TA1 10 mg

▎ TA1 Structure

Source: PubChem

Sequence: SDAAVDTSSEITTKDLKEKKEVVEEAEN Molecular Formula: C 129H 215N 33O55 Molecular Luj: 3108.3 g / mol CAS Nr .: 62304-98-7 PubChem CID: 16130571 Synonyms: Thymalfasin; Zadaxin

▎ TA1 Kev Tshawb Fawb

TA1 yog dab tsi?

TA1 yog polypeptide uas muaj 28 amino acids. Nws ib txwm muaj nyob hauv thymus thiab ua lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev sib txawv ntawm T hlwb.

Dab tsi yog qhov kev tshawb fawb keeb kwm ntawm TA1?

TA1 yog bioactive polypeptide cais thiab purified los ntawm thymosin feem 5, muaj 28 amino acids. thymus yog ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob, uas tsim ntau yam tshuaj uas tswj kev tiv thaiv kab mob, thiab thymosin yog ib qho ntawm lawv. Nrog rau kev kawm tob txog kev ua haujlwm ntawm thymus, tib neeg tau maj mam pom tias cov khoom siv hauv nws tuaj yeem muaj txiaj ntsig zoo rau kev kho mob ntawm ntau yam kab mob.

Lub mechanism ntawm kev txiav txim ntawm TA1 yog dab tsi?

Immunomodulation: 

TA1 yog ib qho kev hloov kho lom neeg uas tuaj yeem qhib ntau lub hlwb hauv lub cev tiv thaiv kab mob. Nws tsuas yog tswj hwm kev tiv thaiv kab mob los ntawm kev txhim kho qhov sib txawv thiab kev loj hlob ntawm T hlwb (Sjogren MH, 2004; Mao L, 2023). Tshwj xeeb, TA1 tuaj yeem cuam tshuam rau thymocytes los ntawm kev txhawb nqa lawv qhov sib txawv lossis hloov lawv mus rau hauv T-hlwb.

Anti-inflammatory mechanism: 

Hauv kev kho mob ntawm COVID-19 mob ntsws, TA1 ua kom rov qab los ntawm kev mob ntsws los ntawm nws cov txheej txheem tiv thaiv kab mob. Nws tuaj yeem txo cov lus teb inflammatory, txhawb kev txo cov tsos mob ntawm COVID-19 mob ntsws xws li ua npaws thiab qaug zog, pab txhawb kev nqus ntawm exudate, thiab ua kom rov zoo los ntawm COVID-19 mob ntsws (Wang Z, 2023).

Thymalfasin induce apoptosis ntawm qog hlwb hauv kev kho mob qog noj ntshav li cas?

Txhim khu kev ua haujlwm ntawm lub cev tiv thaiv kab mob: 

Thymalfasin yog ib qho hluavtaws thymopeptide nrog kev tiv thaiv kab mob siab. Nws tuaj yeem txhim kho cov nyhuv tua ntawm lub cev tiv thaiv kab mob ntawm cov qog hlwb, yog li indirectly inducing apoptosis ntawm qog hlwb. Piv txwv li, nyob rau hauv cov qog microenvironment, Thymalfasin tuaj yeem txhawb kev sib txawv thiab kev loj hlob ntawm T hlwb thiab txhim khu kev ua haujlwm ntawm T hlwb. Raws li ib feem tseem ceeb ntawm lub cev tiv thaiv kab mob, T hlwb tuaj yeem paub thiab tua cov qog hlwb, ua rau apoptosis ntawm cov qog hlwb los ntawm kev tso cov tshuaj cytotoxic thiab lwm yam.

Kev tswj lub cev tiv thaiv kab mob: 

Raws li ib qho tshuaj tiv thaiv kab mob, Thymalfasin tuaj yeem tswj lub cev tiv thaiv kab mob thiab ua rau apoptosis ntawm cov qog hlwb. Nws tuaj yeem txhim kho Th1 lub cev tiv thaiv kab mob. Th1 hlwb feem ntau zais cytokines xws li IFN-γ, uas tuaj yeem ua ncaj qha rau cov qog hlwb thiab ua rau lawv cov apoptosis. Tsis tas li ntawd, Thymalfasin tseem tuaj yeem tswj hwm kev ua haujlwm ntawm lwm lub cev tiv thaiv kab mob, xws li txhawb kev ua haujlwm ntawm NK hlwb. NK hlwb tuaj yeem tua cov qog hlwb ncaj qha thiab tseem ua rau apoptosis ntawm cov qog hlwb los ntawm kev zais cytokines thiab lwm txoj kev ^[1].

Txhim kho cov tshuaj tiv thaiv kab mob thaum kho cov qog nqaij hlav: 

Thaum cov txheej txheem ntawm kev kho mob qog nqaij hlav, cov neeg mob feem ntau ntsib kev tiv thaiv kab mob, uas yuav cuam tshuam rau kev ua haujlwm ntawm cov qog nqaij hlav. Thymalfasin tuaj yeem txhim kho kev tiv thaiv kab mob tsim tawm thaum kho cov qog nqaij hlav, txhim kho lub peev xwm ntawm lub cev tiv thaiv kab mob los tua cov qog hlwb, thiab yog li induce lub apoptosis ntawm qog hlwb. Piv txwv li, thaum chemotherapy lossis radiotherapy, tus neeg mob lub cev tiv thaiv kab mob yuav raug puas tsuaj rau qee yam. Thymalfasin tuaj yeem txhawb kev rov qab los thiab kev loj hlob ntawm lub cev tiv thaiv kab mob, txhim kho kev ua haujlwm ntawm lub cev tiv thaiv kab mob, thiab txhim kho cov nyhuv tua ntawm cov qog hlwb.

Thymosin alpha 1 muaj ntau yam kev ua haujlwm lom neeg.

Source: PubMed ^[6]

Dab tsi yog cov kev siv ntawm Thymalfasin?

Kev kis kab mob: 

Vim nws cov nyhuv immunomodulatory, TA1 feem ntau yog siv los kho cov kab mob. Piv txwv li, thaum lub sijhawm COVID-19 kis thoob qhov txhia chaw, nws tau pom tias muaj txiaj ntsig zoo hauv kev kho mob ntawm COVID-19 mob ntsws. Kev tshawb fawb qhia tau hais tias TA1 tuaj yeem tiv thaiv kev kis tus kab mob COVID-19 mus rau mob ntsws hnyav los ntawm ntau yam kev tiv thaiv kab mob thiab kev tiv thaiv kev tiv thaiv kab mob ^[2] . Tshwj xeeb, rau cov neeg mob kho nrog TA1, lub tsev kho mob nyob hauv tsev kho mob tau luv luv, qhov kev faib ua feem ntawm kev txo qis ntawm cov tsos mob ntsig txog mob ntsws (xws li ua npaws thiab qaug zog) tau siab dua li ntawm pawg tswj hwm, thiab thaj tsam ntawm inflammatory exudation qhia los ntawm CT kuj tseem qis dua li ntawm pawg tswj hwm ^[2] . Tsis tas li ntawd, kev tshuaj xyuas ntau yam ntawm Cox tus qauv qhia tau hais tias cov neeg mob uas siv TA1 thiab cov neeg mob hluas muaj qhov hloov pauv tsis zoo sai ntawm COVID-19 antigens ^[2] . Tα1 (lub ntsiab lus tseem ceeb ntawm TA1) tau nce CD4 + T cell suav hauv cov neeg mob uas tsis tshua muaj pa oxygen nqus pa ntawm lub hauv paus sai dua li kev kho mob, thiab tuaj yeem ua lub luag haujlwm hauv kev kho mob hauv tsev kho mob nrog hypoxemia thiab lymphopenia tshwm sim los ntawm COVID-19 ^[3].

Kev kho kab mob siab: 

TA1 kuj muaj qee yam cuam tshuam rau kev kho kab mob siab. Nws tuaj yeem siv los ua monotherapy rau kab mob siab B lossis ua ke nrog interferon α-2b rau kev kho mob siab C. Tshwj xeeb, ib txoj kev tshawb nrhiav pom tias hauv kev kho kab mob siab B, kev ua tau zoo ntawm TA1 tau soj ntsuam hauv plaub qhov kev sim tshuaj ntsuam xyuas nrog rau 195 tus neeg mob. Hauv ib qho ntawm cov kev tshawb fawb, 9 ntawm 17 tus neeg mob kho nrog TA1 muaj tus kab mob siab B (HBV) DNA tshem tawm ntawm rau lub hlis, piv nrog 10 ntawm 16 tus neeg mob kho nrog interferon α-2b thiab 4 ntawm 15 tus neeg mob hauv pawg tswj keeb kwm.

Adjuvant kho: TA1 kuj tau siv dav hauv kev kho mob qog noj ntshav. Rau cov neeg mob uas muaj cov qog nqaij hlav qog nqaij hlav me me (NSCLC) thiab mob qog noj ntshav, hauv kev kho mob ntxiv, TA1 tuaj yeem txhim kho tag nrho cov ciaj sia taus (OS) (Mao L, 2023). Rau cov neeg mob uas muaj kev kho tsis tau zoo hauv zos NSCLC, TA1 tuaj yeem txo qis lymphopenia thiab mob ntsws uas tshwm sim los ntawm kev siv hluav taws xob thiab tshuaj khomob, thiab muaj qhov sib txawv ntawm kev txhim kho OS ^[4].

Txhim khu kev tiv thaiv qog nqaij hlav: 

Cov pov thawj preclinical qhia tau hais tias TA1 tuaj yeem thim rov qab M2 polarization tshwm sim los ntawm efferocytosis ntawm macrophages los ntawm kev ua kom lub TLR7 / SHIP1 axis, txhim khu kev ua tau zoo ntawm kev kho mob qog noj ntshav, thiab txhim kho kev tiv thaiv qog nqaij hlav los ntawm kev hloov 'mob khaub thuas' rau 'cov qog kub' 2. Tsis tas li ntawd, TA1 kuj tseem muaj kev tiv thaiv los ntawm kev txo cov kab mob colitis tshwm sim los ntawm kev tiv thaiv kab mob tiv thaiv kab mob (ICIs) thiab tuaj yeem txhim kho kev kho mob ntawm ICIs ^[4] . Tα1 raws li kev kho mob tom qab phais mob qog noj ntshav tuaj yeem txhim kho qhov kev cia siab ntawm cov neeg mob me me hepatocellular carcinoma. Hauv kev tshawb nrhiav kev rov qab los, cov neeg mob uas muaj kab mob hepatocellular me me uas tau kuaj xyuas lub siab tau muab faib ua ob pawg, pawg A (resection + Tα1) thiab pab pawg B (tsuas yog resection). Tom qab kev soj ntsuam nruab nrab ntawm 47.0 lub hlis, 1-, 3-, thiab 5-xyoo tag nrho cov ciaj sia taus thiab cov neeg mob tsis muaj kev rov qab los ntawm cov neeg mob hauv pawg A tau siab dua cov neeg nyob hauv pawg B. Kev tshuaj xyuas ntau yam qhia tau tias Tα1 yog ib qho kev ywj pheej prognostic rau tag nrho cov ciaj sia taus thiab rov muaj sia nyob tsis muaj tus nqi ^[5].

Restoring tiv thaiv kev ua haujlwm thiab kev txhaj tshuaj tiv thaiv: 

TA1 tuaj yeem siv los kho cov kab mob tiv thaiv kab mob thiab cov kab mob malignancies thiab ua ib qho kev txhim kho ntawm cov lus teb tshuaj tiv thaiv ^{[4, 6]} . Nws tuaj yeem tswj hwm lub cev tiv thaiv kab mob thiab txhim kho T cell muaj nuj nqi, thiab tej zaum yuav muaj txiaj ntsig kho mob rau cov kab mob uas tsis muaj zog lossis tsis muaj zog tiv thaiv kab mob xws li mob hnyav thiab mob ntev, mob qog noj ntshav, thiab tshuaj tiv thaiv tsis teb ^[4] . Cov kev tshawb fawb tau ua pov thawj tias hauv kev mob hnyav heev, TA1 tau pom tias yuav rov ua kom lub cev tsis muaj zog thiab pab txo qis kev tuag ntawm cov neeg mob ^[4].

Tiv thaiv COVID-19 kev kis kab mob thiab teeb meem hauv cov neeg mob uas lub raum lim ntshav: 

Cov neeg mob uas muaj kab mob hauv lub raum kawg (ESRD) tau txais hemodialysis (HD) yog suav tias yog qhov tshwj xeeb tshaj plaws rau kev kis tus kab mob SARS-CoV2 vim muaj ntau yam xws li hnub nyoog laus dua, lub nra hnyav, kev siv tshuaj, thiab xav tau mus ntsib cov chaw kho mob ntshav qab zib ntau zaus. Cov kev tshawb fawb thaum ntxov tau pom tias TA1, ua ib qho ntxiv rau cov tshuaj tiv thaiv kab mob khaub thuas, tuaj yeem txhim kho cov tshuaj tiv thaiv kab mob ntawm cov neeg laus (xws li cov neeg mob HD) rau cov tshuaj tiv thaiv kab mob khaub thuas thiab txo cov kab mob khaub thuas. Thaum ntxov ntawm COVID-19 kis thoob qhov txhia chaw, cov kws tshawb fawb tau kwv yees tias kev tswj hwm TA1 rau HD cov neeg mob tuaj yeem txo qhov xwm txheej thiab qhov hnyav ntawm COVID-19. Raws li lub Xya Hli 1, 2022, 254 ESRD / HD cov neeg mob los ntawm tsib lub chaw lim ntshav hauv Kansas City, Missouri tau suav nrog hauv txoj kev tshawb no, ntawm 194 tus neeg mob tau muab faib ua pawg A (subcutaneous txhaj ntawm 1.6mg TA1 ob zaug hauv ib lub lis piam rau 8 lub lis piam) thiab pawg B (tswj pab pawg, tsis tau txais TA1 ⁾.

Nyob rau hauv xaus, raws li ib tug polypeptide nrog tshwj xeeb immunomodulatory functions, TA1 tau qhia muaj peev xwm siv nyob rau hauv ntau yam hauv kev kho mob. Hauv kev kho mob kis kab mob, nws muaj txiaj ntsig zoo rau cov kab mob xws li kab mob siab B thiab COVID-19. Nws tuaj yeem tsis tsuas yog ua kom txo qis cov tsos mob thiab txo qhov mob, tab sis kuj tiv thaiv kev loj hlob ntawm tus kab mob thiab txhim kho tus nqi rov qab ntawm cov neeg mob. Hais txog kev kho mob qog, nws tuaj yeem ua rau apoptosis ntawm cov qog hlwb los ntawm ntau txoj hauv kev, txhim kho kev tua cov kab mob hauv cov qog nqaij hlav, thiab txhim kho lub xeev kev tiv thaiv kab mob, qhia txog kev ua tau zoo hauv kev kho mob qog noj ntshav xws li mob ntsws cancer thiab mob qog noj ntshav.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Wang Z yog tus kws tshawb fawb nrog ntau hom kev kawm keeb kwm yav dhau los thiab kev sib koom tes dav dav thoob plaws ntau lub tsev kawm. Lawv cov kev tshawb fawb txaus siab cuam tshuam txog kev sib koom tes xws li Engineering, Spectroscopy, Chemistry, Dentistry, Oral Surgery & Medicine, thiab Physics. Wang Z tau koom nrog cov koom haum tseem ceeb thiab cov tsev kawm ntawv qib siab, suav nrog University of Suav Academy of Sciences (CAS), Yunnan University, Peking University, Hunan Agricultural University, Shanghai Jiao Tong University, thiab ntau lwm tus. Lawv txoj haujlwm qhia txog kev tsom mus rau kev tsim kho tshiab thiab kev sib koom tes, tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam uas muaj feem xyuam nrog lub teeb pom kev lag luam optoelectronic engineering, kev siv kho mob, thiab cov ntaub ntawv qib siab. Los ntawm kev koom tes nrog cov koom haum xws li Jiangsu Provincial Research Center for Light Industrial Optoelectronic Engineering & Technology thiab Air Force Military Medical University, Wang Z tau pab txhawb rau ob qho tib si theoretical kev nce qib thiab kev siv tswv yim hauv lawv cov kev txawj ntse. Wang Z tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [2].

▎ Cov Lus Qhia Tseem Ceeb

[1] Sjogren M H. Thymalfasin: ib qho kev tiv thaiv kab mob tiv thaiv kab mob rau kev kho mob siab [J]. Phau ntawv Journal of Gastroenterology thiab Hepatology, 2004,19 Suppl 6:S69-S72. DOI: 10.1111/j.1440-1746.2004.03635.x

[2] Wang Z, Wang C, Fei X, et al. Thymalfasin kev kho mob nrawm rau COVID-19 kev kho mob ntsws ntsws los ntawm kev siv tshuaj tiv thaiv kab mob [J]. Pneumonia, 2023,15(1).DOI:10.1186/s41479-023-00116-6.

[3] Shehadeh F, Benitez G, Mylona EK, et al. Kev sim sim ntawm Thymalfasin (Thymosin-α-1) los kho cov neeg mob hauv tsev kho mob nrog Hypoxemia thiab Lymphocytopenia Vim Tus Kab Mob Coronavirus 2019 Kab Mob [J]. Phau ntawv Journal of Infectious Diseases, 2023,227(2):226-235.DOI:10.1093/infdis/jiac362.

[4] Mao L. Thymosin alpha 1-Reimagine nws cov kev siv dav dav hauv immuno-oncology era[J]. International Immunopharmacology, 2023,117.DOI:10.1016/j.intimp.2023.109952.

[5] He C, Peng W, Li C, et al. Thymalfasin, ib qho kev cog lus rau kev kho mob nyob rau hauv me me hepatocellular carcinoma tom qab daim siab resection [J]. Tshuaj, 2017,96(16).DOI:10.1097/MD.0000000000006606.

[6] Dominari A, Hathaway Iii D, Pandav K, et al. Thymosin alpha 1: Kev tshuaj xyuas ntau yam ntawm cov ntaub ntawv.[J]. World Journal of Virology, 2020,9(5):67-78.DOI:10.5501/wjv.v9.i5.67.

[7] Tuthill CW, Awad A, Parrigon M, et al. Ib qho kev sim sim ntawm Thymalfasin (Ta1) los tiv thaiv covid-19 kev kis kab mob thiab mob ntshav qab zib hauv cov neeg mob lub raum: Daim ntawv qhia ua ntej [J]. International Immunopharmacology, 2023,117.DOI:10.1016/j.intimp.2023.109950.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.