ARA-290 miligaramu 16

▎ ARA-290 Jatebɔcogo

Sɔrɔyɔrɔ: PubChem

A kɛcogo: XEQLERALNSS Formula molekilɛri: C 51H 84N 16O21 Molecules girinya: 1257,3g/mol CAS nimɔrɔ:1208243-50-8 PubChem CID:91810664. Bamako, Mali Kɔrɔɲɔgɔnmaw: Cibinetide

▎ ARA-290 Sɛgɛsɛgɛli

ARA-290 ka ɲininiw kɛcogo ye mun ye?  

ARA-290 yiriwali bɔra eritoropoyitini (EPO) furakɛli seko sɛgɛsɛgɛli la. Dɔnniyakɛlaw y’a ye ko EPO tɛ joli-sira-funu dɔrɔn de sabati, nka a bɛ farikolo yɔrɔw lakanani baara fana kɛ i n’a fɔ funu kɛlɛli ani apoptose kɛlɛli. Nka, EPO ka joli-sira-funu lawulili bɛ se ka dɔ fara joli sɔgɔli kan ani farati wɛrɛw, o bɛ dan sigi a tali la banaw furakɛli la minnu tɛ jolidɛsɛ ye. Walasa ka EPO ka farikolo yɔrɔw lakanani nɔw mara ka sɔrɔ k’u yɛrɛ tanga a ka joli-sira-funu kɔlɔlɔw ma, ɲininikɛlaw y’a daminɛ ka pepitiri bɔlenw dilan, o kɛra sababu ye ka ARA-290 da.  

Ni ɲininiw kɛra ka ɲɛ, ARA-290 nafa kɛrɛnkɛrɛnnenw dɔnna dɔɔni dɔɔni. A bɛ banakisɛfagalanw ni farikolo yɔrɔw dilancogo taamasiɲɛw siraw baara ni a sirili ye bangekɔlɔsi fɛɛrɛw la (IRR), o bɛ nɔ ɲumanw jira sukarodunbana gɛlɛyaw, hakiliɲagami ani sugunɛ joginw furakɛli la. O sɔrɔlen ninnu ye ARA-290 ɲinini wɛrɛw ni kɛnɛyaso baarakɛcogo jusigilan sigi senkan ani ka furakɛli fɛɛrɛ kuraw labɛnni sabati minnu sinsinnen bɛ pepitiriw kan minnu bɔra EPO la.  

ARA-290 ka baarakɛcogo ye mun ye?  

Funu kɛlɛli nɔ : ARA-290 bɛ funu sitokiniw bɔli bali, o la, a bɛ dɔ bɔ funu jaabiw la, i n’a fɔ a jiralen bɛ cogo min na bana caman misaliw la. Misali la, sosow ka misali la, lupus érythématose systémique (SLE) la, a bɛ dɔ bɔ funubana sitokiniw IL-6, MCP-1 ani TNF-α hakɛ la joli la, ka SLE taamasiɲɛw ɲɛ{#Dahan, A,2016} (Dahan A, 2016). Sisplatini bɛ sugunɛbilenni modɛli la, a bɛ dɔ bɔ banakisɛfagalanw na minnu bɛ wele ko TNFα, IL6, ani IL1β, ka sugunɛ funu nɔgɔya ^[2] (Ghassemi-Barghi N, 2023). A ka banakisɛfagalanw bɛ se ka kɛ sababu ye ka bangekɔlɔsi dilanbaga (IRR) laɲini, o ye eritoropoyitini minɛbaga ni β-common (CD131) minɛbaga ka hɛtɛrodimɛri ye. Ni i sirilen don IRR la, o bɛ farikolojidɛsɛ taamasiɲɛw siraw baara minnu bɛ duguma, o bɛ funu jigin ^{[1] .}.

Apoptose kɛlɛli nɔ : ARA-290 bɛ selilɛriw ka apoptose bali ani ka farikolo yɔrɔw ka ɲɛnamaya sabati. Jabɛtibanabagatɔw ka sosow ka misali la, a bɛ sugunɛbilenni tubulari selilɛriw ka apoptose bali ani ka dɔ bɔ poroteyizi jɔnjɔnw jirali la apoptose kɛcogo la, o la, a bɛ sugunɛ lakanani nɔw bila. Sisplatini ka sugunɛbilenni misaliw la, a bɛ apoptose ni farikolojɔli dumuniw jiracogo ɲɛnabɔ i n’a fɔ Bax ani Bcl-2, ka Caspase-3 baara bali, ka selilɛriw ka apoptose dɔgɔya, ani ka sugunɛbilenni tiɲɛni nɔgɔya sisplatini ^fɛ.  

Oksidan kɛlɛli nɔ : ARA-290 bɛ oksidan degun tiɲɛni bali ani ka dɔ bɔ fɛn juguw bɔli la i n’a fɔ oksizɛni suguya minnu bɛ se ka kɛ (ROS). Jabɛtibanabagatɔw ka sogo sugunɛ modɛli la, a bɛ sugunɛbilenni jamu jirali bali, ka sugunɛ ROS hakɛ dɔgɔya, ka dɔ bɔ malondialdehyde (MDA) jirali la, o bɛ sugunɛ tiɲɛni nɔgɔya oksidan degun fɛ. Atherosclerose kalanw na, in vitro sɛgɛsɛgɛliw y’a jira ko ARA-290 bɛ ROS bɔli bali makɔrɔfagaw la funu cogoyaw la, o bɛ dɔ bɔ oksidan degun tiɲɛni na farikolokisɛw la.  

Banakisɛfagalanw ka baarakɛcogo ɲɛnabɔli : ARA-290 bɛ farikolo tangalanw ka baara ɲɛnabɔ i n’a fɔ makɔrɔfagaw. In vitro, a bɛ makɔrɔfagaw ka funu baarakɛli bali ka sɔrɔ k’u ka fagositɛri baara yiriwa ka ɲɛsin apoptose selilɛriw ma, ka dɛmɛ don farikolo tangalanw ka homeostase sabatili la ani ka apoptose selilɛriw jɛya walasa ka funu bali min bɛ sɔrɔ u dalajɛli fɛ (Dahan A, 2016). Joli-sira-funu ɲininiw na, ARA-290 bɛ makɔrɔfagaw ka jiginni ni fomu selilɛriw sɔrɔli bali, ka tulumafɛnw bilali dɔgɔya joli-sira-funu-kɔnɔna na ani ka joli-sira-funu taabolo sumaya.

Ɲɛgɛnɛsiraw lakanani fɛɛrɛ : Sosow ka sugunɛbilenni misali dɔ la, ARA-290 bɛ farikolo lakanani nɔw kɛ β-common receptor (βCR) fɛ. A bɛ dɔ bɔ kosɛbɛ senfagabana apoptose ni funu sitokini hakɛ la kunsɛmɛ na, o bɛ senfagabana baara ɲɛ. βCR laɲini siRNA pikiri bɛ ARA-290 ka farikolo tangacogo bali kosɛbɛ, o b’a jira ko βCR jɔyɔrɔ ka bon a kɛcogo ^la.  

Dimimadafura kɛcogo : ARA-290 bɛ se ka dimimadafura nɔ bila a la ni a bɛ dimimadafura minnu bɛ lamini na, olu laɲini k’a ɲɛsin a yɛrɛ ma. Kɔlɔsiliw y’a jira ko a bɛ TRPV1 kanal baara bali kɛrɛnkɛrɛnnenya la ani ka kapisisini ka masin alodiniya nɔgɔya, o b’a jira ko ARA-290 bɛ se ka kɛ kanal kɛlɛlan kura ye, ka hakilina kura di dimi furakɛli ma ^TRPV1 .  

ARA-290 baarakɛcogo ye mun ye?

Furakɛli min bɛ kɛ ni hakiliɲagami banaw ye

Dimi madali ni a taamasiɲɛw ɲɛnabɔli : ARA-290 bɛ dimi mada ka ɲɛ, kɛrɛnkɛrɛnnenya la, farikolojidɛsɛ bɛ bana minnu na i n’a fɔ sukarodunbana ni sarkoyidi. Kɛnɛyaso sɛgɛsɛgɛliw la sarkoidozi banabagatɔw kan, ARA-290 ye farikolojidɛsɛ ni farikolojidɛsɛ taamasiɲɛw ɲɛ kosɛbɛ, ka ɲɛnamaya kɛcogo ɲɛ, ani ka dimi hakɛ dɔgɔya, o nɔ kelenw bɛ sukarodunbanabagatɔw la. A kɛcogo ye a sirili ye bangekɔlɔsi fɛɛrɛbɔlan (IRR) la, ka banakisɛfagalanw ni farikolo yɔrɔw dilan siraw baara, ka farikolo funu labɛn, ani ka dimi nɔgɔya ^[1,.

 

Nɛrɛmuguma seginni sabatili : ARA-290 bɛ nɛrɛmuguma seginni sabati. Sarkoidozi banabagatɔw la, ARA-290 furakɛli tile 28 tugu-tugu ɲɔgɔn na, o ye ɲɛda ɲɛgɛnɛsira fitiniw lasegin, o b’a jira ko a bɛ se ka ɲɛgɛnɛsira kɛrɛnkɛrɛnnenw dilan ani ko a bɛ se ka hakiliɲagami baara ɲɛ, hali ni o ma nɔ bila ɲɛda ɲɛgɛnɛsiraw ^la.  

Nefrotoxicité (banakisɛfagalanw) dɔgɔyali  

Sitotokisi ni genotoxicity dɔgɔyali : Sisplatin-induite nephrotoxicity models kɔnɔ, ARA-290 bɛ dɔ bɔ kosɛbɛ sisplatine ka cytotoxicity ni genotoxicity la, i n’a fɔ ADN tiɲɛni hakɛw dɔgɔyali comet sɛgɛsɛgɛliw la ani micronucleus frequency, ka selilɛriw ka jamu fɛnw lakana ani ka sugunɛbilenniw tiɲɛni ^nɔgɔya.

 

Oksidan degun ni funu kunbɛnni : ARA-290 bɛ oksidan degun min bɛ sɔrɔ sisplatini fɛ, o ɲɛ ka taa a fɛ, a kɛtɔ ka malondialdehyde (MDA) ni ROS hakɛ dɔgɔya ani ka oksidan kɛlɛli anzimu baara caya. A bɛ sugunɛbilenni fana nɔgɔya ni a bɛ sugunɛbilenni dɛmɛni sitokiniw dɔgɔya (misali la, TNF-α, IL-6, IL-1β), ka a tanga sugunɛ joginni ma min bɛ sɔrɔ sisplatini ^fɛ .  

Apoptose balili : ARA-290 bɛ apoptose min bɛ sɔrɔ sisplatini fɛ, o bali ni a bɛ apoptose ni farikolojɔlifɛnw labɛn minnu bɛ tali kɛ apoptose la (misali la, Caspase-3 ni Bax jirali dɔgɔyali, Bcl-2 jirali caya), ka sugunɛbilenniw ka ɲɛnamaya sabati ani ka se ka sugunɛ jogin jugumanba ^furakɛ.  

Degun taamasiɲɛw ɲɛnabɔli  

Degun min bɛ i n’a fɔ degun, o nɔgɔyali : Sosow ka misaliw la, minnu bɛ degun misɛnni basigilenw na minnu tɛ se ka fɔ ka ɲɛ ani degun basigilen minnu bɛ sɔrɔ sigida la, ARA-290 tali don o don, o ye degun ɲɔgɔnna kɛcogo ɲɛ, o bɛ se ka suma ni degun fura ye min bɛ kɛ tuma bɛɛ, n’o ye fluoxetine ye. ARA-290 ye degun furaw kɛ ka sɔrɔ a ma nɔba bila farikolo kɔkanna ɛmoɲini walima joli kuru bilenmanw na ^{[5] .}.  

Banakisɛfagalanw ni funu kunbɛnni : ARA-290 bɛ dɔ fara degun basigilenw kan minnu bɛ sɔrɔ CD11b+Ly6Ghi neutrophils ni CD11b+Ly6Chi monocytes caya ni u hakɛ la kolotugudaw ni ɲɛgɛnɛsiraw la, ka fara microglial activation kan, ka degun taamasiɲɛw nɔgɔya ni funu kɛlɛli nɔw ye ani ka furakɛli kura di degun siraw ^{[5] .}.  

Lakanali sukarodunbana fɛ sugunɛ tiɲɛni na  

Sugunɛbilenni balili : ARA-290 bɛ sugunɛbilenni banakisɛw fagali bali, ka dɔ bɔ farikolokisɛw ka saya bolodalen na ani ka sugunɛbilenniw lakana.  

Sugunɛbilenni taamasiɲɛw ɲɛnabɔli : ARA-290 bɛ sugunɛbilenni albumini bɔli hakɛ dɔgɔya sukarodunbanabagatɔw la, ka sugunɛbaralabana tiɲɛni nɔgɔya, ka sugunɛ baara ɲɛ, ani ka sukarodunbana sugunɛbana taabolo bila kɔfɛ.  

Lupus Érythématose systémique (SLE) furakɛli .  

Autoanticorps bɔli balili ani farikolo tangalanw bilali balili : ARA-290 bɛ serum antinucléaire anticorps (ANA) ni anti-double-stranded ADN anticorps hakɛ bali kosɛbɛ SLE sogow la, ka IgG ni C3 bilali dɔgɔya sugunɛ na, ka sugunɛbilenni taamasiɲɛw nɔgɔya, ani ka bana taabolo ^ɲɛ.  

Jaa 1 ARA290 furakɛli ye funu jaabi bali SLE sogow la minnu bɛ sɔrɔ pristane fɛ. (A) IL‐6, IL‐10, MCP‐1, IFN‐γ, TNF‐α, IL‐12p70 ani TGF‐β hakɛw sɔrɔla joli la furakɛli kɔfɛ min ɲɛfɔlen don ja 1 na (n = 6). (B) Funu makɔrɔfaga F4/80 doncogo tun bɛ damatɛmɛ kosɛbɛ ARA 290 tali fɛ ni i ye a suma ni PBS kɔlɔsili ye. (C) Sɔgɔsɔgɔninjɛ ni ɲɛgɛnɛsiraw girinya jateminɛna ARA290 furakɛli kɔfɛ SLE sogow la (n = 6). Skala baraw bɛ 30 μm jira.

Source:PubMed ^{[6] Bamako, Mali.}

Sitokini funu hakɛ dɔgɔyali : ARA-290 bɛ dɔ bɔ funu sitokini IL-6, MCP-1 ani TNF-α hakɛ la joli la SLE sogow la, o bɛ funu dɔgɔya ani ka bana taamasiɲɛw ^nɔgɔya.  

Apoptose dɔgɔyali : ARA-290 bɛ dɔ bɔ sugunɛbilenni banakisɛw hakɛ la, ka sugunɛbilenniw lakana, ani ka makɔrɔfagaw ka funu baarakɛcogo bali ka sɔrɔ ka u ka apoptose selilɛriw fagositɔsi sabati in vitro, ka farikolo tangalanw labɛn ani ka se ka SLE furakɛli seko ^minɛ.  

Fura minnu bɛ kɛ ni chimiothérapie ye, olu ka toxicité (banakisɛfagalanw) dɔgɔyali  

ADN tiɲɛni dɔgɔyali : Dɔksorubisini (DOX) ka sitotokisisi misaliw la, ARA-290 bɛ dɔ bɔ kosɛbɛ ADN tiɲɛni na min bɛ sɔrɔ DOX fɛ, i n’a fɔ ka kɔ ADN kɛmɛsarada la dɔgɔya komɛti sɛgɛsɛgɛliw la ani mikronukilila caya, ka selilɛriw ka jamufɛnw lakana ani ka chimiothérapie tiɲɛni dɔgɔya farikolokisɛw ^la.  

Oksidan degun ni funu nɔgɔyali : ARA-290 bɛ DOX ka farikolo tangalanw ka baarakɛcogo dɔgɔyali nɔgɔya, ka funu ni apoptose dɔgɔya, ani ka DOX ka oksidan degun ni farikolo tiɲɛni ma, o bɛ se ka kɛ dusukunnabanakisɛw fana sen bɛ o la, walasa ka nɔ juguw nɔgɔya chimiothérapie banabagatɔw ^la.  

Alzheimer bana kunbɛnni ni a furakɛli  

Banakisɛw ka ɲɛtaa sumaya ani hakililata ɲɛtaa : ARA-290 tali joona APP/PS1 sogo denmisɛnninw na (Alzheimer ka misali fɔlɔ) o bɛ β-amiloyi (Aβ) bana taabolo sumaya ani ka hakililata baara ɲɛ, o b’a jira ko a nafa ka bon furakɛli joona ^la.

Monocyte baarakɛcogo ɲɛnabɔli : ARA-290 bɛ Ly6C− kɔlɔsili kɛ monositi kulu fitininw bɔli la kɛrɛnkɛrɛnnenya la, ka dɔ fara u ka farikolojidɛsɛ hakɛ kan, ka Aβ bɔli sabati kunsɛmɛ joli siraw la, ka Aβ doni dɔgɔya kunsɛmɛ na, ani ka bana taabolo bila kɔfɛ. Nka, a tɛ se ka kɛ kosɛbɛ misali labanw na (APP/PS1 sogo kɔrɔlenw), o b’a jira ko a nafa ka bon ka furakɛli kɛ joona ^[8]..  

Jabɛtibana joginda kɛnɛyali sabatili

Joginda datuguli teliya : Sitɛrɛpitozotosini bɛ sɔrɔ sukarodunbana fɛ joginda tigɛlenw ka sosow ka misaliw la, ARA-290 kɛli sigida la, o bɛ joginda datuguli teliya kosɛbɛ, ka joginda seginni waati surunya, ani ka joginda kɛnɛyali nafa ^ɲɛ .  

Farikolo dilan taamasiɲɛw labɛnni : ARA-290 bɛ dɔ fara kolajɛ ni farikolojɔli dumuniw hakɛ kan dilan farikolo yɔrɔw la, ka joli inisɔndiya, joli sukaro, tulumafɛnw hakɛ, farikolo tangalanw cogoya, ani sitokini minnu bɛ funu dɛmɛ, olu hakɛ labɛn, ka sigida fitinin dɔ da min bɛ joginda kɛnɛyali dɛmɛ ani ka fɛɛrɛ kuraw di sukarodunbana senkɔniw furakɛli ^la.  

Dimi Lajɔli  

TRPV1 kanal baarakɛcogo balili : ARA-290 bɛ kapisisini ka masin allodini lajɔ ni a bɛ transient receptor potentiel vanilloïde subtype 1 (TRPV1) kanali baara balili, ka ɲɛsin farikolo yɔrɔw ka nocicepteurs ma k’a ɲɛsin a yɛrɛ ma ani ka furakɛli laɲiniw ni fɛɛrɛ kuraw di dimi furakɛli ^ma.  

Kuncɛli  

ARA-290 ye polipɛtidi ye min bɔra EPO la, a bɛ se ka funu, apoptose ani oksidan kɛlɛ. A bɛ se ka dimi furakɛ sukarodunbana ni sarcoïdose la, ka farikolojidɛsɛ furakɛ, ka sugunɛbilenni, SLE, degun kɛlɛ, ani ka dimi nɔgɔya ni TRPV1 kɛlɛli ye. Ni a bɛ se ka kɛ Alzheimer bana daminɛ na ani baara wɛrɛw la, a bɛ se ka kɛ kɛnɛyaso baarakɛcogo caman na.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Al-Onaizi, Mohamed ye dɔnnikɛla ye min ka dɔnniya ka bon biyomedicine la. A ni kalanko ni ɲininikɛla ŋana caman cɛsirilen don, i n’a fɔ Dasman Diabetes Institute (DDI), Kuweit Iniwɛrisite, Laval Iniwɛrisite, Tlebi Iniwɛrisite (Ontario Tlebi Iniwɛrisite), ani Heburukan Iniwɛrisite Jerusalɛm. A ka ɲininiw ka bon, a bɛ tali kɛ Neurosciences & Neurology, Biochemistry & Molecular Biology, Immunology, Psychiatry, ani barokun wɛrɛw la Life Sciences & Biomedicine la. O kalan ninnu nafa ka bon kosɛbɛ walasa ka faamuyali jugu sɔrɔ hadamaden farikolo cogoyaw kan, banaw taabolo kan, ani fura kuraw labɛnni kan. Al-Onaizi, Mohamɛdi ka ɲininiw ye nɔba sɔrɔ dɔnniya jɔnjɔnw na, wa a ye dɛmɛ nafama di hakilinata siratigɛ la ani bilasirali waleyali la kɛnɛyaso furakɛli ni biyomedikɛli ɲininiw na.. Al-Onaizi, Mohamed tɔgɔ sɛbɛnnen bɛ citation kɔnɔ

▎ Sɛbɛn minnu bɛ tali kɛ o la

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[2] Ghassemi-Barghi N, Ehsanfar Z, Mohammadrezakhani O, ani a ɲɔgɔnnaw. ARA290, n’o ye ligandi kɛrɛnkɛrɛnnen ye Eritoropoyitini/CD131 Hɛtɛroreseptɛri la, ka tangacogo fɛɛrɛ min bɛ kɛ ka ɲɛsin Sisplatini ka ɲɛgɛnɛsiralabanaw ma, apoptose ni funu siraw sendonli ma[J Funu, 2023,46(1):342-358.DOI:10.1007/s10753-022-01737-7.

[3] Wang R, Yang Z, Huang Y, ani mɔgɔ wɛrɛw. Pepitiri ARA290 min bɛ bɔ eritoropoyitini na, o bɛ kɛ sababu ye ka kunsɛmɛnasumaya kɛ $eta$‐common receptor fɛ sosow la minnu bɛ ni kunsɛmɛnasumaya ye[J]. CNS hakili-la-ko & Furakɛcogo, 2024,30. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[4] Zhang W, Yu G, Zhang M. ARA 290 bɛ banakisɛfagalanw dimi lajɔ ni TRPV1 sira laɲini ye: Farikolo tangacogo ni sɔgɔsɔgɔninjɛ cɛ jɛɲɔgɔnya[J]. Pepitidiw, 2016,76:73-79.DOI:10.1016/j.pepitidiw.2016.01.003.

[5] Xu G, Zou T, Deng L, ani mɔgɔ wɛrɛw. Nonerythropoietic Erythropoietin Mimetic Peptide ARA290 bɛ degun basigilenw ka degun ni funu nɔgɔya sosow la[J]. Dancɛw furakɛli la, 2022,13:896601.

DOI:10,3389/fphar.2022.896601 ye baara kɛ ni a ye.

[6] Huang B, Jiang J, Luo B, ani mɔgɔ wɛrɛw. Pepitiri min bɛ bɔ eritoropoyitini na, o tɛ joli-sira-funu ye, o bɛ sosow tanga lupus (lupus érythématose) ma min bɛ sɔrɔ farikolo la[J]. Selulɛri ni molekiyɔmu furakɛli gafe, 2018,22(7):3330-3339.DOI:10.1111/jcmm.13608.

[7] Shokrzadeh M, Etebari M, Ghassemi-Barghi N. Pepitiri min dilannen don ni ɛntɛrinɛti ye, n’o tɛ eritoropoyitiki ye, n’o ye ARA290 ye, o bɛ dɔkisirubisini ka jamu toxicité ni oksidan degun dɔgɔya[J]. Toxicologie in Vitro, 2020,66:104864. Bamako, Mali.

DOI:10.1016/j.tiv.2020.104864. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[8] Al-Onaizi M. A., Thériault P., Lecordier S., ani mɔgɔ wɛrɛw. Monositɛriw sɛgɛsɛgɛli daminɛ na ni pepitiri ARA 290 ye min tɛ joli-sira-funu ye, o bɛ banaw taabolo teliya min bɛ i n’a fɔ AD[J]. Sugunɛ kɛcogo ni farikolo tangacogo, 2022,99:363-382.

DOI:10.1016/j.bbi.2021.07.016. Bamako, Mali.

[9] Mashreghi M, Bayrami Z, Sichani N, ani a ɲɔgɔnnaw. Sɛgɛsɛgɛli dɔ kɛra in vivo kɔnɔ joginda kɛnɛyali baara kan Ligandi kɛrɛnkɛrɛnnen ka dilancogo bangenen na, ARA290, ni sukarodunbana bagan modɛli ye[M]. 2023.DOI:10.21203/rs.3.rs-2520194/v1. Bamako, Mali.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.