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CagrilintideStructure Imiterere ya
Inkomoko: PubChem |
Urukurikirane: Pyr-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP CAS: 1415456-99-3 Inzira: C 174H 269N 45O 52S.2 MW 4409 g / mol |
Research Ubushakashatsi bwa Cagrilintide
Inkomoko ya Cagrilintide ni iyihe?
Cagrilintide - igereranya rya amylin ：
Amylin ni imisemburo isohorwa na pancreatic islet β selile. Mugihe cyimiterere yumubiri, ikorana na insuline kandi ifite ibikorwa byinshi byingenzi byimikorere.
Ubwa mbere, amylin igira uruhare runini mugutera guhaga no kugabanya ibiryo. Uburyo bwibikorwa byabwo ahanini burimo gukora reseptors muri Area Postrema munsi yumushinga wa kane. Ibimenyetso by'imyakura byanduzwa imbere binyuze muri Nucleus yo mu gice cya Solitar. Icyarimwe, zirashobora kandi gushikirizwa mu gice cya Hypothalamic Lateral hamwe nandi matsinda ya kirimbuzi ya hypothalamic binyuze muri Nucleus ya Lateral Parabrachial. Amylin afite ubushobozi bwo gukangura ikigo gihaza ibinyabuzima no kubuza gufata ibiryo mu nyamaswa [1].
Amylin ishoboye kugenzura glucose homeostasis, igerwaho no kubuza gusohora insuline na glucagon [2] . Iyi mikorere igira uruhare runini mu kubungabunga umutekano w’amaraso glucose kandi ifite akamaro kanini mu kuvura indwara nka diyabete.
Byongeye kandi, amylin igira ingaruka zayo muguhindura irekurwa rya neurotransmitter. Kurugero, irabuza irekurwa rya dopamine muri hypothalamus yimbeba, mugihe bigira ingaruka nkeya kuri norepinephrine na serotonine [3] . Mu rwego rwa glucose homeostasis, amylin ikomeza glucose yamaraso mu guhagarika ururenda rwa insuline na glucagon. Muburyo bukubiyemo harimo gukora ku buryo butaziguye islet ya pancreatic islet α selile no kugenzura mu buryo butaziguye glucagon isohoka binyuze mu kwanduza ibimenyetso bya neural muri hypothalamus. Ku barwayi barwaye diyabete, isenywa rya β selile ntiritera gusa kubura insuline ahubwo binagabanya kugabanuka kw'isohoka rya C-peptide na amyline. Ikigaragara ni uko Amylin agira uruhare mu kugenzura glucose homeostasis mu kubuza gusiba gastrica no kubyara hepatike glucose nyuma yo kugabanuka, amaherezo bikagabanya ihindagurika ry’amaraso ya glucose nyuma y’inyuma [4] . Byongeye kandi, amylin irashobora gutinza igifu, ikabuza gastrointestinal peristalsis ikoresheje sisitemu yo hagati yo hagati, kandi ikongerera igihe cyo kurya mu nzira ya gastrointestinal, bityo bikarinda kwiyongera kwamaraso glucose.
Nubwo bimeze bityo, amylin ifite igice gito cyubuzima, igabanya ikoreshwa ryayo. Ubushakashatsi bwerekana ko igereranya rya amylin risanzwe, pramlintide, nk'umuti wungirije wo kuvura diyabete, bisaba ubuyobozi inshuro eshatu kumunsi. Ibi ntibitera gusa ikibazo kubarwayi ahubwo binagabanya kubahiriza [5] . Kugira ngo ikibazo gikemuke igice cya kabiri cyubuzima bwa amyline karemano, Cagrilintide yatejwe imbere nkikigereranyo kirekire. Iterambere rya Cagrilintide rishingiye ku gusobanukirwa byimbitse imikorere ya physiologique ya amyline karemano. Igamije kwigana uburyo bwibikorwa bya amylin mugihe byongera umutekano hamwe nigihe kirekire cyimiti yibiyobyabwenge kugirango byuzuze ibisabwa mubuvuzi.
Ibishobora na Farumasi Ibintu bya Cagrilintide
Cagrilintide nigitabo kimaze igihe kinini gikora amylin analogue ifite imbaraga zikomeye, kigaragaza ingaruka zidasanzwe mukuvura umubyibuho ukabije na diyabete. Ifite amavuta kandi ifite imiterere ihamye-ikora [5] . Amylin ni imisemburo ifatanije na pancreatic β selile hamwe na insuline, itera guhaga ikora mukarere ka homeostatike na hedonic yubwonko. Nka analogue ya amylin, Cagrilintide irashobora kwigana izi ngaruka, itera guhaga bityo igafasha kugenzura ibiro. Byongeye kandi, Cagrilintide ni amiline ebyiri na calcitonine reseptor agonist, ikomoka ku mugongo wa amylin, ikayiha uburyo bwihariye bwo gukora mu kugenzura metabolike.
Iterambere ryubushakashatsi bwa Clinical kuri Cagrilintide
Mu bigeragezo bivura, Cagrilintide yatanze ibisubizo bitanga umusaruro mukugabanya ibiro. Kurugero, murwego rwinshi, ruteganijwe, impumyi ebyiri, igenzurwa na platbo, kandi igenzurwa cyane nicyiciro cya 2 cyo gushakisha dose, abitabiriye ubuvuzi hamwe na Cagrilintide berekanye ko bagabanutse ibiro ugereranije nabakiriye ikibanza. Ikigereranyo cyo kugabanya ibiro uhereye kumurongo wibanze kuri dosiye zose za Cagrilintide (0.3 - 4.5 mg) yari hejuru (6.0% - 10.8%) ugereranije niyitsinda rya placebo (3.0%). Kugabanya ibiro mu itsinda byavuwe hamwe na 4.5 mg ya Cagrilintide nabyo byari byinshi kuruta ibyo mu itsinda ryavuwe na mg 3.0 za liraglutide (10.8% na 9.0%). Ibisubizo byerekana ko Cagrilintide ishobora kuba uburyo bwiza bwo gucunga ibiro [6].
Cagrilintide na GLP-1 reseptor agonist semaglutide ifite uburyo butandukanye ariko bufitanye isano. Semaglutid igira ingaruka zayo ikora kuri reseptor ya GLP-1 muri hypothalamus, biganisha ku kugabanuka kwa appetit, kwiyongera kwa insuline, no gutinda gusohora gastric. Ibinyuranye, Cagrilintide irwanya ubushake bwo kurya mugukoresha reseptor ya amylin. Ubuyobozi bukomatanyije bwibi bikoresho byombi butera ingaruka zidasanzwe kuri appetit hakoreshejwe uburyo bwinshi, bikazamura cyane ibiro byo kugabanya ibiro [7] . Urebye imiterere igoye yumubyibuho ukabije, kuvura hamwe byibanda kumpamvu nyinshi za pathophysiologique byerekana ingamba zifatika kandi nziza.
Byongeye kandi, Cagrilintide yerekanye kandi ubushobozi bwo kugenzura amaraso glucose mu barwayi bafite diyabete yo mu bwoko bwa 2. Iperereza ry’amavuriro ryerekanye ko Cagrilintide igaragaza ituze kandi ikora neza mu gucunga umubyibuho ukabije ndetse na diyabete yo mu bwoko bwa 2. Kurugero, mugeragezwa kwa clinique irimo abarwayi ba diyabete yo mu bwoko bwa 2, guhuza Cagrilintide na GLP-1 reseptor agonist semaglutide byagaragaje uburyo budasanzwe bwo kugenzura amaraso glucose ningaruka zo kugabanya ibiro. Ibi byerekana ko Cagrilintide ikomeza urwego rwo hejuru ruhamye mubikorwa byubuvuzi kandi ikaba ishobora kugira ingaruka zihoraho zo kuvura. Mu kindi kigeragezo cy’amavuriro, Cagrilintide, yaba ikozwe wenyine cyangwa ifatanije na semaglutide, yerekanye kwihanganira umutekano n’umutekano [8] . Ibi kandi bishimangira ituze rya Cagrilintide, nkuko mubisabwa mubuvuzi, ituze ryibiyobyabwenge rifitanye isano cyane no kwihanganira umutekano.
Hanyuma, mubigeragezo byamavuriro, kuvura hamwe na cagrilintide byihanganiye. Mu cyiciro cya 2 ikigereranyo cyo gushakisha, ibipimo byo guhagarika imiti ihoraho byagereranijwe mumatsinda atandukanye yo kuvura, ahanini biterwa nibintu bibi. Nubwo bimeze bityo ariko, ibintu byakunze kugaragara cyane ni indwara zo mu gifu no gutera inshinge, aho usanga benshi bitagoranye kandi bikabije. Mu igeragezwa ryateganijwe, rigenzurwa icyiciro cya 1b, kuvura hamwe na cagrilintide na mg 2,4 za semaglutide nabyo byagaragaje kwihanganira neza hamwe numwirondoro wumutekano wemewe [9]. Ibigeragezo binini kandi birebire biremewe mugihe kizaza kugirango dusuzume byimazeyo imikorere numutekano byiyi miti ivura.
Imiterere yuburyo bwa Cagrinlintide
Inkomoko: PubMed [5]
Akamaro ko gukoresha Cagrilintide
Kugaragara kwa Cagrilintide byazanye ibyiringiro bishya byo kuvura umubyibuho ukabije na diyabete yo mu bwoko bwa 2. Nubwo ubukana bwikibazo cy’umubyibuho ukabije ku isi, uburyo bwemewe bwo kuvura imiti buracyari buke. Nkigitabo kimaze igihe kinini cyitwa amylin analogue, Cagrilintide itanga uburyo bushya bwo kuvura abarwayi bafite umubyibuho ukabije, cyane cyane abadafite ibisubizo bibi kubuzima bwabo kandi ntibakwiriye kubagwa ibibari. Igera ku micungire y’ibiro ikoresheje uburyo bwihariye bwibikorwa, itanga ibitekerezo nuburyo bushya bwo kuvura umubyibuho ukabije, kandi irashobora kwerekana imikorere myiza n’umutekano ugereranije n’ibiyobyabwenge gakondo birwanya umubyibuho ukabije [7] . Byongeye kandi, ikibazo cyatsinzwe cyo guhuza Cagrilintide na semaglutide (CagriSema) cyerekana ko uburyo bwo kuvura bwibasiye intego nyinshi za patrophysiologique ari ingamba zifatika zo kongera igisubizo cy’ubuvuzi mu mubyibuho ukabije [8] . Ubu buryo bwo kuvura butandukanye ntabwo butanga paradizo nshya yo gucunga umubyibuho ukabije ahubwo binazana iterambere ryinshi rya metabolike kubarwayi barwaye diyabete yo mu bwoko bwa 2.
Mu gusoza, nk'igitabo kimaze igihe kinini gikora amylin analogue, Cagrilintide ifite imbaraga zidasanzwe zo kugabanya ibiro no kurwanya glucose yamaraso. Ikora inzira yerekana ibimenyetso byuzuye yigana ibikorwa bya amylin kandi igenga metabolisme nka agoniste ya reseptor ebyiri. Igeragezwa rya Clinical ryerekanye ko Cagrilintide, ikoreshwa wenyine cyangwa ifatanije na semaglutide, ishobora kugabanya cyane ibiro byumubiri kandi irihanganirwa. Byongeye kandi, yerekanye kandi ubushobozi bwiza bwo kugenzura amaraso glucose ku barwayi barwaye diyabete yo mu bwoko bwa 2, itanga amahitamo mashya yo kuvura umubyibuho ukabije na diyabete no kuziba icyuho mu buryo bwo kuvura buriho, cyane cyane ku barwayi bafite ibibazo bidakwiriye ku mibereho yabo kandi badakwiriye kubagwa. Ingamba zayo zitandukanye zo kuvura zitanga ubumenyi bushya bwo gucunga indwara ziterwa na metabolike.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Dr. DCW Lau ni umwarimu mu ishuri ry'ubuvuzi rya Cumming, kaminuza ya Calgary, muri Kanada. Ibyifuzo bye mubushakashatsi bikubiyemo endocrinology na metabolism, ubuvuzi rusange n’imbere, sisitemu yumutima nimiyoboro yumutima, umutima rusange, ubuzima rusange bwibidukikije ndetse nubuzima bwakazi, ndetse na onkologiya. Afite kandi imyanya muri serivisi z'ubuzima za Alberta (AHS) na Obesity Canada kandi akora mu kigo cy’ubushakashatsi cya Diabete ya Julia McFarlane. Dr. Lau afite ubunararibonye mu bijyanye na diyabete n'ubushakashatsi bw'umubyibuho ukabije, hamwe n'ibikorwa bye byasohotse mu binyamakuru byigisha nk'ikinyamakuru cyo muri Kanada cya Diyabete. Muganga DCW yanditse kurutonde rwibisobanuro [6].
