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1kits （10Ibikoresho）
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▎ Imiterere ya TA1
Inkomoko: PubChem |
Urukurikirane: SDAAVDTSSEITTKDLKEKKEVVEEAEN Inzira ya molekulari: C 129H 215N 33O.55 Uburemere bwa molekuline: 3108.3 g / mol Numero ya CAS: 62304-98-7 PubChem CID: 16130571 Synonyme: Thymalfasin ； Zadaxin |
▎ TA1 Ubushakashatsi bwa
TA1 ni iki?
TA1 ni polypeptide igizwe na aside amine 28. Mubisanzwe bibaho muri thymus kandi bigira uruhare runini mugukura no gutandukanya ingirabuzimafatizo za T.
Ni ubuhe bushakashatsi bwakozwe muri TA1?
TA1 ni bioactive polypeptide yitaruye kandi isukurwa mu gice cya thymosine 5, igizwe na aside amine 28. Tymus ni urugingo rukomeye rwa sisitemu yumubiri, itanga ibintu bitandukanye bigenga imikorere yumubiri, kandi thymosine nimwe murimwe. Hamwe nubushakashatsi bwimbitse bwimikorere ya thymus, abantu bamenye buhoro buhoro ko ibice bikora birimo bishobora kugira agaciro kokuvura indwara zitandukanye.
Ni ubuhe buryo bwo gukora bwa TA1?
Gukingira indwara:
TA1 nigisubizo cyibinyabuzima gishobora gukora selile zitandukanye mumikorere yumubiri. Igenga cyane cyane imikorere yubudahangarwa mu kongera itandukaniro no gukura kwingirangingo za T (Sjogren MH, 2004; Mao L, 2023). By'umwihariko, TA1 irashobora kugira ingaruka kuri thymocytes itera itandukaniro ryabo cyangwa ikayihindura ingirabuzimafatizo T ikora.
Uburyo bwo kurwanya inflammatory:
Mu kuvura umusonga COVID-19, TA1 yihutisha gukira umusonga binyuze mu buryo bwo kurwanya inflammatory. Irashobora kugabanya igisubizo kibabaza, igateza imbere kugabanya ibimenyetso bifitanye isano na COVID-19 nk'umusonga n'umunaniro, koroshya kwinjiza exudate, no kwihutisha gukira umusonga wa COVID-19 (Wang Z, 2023).
Nigute Thymalfasin itera apoptose ya selile yibibyimba mukuvura kanseri?
Kongera ibikorwa bya selile immunite:
Thymalfasin ni thémopeptide ya syntetique hamwe nibikorwa byinshi byongera ubudahangarwa bw'umubiri. Irashobora kongera imbaraga zo kwica ingirabuzimafatizo ku ngirabuzimafatizo, bityo igatera mu buryo butaziguye apoptose ya selile. Kurugero, muri microen ibidukikije yibibyimba, Thymalfasin irashobora guteza imbere gutandukanya no gukura kwingirangingo za T no kuzamura ibikorwa bya selile T. Nkigice cyingenzi cyimikorere yumubiri, T selile irashobora kumenya no gutera selile yibibyimba, bigatera apoptose yingirabuzimafatizo yibibyimba irekura ibintu bya cytotoxique nubundi buryo.
Kugena igisubizo cyumudugudu:
Nka immunopotentiator, Thymalfasin irashobora kugenga ubudahangarwa bw'umubiri kandi igatera apoptose ya selile yibibyimba. Irashobora kongera ubudahangarwa bwa Th1. Th1 selile isohora cyane cytokine nka IFN-γ, ishobora gukora muburyo butaziguye kanseri yibibyimba kandi igatera apoptose. Mubyongeyeho, Thymalfasin irashobora kandi kugenzura imikorere yizindi selile zumubiri, nko kongera ibikorwa bya selile NK. Ingirabuzimafatizo za NK zirashobora kwica mu buryo butaziguye ingirabuzimafatizo kandi zikanatera apoptose ya selile yibibyimba mu gusohora cytokine n'ubundi buryo [1].
Kunoza immunosuppression mugihe cyo kuvura ibibyimba:
Mugihe cyo kuvura ibibyimba, abarwayi bakunze guhura na immunosuppression, bizagira ingaruka kumikorere yo kuvura ibibyimba. Thymalfasin irashobora kunoza ubudahangarwa bw'umubiri butangwa mugihe cyo kuvura ibibyimba, bikongerera ubushobozi sisitemu yumubiri kwibasira ingirabuzimafatizo, bityo bigatera apoptose ya selile yibibyimba. Kurugero, mugihe cya chimiotherapie cyangwa radiotherapi, sisitemu yumubiri wumurwayi izangirika kurwego runaka. Thymalfasine irashobora guteza imbere gukira no gukwirakwira kwingirangingo z'umubiri, kunoza imikorere yubudahangarwa bw'umubiri, no kongera ingaruka zo kwica ingirabuzimafatizo.
Thymosine alpha 1 ifite ibikorwa byinshi byibinyabuzima.
Inkomoko: Byatangajwe [6]
Ni ubuhe buryo bukoreshwa na Thymalfasin?
Indwara ziterwa na virusi:
Bitewe n'ingaruka zayo zo gukingira, TA1 ikoreshwa mugukiza indwara zanduye. Kurugero, mugihe cyicyorezo cya COVID-19, cyerekanye imikorere myiza yubuvuzi mu kuvura umusonga COVID-19. Ubushakashatsi bwerekana ko TA1 ishobora gukumira indwara zanduye COVID-19 zanduye umusonga bikabije binyuze mu buryo butandukanye bwo kongera ubudahangarwa no kwirinda indwara [2] . By'umwihariko, ku barwayi bavuwe na TA1, ibitaro byaragabanutse ku buryo bugaragara, umubare w'abatabazi ku bimenyetso bifitanye isano n'umusonga (nk'umuriro n'umunaniro) wari hejuru cyane ugereranije n'uw'itsinda rishinzwe kugenzura, kandi agace ko gusohora umuriro na CT na kari kari hasi cyane ugereranije n'itsinda rishinzwe kugenzura [2] . Byongeye kandi, isesengura ry’icyitegererezo cya Cox ryerekanye ko abarwayi bakoresheje TA1 n’abarwayi bakiri bato bafite umuvuduko mwinshi wo guhindura virusi ya COVID-19 [2] . Tα1 (igice cyingenzi cya TA1) yongereye umubare wa selile CD4 + T ku barwayi bafite umwuka uhumeka wa ogisijeni uhumeka neza ku buryo bwihuse kuruta ubuvuzi busanzwe, kandi ushobora kugira uruhare mu kuvura abarwayi bari mu bitaro barwaye hypoxemia na lymphopenia batewe na COVID-19 [3].
Umuti wa hepatite:
TA1 nayo igira ingaruka runaka mukuvura hepatite. Irashobora gukoreshwa nka mitiweli ya hepatite B cyangwa ifatanije na interferon α-2b mu kuvura hepatite C. By'umwihariko, ubushakashatsi bwerekanye ko mu kuvura indwara ya hepatite B, hasuzumwe ingaruka za TA1 mu manza enye z’amavuriro zirimo abarwayi 195. Muri bumwe mu bushakashatsi bwakozwe, abarwayi 9 kuri 17 bavuwe na TA1 barwaye virusi ya hepatite B (HBV) mu mezi atandatu, ugereranije n’abarwayi 10 kuri 16 bavuwe na interferon α-2b na 4 kuri 15 bari mu itsinda rishinzwe kugenzura amateka.
Kuvura Adjuvant: TA1 nayo ikoreshwa cyane mukuvura kanseri. Ku barwayi bafite kanseri y'ibihaha idashobora kwangirika (NSCLC) na kanseri y'umwijima, mu buvuzi bujyanye, TA1 irashobora kuzamura cyane ubuzima rusange (OS) (Mao L, 2023). Ku barwayi bafite NSCLC yateye imbere mu karere, TA1 irashobora kugabanya cyane lymphopenia na pneumoniya iterwa na radiotherapi na chimiotherapie, kandi hariho inzira yo kunoza OS [4].
Kongera ubudahangarwa bw'umubiri:
Ibimenyetso simusiga byerekana ko TA1 ishobora guhindura M2 polarisation iterwa na efferocytose ya macrophage mugukoresha umurongo wa TLR7 / SHIP1, kongera imbaraga za chimiotherapie ya kanseri, no kongera ubudahangarwa bwo kurwanya ibibyimba uhindura 'ibibyimba bikonje ' uhinduka 'ibibyimba bishyushye ' (Mao L, 2023). Byongeye kandi, TA1 igira kandi ingaruka zo gukingira kugabanya colitis iterwa na inhibitori ya immunite (ICIs) kandi irashobora kuzamura imikorere yubuvuzi bwa ICI [4] . Tα1 nk'ubuvuzi bujyanye na kanseri y'umwijima irashobora kunoza imenyekanisha ry'abarwayi bafite kanseri ntoya ya hepatocellular. Mu bushakashatsi bwisubireho, abarwayi bafite kanseri ntoya ya hepatocellular barwaye umwijima bagabanijwemo amatsinda abiri, itsinda A (resection + Tα1) nitsinda B (resection gusa). Nyuma yo gukurikiranwa hagati y’amezi 47.0, imyaka 1-, 3-, na 5 yimyaka muri rusange umubare wokubaho hamwe n’ubuzima bw’abarwayi bo mu itsinda A bwarushijeho kubaho ugereranije n’abari mu itsinda B. Isesengura ryinshi ryerekanye ko Tα1 ari ikintu cyigenga cyerekana ko abantu babaho muri rusange ndetse n’ubuzima budasubirwaho [5].
Kugarura imikorere yubudahangarwa no kongera urukingo:
TA1 irashobora gukoreshwa mu kuvura indwara zidakingiwe hamwe n’indwara mbi ndetse no kongera ibisubizo by’inkingo [4, 6] . Irashobora kugenga sisitemu yubudahangarwa no kongera imikorere ya T selile, kandi irashobora kugira akamaro kivura indwara zifite imikorere mibi yumubiri yangiritse cyangwa idakora neza nkindwara zikaze kandi zidakira, kanseri, ninkingo zititabira [4] . Ubushakashatsi bwerekanye ko muri sepsis ikabije, TA1 yerekanwe kugarura imikorere y’umubiri no gufasha kugabanya imfu z’abarwayi [4].
Kwirinda kwandura COVID-19 nibibazo ku barwayi barimo dialyse yimpyiko:
Abarwayi bafite indwara zimpyiko zanyuma (ESRD) bakira hemodialyse (HD) bafatwa nk’ibasirwa cyane n’ubwandu bwa SARS-CoV2 bitewe n’imyaka nko gusaza, umutwaro utera indwara, gukoresha ibiyobyabwenge, ndetse no gusura amavuriro ya dialyse kenshi. Ubushakashatsi bwakozwe mbere bwerekanye ko TA1, nk’umuti w’urukingo rw’ibicurane, ishobora kongera antibody y’abaturage bageze mu zabukuru (harimo n’abarwayi ba HD) ku rukingo rw’ibicurane no kugabanya kwandura ibicurane. Mu minsi ya mbere y’icyorezo cya COVID-19, abashakashatsi batekereje ko guha abarwayi TA1 abarwayi ba HD bishobora kugabanya ubwandu n’uburemere bw’indwara ya COVID-19. Kuva ku ya 1 Nyakanga 2022, abarwayi 254 ba ESRD / HD bo mu bigo bitanu bya dialyse byo mu mujyi wa Kansas, muri Leta ya Missouri bashyizwe mu bushakashatsi, muri bo abarwayi 194 bagabanijwe ku buryo butunguranye mu itsinda A (inshinge zo mu bwoko bwa 1.6mg TA1 kabiri mu cyumweru mu byumweru 8) n'itsinda B (itsinda rishinzwe kugenzura, batabonye TA1) [7].
Mu gusoza, nka polypeptide ifite imikorere idasanzwe yubudahangarwa, TA1 yerekanye ibishoboka muburyo bwinshi mubuvuzi. Mu kuvura indwara ziterwa na virusi, igira ingaruka zikomeye ku ndwara nka hepatite B na COVID-19. Ntishobora kwihutisha kugabanya ibimenyetso gusa no kugabanya gucana ariko nanone ikabuza iterambere ryindwara no kuzamura umuvuduko w abarwayi. Ku bijyanye no kuvura ibibyimba, irashobora gutera apoptose ya selile yibibyimba binyuze munzira nyinshi, ikongera imbaraga zo kwica ingirangingo z'umubiri ku ngirabuzimafatizo z'ibibyimba, kandi igateza imbere immunosuppressive, ikerekana imikorere myiza mu kuvura kanseri zitandukanye nka kanseri y'ibihaha na kanseri y'umwijima.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Wang Z ni umushakashatsi ufite ubumenyi butandukanye kandi afite ubunararibonye mu bufatanye mu bigo byinshi. Inyungu zabo zubushakashatsi zirimo ibice bitandukanye nka Engineering, Spectroscopy, Chemistry, Dentistry, Oral Surgery & Medicine, na Physics. Wang Z yifatanije n’imiryango ikomeye na kaminuza zikomeye, harimo kaminuza y’ubumenyi y’ubushinwa (CAS), kaminuza ya Yunnan, kaminuza ya Peking, kaminuza y’ubuhinzi ya Hunan, kaminuza ya Shanghai Jiao Tong, n’abandi benshi. Ibikorwa byabo byerekana cyane guhanga udushya nubufatanye, cyane cyane mubice bijyanye ninganda zoroheje za optoelectronic injeniyeri, ubuvuzi, hamwe nibikoresho bya siyansi. Binyuze ku bufatanye n’ibigo nka Centre y’ubushakashatsi y’Intara ya Jiangsu ishinzwe Inganda zoroheje za Optoelectronic Engineering & Technology hamwe na kaminuza y’ubuvuzi ya gisirikare y’ingabo zirwanira mu kirere, Wang Z yagize uruhare mu iterambere ry’imyumvire ndetse no mu bikorwa bifatika mu bumenyi bwabo. Wang Z yanditse ku rutonde rwerekana [2].
