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▎ Retatrutid ka sigicogo
Sɔrɔyɔrɔ: PubChem |
A kɛcogo: YA⊃1;QGTFTSDYSI-L⊃2;LDKK4AQA⊃1;AFIEYLLEGGPSSGAPPPS⊃3; Formula molekilɛri: C 221H 342N 46O68 Molecules girinya: 4731 g/mol CAS nimɔrɔ: 2381089-83-2 PubChem ka CID: 171390338. Bamako, Mali Kɔrɔɲɔgɔnmaw:LY3437943 |
▎ Retatrutid ka ɲininiw
Retatrutid ka ɲininiw kɛcogo ye mun ye?
Retatrutid ka ɲininiw kɛcogo bɛ tali kɛ kosɛbɛ diɲɛ kɔnɔ ko juguw la minnu bɛ ka caya ka taa a fɛ, n’olu ye fasa ni sukarodunbana ye, ka fara furakɛli fura minnu bɛ yen, olu dan ye: fasa ni sukarodunbana bɛ faratiba lase foroba kɛnɛya ma, ni diɲɛ kɔnɔ fasa hakɛ jateminɛna ka se miliyari 4,005 ma san 2035 kɔnɔ, ani sukarodunbanabagatɔ hakɛ bɛna caya ka se 592 ma miliyɔn caman, o bɛ na ni diɲɛ kɛnɛyako musakabaw ye ka da sukarodunbana kan. Pepitiri agoniste recepteurs multi-targets bɔra kɛnɛ kan i n’a fɔ fura, minnu bɛ se ka fasa bali, ka sukarodunbana furakɛ, ani ka fura kɔrɔw kɔlɔlɔ toxicw bali, o b’a to u bɛ kɛ ŋaniya ye fasa ni sukarodunbana furakɛli yiriwali la.
Retatrutid ka baarakɛcogo ye mun ye?
Fanga sɛnɛcogo labɛnni ni sɔrɔyɔrɔ caman baarakɛcogo ye
Retatrutid ye agoniste saba ye min bɛ tali kɛ glucose-dependent insulinotropic polypeptide receptor (GIPR), glucagon-like peptide-1 receptor (GLP-1R), ani glucagon receptor (GCGR) la. A bɛ nin fɛn saba ninnu baara waati kelen na, ka fanga sɛnɛcogo ɲɛnabɔ sira caman fɛ.
GIPR agoniste ka baarakɛcogo:
GIP ye banakɔtaa inisɔndiyalan ye min bɛ bɔ banakɔtaa K selilɛriw fɛ ka bɔ dumuni kɔfɛ. Retatrutid bɛ GIPR baara, ka inisɔndiya bɔli sabati, ka inisɔndiya kɛcogo ɲɛ, o la, a bɛ farikolo dɛmɛ ka sukaro minɛ ka ɲɛ ani ka baara kɛ ni a ye, o la, a bɛ sukaro hakɛ dɔgɔya joli la. Ka fara o kan, GIP bɛ se ka nɔ bila tulumafɛnw falen-falenni na ni a bɛ tulumafɛnw baaracogo ɲɛnabɔ ani ka tulumafɛnw dalajɛli dɔgɔya [1] ..
GLP-1R agoniste ka baarakɛcogo:
GLP-1 ye pepitiri ɔrimɔni ye min bɛ bɔ banakɔtaa L selilɛriw fɛ. GLP-1R baara kɔfɛ, Retatrutid bɛ nafa suguya caman lase. A bɛ se ka inisɔndiya bɔli lawuli cogo la min bɛ bɔ sukaro hakɛ la, o bɛ sukaro hakɛ dɔgɔya joli la. A bɛ se ka kɔnɔbara lankolonya bila kɔfɛ, ka dɔ fara fasa kan, ka dumuni dunta dɔgɔya. GLP-1R agonismu bɛ se ka kɛ fana farikolo cɛmancɛ la, ka dumuni nege ni fanga balansi labɛn, o bɛ dɛmɛ don ka farikolo girinya dɔgɔya [2] ..
GCGR agoniste nɔw:
A ka ca a la, glucagon bɛ dɔ fara joli sukaro hakɛ kan, nka Retatrutid ka fanga kɔrɔ, GCGR agoniste bɛ nɔ wɛrɛw lase mɔgɔ ma. A bɛ glycogenolyse ni gluconeogenesis sabati sugunɛ na. Retatrutid nɔ faralen ɲɔgɔn kan, farikolo tɛ dɔ fara joli sukaro hakɛ kan nɔgɔya la nka o nɔ na, a bɛ fanga sɛnɛcogo labɛn walasa ka tulu tiɲɛni caya, o la, a bɛ se ka mɔgɔ girinya dɔgɔya ani ka farikoloɲɛnajɛ kɛcogo ɲɛ. GCGR agoniste fana bɛ se ka nɔ bila sugunɛbilenni na, ka sugunɛ tulumafɛnw dalajɛli dɔgɔya [3] ..
A bɛ nɔ minnu bila farikoloɲɛnajɛ taabolo la minnu bɛ tali kɛ farikoloɲɛnajɛ la
Ni Retatrutid bɛ baara kɛ waati kelen na fɛn saba kofɔlenw kan, a bɛ nɔ bila farikoloɲɛnajɛ kɛcogo caman na minnu bɛ tali kɛ farikoloɲɛnajɛ la.
Joli sukaro hakɛ labɛnni:
Ni Retatrutid ye GIPR ni GLP-1R baara walasa ka inisɔndiya bɔli sabati, ani ka GCGR labɛn ka ɲɛ, Retatrutid bɛ se ka joli sukaro hakɛ dɔgɔya. A ka sukarodunbana nɔ bɛ ye ni sukaro hakɛ cayara, ka sɔrɔ a man teli ka sukarodunbana bila la ni sukaro hakɛ bɛ a la, o min nafa ka bon sukarodunbana kunbɛnni na sukarodunbanabagatɔw lamɔgɔ .
Kisɛya hakɛ jateminɛ:
Retatrutid bɛ nafa caman jira farikolo girinya kunbɛnni na. Ni a bɛ GLP-1R baara, a bɛ kɔnɔbara lankolonya sumaya, ka dɔ fara fasa kan, ka dumuni dunta dɔgɔya; ni a bɛ tulumafɛnw sɛnɛcogo ɲɛnabɔ, a bɛ tulumafɛnw tiɲɛni ni fanga musaka sabati, o la, a bɛ se ka mɔgɔ girinya dɔgɔya. Kɛnɛyaso sɛgɛsɛgɛliw y’a jira ko banabagatɔ minnu fasalen don walima minnu girinya ka ca, minnu furakɛra ni Retatrutid ye, olu girinya bɛ dɔgɔya kosɛbɛ waati dɔ kɔnɔ [5,6]..
Lipidiw labɛnni:
Retatrutid furakɛli bɛ banabagatɔw ka tulumafɛnw hakɛ ɲɛ. A bɛ triglycérides (TG), lipoprotéines low-density cholesterol (LDL-C), ani lipoprotéines colestérol dɔgɔmanba (VLDL-C) hakɛ dɔgɔya, ka sɔrɔ ka apolipoprotéines fana labɛn, i n’a fɔ apolipoprotéine B (apoB) ni apolipoprotéine C -III (apoC-III) hakɛ dɔgɔyali, o la, lipoprotéine fɛnɲɛnamafagalanw hakɛ bɛ dɔgɔya minnu ni ɲɔgɔn cɛ ni joli siraw sɔgɔsɔgɔli ye ani ka dusukun ni jolisiraw kɛnɛya sabati [7] ..
Sugunɛbilenni farikolojɔli ɲɛnabɔli:
Banabagatɔ minnu ka sugunɛbilenni min tɛ dɔlɔ ye (NAFLD) min bɛ tali kɛ farikoloɲɛnajɛ baarakɛbaliya la, Retatrutid bɛ sugunɛ tuluma hakɛ dɔgɔya kosɛbɛ. Kɛnɛyaso sɛgɛsɛgɛliw la minnu bɛ tali kɛ o ko la, banabagatɔ minnu furakɛra ni Retatrutid hakɛ danfaralenw ye, olu y’a jira ko sugunɛ tulu hakɛ dɔgɔyara kosɛbɛ ni i y’a suma ni a daminɛ na, o b’a jira ko Retatrutid bɛ nɔ ɲuman bila sugunɛ tulu sɛnɛcogo la, o min nafa ka bon sugunɛ baarakɛcogo ɲɛ.
Jaa 1 Retatrutid ka baarakɛcogo [8] ..
Retatrutid ka baarakɛcogo ye mun ye?
Fasa furakɛli:
Fasa kɛra diɲɛ foroba kɛnɛyako gɛlɛnba ye, min ni bana basigilen suguya caman daminɛni n’u taabolo bɛ tali kɛ ɲɔgɔn na kosɛbɛ. Retatrutid ye nafa caman jira fasa furakɛli la. Banabagatɔ fasalenw minnu furakɛra ni Retatrutid ye, olu farikolo girinya dɔgɔyara kosɛbɛ. Dɔgɔkun 48 kɔnɔ, Fasa 2nan sɛgɛsɛgɛli la, banabagatɔ minnu furakɛra ni Retatrutid miligaramu 8 ni miligaramu 12 ye, olu girinya dɔgɔyara ni 22,8% ani 24,2% ye. Fasa 2 sɛgɛsɛgɛli wɛrɛ la, min kɛra ni fiyentɔya fila ye, min kɛra ni mɔgɔw ye, min kɛra ni furakisɛ ye, banabagatɔ minnu tun bɛ fura tata hakɛ danfaralenw na, olu girinya hakɛ tɛ kelen ye dɔgɔkun 24 ni dɔgɔkun 48 kɔnɔ. Miligaramu 12 ta kulu ye 24,2% dɔgɔya dɔgɔkun 48 kɔnɔ, ka sɔrɔ furakisɛ ta kulu ye -2,1% dɔrɔn dɔgɔya. Retatrutid bɛ farikolo girinya dɔgɔya kosɛbɛ banabagatɔ fasalenw na, o bɛ kɛ baarakɛminɛn kura ni barikama ye fasa furakɛli la. Retatrutid furakɛli fasa la, o tɛ farikolo girinya dɔgɔya dɔrɔn, nka a bɛ se ka kɛnɛyako wɛrɛw fana ɲɛ ka taa a fɛ, minnu bɛ tali kɛ fasa la, i n’a fɔ ka kolotugudaw degunw nɔgɔya ani ka kolotugudaw banaw taamasiɲɛw nɔgɔya farikolojidɛsɛ fɛ girinya dɔgɔyali fana bɛ se ka dɛmɛ don ka fasa gɛlɛyaw ɲɛnabɔ i n’a fɔ sunɔgɔbaliya [3,6]..
Sukarodunbana suguya 2 furakɛli:
Sukarodunbana suguya 2 ye farikoloɲɛnajɛ basigilen ye min ka teli ka sɔrɔ, a bɛ sɔrɔ inisɔndiya tali fɛ ani inisɔndiya bɔli dafalen na. Nafa bɛ se ka kɛ retatrutidi la sukarodunbana suguya 2 furakɛli la. A bɛ inisɔndiya bɔli lawuli ni a bɛ GLP-1 minɛbaga baara, ka inisɔndiya kunbɛncogo ɲɛ, ani ka joli sukaro hakɛ dɔgɔya. A ka girinya dɔgɔyali nɔ fana bɛ dɛmɛ ka sukarodunbana suguya 2 banabagatɔw ka cogoya ɲɛ, barisa fasa ye faratiba ye sukarodunbana suguya 2 ma, wa farikolo girinya dɔgɔyali bɛ se ka inisɔndiya sabati, o bɛ dɛmɛ wɛrɛ don joli sukaro hakɛ kunbɛnni na. Kalan minnu kɛra sukarodunbana suguya 2 banabagatɔw kan, Retatrutid kɛra sababu ye ka mɔgɔ farikolo girinya dɔgɔya kosɛbɛ ani ka dɔ bɔ kosɛbɛ ɛmoɲini A1c (HbA1c) hakɛ la, ni HbA1c dɔgɔyara ni 1,64% ye ni i ye a suma ni furakisɛ ta ye. O b’a jira ko Retatrutid tɛ joli sukaro hakɛ dɔrɔn kɔlɔsi ka ɲɛ, nka a bɛ sukarodunbana suguya 2 bɛ banabagatɔ minnu na, olu bɛɛ ka cogoya bɛɛ ɲɛ fana fɛɛrɛ caman fɛ, i n’a fɔ u girinya dɔgɔyali, o la, a bɛ u ka ɲɛnamaya kɛcogo ɲɛ.
Sugunɛbilenni min tɛ dɔlɔ ye (NAFLD) furakɛli:
NAFLD ye sugunɛ jogin ye min bɛ sɔrɔ farikoloɲɛnajɛ degun fɛ, min ni inisɔndiya kunbɛnni ni jamu sɔrɔli bɛ tali kɛ ɲɔgɔn na kosɛbɛ, a bɛ bana caman lajɛ i n’a fɔ sugunɛ tuluma nɔgɔman min tɛ dɔlɔ ye, sugunɛbilenni min tɛ dɔlɔ ye, ani sirozi min bɛ tali kɛ o la. Retatrutid bɛ se ka layidu ta NAFLD furakɛli la. Kɔrɔbɔli dɔ la, min kɛra ni mɔgɔw ye, ni fiyentɔ fila ye, ni furakisɛw ye, minnu kɛra ni mɔgɔ minnu ye, minnu ka sugunɛbilenni bɛ tali kɛ farikoloɲɛnajɛ baarakɛbaliya la, ani sugunɛ tuluma hakɛ ≥10%, dɔgɔkun 24 kɔnɔ, sugunɛ tuluma hakɛ caman yeli hakɛ danmadɔ ka bɔ a daminɛ na, o tun tɛ kelen ye kosɛbɛ Retatrutid tata hakɛ kuluw bɛɛ la: -81,4% miligaramu 8 kulu la, -82,4% miligaramu 12 la kulu la, ani +0,3% furakisɛ kulu la. O b’a jira ko Retatrutid bɛ se ka sugunɛ tulu hakɛ dɔgɔya kosɛbɛ, o min nafa ka bon kosɛbɛ NAFLD banabagatɔw ka sugunɛbana furakɛli la. A bɛ layidu ta i n’a fɔ furakɛlicogo kura NAFLD la, min bɛ se ka bana taabolo sumaya ani ka gɛlɛya jugumanw farati dɔgɔya i n’a fɔ sirozi [3]..
Kuncɛli
Retatrutid bɛ seko ɲuman jira NAFLD banabagatɔw ka sugunɛbana cogoya ɲɛnabɔli la, a bɛ baara kɛ ni fɛɛrɛ caman ye i n’a fɔ fanga sɛnɛcogo ɲɛnabɔli, inisɔndiya kunbɛncogo ɲɛnabɔli, funu kɛlɛli nɔw, ani tulumafɛnw sɛnɛcogo caman sɛgɛsɛgɛli.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Rosenstock, J ye dɔnnikɛla ŋana ye min ka baara bɛ tali kɛ kosɛbɛ baarada tɔgɔba caman na, i n’a fɔ Texas Iniwɛrisite Saheli-Tilebin-yanfan dɔgɔtɔrɔso, Texas Iniwɛrisite Dallas, ani Kanada VIGOR Centre. A ka ɲininiw bɛ dakun caman na i n’a fɔ Endocrinology & Metabolism, General & Internal Medicine, Cardiovascular System & Cardiology, Pharmacology & Pharmacy, ani Research & Experimental Medicine. A ka dɛmɛ kabakoma minnu kɛra kalanko jɛkulu kɔnɔ, o y’a to a ye bonya sɔrɔ kosɛbɛ, i n’a fɔ a jiralen bɛ cogo min na a ka sugandili segin-segin na ka kɛ 'Sɛgɛsɛgɛlikɛla min tɔgɔ fɔra kosɛbɛ kɛnɛyako furakɛli siratigɛ la' k’a ta san 2017 la ka se san 2024 ma, o y’a jira k’a jɔyɔrɔba n’a nɔba bɛ kɛnɛyako ɲininiw na. Rosenstock J tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [4].
