CJC 1295 ni DAC miligaramu 5

▎ CJC1295 Ni DAC Jatebɔ ye

▎ CJC1295 Ni DAC ka ɲininiw ye

CJC1295 Ni DAC ka ɲininiw kɛcogo ye mun ye?

Laadalata bonya hormone (GHRH) tali furakɛli la, o dan ye a ka baara kuntaala surun ye. O ye ɲininikɛlaw bila ka bonya hormone bɔlenw ɲɔgɔnna caman ɲini minnu bɛ baara kɛ waati jan kɔnɔ walasa ka furakɛli nafa ni nɔgɔya ɲɛ. Mɔgɔw ​​bɛ kɛnɛya ni cɛɲi ɲinini fɛ, foroba furakɛli ɛntɛrinɛti kan, o ye dusu don sira surunw na walasa ka farikolo fanga bonya, ka tulumafɛnw dɔgɔya, ani ka funankɛya fari sɔrɔ. O hukumu kɔnɔ, bonya hormone analogues synthétiques i n’a fɔ CJC1295 With DAC ye mɔgɔw hakili sama. Sɛgɛsɛgɛliw y’a jira ko forobaciyɛn baarakɛlaw bɛ seko ni dɔnko jira a baaracogo caman na, wa kun minnu b’u sugandi ka baara kɛ ni o fɛn suguw ye, olu ye farikolo girinya dɔgɔyali ye, farikolo fanga bonya, farikolo kɛnɛyali, sunɔgɔ ka ɲɛ, ani joginda kɛnɛyali, ^a ɲɔgɔnnaw I n’a fɔ bonya ɔrimɔni bɔli ɔrimɔni analozi min bɛ baara kɛ waati jan kɔnɔ, CJC1295 Ni DAC yiriwali sinsinnen bɛ bonya hormone ka labɛncogo faamuyali jugu kan. Hali ni denmisɛn fanba minnu ka bonyali hormone isolé (GH) dɛsɛ bɛ u la, olu ka bonya jaabi ɲuman bɛ GHRH la, GHRH tilancɛ si hakɛ ka surun kosɛbɛ, o bɛ dan sigi a furakɛli nɔ na. Walasa ka nin ko in ɲɛnabɔ, ɲininikɛlaw ye CJC1295 With DAC labɛn, o ye GHRH analozi ye min bɛ baara kɛ waati jan kɔnɔ. Kɔlɔsiliw y’a jira ko a bɛ maleimidi kulu baarakɛta dɔ don a la C-terminus la, o b’a to a bɛ se ka siri joli la farikolojɔli dumuniw na ni covalent ye i n’a fɔ serum albumin, o la, a bɛ dɔ fara a tilancɛ si hakɛ kan ani ka se ka bonya hormone dilanni lawuli hadamadenw na ka tɛmɛ tile wɔɔrɔ kan a tali siɲɛ kelen ^kɔfɛ

CJC1295 Ni DAC ka baara kɛcogo ye mun ye bana kɛrɛnkɛrɛnnenw furakɛli la?

Bonya hormone bɔli wulicogo: 

CJC1295 Ni DAC ye fura ye min sinsinnen bɛ pepitiridi kan, min bɛ se ka bonya hormone (GH) bɔli lawuli ka bɔ ɲɛgɛnɛsira la ^{[2, 3]} A bɛ maleimidi kulu baarakɛta dɔ don a kɔnɔ C-terminus la, o b’a to a bɛ se ka siri joli la farikolojɔli dumuniw na ni covalent ye i n’a fɔ serum albumin. O sirili in bɛ CJC1295-protéine conjugate di a tilancɛ janya kosɛbɛ, wa a b’a to a bɛ se ka GH bɔli lawuli hadamadenw na ka tɛmɛ tile wɔɔrɔ kan a tali siɲɛ kelen kɔfɛ. Kɔlɔsiliw y’a jira ko CJC1295 pikiri kɛli farikolo jukɔrɔ ni DAC ye, o bɛ se ka kɛ sababu ye ka GH ni inisɔndiyalan I (IGF-I) hakɛ caya ka mɛn, ka kɛɲɛ ni a tata hakɛ ye baliku kɛnɛmanw na ^{[2, 3]} CJC1295 pikiri kelen kɔfɛ Ni DAC ye, joli la GH hakɛ cayalenba bɛ caya siɲɛ 2-10 ani ka mɛn tile 6 kɔnɔ walima ka jan, ani IGF-I hakɛ cayalenba joli la, o cayara siɲɛ 1,5-3 ani ka mɛn tile 9-11 kɔnɔ. CJC1295 Ni DAC tilancɛ hakɛ jateminɛlen ye tile 5,8-8,1 ye. A tali siɲɛ caman kɔfɛ, IGF-I hakɛ dantɛmɛnen tora a daminɛ hakɛ sanfɛ fo ka se tile 28 ma.

Jɔrɔ min bɛ bonya hormones dɛsɛ la: 

Baganw ka misaliw la minnu ka bonya hormone (GH) dɛsɛ bɛ u la, CJC1295 Ni DAC ye nɔ ɲumanw jira. GHRH jamu bɔli bɛ sogo minnu na, bagan minnu bɛ CJC1295 ni DAC ta don o don, olu farikolo girinya ni u farikolo janya bɛ cogo la ^[4] Sogo minnu furakɛra sanga 48 ni 72 o lɛri 72, olu girinya ni u farikolo janya tun ka ca ni baganw ye minnu furakɛra ni furakisɛ ye. Hali ni bonya normalisation dafalen ma sɔrɔ, ɲɛtaa dɔw fana jirala. Furakɛli kulu bɛɛ la, farikolojidɛsɛ hakɛ ni farikolo jukɔrɔla tulu hakɛ tun bɛ cogo la. CJC1295 Ni DAC fana ye dɔ fara pituitaire ARN bɛɛ lajɛlen ni GH mRNA kan, o b’a jira ko somatotrophe cellules falen don, o nɔ min sinsinnen don immunohistochimique ja fɛ.

CJC1295 Ni DAC bɛ se ka nɔ sabatilen sɔrɔ cogo di sigicogo siratigɛ la?

Kovalɛn sirili ni serum albumin ye: 

CJC-1295 bɛ maleimidi kulu baarakɛta dɔ don a kɔnɔ C-terminus la, o min b’a to fɛn in bɛ se ka siri joli la farikolojɔli dumuniw na ni kovalence ye i n’a fɔ serum albumin ^[2] O jɛɲɔgɔnya in bɛ kɛ sababu ye CJC-1295 ka to baara la joli la, wa a ka baara kuntaala ka jan kosɛbɛ ka tɛmɛ pepitiri furaw kan minnu tɛ fara ɲɔgɔn kan, minnu bɛ bɔ joona. Ni a sirilen don serum albumin na, CJC-1295 bɛ kɛ fɛn ye min bɛ sabati kosɛbɛ, o la a bɛ a ka baara kɛ waati janya farikolo la. Misali la, ni CJC-1295 ka maleimidi kulu sirilen don kovalɛn na ni galaka hɔrɔnyalen ye serum albumin kan, a tilancɛ hakɛ bɛ caya joli la kosɛbɛ. Nin ɲɔgɔndan fɛɛrɛ in ɲɔgɔn tɛ pepitiriw la minnu bɛ baara kɛcogo ɲɛ, wa a bɛ CJC-1295 nɔ sabatili jusigilan sigi ^{[5] .}.

Ka sabatili ɲɛ ka taa a fɛ: 

Maleimidi bɔlen saba kɛra ni hadamaden ka bonya hormone-releasing factor(hGRF) caman cili ye, minnu cɛma CJC-1295 ye hGRF suguya tetara-substitué ye (1-29), ni Nε-3-maleimidopropionamide bɔlen ye lysine la, o farala a kan C-terminus la ^sabatili in vitro ka ɲɛsin dipeptidil peptidase-IV ma. Sogow ka ɲɛgɛnɛsira ɲɛfɛla selilɛriw falenw ka bonya hormone bɔli sɛgɛsɛgɛli la, hadamadenw ka serum albumin conjugués saba bɛɛ tun bɛ baara kɛ ni ɲɛnamaya ye. Ni maleimidi bɔlenw pikiri kɛra farikolo jukɔrɔ u kelen na Sprague Dawley wulu cɛmanw na minnu ka kɛnɛ, bonya hormone acute bɔli sɔrɔla joli la. Olu cɛma, CJC-1295 ye dɔ farali jira siɲɛ 4 yɔrɔ la min bɛ bonya hormone curve jukɔrɔ ni i ye a suma ni hGRF (1-29) ye sanga 2 kɔnɔ. Ka fara o kan, Western blot sɛgɛsɛgɛli kɛra wulu minnu pikirila ni CJC-1295 ye, olu joli la, o y’a jira ko CJC-1295 farikolo tangalan bɛ sɔrɔ bandi la min bɛ bɛn serum albumin ma, o min bɛ bɔ miniti 15 pikiri kɛlen kɔfɛ, ka to joli la ka tɛmɛ lɛri 24 kan. Nin jaabi ninnu b’a jira ko CJC-1295 ye hGRF (1-29) analozi sabatilen ye ani a bɛ baara kɛ, a joli tilancɛ si hakɛ bɛ janya ^{[6] .}.

CJC-1295 nɔ min bɛ farikolo girinya bɛɛ lajɛlen na (TBW; kɔrɔ ye±SE). Dɔgɔkun 5 furakɛli waati laban na, CJC/24 h kulu ye TBW jira pewu. CJC/48 h ani CJC/72 h kuluw sera TBW hakɛ cayalenba ma ni i ye a suma ni GHRHKO/pbo kulu ye, hali ni a tora ka dɔgɔya ka tɛmɛ HTZ/pbo kulu kan.

Soso:PubMed ^{[4] Ɲɛjirali dɔw.}

CJC1295 Ni DAC ka baarakɛcogo ye mun ye kɛnɛyaso la?

CJC1295 Ni DAC bɛ a la, o bɛ se ka bonya hormone (GH) bɔli lawuli ka ɲɛ. Kalan caman y’a jira ko fura in bɛ se ka dɔ fara GH hakɛ cayalenba kan joli la baliku kɛnɛmanw na cogo la min bɛ bɔ a tata hakɛ la ^[3] . Misali la, mɔgɔ kɛnɛmanw ka sɛgɛsɛgɛli la, mɔgɔ minnu si bɛ san 21 ni san 61 cɛ, olu ka GH hakɛ cayalenba joli la siɲɛ 2-10 tile 6 kɔnɔ walima ka tɛmɛ o kan, CJC1295 Ni DAC pikiri kɛlen kɔfɛ farikolo jukɔrɔ. Nin nɔ min bɛ bonya hormone bɔli lawuli, o nafa ka bon kosɛbɛ banabagatɔw ma minnu ka bonya hormone dɛsɛ bɛ u la.

Denmisɛn minnu ka bonya hormone dɛsɛ bɛ u la, hali ni denmisɛn fanba bɛ bonya jaabi ɲuman sɔrɔ ka ɲɛsin bonya hormone bɔli hormone (GHRH) ma, GHRH tilancɛ waati kunkurunnin bɛ dan sigi a kɛcogo la kɛnɛyaso la. I n’a fɔ GHRH analozi min bɛ baara kɛ waati jan kɔnɔ, CJC1295 Ni DAC bɛ se ka sugandi ka siri albumini kɔnɔbara la ni kovalɛn ye, o la a bɛ a tilancɛ si hakɛ ni a ka baara kɛ waati janya. GHRH gene knockout (GHRHKO) sogow ka sɛgɛsɛgɛli la, a jirala ko CJC1295 ni DAC tali siɲɛ kelen don o don, o bɛ se ka sosow farikolo girinya ni u farikolo janya cogo bɛnnen mara, o b’a jira ko nin fura in nafa bɛ se ka kɛ denmisɛnninw ka bonya hormone dɛsɛ furakɛli ^la .

CJC1295 Ni DAC bɛ a la, o tɛ se ka bonya hormone bɔli lawuli dɔrɔn, nka a bɛ dɔ fara fana inisɔndiya ɲɔgɔnna bonyalan I hakɛ kan. Ani fana furakɛli caman kɛlen kɔfɛ, IGF-I hakɛ dantɛmɛnen bɛ se ka to a daminɛ hakɛ sanfɛ fo ka se tile 28 ma ^[4] . IGF-I bɛ farikolo baara nafama suguya caman kɛ hadamaden farikolo la, i n’a fɔ ka farikolokisɛw caya, ka danfara don u ni ɲɔgɔn cɛ, ani ka u ɲɛnamaya, ani ka farikoloɲɛnajɛ labɛn, a ɲɔgɔnnaw O la, ni dɔ farala IGF-I hakɛ kan, o bɛ se ka nɔ ɲuman bila bana suguya caman furakɛli la.

CJC1295 Ni DAC bɛ se ka kɛ mun ye kɛnɛyaso ni a ɲɔgɔnnaw na?

Bonya hormone dɛsɛ: 

CJC1295 Ni DAC bɛ a la, o bɛ se ka to ka ɲɛgɛnɛsira lawuli walasa ka bonya hormone bɔ. Banabagatɔ minnu ka bonya hormone bɔli man ca ka a sababu kɛ kun caman ye, kɛrɛnkɛrɛnnenya la denmisɛnw ni funankɛninw, a bɛ se ka bonya ni yiriwali kɔtigɛbaliya cogoya ɲɛ ka ɲɛ ani ka janya bonya sabati. Bonya furaw dɛsɛ furakɛli la, laadala bonya hormone sinsinni furakɛli ye nɔ dɔw sɔrɔ, nka CJC1295 Ni DAC nafa ɲɔgɔn tɛ. A bɛ se ka siri albumini kɔnɔna na ni kovalence ye, o la a bɛ a tilancɛ janya ni a ka baara kɛ waati janya ^[4] . Misali la, GHRH jamu knockout sogow ka sɛgɛsɛgɛli la, a jirala ko CJC-1295 furakɛli don o don, o bɛ se ka GHRHKO sogow farikolo cogoya ni u bonya cogo bɛnnen mara, i n’a fɔ farikolo girinya, farikolo janya, farikolojidɛsɛ hakɛ, ani farikolo jukɔrɔ tulu hakɛ, wa o waati kelen na, a bɛ se ka kɛ sababu ye fana ka dɔ fara ARN bɛɛ lajɛlen kan min bɛ wele ko pituitaire ARN ni GH mRNA, o bɛ bonya jira ɔrimɔni bɔli selilɛriw (Alba M, 2006).

Banabagatɔ baliku minnu ka bonya hormone dɛsɛ bɛ u la, CJC1295 Ni DAC tɛ se ka farikolo labɛncogo ɲɛ dɔrɔn, ka farikolo fanga bonya, ka farikolo tulu dɔgɔya, nka a bɛ se ka ɲɛnamaya kɛcogo fana ɲɛ. Bonya hormone fana jɔyɔrɔ ka bon baliku farikolo la. A sen bɛ farikolojɔli dumuniw, tulumafɛnw ani witaminiw ka farikoloɲɛnajɛ labɛnni na. Bonya hormone dɛsɛ bɛna na ni gɛlɛyaw ye i n’a fɔ farikolo tulu caya, farikolo fanga dɔgɔyali, ani koloci dɔgɔyali. CJC1295 ni DAC tali bɛ se ka nin fɛn ninnu latilen fo ka se hakɛ dɔ ma ani ka banabagatɔw farikolo cogoya ɲɛ.

Kɔrɔya kɛlɛli: 

Ni mɔgɔ si hakɛ cayara, hadamaden ka bonya hormone bɔli bɛ dɔgɔya dɔɔni dɔɔni, o bɛna fɛn caman bila mɔgɔ la minnu bɛ tali kɛ kɔrɔya la. CJC1295 Ni DAC bɛ se ka kɛ baarakɛcogo la kɔrɔya kɛlɛli la. A bɛ se ka dɔ fara bonya hormone bɔli kan fo ka se hakɛ dɔ ma, o bɛ dɛmɛ ka farikolo baara dɔgɔyali ɲɛ ka ɲɛsin kɔrɔya ma. Misali la, a bɛ se ka dɔ fara kolo gɛlɛya kan. Bonya hormone bɛ se ka kolotugudaw ka baara sabati, ka kolotugudaw caya, ka koloci bali; farikolo fanga bonya. Bonya hormone bɛ se ka farikolojɔli dumuniw labɛnni lawuli, ka farikolo fanga ni fanga bonya; fari ka wulicogo ni a kɛnɛyacogo ɲɛ. Bonya ɔrimɔni bɛ se ka fari jɔ ani ka sɔgɔsɔgɔ ni a bɛ kolajɛ sɔrɔli sabati ^{[4] .}.

Spor furakɛli ni a labɛnni: 

CJC1295 Ni DAC bɛ se ka baara kɛ ni a ye farikoloɲɛnajɛ joginw labɛnni na ani farikoloɲɛnajɛ kɛcogo ɲɛtaa la. A bɛ se ka farikolo dilancogo ni a lasegincogo sabati ani ka joginda kɛnɛyali teliya. Ni farikoloɲɛnajɛla dɔ jogin na, farikolo ka kan ka farikolo yɔrɔ tiɲɛnenw dilan joona walasa ka farikoloɲɛnajɛ seko segin a ma. Bonya hormone jɔyɔrɔ ka bon o wale in na. A bɛ se ka farikolokisɛw caya ni u ka danfara lawuli, ka farikolojɔli dumuniw dilanni sabati, ani ka farikolo ni farikolo yɔrɔ wɛrɛw dilan teliya ^[4] . O waati kelen na, CJC1295 Ni DAC bɛ se ka dɔ fara farikolo fanga ni muɲuli kan ani ka farikoloɲɛnajɛ seko bonya. Bonya hormone bɛ se ka dɔ fara farikolo fanga kan ani ka farikolo yɔrɔw ka sɔgɔsɔgɔli seko ɲɛ, o bɛ farikoloɲɛnajɛla fanga ni muɲuli bonya ^{[4] .} .

Farikoloɲɛnajɛ banaw: 1 . 

Farikoloɲɛnajɛ bana dɔw la i n’a fɔ fasa ni inisɔndiya, CJC1295 Ni DAC bɛ se ka nɔ bila fanga farikoloɲɛnajɛ ni tulumafɛnw tilatilali la ani ka inisɔndiya kɛcogo ɲɛ ka kɛɲɛ ni bonya hormone-insuline-like growth factor axis labɛnni ye. Fasa ye farikoloɲɛnajɛ bana ye min bɛ sɔrɔ tuma caman, wa a sɔrɔli bɛ tali kɛ balanbaliya la fanga sɔrɔli ni a dunni cɛ. Bonya hormone bɛ se ka tulumafɛnw tiɲɛni sabati ani ka dɔ fara fanga dunni kan, o la, a bɛ dɛmɛ ka farikolo girinya kunbɛn. Insuline (insuline) kɛlɛli bɛ tali kɛ farikolo ka insuline (insuline) tali dɔgɔyali la, o bɛ na ni sukaro hakɛ caya ye joli la. Bonya hormone bɛ se ka inisɔndiya kɛcogo ɲɛ ani ka sukaro hakɛ dɔgɔya joli la ^{[4] .}.

Kuncɛli la, CJC1295 Ni DAC ye nɔ ɲuman jira fan caman na bonya hormones labɛnni siratigɛ la. Nafa nafama b’a la, a tɛ dan bonya furakɛli la dɔrɔn, nka a bɛ kɛ fana farikoloɲɛnajɛ furakɛli ni a labɛnni ni kɔrɔya kɛlɛli ɲininiw na. A kɛcogo min bɛ mɛn sen na, o bɛ dɔ bɔ a tali caya la, wa a lakanani ɲuman ni a muɲuni fana bɛ dɛmɛ barikama di a kɛcogo ma kɛnɛyaso la. Hali n’a bɛ ɲinini siratigɛ la hali bi ko dɔw la i n’a fɔ kɔrɔya kɛlɛli, a nɔ minnu jirala kaban, olu bɛ se k’a nafa kɛrɛnkɛrɛnnenw n’a baarakɛcogo caman jira ɲɛnamaya dɔnniyaw ni a ɲɔgɔnnaw siratigɛ la.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Teichman SL ye dɔnnikɛla ye min ka ko dɔn kosɛbɛ ani min bɛ se ka baara kɛ furakɛli ni fura dilanni siratigɛ la. A ni baarada ni tɔn lakodɔnnen caman cɛsirilen don kosɛbɛ, i n’a fɔ Organizations Concentr Analges Inc, Teichman Drug Dev Consulting, Wroclaw Medical University, BEAT Biotherapeut Corp, Corthera Inc n’a ni a ɲɔgɔnna tɔnw Corthera, Chiasma, ARYx Therapeut Inc, wdfl Ka fara o kan, a ni Athens Univ Hosp ani Albert Einstein College of Medicine fana bɛ jɛ, o b’a jira ko a barika ka bon dɔnniya sɔrɔ furakɛli ɲininiw ni kɛnɛyaso baarakɛcogo la. A ka baarakɛyɔrɔw bɛ baara caman kɛ i n’a fɔ Cardiovascular System & Cardiology, General & Internal Medicine, Engineering, Endocrinology & Diabetes, ani Pharmacology & Pharmacy, ni ɲɛtaa kabakomaw ni dɛmɛ ye kɛrɛnkɛrɛnnenya la furaw dilanni ni biyoterapi la. Teichman SL tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [3].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Van Hout MC, Hearne E. Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Ɲɛgɛnɛsiraw ni furaw[J]. Fɛnɲɛnɛmafagalanw tali ni u tali jugu, 2016,51(1):73-84.DOI:10.3109/10826084.2015.1082595.

[2] Timms M, Ganio K, Steel R. Fɛɛrɛ min bɛ CJC-1295 tiɲɛni dafa sow joli la ni LC-MS/MS[J] ye. Fura sɛgɛsɛgɛli ni u sɛgɛsɛgɛli, 2019,11(8):1248-1257.DOI:10.1002/dta.2599.

[3] Teichman S. L., Neale A., Lawrence B., ani a ɲɔgɔnnaw. Bonya hormone (GH) ni inisɔndiya ɲɔgɔnna bonya factor I bɔli lawulili kuntaalajan na CJC-1295 fɛ, o ye GH bɔli hormone bɔɲɔgɔnko ye min bɛ baara kɛ waati jan kɔnɔ, baliku kɛnɛmanw na[J]. Ɲɛnamaya kɛcogo ɲuman ni sukarodunbana, 2006,91(3):799-805.DOI:10.1210/jc.2005-1536.

[4] Alba M, Fintini D, Sagazio A, ani mɔgɔ wɛrɛw. CJC-1295 tali siɲɛ kelen don o don, o ye bonya hormone bɔli hormone (GHRH) analozi ye min bɛ baara kɛ waati jan kɔnɔ, o bɛ GHRH knockout soso ka bonya kɛ cogo la[J]. Ameriki ka farikoloɲɛnajɛ-kɔnɔna ni sukarodunbana gafe, 2006,291(6):E1290-E1294.DOI:10.1152/ajpendo.00201.2006.

[5] Timms M, Ganio K, Forbes G, ani mɔgɔ wɛrɛw. Immuno polymerase chain reaction screen min bɛ CJC-1295 ni bonya-hormone-releasing hormone analogues wɛrɛw sɔrɔ sow joli la[J]. Fura sɛgɛsɛgɛli ni u sɛgɛsɛgɛli, 2019,11(6):804-812.DOI:10.1002/dta.2554.

[6] Jetté L, Léger R, Tibaudeau K, ani mɔgɔ wɛrɛw. Adamadenw ka bonya hormone-releasing factor (hGRF) _1-29 -albumin bioconjugates bɛ GRF minɛbaga baara kɛ pituitaire ɲɛfɛla la sosow la:: CJC-1295 dɔnni i n’a fɔ GRF analozi min bɛ mɛn[J Endocrinologie, 2005,146(7):3052-3058.DOI:10.1210/en.2004-1286. Ɲɛgɛnɛsiraw ani mɔgɔ dogoyɔrɔw.

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Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.