Timogène miligaramu 20

▎ Timogène (Timogène) jɔcogo

▎ Timojeni ɲinini

Thymogen ka ɲininiw kɛcogo ye mun ye?

Kabini san 1960 waatiw la, baganw ka farikolo tangacogo yɔrɔ kolomaw — i n’a fɔ kolotugudaw, timi ani sɔgɔsɔgɔninjɛ — ye dɔnniyaba sɔrɔ u ka seko la ka fɛnɲɛnamafagalanw dilan minnu bɛ nɔ bila farikolo tangacogo la ani ka furakɛli layidu ta. San 1960 cɛmancɛ la, ɲininikɛlaw ye yɔrɔ dɔ sɔrɔ misiden ka timisɛni asetɔni bɔlenw kɔnɔ min bɛ ɲɛnamaya kɛcogo nafama jira min bɛ se ka farikolo tangacogo damatɛmɛlenw segin sosow la. O kɔfɛ, o ɲɔgɔnna furakisɛw bɔra kɛnɛ kan i n’a fɔ timosini, timopɛtidi ani T-activateur, u ye baarakɛcogo danma sɔrɔ furakɛli la i n’a fɔ farikolo tangalanw minnu bɛ se ka kɛ fɛn caman ye, olu bɔnsɔn fɔlɔw.

Sɛgɛsɛgɛli kunbaba minnu kɛra o kɔfɛ timosini yɔrɔ 5 kan, o kɛra sababu ye ka pepitiri ɔrimɔni fɔlɔw sɔrɔ minnu bɛ baganw farikolo tangacogo baara ɲɛnabɔ, i n’a fɔ timosini α1 (amino acide tolen 28 bɛ min na), timosini β4 (a tolen 43 bɛ a la), ani timosini beta (to 49 bɛ min kɔnɔ). O ɲininiw cayalenba in cɛma, Thymogen bɔra kɛnɛ kan. Timojɛni ye pepitiri surun ye min dilannen don ni asidi aminiki fila dɔrɔn ye (asidi glutamiki-triptofan, Glu-Trp), n’a kɛcogo ye L-α-glutamine kɔgɔ monosodiyɔmu ye - L-triptofan monosodium kɔgɔ, o ni fɛnɲɛnamafagalan nafama min bɛ bɔ timisi bɔlen na ni chromatographie ye, o bɛ tali kɛ ɲɔgɔn na. A ka molekiyɔmuw jɔcogo kɛrɛnkɛrɛnnen ani a ka se ka farikolo tangacogo caman kɛ, o kɛra sababu ye ka dɔnniya ɲinini kɛ a ka baarakɛcogo kan farikolo tangacogo labɛnni na, farikolo yɔrɔw dilancogo la, ani selilɛriw ka taamasiɲɛw siraw la, n’o laɲini ye ka bana suguya caman kunbɛnni n’u furakɛli sɔrɔ.

Timojeni ka baara kɛcogo ye mun ye?

Banakisɛfagalanw ka baarakɛcogo:

Banakisɛfagalanw ni taamasiɲɛw siraw baarakɛli : Kɔlɔsiliw y’a jira ko Thymogen bɛ farikolo tangalanw TLR/RLR sɔrɔyɔrɔw ni u taamasiɲɛw kɛcogo jamu baara. THP-1 monositɛri jolidɛsɛbanakisɛw ni joli dibaga kɛnɛmanw ka sɛnɛfɛnw na, Thymogen bɛ TLR3/7/8/9 minɛbagaw, sitoplasma sensɛriw RIG1/MDA5, ani taamasiɲɛw jirali lawuli ^{NFκB1 ni} MAVS O b’a jira ko Timojeni bɛ farikolo farikolo tangacogo sɛmɛntiya ani ka farikolo tangacogo fanga bonya ni a bɛ nin farikolo tangalan nafamaw ni taamasiɲɛw siraw baara. Misali la, NFκB1 bɛ a sen don funu jaabiw ni farikolo tangacogo labɛnni na; Timojɛni ka a taamasiɲɛw dilanbagaw ka jamu lawuli, o bɛ dɛmɛ ka farikolo tangalanw ka jaabi bɛnnenw daminɛ walasa ka a yɛrɛ tanga banakisɛw ka binkanni ma.

Sitokini bɔli caman sɛgɛsɛgɛli : Selilu sɛnɛcogo minnu kofɔlen don ka tɛmɛ, Timojeni bɛ sitokini funu TNF-α ni IL-1β bɔli bila mɔgɔ la. Sitokiniw jɔyɔrɔ ka bon kosɛbɛ kumaɲɔgɔnya ni labɛnni na farikolo tangalanw na. TNF-α ni IL-1β sen bɛ funu jaabiw daminɛni ni u ladilanni na. U bɔli cayalenba b’a jira ko Timojeni bɛ se ka farikolo farikolo tangacogo ɲɛminɛ ka ɲɛsin banakisɛw lafasali ma, a kɛtɔ ka sitokini bɔli labɛn ^{[1] .}.

Jɛnɛya jiracogo ɲɛnabɔli : Timojɛni yɔrɔw, i n’a fɔ EW dipɛtidi (o kɔrɔ ye ko Timojɛni yɛrɛ), olu bɛ se ka jeninida jiracogo sɛmɛntiya. A bɛ funteni-sɔrɔ-poroteyini, sitokiniw, fibrinolisi, kɔrɔya jɛnɛya, ani fɛn wɛrɛw labɛnni ɲɛnabɔ, ka fara selilɛriw ka taabolo kan i n’a fɔ danfara, caya ani apoptose. Misali la, funteni-sɔrɔ-poroteyini jɔyɔrɔ ka bon selilɛriw ka degun jaabiw la. Timojɛni ka u labɛncogo ɲɛnabɔ, o bɛ farikolokisɛw dɛmɛ u ka se ka u yɛrɛ labɛn ka ɲɛ sigida fɛn caman yeli la ani ka tiɲɛniw kɛlɛ ^{[2] .}.

Banakisɛfagalanw nɔ minnu bɛ sɔrɔ:

Banakisɛfagalanw ka baara tilennen : Kɔrɔbɔli minnu kɛra in vitro la, olu b’a jira ko Timojeni fiyɛli bɛ sigida banakisɛfagalanw baara jira SARS-CoV-2 kama banakisɛ hakɛ la min ye 5,2 log TCID50 ye Vero CCL81 selilɛriw la. O bɛ kɛ ni banakisɛ in ka jɛɲɔgɔnya tilennen ye, ka nɔ bila walew la i n’a fɔ a tali, a doncogo, ani a camanbɔli, o la, a bɛ banakisɛw ka banakisɛ sɔrɔli ni a jɛnsɛnni ^bali.

Banakisɛfagalanw ka nɔ jugu minnu bɛ sɔrɔ farikolo tangalanw fɛ: K’a sababu kɛ a ka farikolo tangalanw ye, Timojeni bɛ farikolo tangalanw ni taamasiɲɛw siraw baara, ka sitokiniw bɔli ɲɛnabɔ, ani ka farikolo ka farikolo tangacogo fanga bonya. A bɛ banakisɛw kɛlɛ cogo la min tɛ ɲɛ, a kɛtɔ ka farikolo tangacogo bɛɛ lajɛlen fanga bonya. Misali la, farikolo tangalanw minnu bɛ baara kɛ, olu bɛ se ka banakisɛfagalanw dɔn ka ɲɛ ani ka u ban, o la, u bɛ se ka banakisɛfagalanw sɔrɔ ^{[1] .}.

Jaa 1 TRH-TSH-T3 ka jaabiw labɛncogo ^{[3] .}.

Kɔnɔnatumuw dilancogo ani u lasegincogo:

Oksidan kɛlɛli nɔw : Sugunɛ joginni jugumanba kɛlɛli la, Timojeni bɛ oksidan perokisidi walew bali. Ni a kɛra sugunɛ jogin kɔfɛ, min bɛ sɔrɔ tetarasikilini karɔbɔni fɛ, Thymogen ye malondialdehyde (MDA) hakɛ dɔgɔya, o b’a jira ko a bɛ se ka farikolo tiɲɛni nɔgɔya oksidan degun fɛ. O bɛ kɛ barisa oksidan degun bɛ radikaliw labɔ minnu ka ca kojugu, minnu bɛ bin selilɛri kɔnɔ biyomolekuli kan — i n’a fɔ tulumafɛnw, farikolojɔlifɛnw ani ADN — o bɛ na ni selilɛriw joginni ni baarakɛbaliya ye. Timojeni ka farikolo tangacogo bɛ farikolokisɛw tanga tiɲɛni ma ^{[5] .}.

Kɔnɔnatumuw labɛncogo kura lawulili : O cogo kelen na, sugunɛ jogincogo jugumanba misaliw la, Timojeni bɛ sugunɛbilenniw labɛncogo kura lawuli. A ka c’a la, o bɛ kɛ ni jamu minnu bɛ tali kɛ farikolokisɛw caya, u danfara ani u fagali la, olu jiracogo labɛnni fɛ. Misali la, a bɛ sugunɛbilenni caya, ka sugunɛ tiɲɛnenw dilancogo ni u lasegincogo teliya walasa ka sugunɛ kɛcogo ɲuman segin ^{[5] .}.

A nɔ minnu bɛ sɔrɔ fɛnɲɛnamafagalanw, ɲɛgɛnw ni tulumafɛnw falenni na : Sogow ka sɛgɛsɛgɛliw la minnu kɛra sokɔnɔna joginw na, ni Timojɛni donna furakɛli sariyaw kɔnɔ wulu joginlenw na, o ye fɛnɲɛnamafagalanw falencogo nɔgɔya kosɛbɛ ka sɔrɔ ka ɲɛgɛnw ni tulumafɛnw sɛnɛcogo tiɲɛni dɔgɔya. O b’a jira ko Timojeni bɛ nɔ bila fɛnɲɛnamafagalanw, ɲɛgɛnw ani tulumafɛnw sɛnɛcogo la, a kɛtɔ ka yɔrɔ kolomaw labɛn farikoloɲɛnajɛ siraw la minnu bɛ tali kɛ o la, o la, farikoloɲɛnajɛ balansi bɛ to sen ^na.

A nɔ minnu bɛ sɔrɔ farikolojɔli dumuniw, azote ani witaminiw sɛnɛcogo la: Kabɔriw ka sɔgɔsɔgɔninjɛ kɔlɔsiliw la, Timojeni ye banakisɛfagalanw ka kataboli fasa caman yeli fanga dɔgɔya kosɛbɛ ani ka biyokimiki taamasiɲɛw nɔgɔya kɔlɔsili laban senfɛ. O b’a jira ko Thymogen ka baarakɛcogo bɛ farikolojɔli dumuniw, azote ani witaminiw sɛnɛcogo la, o bɛ se ka farikoloɲɛnajɛ sabatili sabati ni a bɛ nɔ bila farikolojɔlifɛn nafamaw ka baara walima u ka jeninida jirali ^la.

Timojeni baarakɛcogo ye mun ye?

Banakisɛfagalanw ka baarakɛyɔrɔ : Kalan minnu kɛra ka ɲɛsin coronavirus kura ma, kɔlɔsili minnu kɛra Vero CCL81 selilɛriw kan, olu ye Thymogen® fiyɛli ni banakisɛfagalan Miramistin® jilama suma ɲɔgɔn na walasa k’u ka sigida banakisɛfagalanw baara sɛgɛsɛgɛ SARS-CoV-2 kan. Jateminɛw y’a jira ko baga tɛ Vero selilɛriw la hakɛ minnu sɛgɛsɛgɛra. Ka fara o kan, kɔlɔsili caman kɔnɔ, Thymogen® fiyɛli ye sigida banakisɛfagalan baara jira SARS-CoV-2 kama banakisɛ hakɛ la min ye 5,2 log TCID50 ye. O b’a jira ko sebaayaba bɛ Thymogen® nugulafura la i n’a fɔ fura min bɛ kɛ fari la walasa ka COVID-19 kunbɛn ani k’a furakɛ ^{[3] .}.

Sugunɛbana furakɛcogo : Sugunɛbana jugumanba ka sɛgɛsɛgɛliw la, tetarasikilini karɔbɔni tali kɛli kɔnɔbara la ka taa a fɛ tile 5 kɔnɔ, o ye sugunɛbilenni bila mɔgɔ la, ka katalazi baara dɔgɔya, ani ka malondialdehyde hakɛ caya. Timojeni ni a jɔcogo misaliw tali (min bɛ sɔrɔ ni asidi aminiki D-Ala nɔrɔli ye pepitiri mɔlikulu N- walima C-terminus la) ye oksidan perokisidi walew bali ani ka sugunɛbilenniw dilancogo ni u lasegincogo lawuli. Olu cɛma, Timojeni analoziw ye sugunɛbilenni ni farikolo tangalan nɔ jira ka caya ni i ye a suma ni Timojeni ye. O nɔ tun bɛ ye kosɛbɛ ni asidi aminiki farala o mɔlikulu C-terminus kan. O b’a jira ko Thymogen ni a ɲɔgɔnnaw bɛ nɔ ɲuman bila sugunɛ joginw dilancogo la ^{[5] .}.

Banakisɛfagalanw tali ni banakisɛfagalanw tali : Pepitiri fura timalini bɛ se ka kɛ bana suguya caman na minnu bɛ tali kɛ farikolo tangacogo la, banakisɛw ni banakisɛw ka banaw, farikolo tangacogo kura, farikolo tangacogo, ani joli bɔli damatɛmɛni chimiothérapie ni radiothérapie kɔfɛ. A yɔrɔ dɔ, n’o ye EW dipɛtidi ye (o kɔrɔ ye ko fura min tɔgɔ ye ko Thymogen), o bɛ jeninida jiracogo ɲɛnabɔ, ka funteni sɔgɔsɔgɔninjɛ furakisɛw dilan, sitokiniw, fibrinolisi, kɔrɔya jamu, ani selilɛriw ka danfara, u caya ani apoptose. Timojeni bɛ se ka banakisɛ suguya caman kɛlɛ, wa a bɛ furakɛli nafa jira COVID-19 furakɛli bɛɛ lajɛlen na, min bɛ sɔrɔ korona banakisɛ fɛ ^{[2] .}.

Kuncɛli

Timojeni bɛ ɲɛnamaya kɛcogo caman jira. A bɛ farikolo tangalanw ka homeostasis mara ani ka banakisɛfagalanw fanga bonya ni a bɛ farikolo tangalanw TLR/RLR sɔrɔyɔrɔw baara, ka sitokiniw bɔli ɲɛnabɔ (misali la, TNF-α, IL-1β), ani ka farikolo tangalanw ka baara kɛcogo sɛmɛntiya. A bɛ banakisɛfagalanw baara jira in vitro SARS-CoV-2 kɛlɛli la. Ka fara o kan, a bɛ tiɲɛni nɔgɔya ni a bɛ oksidan degun bali ani ka farikolo yɔrɔw dilancogo/segincogo lawuli (misali la, sugunɛbilenniw). ka sɔrɔ ka jolisegindumuniw, ɲɛgɛnw ani tulumafɛnw sɛnɛcogo ɲɛnabɔ walasa ka farikoloɲɛnajɛ balansi mara. A bɛ se ka dɛmɛ don COVID-19 kunbɛnni n’a furakɛli la, ka sugunɛ tiɲɛnenw dilan, ka kɛ ka farikolo tangacogo ɲɛnabɔ sani opereli ka kɛ kansɛribanatɔ kɔrɔbaw la walasa ka opereli kɔfɛ gɛlɛyaw dɔgɔya ani ka kɛnɛya waati surunya. O b’a to a nafa ka bon farikolo tangacogo banaw ni farikolo yɔrɔw dilancogo labɛnni na.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Kim H ye ɲininikɛla ye min sinsinnen bɛ kolotugudaw ka ɲɛnamayako kan ani sɔgɔsɔgɔninjɛ hormones farikolo baarakɛcogo kan. U ka ɲininiw sinsinnen bɛ kosɛbɛ sɔgɔsɔgɔninjɛ hormones jɔyɔrɔ kan min bɛ kɛ ka ɲɛsin kolotugudaw yiriwali ma, minnu bɛ tali kɛ fɛnɲɛnamaw ka baarakɛcogo la, n’u sinsinnen bɛ molekiyɔmu ni selilɛriw ka baarakɛcogo basigilenw sɛgɛsɛgɛli kan. Kim H ka teli ka baara kɛ ni kɔrɔbɔli fɛɛrɛw faralen ye ɲɔgɔn kan i n’a fɔ molekiyɔmu biologi fɛɛrɛw ani biologique model systems walasa ka kalan kuncɛlenw kɛ, k’a laɲini ka hakilinata faamuyali nafa bonya endokirini fɛnw ni kolo kɛnɛya cɛ jɛɲɔgɔnya kan. Kim H tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [4].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Sokolova T. M., Poloskov V. V., Shuvalov A. N., Burova O. S., Sokolova Z. A., ani mɔgɔ wɛrɛw. Siginiden TLR/RLR-fɛɛrɛ minnu bɛ ingavirini ni timozɛni labɛnw ka farikolo tangacogo la. Irisi jamana ka gafe min bɛ wele ko Biothérapie 2019.

Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[2] Khavinson V. K., Linkova N. S., Chalisova N. I., Ivko O. M., ani mɔgɔw ye baara kɛ ni u ye. Timalin tali farikolo tangacogo la ani ɲɛnamaya kɛcogo molekilɛriw la. Biologi Bulletin lajɛw 2021; 11(4): 377-382. Ɲɛjirali dɔw. 10.1134/S2079086421040046. Bamako, Mali.

[3] Leneva I. A., Smirnov V. S., Kudryavtseva T. A., ani a ɲɔgɔnnaw. Fura min bɛ wele ko Thymogen extregistered, o ka sigida la banakisɛfagalanw, o min bɛ kɛ ni nugula ye, o bɛ SARS-CoV-2 coronavirus kɛlɛ in vitro. Banakisɛfagalanw ni Chimiothérapie 2021.

Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[4] Kim H, Mohan S. Thyroïde hormone jɔyɔrɔ ni a kɛcogoyaw kolotugudaw yiriwali kan. Kolow ɲinini 2013 sàn; 1(1): 146-161.DOI: 10.4248/BR201302004. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[5] Chulanova A. A., Smakhtin M. Y., Bobyntsev II, Mishina E. S., Artyushkova E. B., Smakhtina A. M. Immunomodulateur Thymogène ka analogues kuraw ka reparatif ni antioxydant nɔw sugunɛ tiɲɛni modɛli kɔrɔbɔli la. Bulletin de Biologie Expérimentale et Médecine 2023; 175(5): 700-703.DOI: 10.1007/s10517-023-05929-5. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.

[6] Reshetnyak V, Burdeyniy V, Malakhova L, Yelokhin M, Stekolnikov A. TIMOJƐN KA ƝƐNABƆLI ƝƐNABƆLI BANAW LA MINƐRIW, PIGMENT ANI LIPIDI ƝƐNABƆLI ƝƐNABƆLI KAN. Duniya kɔnɔ baganw ka furakɛli gafe 2022: 187-192.DOI: 10.52419/issn2072-2419.2022.3.187.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, olu BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.