Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
(1) Asrã Kple Aɖuɖɔtoedɔléle Si Nɔa Anyi Didi ƒe Nɔnɔme Kple Afɔku Siwo Le Fifia
Asrã nye yaƒoƒomɔ̃ ƒe dɔléle si nɔa anyi didi si bɔ eye wòbɔ ɖe xexeame katã ŋutɔ. Eƒe nɔnɔme vevitɔwoe nye yaƒoƒomɔ̃ ƒe dɔdzẽ si nɔa anyi didi, yaƒoƒomɔ̃ ƒe dɔwɔwɔ fũ akpa, kple ya ƒe sisi ƒe seɖoƒe si woate ŋu atrɔ. Zi geɖe la, dɔnɔwo kpɔa dzesiwo abe ʋuʋudedi, gbɔgbɔtsixetsixe, akɔta ƒe tete, kple kɔdzidɔ ene, si gblẽa nu le agbenɔnɔ ƒe nyonyome ŋu vevie eye ate ŋu ade agbe gɔ̃ hã afɔku me. Aɖuɖɔtoedɔléle si nɔa anyi didi koŋue nyea aɖuɖɔtoewo ƒe dɔdzẽ si mebɔ o atraɖii, eye kɔdzidɔ kple aɖuɖɔtoe ƒe dodo nye dɔlélea ƒe dzesi vevitɔwo. Nɔnɔmea nɔa anyi ɣleti etɔ̃ ya teti ƒe sia ƒe hena ƒe eve tsiã ɖe enu alo esi wu nenema.
(2) Akpa Vevi si Yame ƒe Dzoxɔxɔ Wɔna Le Asrã Kple Aɖuɖɔtoedɔléle Si Nɔa Anyi Me
Yaƒoƒomɔ̃ ƒe Dzoxɔxɔ le Asrã me
Le asrã ƒe tsitsi me la, woxɔa dɔdzẽ ƒe lãmenugbagbevi vovovowo abe eosinophils, mast cells, kple T lymphocytes ene ɖe yaƒoƒomɔ̃wo me, si wɔnɛ be dɔdzẽ ƒe domenɔlawo kple cytokines vovovowo dona, siwo dometɔ aɖewoe nye interleukin-4 (IL-4), interleukin-5 (IL-5), kple interleukin-13 (IL-13), siwo hea yaƒoƒomɔ̃wo ƒe dɔdzẽ vɛ. Dzoxɔxɔ ƒe ŋuɖoɖo siawo nana yaƒoƒomɔ̃a ƒe lãkusi gblẽna, ʋuʋudedi ƒe dodo dzina ɖe edzi, yaƒoƒomɔ̃ ƒe lãmeka siwo le gbadzaa ƒe tete kple tɔtrɔ yeye, si wɔnɛ be yaƒoƒomɔ̃a ƒe dɔwɔwɔ fũ akpa eye ya ƒe sisi dzi ɖena kpɔtɔna.
Nɔnɔmetata 1 Yaƒoƒomɔ̃a ƒe lãkusi nyea nu vevitɔ si doa go le nutoa me kple lãkusia dome.
Yaƒoƒomɔ̃wo ƒe Dzoxɔxɔ le Aɖuɖɔtoedɔléle si Nɔa Anyi Me
Neutrophils, macrophages, kple lãmenugbagbevi bubuwo koŋue naa yaƒoƒomɔ̃wo ƒe dɔdzẽ le aɖuɖɔtoedɔléle si nɔa anyi didi me. Proteases, oxygen ƒomevi siwo wɔa dɔ, kple nu bubu siwo dona le dɔdzẽ ƒe dɔwɔwɔ me gblẽa nu le yaƒoƒomɔ̃a ƒe wɔwɔme kple dɔwɔwɔ ŋu, si wɔnɛ be yaƒoƒomɔ̃a ƒe gliwo ƒoa tititi eye yaƒoƒomɔ̃a ƒe ʋuƒoa tsina, si wɔnɛ be ya ƒe asitɔtrɔ gblẽna. Dzoxɔxɔ ƒe ʋuʋu ɣeyiɣi didi hã ate ŋu ado dɔlélea ƒe ŋgɔyiyi ɖe ŋgɔ eye wòana kuxiwo abe lãkusi ƒe dɔmawɔmawɔ nyuie kple dzitodzito me dɔléle ƒe afɔkua nadzi ɖe edzi.
(4) Numekuku si Ku Ðe Bronchogen Ŋu Be Ate Ŋu Azã Atikewɔwɔ
Ne míebu alesi wowɔa yaƒoƒomɔ̃ ƒe dɔdzẽ le asrã kple aɖuɖɔtoedɔléle si nɔa anyi didi ƒe atikewɔwɔ ƒe nɔnɔme si li fifia ŋu la, atike yeye siwo le dedie, eye wowɔa dɔ nyuie la didi le vevie ŋutɔ le atikewɔnyawo me. Bronchogen ate ŋu atrɔ asi le dɔdzẽ ƒe ŋuɖoɖowo ŋu to mɔ vovovowo dzi, si ate ŋu axe mɔ ɖe yaƒoƒomɔ̃wo ƒe dɔdzẽ nu le dɔnɔ siwo ŋu asrã kple aɖuɖɔtoedɔléle si nɔa anyi didi le ŋu, si ana wòakpe ɖe nɔnɔme siawo dada ŋu.
Bronchogen ƒe Mɔxenu ƒe Ŋusẽkpɔɖeamedzi ɖe Yame ƒe Dzoxɔxɔ Dzi Le Asrã Dɔnɔwo Me
(1) Dɔwɔɖoɖowo ƒe Ŋusẽkpɔɖeamedzi ɖe Lãmenugbagbevi Siwo Dzea Dɔlékuiwo Dzi
Eosinophils ƒe lãwo
Eosinophils wɔa akpa vevi aɖe le yaƒoƒomɔ̃wo ƒe dɔdzẽ me le asrã me. Aɖi siwo woɖena ɖe go, abe eosinophil cationic protein ene, ate ŋu agblẽ nu le yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo ŋu eye wòana dɔdzẽ ƒe ŋuɖoɖowo nagado gã ɖe edzi. Bronchogen ate ŋu axe mɔ ɖe chemotaxis kple eosinophils ƒe dɔwɔwɔ nu, si ana woƒe gege ɖe yaƒoƒomɔ̃wo me dzi naɖe akpɔtɔ. To chemokine receptors, vevietɔ CC chemokine receptor 3 (CCR3) ƒe ɖeɖefia dzi kpɔkpɔ me la, exea mɔ na eosinophils kple yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo kpakple endothelial cells ƒe ƒoƒo ɖe wo nɔewo ŋu, si wɔnɛ be woƒe ƒuƒoƒo ɖe yaƒoƒomɔ̃ ƒe lãkusiwo me dzi ɖena kpɔtɔna.
T ʋumenugbagbevi dzĩwo
Th2 lãmenugbagbeviwo nye dɔlélenutsiŋutete ƒe lãmenugbagbevi veviwo le asrã ƒe dɔdzẽ me, woɖea cytokines abe IL-4, IL-5, kple IL-13, si doa eosinophil ƒe dɔwɔwɔ kple yaƒoƒomɔ̃ ƒe dɔwɔwɔ fũu akpa ɖe ŋgɔ. Bronchogen xea mɔ na Th2 lãmenugbagbeviwo ƒe vovototodedeameme kple dɔwɔwɔ, si ɖea cytokines siawo wɔwɔ dzi kpɔtɔna. Bronchogen hã ɖɔa T lãmenugbagbevi siwo kpɔa ŋusẽ ɖo (Tregs) ƒe xexlẽme kple dɔwɔwɔ dzi, si naa Tregs ƒe mɔxexeɖedɔléle nu ƒe ŋusẽ ɖe Th2 lãmenugbagbeviwo dzi, ena dɔlélenutsiŋutete da sɔ, eye wòɖea yaƒoƒomɔ̃wo ƒe dɔdzẽ dzi kpɔtɔna.
Mast cells ƒe lãmenugbagbeviwo
Mast cells ɖea domenɔla siwo naa dɔdzẽ abe histamine kple leukotrienes ene ɖe go kabakaba le asrã ƒe amedzidzedze me, si wɔnɛ be yaƒoƒomɔ̃ ƒe lãmeka siwo le gbadzaa ƒe tete eye ʋukawo ƒe gege ɖe lãme na ame dzina ɖe edzi. Bronchogen nana mast cell membranes li ke, xea mɔ na degranulation, eye wòɖea domenɔla siwo naa dɔdzẽ ƒe dodo dzi kpɔtɔna, si wɔnɛ be yaƒoƒomɔ̃wo ƒe dɔdzẽ sesẽ dzi ɖena kpɔtɔna.
(2) Ŋusẽ si wòkpɔna ɖe dɔdzẽ ƒe domenɔlawo kple cytokines dzi
Dɔdzẽ ƒe domenɔlawo ƒe dodo dzi ɖeɖe kpɔtɔ
Tsɔ kpe ɖe mɔxexe ɖe histamine kple leukotrienes ƒe dodo tso mast cells me nu ŋu la, Bronchogen ɖea dɔdzẽ ƒe domenɔla bubuwo abe prostaglandin D2 (PGD2) kple thromboxane A2 (TXA2) ene hã ƒe agbɔsɔsɔ dzi kpɔtɔna. Dɔdzẽ ƒe domenɔla siawo ate ŋu ana aɖuɖɔtoe ƒe lãmeka siwo le gbadzaa natsi, ʋuʋudedi nadzi ɖe edzi, eye ʋukawo nakeke, si ana aɖuɖɔtoe me dɔdzẽ nagado gã ɖe edzi. To mɔxexe ɖe enzymewo abe cyclooxygenase (COX) ƒe dɔwɔwɔ nu me la, Bronchogen ɖea PGD2 kple TXA2 ƒe wɔwɔ dzi kpɔtɔna, si wɔnɛ be aɖuɖɔtoe me dɔdzẽ ƒe ŋuɖoɖowo dzi ɖena kpɔtɔna.
Cytokine Network ƒe Ðoɖowɔwɔ
Abe alesi míegblɔe va yi ene la, asrãdɔnɔwo ɖea cytokines vovovo siwo le yaƒoƒomɔ̃wo me ƒe masɔmasɔ fiana, eye Th2-ƒomevi cytokines abe IL-4, IL-5, kple IL-13 ƒe agbɔsɔsɔ dzina ɖe edzi, evɔ cytokines siwo tsia dzodzodzoetsitsi nu abe IL-10 ene dzi ɖena kpɔtɔna. Bronchogen ateŋu adzi anti-inflammatory cytokines abe IL-10 ene ƒe ɖeɖefia ɖe dzi, esime wòxea mɔ na pro-inflammatory cytokines abe IL-4, IL-5, kple IL-13 ƒe wɔwɔ, si toa esia me ɖɔa cytokine network ƒe masɔmasɔwo ɖo eye wòɖea yaƒoƒomɔ̃ ƒe dɔdzẽ dzi kpɔtɔna. Bronchogen xea mɔ na cytokines abe tumor necrosis factor-α (TNF-α) kple interferon-γ (IFN-γ) hã ƒe dɔwɔwɔ, siwo hã wɔa akpa vevi aɖe le asrã ƒe yaƒoƒomɔ̃ ƒe dɔdzẽ kple yaƒoƒomɔ̃ ƒe tɔtrɔ me.
Nɔnɔmetata 2 Asrã, si nye yaƒoƒomɔ̃ ƒe dɔléle si nɔa anyi didi, ƒe dzesi enye eosinophilic inflammation, mucus hypersecretion, goblet cell hyperplasia, yaƒoƒomɔ̃wo ƒe dɔwɔwɔ fũ akpa, kple gbɔgbɔtsixetsixe.
(3) Ametakpɔkpɔ ƒe ŋusẽkpɔɖeamedzi ɖe yaƒoƒomɔ̃ ƒe lãmenugbagbevi siwo le lãkusi me dzi
Lãmenugbagbevi siwo le lãkusi me ƒe gbegblẽ dzi ɖeɖe kpɔtɔ
Asrã ƒe yaƒoƒomɔ̃ ƒe dɔdzẽ ate ŋu agblẽ nu le yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo ŋu, si agblẽ nu le yaƒoƒomɔ̃ ƒe mɔxenu ƒe dɔwɔwɔ ŋu. Bronchogen doa yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ, si wɔnɛ be woƒe mɔxenu ƒe dɔwɔwɔ nyona ɖe edzi. Bronchogen doa ŋusẽ protein siwo doa ka kplikplikpli abe occludin kple junction protein-1 (ZO-1) ene ƒe ɖeɖefia ɖe dzi, si wɔnɛ be kadodo sesẽwo nɔa lãmenugbagbevi siwo le lãkusi me dome eye wòɖea domenɔla siwo naa dɔdzẽ kple nusiwo nana ame ƒe ŋutilã mewɔa dɔ nyuie o ƒe gege ɖe lãme na ame dzi kpɔtɔna.
Mɔxexe ɖe ʋuʋudedi ƒe dodo fũ nu
Aɖuɖɔtoewo ƒe dodo fũu akpa le yaƒoƒomɔ̃wo me nye dɔléle vevi siwo ɖea dzesi le asrãdɔ ŋu la dometɔ ɖeka. Aɖuɖɔtoe si gbɔ eme ate ŋu axe mɔ na yaƒoƒomɔ̃wo eye wòana ya ƒe sisi ƒe seɖoƒe nasẽ ɖe edzi. Bronchogen ɖea ʋuʋudedi ƒe wɔwɔme kple eƒe dodo dzi kpɔtɔna to mɔxexe ɖe mucin (MUC) domenyiŋusẽfianuwo ƒe ɖeɖefia nu le yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo me. Tsɔ kpe ɖe eŋu la, ewɔa ɖoɖo ɖe mucociliary clearance dɔwɔwɔ ŋu, si doa ʋuʋudedi ɖeɖeɖa le yaƒoƒomɔ̃wo me ɖe ŋgɔ eye wònana yaƒoƒomɔ̃wo nɔa ʋuʋu ɖi.
(4) Ŋusẽ si wòkpɔna ɖe yaƒoƒomɔ̃wo ƒe gbugbɔgaɖɔɖo dzi
Mɔxexe ɖe lãmeka gbadzawo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple ʋuʋu nu
Yaƒoƒomɔ̃ ƒe gbugbɔgaɖɔɖo nye dɔléle ƒe tɔtrɔ vevi aɖe le asrã me, si me yaƒoƒomɔ̃ ƒe lãmeka si le gbadzaa ƒe ƒoƒo kple lãmenugbagbeviwo godo ƒe matriki ƒe ƒuƒu hã le. Bronchogen xea mɔ na yaƒoƒomɔ̃ ƒe lãmeka gbadzawo ƒe dzidziɖedzi kple woƒe ʋuʋu, si wɔnɛ be woƒe xexlẽme kple woƒe lolome dzi ɖena kpɔtɔna. To protein siwo do ƒome kple lãmenugbagbeviwo ƒe tsatsam, cyclin-dependent kinases (CDKs), kple cyclins ƒe ɖeɖefia dzi kpɔkpɔ me la, Bronchogen nana yaƒoƒomɔ̃ ƒe lãmeka gbadzawo ƒe lãmenugbagbeviwo léna le lãmenugbagbeviwo ƒe tsatsam ƒe akpa aɖewo koŋ, si wɔnɛ be woxea mɔ na woƒe dzidziɖedzi.
Lãmenugbagbeviwo godo ƒe matriki ƒe tsɔtsɔ dzi ɖeɖe kpɔtɔ
Le asrã ƒe yaƒoƒomɔ̃wo gbugbɔgaɖɔɖo me la, fibroblasts wɔa lãmenugbagbeviwo godo ƒe matrix ƒe akpa siwo sɔ gbɔ abe collagen kple fibronectin ene heɖea wo ɖe go, si wɔnɛ be yaƒoƒomɔ̃a ƒe gliwo ƒoa ke ɖe to. Bronchogen ate ŋu axe mɔ na fibroblasts ƒe dɔwɔwɔ kple woƒe dzidziɖedzi, si aɖe lãmenugbagbeviwo godo ƒe matrix ƒe akpawo ƒe wɔwɔme kple wo ƒuƒu dzi akpɔtɔ. Ate ŋu aɖɔ matrix metalloproteinases (MMPs) kple woƒe tissue inhibitors (TIMPs) dome dadasɔ hã ɖo, si ado lãmenugbagbeviwo godo ƒe matrix ƒe gbegblẽ ɖe ŋgɔ eye wòaɖe alesi gbegbe yaƒoƒomɔ̃wo ƒe gbugbɔgaɖɔɖo dzi akpɔtɔ.
Bronchogen ƒe mɔxexeɖedɔléle nu ƒe ŋusẽkpɔɖeamedzi ɖe yaƒoƒomɔ̃ ƒe dɔdzẽ dzi le dɔnɔ siwo ŋu aɖuɖɔtoedɔléle si nɔa anyi didi le me
(1) Dɔdzẽ ƒe lãmenugbagbeviwo ƒe amewo xɔxɔ kple woƒe dɔwɔwɔ dzi kpɔkpɔ
Neutrophils ƒe dɔwɔwɔ
Neutrophils ɖua yaƒoƒomɔ̃ ƒe dɔdzẽ dzi le aɖuɖɔtoedɔléle si nɔa anyi didi me, eye protease siwo woɖena ɖe go, abe elastase ene, ate ŋu agblẽ nu le yaƒoƒomɔ̃ ƒe wɔwɔme ŋu. Bronchogen ate ŋu axe mɔ na neutrophil chemotaxis kple dɔwɔwɔ, si aɖe woƒe ƒoƒo ɖe yaƒoƒomɔ̃wo me dzi akpɔtɔ. Esi wòxe mɔ ɖe integrins ƒe ɖeɖefia nu le neutrophils, abe β2 integrin ene, ƒe anyime nu la, eɖea neutrophils ƒe ƒoƒo ɖe endothelial cells ŋu dzi kpɔtɔna, si wɔnɛ be woƒe ʋuʋu yi yaƒoƒomɔ̃wo me dzi ɖena kpɔtɔna.
Macrophages ƒe lãmenugbagbevi gãwo
Menye ɖeko macrophages kpɔa gome le dɔlékuiwo ɖeɖeɖa me le aɖuɖɔtoedɔléle si nɔa anyi didi ƒe dɔdzẽ ƒe dɔwɔwɔ me ko o, ke woɖea domenɔla vovovowo hã ɖea go. Bronchogen ateŋu aɖɔ macrophages ƒe polarization nɔnɔme ɖo, si doa woƒe tɔtrɔ ɖe ŋgɔ va zu anti-inflammatory (M2-type) macrophages, to esia me ɖea pro-inflammatory cytokines abe IL-1β kple TNF-α ƒe dodo dzi kpɔtɔna esime wòdzia anti-inflammatory cytokines abe IL-10 ƒe dodo ɖe ŋgɔ, si wɔnɛ be yaƒoƒomɔ̃wo ƒe dɔdzẽ dzi ɖena kpɔtɔna.
(2) Ŋusẽkpɔɖeamedzi ɖe Dzoxɔxɔ ƒe Domenɔlawo Kple Proteases Dzi
Dzoxɔxɔ ƒe Domenɔlawo ƒe Agbɔsɔsɔme Dzi Ðeɖe Akpɔtɔ
Le dɔnɔ siwo ŋu aɖuɖɔtoedɔléle si nɔa anyi didi le gome la, dɔdzẽ ƒe domenɔla vovovowo dzina ɖe edzi le yaƒoƒomɔ̃wo me, abe IL-8 kple leukotriene B4 (LTB4) ene. Dzoxɔxɔ ƒe domenɔla siawo hea neutrophils kple dɔdzẽ ƒe lãmenugbagbevi bubuwo, si wɔnɛ be dɔdzẽ ƒe ŋuɖoɖoa nu sẽna ɖe edzi. Bronchogen ate ŋu axe mɔ ɖe dɔdzẽ ƒe domenɔla siawo ƒe wɔwɔ kple woƒe dodo nu to dɔdzẽ ƒe dzesimɔwo abe nuklia factor-κB (NF-κB) ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ me, si ana domenyiŋusẽfianu ƒe nuŋɔŋlɔ kple dɔdzẽ ƒe domenɔlawo ƒe wɔwɔme dzi naɖe akpɔtɔ.
Mɔxexe ɖe protease ƒe dɔwɔwɔ nu
Protease siwo neutrophils abe elastase kple cathepsin ene ɖena ɖe go ate ŋu agblẽ elastic fibers kple collagen siwo le yaƒoƒomɔ̃wo me, si ana yaƒoƒomɔ̃a ƒe gliwo nagblẽ. Protease mɔxexeɖedɔléle ƒe dɔwɔwɔ le bronchogen ŋu, si xea mɔ na protease siawo ƒe dɔwɔwɔ tẽ eye wòɖea nusiwo gblẽ le yaƒoƒomɔ̃wo ŋu dzi kpɔtɔna. Ate ŋu aɖɔ proteasewo kple woƒe mɔxenuwo hã ƒe dadasɔ ɖo, si ana protease mɔxenuwo abe α1-antitrypsin ene ƒe agbɔsɔsɔ nadzi ɖe edzi, si ana nusiwo protease gblẽna le yaƒoƒomɔ̃wo ŋu dzi naɖe akpɔtɔ geɖe wu.
(3) Yaƒoƒomɔ̃ ƒe ʋuʋudedi ƒe dodo fũ kple lãkusi ƒe dɔwɔwɔ ƒe nyonyo
Mucus ƒe dodo dzi ɖeɖe kpɔtɔ
Zi geɖe la, dɔnɔ siwo ŋu aɖuɖɔtoedɔléle si nɔa anyi didi le la kpɔa ʋuʋudedi si dona le yaƒoƒomɔ̃wo me dzina ɖe edzi, si wɔnɛ be kɔdzi kple aɖuɖɔtoewo gagblẽna ɖe edzi. Bronchogen ate ŋu aɖe ʋuʋudedi ƒe wɔwɔme kple eƒe dodo dzi akpɔtɔ to mɔxexe ɖe MUC domenyiŋusẽfianu ƒe ɖeɖefia nu le yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo me. Ate ŋu aɖɔ yaƒoƒomɔ̃ ƒe ʋuʋudedi ƒe dzɔdzɔmeŋusẽŋununya hã ɖo, si aɖe eƒe ʋeʋẽ dzi akpɔtɔ eye wòana wòanɔ bɔbɔe be woaɖee ɖa.
Ciliary ƒe dɔwɔwɔ dodo ɖe ŋgɔ
Ciliary ƒe ʋuʋu si sɔ le yaƒoƒomɔ̃wo me nye mɔnu vevi aɖe si dzi woato akɔ yaƒoƒomɔ̃wo me tsiwo ɖa. Le dɔnɔ siwo ŋu aɖuɖɔtoedɔléle si nɔa anyi didi le gome la, aɖuɖɔtoewo ƒe dɔwɔwɔ ƒe gbegblẽ nana be ʋuʋudediwo dona. Bronchogen doa yaƒoƒomɔ̃ ƒe lãmenugbagbevi siwo me ʋuʋudedi le ƒe dzadzraɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ, si wɔnɛ be lãkusiwo ƒe ƒoƒo zi gbɔ zi geɖe kple woƒe lolome dzina ɖe edzi, si wɔnɛ be mucociliary clearance ƒe dɔwɔwɔ nyona ɖe edzi. Esia kpena ɖe ame ŋu woɖea yaƒoƒo kple dɔlékuiwo ɖa le yaƒoƒomɔ̃wo me, si wɔnɛ be yaƒoƒomɔ̃wo ƒe dɔdzẽ dzi ɖena kpɔtɔna.
(4) Yaƒoƒomɔ̃ ƒe wɔwɔme kple dɔwɔwɔ takpɔkpɔ
Yaƒoƒomɔ̃ ƒe gli ƒe titrime dzi ɖeɖe kpɔtɔ
Yaƒoƒomɔ̃ ƒe dɔdzẽ atraɖii ate ŋu ana yaƒoƒomɔ̃a ƒe gliwo nalolo eye yaƒoƒomɔ̃a natsi le dɔnɔ siwo ŋu aɖuɖɔtoedɔléle si nɔa anyi didi le gome. Bronchogen ɖea yaƒoƒomɔ̃ ƒe gli ƒe ƒoƒo ƒe lolome dzi kpɔtɔna to mɔxexe ɖe dɔdzẽ ƒe lãmenugbagbeviwo ƒe gege ɖe lãme nu, eɖea nusiwo dɔdzẽ ƒe domenɔlawo kple proteasewo gblẽna dzi kpɔtɔna, eye wòɖɔa lãmenugbagbeviwo godo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo, si wɔnɛ be yaƒoƒomɔ̃awo ƒe wɔwɔme kple woƒe ʋuʋu si sɔ la nɔa anyi.
Aɖuɖɔtoe ƒe dɔwɔwɔ nyuie wu
To yaƒoƒomɔ̃wo ƒe dɔdzẽ dzi ɖeɖe kpɔtɔ, ʋuʋudedi ƒe dodo dzi ɖeɖe kpɔtɔ, ɖa ƒe dɔwɔwɔ nyuie, kple yaƒoƒomɔ̃ ƒe wɔwɔme takpɔkpɔ me la, Bronchogen kpena ɖe dɔnɔ siwo ŋu aɖuɖɔtoedɔléle si nɔa anyi didi le ƒe lãkusi ƒe dɔwɔwɔ nyuie wu ŋu. Numekukuwo ɖee fia be le Bronchogen zazã vɔ megbe la, dɔnɔwo ƒe lãkusi ƒe dɔwɔwɔ ƒe nɔnɔmewo abe gbɔgbɔtsixe ƒe sesẽme si wozi ɖe wo dzi le sɛkɛnd ɖeka me (FEV1) kple ŋutete vevi si wozi ɖe wo dzi (FVC) nyo ɖe edzi ŋutɔ, eye dzesiwo abe gbɔgbɔtsixetsixe ene dzi ɖe kpɔtɔ ŋutɔ.
Nyanuwuwuw
Kpuie ko la, Bronchogen, abe atike si ate ŋu ada yaƒoƒomɔ̃ ƒe dɔdzẽ le asrã kple aɖuɖɔtoedɔléle si nɔa anyi didi me ene la, ƒe dɔwɔwɔ ƒe mɔnu si wozãna tsɔ tsia dɔdzẽ nu si ŋu taɖodzinu geɖe le, si to mɔ vovovowo dzi la le esi. To dɔdzẽ ƒe lãmenugbagbeviwo, dɔdzẽ ƒe domenɔlawo, yaƒoƒomɔ̃ ƒe lãmenugbagbeviwo, kple yaƒoƒomɔ̃wo ƒe tɔtrɔ dzi kpɔkpɔ me la, Bronchogen tea yaƒoƒomɔ̃wo ƒe dɔdzẽ ɖe to nyuie le asrã kple aɖuɖɔtoedɔléle si nɔa anyi didi dɔnɔwo me, enaa yaƒoƒomɔ̃wo ƒe wɔwɔme kple dɔwɔwɔ nyona ɖe edzi, eye wònaa dɔnɔwo ƒe agbenɔnɔ nyona ɖe edzi.
Dzɔtsoƒewo
[1] Son JW, Lim S. Glucagon-Like Peptide-1 ƒe Atikewɔwɔ: Mɔnukpɔkpɔ Yeye le Lolo akpa Dzikpɔkpɔ me[J]. Endocrinology kple lãmenugbagbeviwo ƒe dɔwɔwɔ, 2024,39 (2): 206-221.DOI: 10.3803 / EnM.2024.1940.
[2] Hough K. P., Curtiss M. L., Blain T. J., kple ame bubuwo. Yameʋuɖoɖo ƒe Gbugbɔgaɖɔɖo le Asrã me[J]. Liƒowo le Atikewɔwɔ me, 2020,Babla 7.DOI:org/10.3389/fmed.2020.00191.
[3] Athari S S. Lãmenugbagbeviwo ƒe dzesiwo ƒe taɖodzinu le asrã si ŋu nulɔdɔ le me[J]. Dzesiwo ƒe tɔtrɔ kple atikewɔwɔ si woɖo taɖodzinu na, 2019, 4 (1): 45.DOI: 10.1038 / s41392-019-0079-0.
Adzɔnu si li na numekuku zazã ɖeɖeko:
