TA1 miligaramu 10

▎ TA1 Jatebɔcogo

Sɔrɔyɔrɔ: PubChem

A kɛcogo: SDAAVDTSSEITTKDLKEKKEVVEEAEN Formula molekilɛri: C 129H 215N 33O55 Molecules girinya: 3108,3 g/mol CAS nimɔrɔ: 62304-98-7 PubChem ka CID: 16130571. Bamako, Mali Kɔrɔɲɔgɔnmaw: Timalfasin;Zadaxin

▎ TA1 Sɛgɛsɛgɛli

TA1 ye mun ye?

TA1 ye polipɛtidi ye min bɛ kɛ ni asidi aminiki 28 ye. A bɛ sɔrɔ timisi la a yɛrɛ la wa a jɔyɔrɔ ka bon T-cellw kɔgɔli ni u danfara la.

TA1 ka ɲininiw kɛcogo ye mun ye?

TA1 ye polipɛtidi biyoaktif ye min bɔra timozini tilayɔrɔba 5 la ka saniya, a bɛ kɛ ni asidi aminiki 28 ye. Timi ye farikolo tangalan nafama dɔ ye, min bɛ fɛn suguya caman dilan minnu bɛ farikolo tangacogo ɲɛnabɔ, wa timosini ye o dɔ ye. Ni timi ka baarakɛcogo sɛgɛsɛgɛli kuncɛlen don, mɔgɔw y’a ye dɔɔni dɔɔni ko a kɔnɔfɛn minnu bɛ baara kɛ, olu bɛ se ka nafa sɔrɔ bana suguya caman furakɛli la.

TA1 ka baarakɛcogo ye mun ye?

Banakisɛfagalanw tali: 

TA1 ye biologique réponse modifier ye min bɛ se ka farikolokisɛ suguya caman kɛ farikolo tangalanw na. A bɛ farikolo tangalanw ka baara ɲɛnabɔ kosɛbɛ ni T-cellw ka danfara ni u kɔgɔli sabatili ye (Sjogren MH, 2004; Mao L, 2023). Kɛrɛnkɛrɛnnenya la, TA1 bɛ se ka nɔ bila timositɛriw la ni a bɛ u danfara lawuli walima k’u sɛmɛntiya ka kɛ T-cell baarakɛtaw ye.

Banakisɛfagalanw tali fɛɛrɛ: 

COVID-19 sɔgɔsɔgɔninjɛ furakɛli la, TA1 bɛ sɔgɔsɔgɔninjɛ kɛnɛyali teliya a ka banakisɛfagalanw fɛ. A bɛ se ka dɔ bɔ funu jaabi la, ka COVID-19 sɔgɔsɔgɔninjɛ taamasiɲɛw nɔgɔya i n’a fɔ sumaya ni sɛgɛn, ka fɛnɲɛnamafagalanw tali nɔgɔya, ka kɛnɛya teliya ka bɔ COVID-19 sɔgɔsɔgɔninjɛ la (Wang Z, 2023).

Thymalfasin bɛ tumokisɛw ka apoptose bila cogo di kansɛri furakɛli la?

Banakisɛfagalanw ka baara sabatili: 

Timalfasini ye timopepitidi dilannen ye min farikolo tangacogo ka bon. A bɛ se ka farikolo tangalanw ka fagali fanga bonya tumuw kan, o la, a bɛ tumuw ka apoptose (banakisɛfagalanw fagali) bila sen kan cogo la min tɛ ɲɛ. Misali la, tumuw ka sigida fitininw na, Timalfasini bɛ se ka T-cellw ka danfara ni u kɔgɔli sabati ani ka T-cellw ka baara caya. I n’a fɔ farikolo tangalan yɔrɔ nafama dɔ, T-cell bɛ se ka tumokisɛw dɔn ani ka bin u kan, ka tumuw ka apoptose (banakisɛfagalanw fagali) bila mɔgɔ la ni u bɛ sitotokisi fɛnw bɔ ani fɛɛrɛ wɛrɛw.

Banakisɛfagalanw ka jaabiw labɛnni: 

I n’a fɔ farikolo tangalan, Timalfasin bɛ se ka farikolo tangacogo ɲɛnabɔ ani ka tumuw ka apoptose (banakisɛfagalanw fagali) bila mɔgɔ la. A bɛ se ka Th1 farikolo tangacogo ɲɛ. Th1 selilɛriw bɛ sitokiniw bɔ kosɛbɛ i n’a fɔ IFN-γ, olu bɛ se ka baara kɛ tumuw kan k’u ɲɛsin u ka apoptose ma. Ka fara o kan, Thymalfasin bɛ se fana ka farikolo tangalan wɛrɛw ka baara ɲɛnabɔ, i n’a fɔ ka NK selilɛriw ka baara caya. NK selilɛriw bɛ se ka tumuw faga k’a ɲɛsin u ma ani fana ka tumuw ka apoptose bila mɔgɔ la ni sitokiniw bɔli ye ani fɛɛrɛ wɛrɛw ^{[1] .}.

Farikolo tangacogo ɲɛnabɔli tumuw kɛlɛli waati: 

Tumu furakɛli senfɛ, banabagatɔw ka teli ka farikolo tangalanw sɔrɔ, o bɛna nɔ bila tumu furakɛli nafa la. Timalfasin bɛ se ka farikolo tangacogo ɲɛ min bɛ sɔrɔ tumuw kɛlɛli furakɛli senfɛ, ka farikolo tangalanw seko bonya ka bin tumuw kan, ani o cogo la ka tumuw ka apoptose (banakisɛfagalanw fagali) bila mɔgɔ la. Misali la, chimiothérapie walima radiothérapie waati, banabagatɔ farikolo tangacogo bɛna tiɲɛ fo ka se hakɛ dɔ ma. Timalfasini bɛ se ka farikolo tangalanw kɛnɛyali ni u caya, ka farikolo tangalanw ka baara ɲɛ, ani ka mɔgɔfaga nɔ bonya tumuw la.

Timosini alfa 1 bɛ ni ɲɛnamaya kɛcogo caman ye.

Soso:PubMed ^{[6] Ɲɛjirali dɔw.}

Thymalfasin (Timalfasin) kɛcogo ye mun ye?

Banakisɛ minnu bɛ sɔrɔ banakisɛw fɛ: 

K’a sababu kɛ a farikolo tangacogo ye, TA1 ka teli ka kɛ ka banakisɛw furakɛ. Misali la, COVID-19 banaba waati la, a y’a jira ko a bɛ se ka kɛnɛyako ɲuman jira COVID-19 sɔgɔsɔgɔninjɛ furakɛli la. Sɛgɛsɛgɛliw y’a jira ko TA1 bɛ se ka COVID-19 banakisɛ minnu bɛ sɔrɔ tuma caman na tangacogo ni banakisɛfagalanw lakanani fɛɛrɛ suguya caman sababu fɛ ^farikolo , olu ka taa ɲɛ ka se sɔgɔsɔgɔninjɛ jugumanba ma, Kɛrɛnkɛrɛnnenya la, banabagatɔ minnu furakɛra ni TA1 ye, dɔgɔtɔrɔso sigili surunyara kosɛbɛ, sɔgɔsɔgɔninjɛ taamasiɲɛw (i n’a fɔ sumaya ni sɛgɛn) lafiya hakɛ tun ka ca kosɛbɛ ka tɛmɛ kɔrɔsili kulu ta kan, ani funu bɔli yɔrɔ min jirala CT fɛ, o fana tun ka dɔgɔ kosɛbɛ ka tɛmɛ kɔrɔsili kulu ^kan ta Ka fara o kan, Cox model analysis multivariate y’a jira ko banabagatɔ minnu ye TA1 ta ani banabagatɔ fitininw, olu ka COVID-19 antigènes jiginni jugumanba teliyalen ^don kosɛbɛ Tα1 (TA1 yɔrɔba) ye dɔ fara CD4+ T selilɛri hakɛ kan banabagatɔw la minnu ka oksizɛni fiyɛli dɛmɛni ka dɔgɔn u daminɛ na joona ka tɛmɛ furakɛli kɛcogo kɔrɔ kan, wa a bɛ se ka jɔyɔrɔba ta dɔgɔtɔrɔso la banabagatɔw furakɛli la minnu ka jolidɛsɛ ni jolidɛsɛ bɛ sɔrɔ COVID-19 ^fɛ.

Sugunɛbilenni furakɛli: 

TA1 fana bɛ nɔ dɔ bila sugunɛbilenni furakɛli la. A bɛ se ka kɛ sugunɛbilenni furakɛli kelen ye walima ni a ni interferon α-2b faralen don ɲɔgɔn kan sugunɛbilenni C furakɛli la Kɛrɛnkɛrɛnnenya la, sɛgɛsɛgɛli dɔ y’a jira ko sugunɛbilenni B furakɛli la, TA1 nafa jateminɛna kɛnɛyaso sɛgɛsɛgɛli naani kɔnɔ minnu kɛra banabagatɔ 195 kan. Nin ɲinini dɔ la, banabagatɔ 17 minnu furakɛra ni TA1 ye, olu la, 9 tun bɛ ni sugunɛbilenni banakisɛ (HBV) ADN bɔli ye kalo wɔɔrɔ kɔnɔ, ni i ye o suma ni banabagatɔ 10 ye 16 la minnu furakɛra ni interferon α-2b ye ani banabagatɔ 4 15 la minnu tun bɛ tariku kɔlɔsili kulu la.

Furakɛli dɛmɛnan : TA1 fana bɛ kɛ kosɛbɛ kansɛri furakɛli la. Banabagatɔ minnu ka fogonfogon kansɛri bɛ se ka tigɛ (NSCLC) ani sugunɛ kansɛri, furakɛli dɛmɛnanw na, TA1 bɛ se ka ɲɛnamaya hakɛ bɛɛ lajɛlen (OS) ɲɛ kosɛbɛ (Mao L, 2023). Banabagatɔ minnu ka NSCLC min tɛ se ka tigɛ, o ka jugu sigida la, TA1 bɛ se ka dɔ bɔ kosɛbɛ farikolojidɛsɛ ni sɔgɔsɔgɔninjɛ la min bɛ sɔrɔ kɛnɛyaji ni chimiothérapie fɛ, wa OS bɛ ɲɛ ka taa a ^fɛ.

Tumu kɛlɛli farikolo tangacogo sabatili : 

Dalilu minnu kɛra ka kɔn kɛnɛyaso ɲɛ, olu b’a jira ko TA1 bɛ se ka M2 polarisation kɔsegin min bɛ sɔrɔ makɔrɔfagaw ka efɛrositɔsi fɛ ni TLR7/SHIP1 aksidan baara ye, ka kansɛri furakɛli nafa bonya, ani ka tumu kɛlɛli farikolo tangacogo bonya ni 'tumu nɛnɛma' jiginni ye ka kɛ 'tumu funteni' ye (Mao L, 2023). Ka fara o kan, TA1 fana bɛ se ka mɔgɔ tanga kɔnɔboli dɔgɔyali la min bɛ sɔrɔ farikolo tangalanw fɛ (ICI) ani a bɛ se ka ICIw ka kɛnɛyako nafa bonya ^[4] . Tα1 i n’a fɔ furakɛli dɛmɛnan sugunɛ kansɛri bɔli kɔfɛ, o bɛ se ka sugunɛbilenni kansɛri fitini bɛ banabagatɔ minnu na, olu ka ɲɛnamaya ɲɛfɔcogo ɲɛ. Sɛgɛsɛgɛli dɔ la min kɛra kɔfɛ, sugunɛbilenni kansɛri fitini bɛ banabagatɔ minnu na, ni u ye sugunɛ tigɛ, olu tilalen don kulu fila ye, kulu A (resection + Tα1) ani kulu B (resection dɔrɔn). Kalo 47,0 kɔlɔsili kɔfɛ, san 1, san 3 ani san 5 kɔnɔ, banabagatɔ minnu bɛ kulu A kɔnɔ, olu bɛɛ ka ɲɛnamaya hakɛ ni u ka ɲɛnamaya hakɛ min tɛ segin ka kɛ, o tun ka ca ni kulu B ta ye ^..

Banakisɛfagalanw ka baarakɛcogo seginni ani boloci fanga bonya: 

TA1 bɛ se ka kɛ ka farikolo tangalanw ni bana juguw furakɛ ani ka kɛ boloci jaabiw fanga bonyalan ye ^{[4, 6]} . A bɛ se ka farikolo tangacogo ɲɛnabɔ ani ka T-cell baara sabati, wa a bɛ se ka nafa sɔrɔ kɛnɛyaso la banaw la minnu farikolo tangacogo ka dɔgɔn walima minnu tɛ baara kɛ i n’a fɔ banakisɛ jugumanw ni bana basigilenw, kansɛri, ani boloci ^tɛ jaabi Kɔlɔsiliw y’a jira ko banakisɛfagalanw ka bana jugumanba la, a jirala ko TA1 bɛ farikolo tangacogo segin a cogo kɔrɔ la ani ka dɛmɛ don ka banabagatɔw ka saya hakɛ dɔgɔya ^{[4] .}.

COVID-19 banakisɛw ni gɛlɛyaw kunbɛnni banabagatɔw la minnu bɛ sugunɛbilenni kɛ : 

Banabagatɔ minnu bɛ sugunɛbana laban na (ESRD) minnu bɛ joli segin furakɛli (HD) kɛ, olu jatera ko u ka teli ka SARS-CoV2 banakisɛ sɔrɔ kɛrɛnkɛrɛnnenya la ka a sababu kɛ fɛn dɔw ye i n’a fɔ u kɔrɔbayali, bana wɛrɛw doni, fura tali, ani u ka kan ka taa diyalizi dɔgɔtɔrɔsow la tuma caman. Kalan fɔlɔw y’a jira ko TA1, n’o ye dɛmɛnan ye kunfilanitu boloci la, o bɛ se ka mɔgɔkɔrɔbaw (HD banabagatɔw fana sen bɛ o la) ka farikolo tangacogo ɲɛ kunfilanitu boloci la ani ka kunfilanitu banakisɛw dɔgɔya. COVID-19 bana daminɛ donw na, ɲininikɛlaw y’a jira ko TA1 tali HD banabagatɔw la, o bɛ se ka dɔ bɔ COVID-19 banakisɛw sɔrɔli hakɛ n’a juguya la. San 2022 zuluyekalo tile fɔlɔ la, ESRD/HD banabagatɔ 254 minnu bɔra diyalizi yɔrɔ duuru la Kansas City, Missouri, olu tun bɛ nin sɛgɛsɛgɛli in na, banabagatɔ 194 tilalen don k’u kɛ kulu A ye (TA1 miligaramu 1,6 pikiri fari jukɔrɔ siɲɛ fila dɔgɔkun kɔnɔ dɔgɔkun 8 kɔnɔ) ani kulu B (kɔlɔsili kulu, k’a sɔrɔ u ma TA1 sɔrɔ ⁾.

Kuncɛli la, i n’a fɔ polipɛtidi min bɛ ni farikolo tangalan baara kɛrɛnkɛrɛnnenw ye, TA1 y’a jira ko a bɛ se ka baara kɛ cogo caman na furakɛli siratigɛ la. Banakisɛfagalanw furakɛli la, a bɛ nɔba bila banaw la i n’a fɔ sugunɛbilenni ni COVID-19. A tɛ se ka bana taamasiɲɛw nɔgɔyali teliya dɔrɔn ani ka funu dɔgɔya, nka a bɛ se ka bana in ka taa ɲɛ fana ani ka banabagatɔw kɛnɛyali hakɛ ɲɛ. Tumu furakɛli siratigɛ la, a bɛ se ka tumuw ka apoptose bila sira caman fɛ, ka farikolo tangalanw ka fagali fanga bonya tumuw kan, ka farikolo tangacogo ɲɛ, ka baara ɲuman jira kansɛri suguya caman furakɛli la i n’a fɔ fogonfogon kansɛri ani sugunɛ kansɛri.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Wang Z ye ɲininikɛla ye min ka kalanko dɔnniya ka ca, wa a ka jɛkafɔ dɔnniya ka bon baarada caman kɔnɔ. U ka ɲininiw ɲɛsinnen bɛ baarabolow ni ɲɔgɔn cɛ i n’a fɔ Ɛntɛrinɛti, spektroskɔpi, Simi, Denso, Da kɔnɔ opereli & furakɛli, ani Fiziki. Wang Z ye tɔnba ni iniwɛrisite tɔgɔba dɔw jɛ, i n’a fɔ Sinuwa Iniwɛrisite ka dɔnniyakalanso (CAS), Yunnan Iniwɛrisite, Pekin Iniwɛrisite, Hunan sɛnɛko Iniwɛrisite, Shanghai Jiao Tong Iniwɛrisite, ani mɔgɔ caman wɛrɛw. U ka baara b’a jira ko u sinsinnen don kosɛbɛ kokuradonni ni jɛkafɔ kan, kɛrɛnkɛrɛnnenya la, yɔrɔ minnu ɲɛsinnen bɛ izini yeelenma ɲɛnayeli, furakɛli baarakɛcogo, ani fɛn dilanni dɔnniya kɔrɔlenw ma. Jɛɲɔgɔnya sababu fɛ ni baaradaw ye i n’a fɔ Jiangsu mara ɲininikɛyɔrɔ min bɛ wele ko Light Industrial Optoelectronic Engineering & Technology ani Air Force Military Medical University, Wang Z ye dɛmɛ don ka ɲɛsin hakililata ɲɛtaa ma ani waleyali waleyali ma u ka dɔnniya siratigɛ la. Wang Z tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [2].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Sjogren M H. Thymalfasin: farikolo tangalan ye min bɛ sugunɛbana furakɛ.[J]. Gastroenterologie et hepatologie gafe, 2004,19 Suppl 6:S69-S72. DOI:10.1111/j.1440-1746.2004.03635.x. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew

[2] Wang Z, Wang C, Fei X, ani mɔgɔ wɛrɛw. Timalfasin furakɛli bɛ COVID-19 sɔgɔsɔgɔninjɛ furakɛli teliya ni banakisɛfagalanw ye[J]. Sɔgɔsɔgɔninjɛ, 2023,15(1).DOI:10.1186/s41479-023-00116-6.

[3] Shehadeh F, Benitez G, Mylona E. K., ani mɔgɔ wɛrɛw. Timalfasini (Thymosin-α-1) sɛgɛsɛgɛli piloti dɔ walasa ka dɔgɔtɔrɔso banabagatɔw furakɛ minnu ka jolidɛsɛ ni jolisegindumuni bɛ u la ka da Coronavirus bana 2019 banakisɛ kan[J]. Banakisɛfagalanw ka gafe, 2023,227(2):226-235.DOI:10.1093/infdis/jiac362.

[4] Mao L. Thymosin alpha 1-Aw ye a kɛcogo caman jateminɛ kokura farikolo tangalanw ni kansɛri furakɛli waati la[J]. Duniya kɔnɔ farikolo tangalanw, 2023,117.DOI:10.1016/j.intimp.2023.109952.

[5] He C, Peng W, Li C, ani a ɲɔgɔnnaw. Timalfasini, o ye furakɛli dɛmɛnan ye min bɛ layidu ta sugunɛbilenni kansɛri misɛnniw na sugunɛ tigɛlen kɔfɛ[J]. Furakɛcogo, 2017,96(16).DOI:10.1097/MD.0000000000006606.

[6] Dominari A, Hathaway Iii D, Pandav K, ani a ɲɔgɔnnaw. Thymosin alpha 1: Sɛbɛnw lajɛcogo bɛɛ lajɛlen.[J]. Diɲɛ kɔnɔ banakisɛfagalanw ka gafe, 2020,9(5):67-78.DOI:10.5501/wjv.v9.i5.67.

[7] Tuthill C. W., Awad A., Parrigon M., ani a ɲɔgɔnnaw. Thymalfasin (Ta1) sɛgɛsɛgɛli fɔlɔ dɔ kɛra walasa ka covid-19 banakisɛw ni banaw bali sugunɛbilenni banabagatɔw la: Rapport preliminaire[J]. Duniya kɔnɔ farikolo tangalanw, 2023,117.DOI:10.1016/j.intimp.2023.109950.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, olu BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *in glass*, o kɔrɔ ye gilasi minɛnw na) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.