịa. Corgaten nwere ike ịhazi oke nnabata na ojiji nke mkpụrụ ndụ myocardial, dị ka glucose na fatty acids (FFAs), na-enyere myocardium aka ịhọrọ mkpụrụ dabara adaba karịa n'oge metabolism ike iji gboo mkpa ume obi. N'okpuru ọnọdụ nkịtị, akwara obi na-ejikarị acid fatty eme ihe maka ume, mana na nkụda mmụọ obi, ojiji glucose na-abawanye, Corgaten nwere ike rụọ ọrụ nchịkwa na mgbanwe a.
Ọdịiche dị na mmetụta nchebe Corgaten na arụ ọrụ obi na nkụda obi nke etiologies dị iche iche
Maka ndị ọrịa DCM na PPCM: Nyere na ọrịa myocardial ume metabolism bụ ihe dị mkpa na-akpata pathogenic na ọrịa abụọ a, ọ bụrụ na Corgaten nwere ike ịhazigharị ume ike nke ọma ma weghachite ike myocardial, ọ nwere ike inwe mmetụta nchebe dị ịrịba ama na ọrụ obi na ndị ọrịa abụọ a. Site n'ịkwalite metabolism ike, ọ nwere ike ibelata ajọ usoro ngbanwe nke ventricular aka ekpe nke ụkọ ike kpatara, kwalite systolic obi na ọrụ diastolic, ma kwalite nhazi ọrụ obi ndị ọrịa.
Maka ndị ọrịa HCM: N'ihi ọrụ pụrụ iche nke mmeghachi omume mgbochi na mkpasu iwe na ọganihu ọrịa, mmetụta nchebe Corgaten na ọrụ obi nwere ike ịdị ntakịrị. Ikike ya ịchịkwa metabolism ike nwere ike ime ka ọrụ obi dịkwuo mma; Otú ọ dị, nzaghachi mgbochi na mkpasu iwe nwere ike igbochi usoro Corgaten si arụ ọrụ, na-ebute mmetụta nchebe na-adịghị ahụkebe ma e jiri ya tụnyere ndị ọrịa nwere HF kpatara naanị nsogbu metabolism ume. Ndị ogbugbo mkparị nwere ike imetụta njikọ nke Corgaten na ebumnuche ndị dị mkpa na sel myocardial, si otú ahụ na-ebelata ikike ya ịhazi metabolism ike.
Maka ndị ọrịa ICM: Myocardial ischemia na ndị ọrịa ICM na-eduga na nsogbu metabolism ike. Ọ bụ ezie na ụkpụrụ nke Corgaten nke metabolism ike nwere ike ime ka ike myocardial dịkwuo mma ruo n'ókè ụfọdụ, ọrụ nchebe obi ya nwekwara ike ịdị oke n'ihi ọnụnọ ischemia na-adịgide adịgide. Tụnyere HF nke etiologies ndị ọzọ kpatara, Corgaten nwere ike imeziwanye ọkọnọ ọbara myocardial dị ka ihe a ga-achọrịrị iji gosipụta mmetụta nchebe ya nke ọma na ọrụ obi.
Mmechi
N'ozuzu, mmetụta nchebe nke Corgaten na ọrụ obi dị iche iche n'etiti ndị ọrịa nwere nkụda mmụọ nke etiologies dị iche iche kpatara.
Isi mmalite
[1] Sun H, Li X, Yuan H, et al. Ọmụmụ ihe atụnyere ọganihu ọrịa maka ịda mbà n'obi na etiologies dị iche iche site na nyocha netwọk oge [J]. Akwụkwọ akụkọ American Journal of Translational Research, 2022,14 (9): 6604-6617.
[2] Wenzl FA, Ambrosini S, Mohammed SA, et al. Mbufụt na Metabolic Cardiomyopathy [J]. Oke na ọgwụ obi obi, 2021, Mpịakọta 8.DOI:10.3389/fcvm.2021.742178.
[3] Wang Y, Fu M, Wang J, et al. Qiliqiangxin na-eme ka ọrụ obi dịkwuo mma site n'ịchịkwa ike metabolism site na HIF-1a-Dabere na usoro nke onwe ya na oke ọdịda obi na-ada mbà mgbe Myocardial Infarction [J]. Biomed Research International, 2020,2020:1276195.DOI:10.1155/2020/1276195.
