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1 kits (10 Vials)
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▎ Tsarin TA1
Source: PubChem |
Jeri: SDAAVDTSSEITTKDLKEKKEVVEEAEN Tsarin kwayoyin halitta: C 129H 215N 33O55 Nauyin Kwayoyin: 3108.3 g/mol Lambar CAS: 62304-98-7 Saukewa: 16130571 Synonyms: Thymalfasin; Zadaxin |
▎ TA1 Bincike
Menene TA1?
TA1 polypeptide ne wanda ya ƙunshi amino acid 28. A zahiri yana wanzuwa a cikin thymus kuma yana taka muhimmiyar rawa a cikin balaga da tsarin bambance-bambancen ƙwayoyin T.
Menene asalin bincike na TA1?
TA1 wani nau'in polypeptide ne na bioactive wanda aka ware kuma an tsarkake shi daga juzu'in thymosin 5, wanda ya ƙunshi amino acid 28. Thymus wani muhimmin sashi ne na tsarin garkuwar jiki, wanda ke samar da abubuwa daban-daban masu daidaita aikin rigakafi, kuma thymosin yana daya daga cikinsu. Tare da zurfin nazarin ayyukan thymus, mutane sun fahimci sannu a hankali cewa abubuwan da ke aiki a cikinsa na iya samun mahimmancin mahimmanci don maganin cututtuka daban-daban.
Menene tsarin aikin TA1?
Immunomodulation:
TA1 shine mai gyara martanin halittu wanda zai iya kunna sel daban-daban a cikin tsarin rigakafi. Ya fi daidaita aikin rigakafi ta hanyar haɓaka bambance-bambance da maturation na ƙwayoyin T (Sjogren MH, 2004; Mao L, 2023). Musamman, TA1 na iya shafar thymocytes ta hanyar haɓaka bambance-bambancen su ko canza su zuwa ƙwayoyin T masu aiki.
Tsarin hana kumburi:
A cikin maganin COVID-19 ciwon huhu, TA1 yana hanzarta murmurewa daga ciwon huhu ta hanyar hana kumburi. Yana iya rage martanin kumburi, inganta rage alamun COVID-19 masu alaƙa da ciwon huhu kamar zazzabi da gajiya, sauƙaƙe ɗaukar exudate, da hanzarta murmurewa daga cutar huhu ta COVID-19 (Wang Z, 2023).
Ta yaya Thymalfasin ke haifar da apoptosis na ƙwayoyin ƙari a cikin maganin ciwon daji?
Haɓaka ayyukan ƙwayoyin rigakafi:
Thymalfasin shine thymopeptide na roba tare da babban aikin haɓaka rigakafi. Yana iya haɓaka tasirin kisa na ƙwayoyin rigakafi akan ƙwayoyin ƙari, ta yadda a kaikaice ke haifar da apoptosis na ƙwayoyin ƙari. Alal misali, a cikin ƙananan ƙwayoyin cuta, Thymalfasin na iya inganta bambance-bambance da balaga da ƙwayoyin T da haɓaka ayyukan ƙwayoyin T. A matsayin wani muhimmin ɓangare na tsarin rigakafi, ƙwayoyin T na iya ganewa da kuma kai farmaki ga ƙwayoyin tumor, haifar da apoptosis na ƙwayoyin tumo ta hanyar sakin abubuwan cytotoxic da sauran hanyoyi.
Daidaita amsawar rigakafi:
A matsayin immunopotentiator, Thymalfasin zai iya daidaita amsawar rigakafi kuma ya haifar da apoptosis na ƙwayoyin tumor. Yana iya haɓaka amsawar rigakafi Th1. Kwayoyin Th1 galibi suna ɓoye cytokines kamar IFN-γ, waɗanda zasu iya yin aiki kai tsaye akan ƙwayoyin ƙari kuma su haifar da apoptosis. Bugu da ƙari, Thymalfasin kuma zai iya tsara ayyukan sauran ƙwayoyin rigakafi, kamar haɓaka ayyukan ƙwayoyin NK. Kwayoyin NK na iya kashe ƙwayoyin tumor kai tsaye kuma su haifar da apoptosis na ƙwayoyin ƙari ta hanyar ɓoye cytokines da sauran hanyoyin [1].
Inganta rigakafin rigakafi yayin maganin cutar kansa:
A lokacin aiwatar da maganin ciwon daji, marasa lafiya sukan fuskanci maganin rigakafi, wanda zai shafi tasirin maganin ciwon daji. Thymalfasin na iya inganta haɓakar rigakafi da aka haifar a lokacin maganin ƙwayar cuta, haɓaka ƙarfin tsarin rigakafi don kai hari ga ƙwayoyin tumo, kuma ta haka ne ya haifar da apoptosis na ƙwayoyin tumor. Misali, a lokacin chemotherapy ko radiotherapy, tsarin garkuwar jikin majiyyaci zai lalace zuwa wani matsayi. Thymalfasin na iya inganta farfadowa da yaduwa na ƙwayoyin rigakafi, inganta aikin tsarin rigakafi, da haɓaka tasirin kisa akan ƙwayoyin tumo.
Thymosin alpha 1 yana da fa'idodin ayyukan nazarin halittu.
Source:PubMed [6]
Menene aikace-aikacen Thymalfasin?
Kwayoyin cututtuka:
Saboda tasirinsa na immunomodulatory, ana amfani da TA1 sau da yawa don magance cututtukan cututtuka. Misali, yayin bala'in COVID-19, ya nuna ingantaccen ingancin asibiti a cikin kula da cutar huhu ta COVID-19. Bincike ya nuna cewa TA1 na iya hana ci gaban cututtukan COVID-19 na yau da kullun zuwa matsanancin ciwon huhu ta hanyar haɓaka rigakafi daban-daban da hanyoyin kariya masu kumburi [2] . Musamman, ga marasa lafiya da aka yi amfani da su tare da TA1, an rage zaman asibiti sosai, rabon taimako na alamun ciwon huhu (irin su zazzaɓi da gajiya) ya fi girma fiye da na ƙungiyar kulawa, kuma yanki na exudation mai kumburi da CT ya nuna shi ma ya ragu sosai fiye da na ƙungiyar kulawa [2] . Bugu da ƙari, nazarin samfurin Cox multivariate ya nuna cewa marasa lafiya da suka yi amfani da TA1 da ƙananan marasa lafiya suna da saurin canzawa mara kyau na COVID-19 antigens [2] . Tα1 (babban sashin TA1) yana haɓaka ƙididdigar ƙwayoyin CD4 + T a cikin marasa lafiya tare da tallafin iskar oxygen mai ƙarancin gudu a tushe cikin sauri fiye da daidaitaccen magani, kuma yana iya taka rawa a cikin kula da marasa lafiya na asibiti tare da hypoxemia da lymphopenia wanda COVID-19 [3] ya haifar..
Maganin ciwon hanta:
TA1 kuma yana da wani tasiri a cikin maganin cutar hanta. Ana iya amfani da shi azaman monotherapy don hepatitis B ko a hade tare da interferon α-2b don maganin ciwon hanta na C. Musamman, wani binciken da aka gano cewa a cikin maganin ciwon hanta B, an kimanta tasirin TA1 a cikin gwaje-gwaje na asibiti guda hudu da suka shafi marasa lafiya 195. A cikin daya daga cikin binciken, 9 daga cikin 17 marasa lafiya da aka bi da TA1 suna da kwayar cutar hepatitis B (HBV) DNA a cikin watanni shida, idan aka kwatanta da 10 daga cikin 16 marasa lafiya da aka bi da su tare da interferon α-2b da 4 daga 15 marasa lafiya a cikin rukunin kulawa na tarihi.
Magani mai ɗorewa: TA1 kuma ana amfani dashi sosai a cikin maganin ciwon daji. Ga marasa lafiya tare da ciwon huhu marasa ƙananan ƙwayoyin cuta (NSCLC) da ciwon hanta, a cikin maganin adjuvant, TA1 na iya inganta ƙimar rayuwa gaba ɗaya (OS) (Mao L, 2023). Ga marasa lafiya tare da NSCLC mai ci gaba na gida, TA1 na iya rage yawan lymphopenia da ciwon huhu da ke haifar da radiotherapy da chemotherapy, kuma akwai yanayin inganta OS [4].
Haɓaka rigakafin ƙwayar cuta:
Shaida ta farko ta nuna cewa TA1 na iya juyar da polarization na M2 da efferocytosis na macrophages ta haifar ta hanyar kunna TLR7/SHIP1 axis, haɓaka ingancin maganin cutar kansa, da haɓaka rigakafin ƙwayar cuta ta hanyar canza “ciwon daji masu sanyi” zuwa “ciwon daji mai zafi” (Mao L, 202). Bugu da ƙari, TA1 kuma yana da tasiri mai kariya a cikin rage colitis da ke haifar da masu hanawa na rigakafi (ICIs) kuma yana iya haɓaka tasirin asibiti na ICI [4] . Tα1 a matsayin magani na adjuvant bayan maganin ciwon hanta na iya inganta yanayin marasa lafiya tare da ƙananan ciwon hanta. A cikin binciken da aka yi nazari na baya-bayan nan, marasa lafiya tare da ƙananan ciwon hanta da suka yi amfani da hanta sun kasu kashi biyu, rukuni A (resection + Tα1) da kuma rukuni B (resection kawai). Bayan bin tsaka-tsakin watanni na 47.0, 1-, 3-, da 5-shekara yawan adadin rayuwa da kuma sake dawowa da marasa lafiya a cikin rukuni na A sun fi wadanda ke cikin rukunin B. Nazarin Multivariate ya nuna cewa Tα1 wani abu ne mai zaman kanta mai zaman kanta ga yawan rayuwa da kuma sake dawowa ba tare da sake dawowa ba ..
Maido da aikin rigakafi da haɓaka rigakafin rigakafi:
Za a iya amfani da TA1 don magance jihohin da ba a yarda da su ba da kuma malignancies kuma a matsayin mai haɓaka maganin rigakafi [4, 6] . Yana iya daidaita tsarin rigakafi da haɓaka aikin ƙwayar ƙwayar cuta ta T, kuma yana iya samun fa'idodin asibiti don cututtuka tare da rauni ko rashin aiki na rigakafi kamar cututtuka masu tsanani da na yau da kullum, ciwon daji, da kuma maganin rigakafi marasa amsa [4] . Nazarin ya tabbatar da cewa a cikin mai tsanani sepsis, TA1 an nuna don mayar da aikin rigakafi da kuma taimakawa wajen rage yawan mace-mace na marasa lafiya [4].
Hana kamuwa da cututtukan COVID-19 da rikice-rikice a cikin majinyata da ke yin dialysis na koda:
Marasa lafiya masu fama da cutar renal na ƙarshen zamani (ESRD) waɗanda ke karɓar hemodialysis (HD) ana ɗaukarsu suna da rauni musamman ga kamuwa da cuta ta SARS-CoV2 saboda dalilai kamar tsufa, nauyin ƙwayar cuta, amfani da miyagun ƙwayoyi, da buƙatar ziyartar asibitocin dialysis akai-akai. Nazarin farko ya nuna cewa TA1, a matsayin mai ba da shawara ga maganin mura, zai iya haɓaka amsawar rigakafin tsofaffi na tsofaffi (ciki har da marasa lafiya HD) zuwa maganin mura da kuma rage cututtuka na mura. A farkon cutar ta COVID-19, masu bincike sun yi hasashen cewa gudanar da TA1 zuwa HD marasa lafiya na iya rage aukuwa da tsananin cututtukan COVID-19. Tun daga Yuli 1, 2022, 254 ESRD / HD marasa lafiya daga cibiyoyin dialysis guda biyar a Kansas City, Missouri an haɗa su a cikin binciken, wanda aka rarraba marasa lafiya 194 zuwa rukuni A (alurar subcutaneous na 1.6mg TA1 sau biyu a mako don makonni 8) da rukuni B (ƙungiyar kulawa, ba tare da karɓar TA1 ba) [7].
A ƙarshe, a matsayin polypeptide tare da ayyuka na musamman na immunomodulatory, TA1 ya nuna yiwuwar aikace-aikace a yawancin fannoni a fannin likitanci. A cikin maganin cututtukan ƙwayoyin cuta, yana da tasiri mai mahimmanci akan cututtuka irin su hepatitis B da COVID-19. Ba wai kawai zai iya hanzarta kawar da alamun bayyanar cututtuka da rage kumburi ba amma kuma ya hana ci gaban cutar da inganta yawan dawowar marasa lafiya. Dangane da maganin ƙwayar cuta, yana iya haifar da apoptosis na ƙwayoyin tumor ta hanyar hanyoyi masu yawa, haɓaka tasirin kashe ƙwayoyin cuta akan ƙwayoyin tumor, da inganta yanayin rigakafi, yana nuna kyakkyawan aiki a cikin maganin cututtuka daban-daban kamar ciwon huhu da ciwon hanta.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Wang Z mai bincike ne da ke da ilimin ilimi daban-daban da ƙwarewar haɗin kai a cikin cibiyoyi da yawa. Abubuwan da suka shafi binciken su sun shafi fannoni daban-daban kamar Injiniya, Spectroscopy, Chemistry, Dentistry, Surgery Oral & Medicine, da Physics. Wang Z yana da alaƙa da manyan kungiyoyi da jami'o'i, ciki har da Jami'ar Kwalejin Kimiyya ta Sin (CAS), Jami'ar Yunnan, Jami'ar Peking, Jami'ar Aikin Noma ta Hunan, Jami'ar Shanghai Jiao Tong, da dai sauransu. Ayyukan su yana nuna mai da hankali sosai kan ƙirƙira da haɗin gwiwa, musamman a cikin wuraren da suka shafi aikin injiniyan optoelectronic masana'antu haske, aikace-aikacen likita, da kimiyyar kayan haɓaka. Ta hanyar haɗin gwiwa tare da cibiyoyi kamar Cibiyar Nazarin Lardin Jiangsu don Hasken Masana'antu Optoelectronic Engineering & Fasaha da Jami'ar Kiwon Lafiyar Sojan Sama, Wang Z ya ba da gudummawa ga ci gaban ka'idoji da aikace-aikace masu amfani a fannonin gwaninta. An jera Wang Z a cikin ambaton ambaton [2].
