Tesamoreli miligaramu 10

▎ Tesamoreli ka jɔcogo

Sɔrɔyɔrɔ: PubChem

Ɲɛfɔli: YADAI F TNSY RKVL GQLS A RK L LQDI M SRQ QGE S NQ E RGA R ARL Formula molekilɛri: C 221H 366N 72O 67S Molecules girinya: 5136 g/mol CAS nimɔrɔ: 218949-48-5 PubChem ka CID: 16137828. Bamako, Mali Kɔrɔɲɔgɔnmaw: Egrifta

▎ Tesamoreli ka ɲininiw

Tesamoreli ka ɲininiw kɛcogo ye mun ye?

Ni hadamaden ka bonya hormone (rhGH) faralen ɲɔgɔn kan (rhGH) bɛ kɛ ka bonya hormone (GH) dɛsɛ furakɛ, hali ni a nafa ka bon kɛnɛyaso la, a kɔlɔlɔ suguya caman fana bɛ taa ɲɔgɔn fɛ. O ko in kɛra sababu ye ka hadamadenw ka bonya hormone-releasing factor (GFR) analogues (GFR) dilan, barisa u bɛ se ka muɲu ka ɲɛ. Tesamoreli ye GFR dilannen ye min dabɔra ka kɛ fura ye min bɛ se ka kɛ bana suguya caman furakɛli ye minnu bɛ se ka kɛ sababu ye ka GH dɛsɛ hakɛ dɔ sɔrɔ, sidabanakisɛ ka tulumafɛnw fana sen bɛ o la.

Tesamoreli ka baara kɛcogo ye mun ye?

Baara kɛcogo sugunɛbilenni min tɛ dɔlɔ ye (NAFLD) min bɛ sɔrɔ sidabanakisɛ fɛ .

Jɛnɛya jiracogo ɲɛnabɔli: 

NAFLD min bɛ tali kɛ sidabanakisɛ la, ni jeninida caman falenfalen sɛgɛsɛgɛli ye, a jirala ko Tesamoreli ye dɔ fara siginiden jeninida jirali kan min bɛ tali kɛ fosforilasi oksidan na sugunɛ na, ka sɔrɔ ka dɔ bɔ jeninida kuluw jirali la minnu bɛ tali kɛ funu, farikolo yɔrɔw dilancogo, ani selilu ^la tilali Kɛrɛnkɛrɛnnenya la, Tesamoreli ye sugunɛ jamu kuluw dɔgɔya minnu bɛ tali kɛ funu, farikolo yɔrɔw dilancogo ani farikolokisɛw tilali la, o b’a jira ko a b’a nɔ jira ni o jamu ninnu jiracogo ɲɛnabɔli ye.

Cɛsiribaa jɔnjɔnw balili: 

Tesamoreli bɛ se ka joli-sira-funu, fibrose ani pro-inflammatory mediators (banakisɛfagalan) kunbabaw bali. Misali la, a bɛ se ka joli-sira-funu-kɔnɔ-fɛnw falen-falen A (VEGFA), bonya-facteur β1 (TGFB1) ani makɔrɔfaga koloni-stimulant 1 (CSF1) hakɛ dɔgɔya kosɛbɛ. Tesamoreli furakɛli kɛbagaw la, joli la VEGFA ni CSF1 dɔgɔyali bɛ tali kɛ sugunɛbilenni tuluma baara hakɛ dɔgɔyali la min tɛ dɔlɔ ye, ani TGFB1 ni CSF1 dɔgɔyali bɛ tali kɛ fiɲɛbɔ hakɛ dɔgɔyali la jamu ^la hakɛ I n’a fɔ monositɛriw tali ni u baaracogo ɲɛnabɔbaga, CSF1 bɛ se ka kɛ furakɛli laɲini kura ye NAFLD la min bɛ sɔrɔ sidabanakisɛ fɛ.

Fɛɛrɛ min bɛ kɛ ka ɲɛsin farikolo yɔrɔw joginni ma: 

Nɛrɛmuguma joginni furakɛli la, a bɛ fɔ ko Tesamoreli bɛ axonal regeneration (axonal regeneration) sabati, ka farikolojidɛsɛ dɔgɔya, ani ka baarakɛcogo ɲɛ. Sɛgɛsɛgɛli minnu kɛra sisan, olu y’a jira ko Tesamoreli bɛ se k’a nɔ bila a kɛtɔ ka farikolo yɔrɔw labɛncogo kura ni u dilancogo sabati. A kɛcogo kɛrɛnkɛrɛnnen ma faamuya ka ɲɛ fɔlɔ, nka a bɛ se ka kɛ ko a bɛ kɛ ni farikolojidɛsɛ furaw labɛnni ye, ka axonal falenni sabati, ani ka myelination, a ^ɲɔgɔnnaw.

Fɛɛrɛ kɛrɛnkɛrɛnnen jumɛn bɛ kɛ ka Tesamoreli ka kɔnɔnatumu ni sugunɛ tulu dɔgɔya sidabanakisɛ bɛ mɔgɔ minnu na?

Labɛnni nɔ min bɛ kɛ ka ɲɛsin bonya hormone ma

Bonya hormone bɔli lawulili: 

Tesamoreli ye bonya hormone (GHRH) ye min dilannen don, o bɛ se ka bonya hormone bɔli lawuli. Sidabanakisɛ bɛ mɔgɔ minnu na, o bɛ se ka nɔ bila bonya hormone bɔli la, wa Tesamoreli bɛ se ka bonya hormone bɔli sabati ka bɔ ɲɛgɛnɛsira ɲɛfɛla la, a kɛtɔ ka GHRH ka baara ^ladege.

Tulumafɛnw falen-falencogo ɲɛnabɔli: 

Bonya hormone jɔyɔrɔ ka bon tulumafɛnw falenni na. A bɛ se ka tulumafɛnw tiɲɛni sabati, ka dɔ fara asidi tulumafɛnw ka oksidan kan, ani ka tulumafɛnw dalajɛli dɔgɔya. Ni Tesamoreli bɛ bonya hormone bɔli lawuli, a bɛ se ka tulumafɛnw falenfalencogo ɲɛnabɔ cogo la min tɛ ɲɛ ani ka dɔ bɔ kɔnɔnatumu ni sugunɛ tulu dalajɛli la ^[4-6]..

A bɛ nɔ bila sugunɛ ka jeninida jirali la

Jɛnɛya siraw caman cili: 

Kɔlɔsiliw y’a jira ko Tesamoreli bɛ se ka dɔ fara siginiden jɛnɛya kulu jirali kan min bɛ tali kɛ oksidan fosforilasi la sugunɛ na, ka sɔrɔ ka dɔ bɔ jɛnɛya kuluw jirali la minnu bɛ tali kɛ funu, farikolo yɔrɔw dilancogo ani selilɛri tilali ^la.

Jɛnɛya minnu bɛ nɔ bila sugunɛbilenni kansɛri ɲɛfɔli la: 

Tesamoreli bɛ se fana ka jamu kuluw labɛn minnu bɛ tali kɛ sugunɛbilenni kansɛri ɲɛfɔli la, ka jamu kuluw labɛn sanfɛ minnu bɛ tali kɛ ɲɛfɔli ɲuman na ani ka jamu kuluw labɛn minnu bɛ tali kɛ ɲɛfɔli jugu la, o cogo ^na kelen Nin fɛn caman Changements dans la gènes (Jɛnɛya jiracogo) bɛ se ka kɛ sababu ye ka Tesamoreli nɔ bila sugunɛ tulu dɔgɔyali la.

Jɛɲɔgɔnya ni fibrose bɛ tali kɛ jeninida hakɛw la: 

Mɔgɔ minnu furakɛra ni Tesamoreli ye, o fɛn caman yeli sugunɛ kɛcogo la, olu tun bɛ tali kɛ fibrose ni fɛnɲɛnamafagalanw ka jeninida hakɛw ɲɛnabɔli la. O b’a jira ko Tesamoreli bɛ se ka sugunɛbilenni cogoya ɲɛ ni a bɛ sugunɛ ka jeninida jiracogo ɲɛnabɔ, o bɛ sugunɛ tulu dɔgɔya ^{[1] .}.

A bɛ nɔ bila joli la farikolojɔli dumuniw na

Cɛsiribaa jɔnjɔnw balili: 

Tesamoreli bɛ se ka joli la farikolojɔli dumuniw hakɛ dɔgɔya kosɛbɛ i n’a fɔ joli siraw kɔnɔfɛnw falenfalen A (VEGFA), bonya fɛn caman tigɛli beta 1 (TGFB1), ani makɔrɔfaga koloni-sɛnɛfɛn 1 ( ⁾ CSF1 Nin farikolojɔli dumuni ninnu bɛ tali kɛ joli-sira-funu, fiɲɛbana (fibrose) ani funu na, wa ni Tesamoreli ye u bali, o bɛ se ka kɛ sababu ye ka sugunɛ tulu ni funu dɔgɔya.

Jɛɲɔgɔnya ni bana hakɛw ye: 

Mɔgɔ minnu furakɛra ni Tesamoreli ye, joli la VEGFA ni CSF1 dɔgɔyali bɛ tali kɛ sugunɛbilenni tulumabali (NAFLD) baarakɛcogo hakɛ dɔgɔyali la, ani TGFB1 ni CSF1 dɔgɔyali bɛ tali kɛ fiɲɛbɔ hakɛ dɔgɔyali la jamu ^hakɛ la O b’a jira ko nin joli-sira-funu-fɛnw labɛnni Tesamoreli fɛ, o bɛ se ka kɛ sababu ye ka sugunɛbana cogoyaw ɲɛnabɔ.

Soso:PubMed ^{[1] Ɲɛjirali dɔw.}

Tesamoreli baarakɛcogo ye mun ye?

A nɔ minnu bɛ sidabanakisɛ bɛ mɔgɔ minnu na

Kɔnɔnatumu tulu ni sugunɛ tulu dɔgɔyali: 

Kalan dɔw y’a jira ko sidabanakisɛ bɛ mɔgɔ minnu na, ni u bɛ furakɛli kɛ ni integrase inhibiteur (INSTI) ye, kɔnɔbara basigilen (VAT) caya ye haminanko ye, barisa PIB bɛ tali kɛ bana wɛrɛw la minnu bɛ duguma i n’a fɔ sugunɛbilenni min tɛ dɔlɔ ye (NAFLD). A jirala ko tesamoreli, n’o ye bonya hormone bɔli hormone analogique ye, o bɛ dɔ bɔ PIB la sidabanakisɛ bɛ mɔgɔ minnu na, ni lipohypertrophy bɛ u la, ka tɛmɛ 15% kan kalo ^kɔnɔ 6 Kɔrɔbɔli min kɛra ni furakisɛ ye, n’o kɛra mɔgɔ 61 kan minnu bɛ ni NAFLD ye min bɛ tali kɛ sidabanakisɛ la, mɔgɔ minnu ye INSTI furakɛli kɛ, olu ka sɛgɛsɛgɛli kɔfɛ, o y’a jira ko kalo 12 kɔfɛ, furakisɛ tabaga ka PIB hakɛ cayara ni 10,8% ye, ka sɔrɔ Tesamoreli furakɛli kulu la, PIB hakɛ dɔgɔyara ni 8,3% ye u bɛɛ lajɛlen na. Ka fara o kan, sugunɛ tuluma hakɛ (HFF) min bɛ Tesamoreli furakɛli kulu la, o dɔgɔyara ni 31% ye ni a bɛ tali kɛ a daminɛ na, o hakɛ tun ka ca kosɛbɛ ni furakisɛ furakɛli kulu ta ^ye.

Ka tulumafɛnw jogo ɲɛ: 

Sidabanakisɛ bɛ mɔgɔ minnu na, banabagatɔ minnu ka fasa cɛmancɛ la, ni u ye Tesamoreli ta, kɔnɔnatumu (VAT) ni farikolo jukɔrɔla tulu (SAT) hakɛ cayara, wa o caya in tun tɛ tulumafɛnw caman yeli ye, o b’a jira ko Tesamoreli fana bɛ se ka PIB ni SAT jogo ɲɛ ka taa a fɛ nin banabagatɔ kulu in ^na.

A bɛ nɔ bila farikolo tangalanw ka baara la: 

Tesamoreli tali kuntaalajan bɛ se ka T-cell ni monositɛri/makɔrɔfaga baara taamasiɲɛw dɔgɔya sidabanakisɛ bɛ mɔgɔ minnu na, olu ka joli la ani ka farikolo tangacogo siraw dɔgɔya sugunɛ na. Kɛrɛnkɛrɛnnenya la, ni i ye a suma ni furakisɛ ye, Tesamoreli ye farikolojɔli dumuni 13 hakɛ dɔgɔya farikolo la, i n’a fɔ kemokini naani, sitokini fila, T-cell ni ɲɔgɔn cɛ mɔlikulu naani, ka fara arginase-1, galectin-9 ani hepatocyte growth factor kan. Réseau sɛgɛsɛgɛli y’a jira ko jɛɲɔgɔnya gɛlɛnw bɛ jeninida siraw ni ɲɔgɔn cɛ minnu bɛ o farikolojɔli dumuniw dɔgɔya, wa transcriptomics laɲinitaw ye farikolo tangalanw jigincogo taamasiɲɛ dafa sugunɛ ^kɔnɔ.

Jɔrɔ min bɛ sugunɛbilenni na min tɛ dɔlɔ ye

Sugunɛ tulu dɔgɔyali ani ka fiɲɛbana bali ka taa ɲɛ: 

Sugunɛbilenni min tɛ dɔlɔ ye, o min bɛ sɔrɔ sidabana fɛ, a jirala ko Tesamoreli bɛ sugunɛ tulu dɔgɔya ani ka fiɲɛ bilali bali. Ɲininikalaw ye jateminɛ sinsinnen kɛ joli-sira-funu-poroteyini 9 kan minnu bɛ bɛn sanfɛla ɲɛmɔgɔyaso jamu kuluw ma jamu kuluw kɔnɔ minnu bɛ labɛn cogo wɛrɛ la, wa u y’a ye ko Tesamoreli kɛra sababu ye ka dɔ bɔ kosɛbɛ joli-sira-funu-kɔnɔ-fɛnw falen-falen-falen A (VEGFA), jiginni-facteur β1 (TGFB1), ani makɔrɔfaga koloni-stimulant facteur 1 (CSF1) la. Mɔgɔ minnu furakɛra ni Tesamoreli ye, joli la VEGFA ni CSF1 dɔgɔyali bɛ tali kɛ sugunɛbilenni tuluma baara hakɛ dɔgɔyali la min tɛ dɔlɔ ye, ani TGFB1 ni CSF1 dɔgɔyali bɛ tali kɛ fibrose hakɛ dɔgɔyali la jeninida hakɛ la. I n’a fɔ monositɛriw tali ni u baaracogo ɲɛnabɔbaga, CSF1 bɛ se ka kɛ furakɛli laɲini kura ye sugunɛ tulumabana na min tɛ dɔlɔ ye sidabanakisɛ ^la.

A bɛ nɔ min bila sugunɛ ka transcriptome profile la: 

Ni baara kɛra ni jeninida nafama sɛgɛsɛgɛli ye, a jirala ko Tesamoreli ye dɔ fara jamu siginiden jɛnɛya jirali kan sugunɛ na min bɛ tali kɛ fosforilasi oksidan na ani ka dɔ bɔ jamu suguya jirali la sugunɛ na min bɛ tali kɛ funu na, farikolo yɔrɔw dilancogo la, ani selilu tilali la. Ka fara o kan, Tesamoreli fana ye jeninida sugandilenw wuli ani ka jigin minnu bɛ tali kɛ sugunɛbilenni kansɛri ɲɛfɔli ɲuman ni a ɲɛfɔcogo jugu la. Lajɛden minnu furakɛra ni Tesamoreli ye, o fɛn caman yeli sugunɛ jiracogo la, olu tun bɛ tali kɛ fibrose ni fɛnɲɛnamafagalanw ka jeninida hakɛw ɲɛnabɔli la ^[2]..

I n’a fɔ sintetiki bonya hormone-releasing hormone analogique, Tesamoreli ye furakɛli seko jira fan caman na. Kuncɛli la, sɛgɛsɛgɛli caman y’a jira ko a bɛ se ka bonya hormone bɔli ɲɛnabɔ ka ɲɛ ani ka farikolo ka farikoloɲɛnajɛ baara ɲɛ. Sidabanakisɛw furakɛli la, a bɛ nɔba bila kɔnɔbara tulumafɛnw dalajɛli dɔgɔyali la. Ni a bɛ bonya hormone bɔli lawuli ani ka tulumafɛnw sɛnɛcogo ɲuman kɛ, a bɛ dɔ bɔ kɔnɔnatumu hakɛ la k’a sɔrɔ a ma nɔ bila farikolo nɔgɔlen na, o bɛ jɔyɔrɔ ɲuman ta banabagatɔw farikolo labɛncogo ladilanni na. Sugunɛbilenni min tɛ dɔlɔ ye, o furakɛli la, sɛgɛsɛgɛli dɔw fana y’a jira ko a bɛ se ka sugunɛ tulu hakɛ dɔgɔya. Tesamoreli nafa ka bon kosɛbɛ. Sidabanakisɛ bɛ banabagatɔ minnu na, a bɛ fɛɛrɛ ɲuman di walasa ka tulumafɛnw falenfalenbaliya minnu bɛ sɔrɔ bana ni furakɛli fɛ, olu ɲɛ, ka banabagatɔw ka ɲɛnamaya kɛcogo ɲɛ, ka dɛmɛ don ka hakili degunw lajɔ minnu bɛ sɔrɔ u ɲɛda cogoya caman yeli fɛ, ani ka dɔ fara u ka jɛɲɔgɔnya hakilina kan sigida la.

A sɛbɛnbaga ko la

Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.

Dɔnniya gafe sɛbɛnbaga

Stanley TL ye dɔnnikɛla ye Harvard Iniwɛrisite la, a bɛ ɲinini ni kalan kɛ baaradaw la i n’a fɔ Harvard dɔgɔtɔrɔso ani Masasi dɔgɔtɔrɔsoba. A ka ɲininiw ye kɔnɔbarako ni farikoloɲɛnajɛ, banakisɛfagalanw, farikolo tangacogo, fɛnɲɛnamafagalanw, ani balo ni dumunikɛcogo ye. A ye ɲinini kunbabaw Kɛ o ko ninnu na, ka hakilinata-jɔ-yɔrɔw Di banaw sɛgɛsɛgɛli, u furakɛli ani u kunbɛnni ma minnu bɛ tali Kɛ ɲɔgɔn na. O waati kelen na, a ni jɛkuluw bɛ jɛ kosɛbɛ i n’a fɔ Harvard dɔgɔtɔrɔso ani Masasi denmisɛnw ka dɔgɔtɔrɔsoba, ka teori ni kɛnɛyaso baarakɛcogo fara ɲɔgɔn kan ani ka dɛmɛ don furakɛli ko la. Stanley TL tɔgɔ sɛbɛnnen bɛ citation (citation) ɲɛfɔli sɛbɛn kɔnɔ [4].

▎ Sɛbɛn minnu bɛ tali kɛ o la

[1] Fourman L. T., Billingsley J. M., Agyapong G., ani a ɲɔgɔnnaw. Tesamorelin nɔ minnu bɛ sugunɛbilenni taamasiɲɛw la NAFLD la min bɛ sɔrɔ sidabanakisɛ fɛ[J]. Jci Hakilila, 2020,5(16).DOI:10.1172/jci.hakilila.140134.

[2] Fourman L. T., Stanley T. L., Billingsley J. M., ani a ɲɔgɔnnaw. Tesamɔrilini jaabi siraw dantigɛli NAFLD la min bɛ sɔrɔ sidabanakisɛ fɛ ni protéomic ni transcriptomic fɛɛrɛ laɲininen ye[J]. Dɔnniya kunnafoniw, 2021,11(1).DOI:10.1038/s41598-021-89966-y.

[3] Jaimie T S. Tesamoreli furakɛli walasa ka Axonal Regeneration (Axonal Regeneration) sabati, ka farikolo-ɲɛnajɛ dɔgɔya ani ka baarakɛcogo ɲɛ ka tugu farikolo yɔrɔw joginni ni a dilancogo kɔ[J]. 2015 sàn.

[4] Rahman F, McLaughlin T, Mesquita P, ani a ɲɔgɔnnaw. Tesamɔrilini nɔ bɛ se ka kɛ sidabanakisɛ bɛ mɔgɔ minnu na, ni kɔkolo tulu bɛ u la ani ni u tɛ u la: Sɛgɛsɛgɛli kɔfɛ, min kɛra fasa III fila-fiyentɔ ye ni furakisɛ ye[J]. Dɔgɔtɔrɔso ni bamanankan dɔnniya gafe, 2022,7(1).DOI:10.1017/cts.2022.515.

[5] Mateo MG, Gutierrez MDM, Domingo P. Tesamoreli ka ɲɛsin kɔnɔbara tuluma tɛmɛnen furakɛli ma sidabanakisɛ 1 banakisɛ bɛ banabagatɔ minnu na, ni farikolojidɛsɛ bɛ u la.[J]. Endocrinologie & Metabolisme dɔnnikɛlaw ka seginkanni, 2011,6(1):21-30.DOI:10.1586/eem.10.83.

[6] Stanley T. L., Falutz J., Marsolais C., ani a ɲɔgɔnnaw. Fasa dɔgɔyali bɛ tali kɛ farikoloɲɛnajɛ kɛcogo ɲuman na sidabanakisɛ bɛ banabagatɔ minnu na minnu bɛ Tesamoreli ta[J]. Bana minnu bɛ sɔrɔ kɛnɛyaso la, 2012,54(11):1642-1651.DOI:10.1093/cid/cis251.

[7] McLaughlin T, Grinspoon S. K., Stanley T., ani mɔgɔ wɛrɛw. 1499. Tesamoreli bɛ farikolo tulumafɛnw ni sugunɛ tulu dɔgɔya INSTI furakɛli kɛlenw na sidabanakisɛ bɛ mɔgɔ minnu na[J]. Forum da wulilen banakisɛw, 2023,10(2):500-1334.DOI:10.1093/ofid/ofad500.1334.

[8] Lake JE, La K, Erlandson K. M., ani a ɲɔgɔnnaw. Tesamoreli bɛ tulu hakɛ ɲɛ ka bɔ tulu hakɛ caman yeli la[J]. Sida, 2021,35(9):1395-1402.DOI:10.1097/QAD.0000000000002897. Bamako, Mali.

[9] Stanley T. L., Fourman L. T., Wong L. P., ani a ɲɔgɔnnaw. Bonya ɔrimɔni min bɛ ɔrimɔni bɔ, o bɛ farikolo tangalanw ka baarakɛcogo taamasiɲɛw dɔgɔya ka kɛɲɛ ni a nɔfɛkow ye sugunɛ farikolo tangacogo siraw kan sidabanakisɛ bɛ mɔgɔ minnu na ani sugunɛbilenni min tɛ dɔlɔ ye[J Bana minnu bɛ sɔrɔ kɛnɛyaso la, 2021,73(4):621-630.DOI:10.1093/cid/ciab019.

BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, olu BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.  

Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.