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1 kits (10 Vials)
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▎ Tsarin Motc
Source: PubChem |
Jeri: MRWQEMGYIFYPRKLR Tsarin kwayoyin halitta: C101H152N28O22S2 Nauyin Kwayoyin Halitta: 2174.6g/mol Lambar CAS: 1627580-64-6 Kamfanin CID na PubChem: 146675088 Synonyms: UNII-A5CV6JFB78 |
▎ Motc Binciken
Menene asalin bincike na Motc?
Mitochondion wuri ne mai mahimmanci don samar da makamashi a cikin sel. Na dogon lokaci, masana kimiyya sun gudanar da bincike mai zurfi da zurfi kan tsari da aikin mitochondria. A cikin wannan tsari, an gane a hankali cewa mitochondria ba wai kawai yana taka muhimmiyar rawa wajen samar da makamashi ba amma yana iya shiga cikin wasu hanyoyin ilimin lissafin jiki na sel ta wasu hanyoyin da ba a sani ba.
Tare da ci gaba da ci gaban fasahar bincike, musamman haɓakar ilimin halittu da fasahohin haɓaka, ya zama mai yiwuwa a gano sabbin ƙwayoyin cuta masu alaƙa da mitochondria. Motc (mitochondrial bude karatun firam na 12S rRNA-c) peptide ne wanda aka samo daga mitochondria wanda yankin 12S rRNA na kwayar halittar mitochondrial ne [1].
Ta hanyar zurfafa bincike na kwayar halittar mitochondrial, masana kimiyya sun gano wasu ƙananan buɗaɗɗen firam ɗin karatu (sORFs), waɗanda za su iya ɓoye wasu peptides tare da takamaiman ayyuka. Bayan ƙarin bincike da tabbatarwa, an gano Motc. Nazarin ya gano cewa an bayyana Motc a cikin nau'ikan kyallen takarda a cikin mutane da dabbobi. Yafi yin aiki akan tsokoki na kwarangwal ta hanyar jini, yana haɓaka haɓakawa da amfani da glucose, don haka inganta juriya na insulin da daidaita ma'aunin metabolism [2]..
Tare da zurfafa bincike, an gano cewa canje-canje a cikin maganganun Motc suna da alaƙa da abubuwan da suka faru da ci gaban tsufa da cututtukan da suka shafi shekaru. Misali, matakin Motc a cikin plasma yana raguwa yayin da shekaru (Zheng Y, 2013). A lokaci guda, an tabbatar da Motc yana da amfani ga cututtukan da suka shafi shekaru, gami da metabolism, cututtukan zuciya, osteoporosis, kiba bayan menopause, da cutar Alzheimer [3].
Menene tsarin aikin Motc?
Sarrafa maganganun kwayoyin halitta:
Motc na iya aiwatar da ayyukansa na physiological ta hanyar daidaita maganganun kwayoyin halitta. Misali, yana iya daidaita maganganun kwayoyin halitta kamar GLUT4, STAT3, da IL-10. Motc galibi yana aiwatar da tasirin sa ta hanyar kunna hanyar siginar AICAR-AMPK da tarwatsa tsarin folate-methionine a cikin sel [4].
Inganta juriya na insulin:
Motc na iya rage juriya na insulin kuma ya hana nau'in 2 metabolism. Hanyar aikinta na iya kasancewa da alaƙa da hanawa na myostatin. Nazarin ya gano cewa matakin plasma Motc yana da alaƙa da mummunan alaƙa da matakin myostatin a cikin jikin ɗan adam. Motc na iya inganta haɓakar insulin ta hanyar hana ayyukan FOXO1 na sama da kuma rage matakin myostatin [5].
Inganta bambancin tsoka:
A cikin ƙwayoyin tsoka, Motc yana hulɗa tare da STAT3 ta hanyar ƙwanƙwasa SH2 mai ɗaure a cikin yankin YIFY, yana rage aikin rubutun na STAT3, don haka inganta haɓakar myotube. Motc peptide-nau'in daji na iya haɓaka haɓakar myotube na ɗan adam (LHCN-M2) da linzamin kwamfuta (C2C12) sel masu haɓaka tsoka da kuma kare ƙwayoyin tsoka daga raguwar tabon myogenin na nukiliya wanda ya haifar da interleukin-6 (IL-6) [6].
Gudanar da aikin mitochondrial:
Motc na iya daidaita metabolism na mitochondrial. Nazarin ya nuna cewa kula da ƙwayoyin dabbobi masu shayarwa tare da Motc na iya ƙara matakan furotin na mitochondrial biogenesis alamomi TFAM, COX4, da NRF1, amma nazarin cytometry na gudana ya nuna cewa yawan mitochondria yana raguwa sosai bayan maganin Motc. Ci gaba da bincike ya gano cewa Motc na iya kunna haɗakar mitochondrial tare da haɓaka matakan furotin na GTPases guda biyu, OPA1 da MFN2, waɗanda ke da mahimmanci don haɗakar mitochondria na mammalian. Hana waɗannan GTPases guda biyu ko buga MFN2 ta hanyar siRNA zai kawar da ikon Motc don haɓaka fassarar GLUT4 da ɗaukar glucose [7].
Motc shine yuwuwar maƙasudin warkewa don cututtukan da ke da alaƙa da tsufa da yawa, gami da neurodegeneration, osteoporosis, cututtukan zuciya, atherosclerosis, sarcopenia, nau'in ciwon sukari na 2, da kiba.
Source:PubMed [8]
Menene aikace-aikacen Motc?
Inganta cututtukan da suka shafi shekaru
Dangantaka da tsufa:
Motc shine peptide wanda aka samo daga mitochondria, kuma canje-canje a cikin maganganunsa suna da alaƙa da abubuwan da suka faru da ci gaban tsufa da cututtukan da suka shafi shekaru. Yayin da mutane ke tsufa, matakin Motc yana raguwa. Nazarin ya gano cewa motsa jiki yana da tasiri mai mahimmanci akan maganganun Motc, kuma Motc na iya daidaita tasirin tsufa na motsa jiki [3].
Metabolism:
Motc na iya inganta glucose na jiki da metabolism na lipid, inganta aikin mitochondrial a cikin sel, kuma yana rage amsawar kumburi na tsarin. Ga masu ciwon sukari, matakin Motc a cikin plasma yana raguwa. Motc na iya daidaita yanayin homeostasis na rayuwa ta hanyar haɓaka ɗaukar glucose da haɓaka haɓakar insulin, kuma yana da tasiri mai kyau akan hana nau'in 2 metabolism [8]..
Cututtukan zuciya:
Gyara tsarin tsarin zuciya da rashin aiki sune rikice-rikice na yau da kullun na metabolism, sau da yawa yana haifar da mummunan al'amuran zuciya. Motc na iya inganta aikin endothelial na jijiyoyin jini kuma shine sabon makasudin warkewa don rikice-rikice na zuciya da jijiyoyin jini na metabolism. Nazarin ya nuna cewa Motc na iya gyara lalacewar mitochondrial na myocardial a cikin berayen masu ciwon sukari da kuma kare systolic na zuciya da ayyukan diastolic [9].
Osteoporosis: Motc na iya inganta haɓakawa, bambance-bambance, da ma'adinai na osteoblasts, hana ƙwayar osteoclast, da daidaita tsarin kashi da gyaran kashi. Motsa jiki na iya daidaita ma'anar Motc yadda ya kamata, amma takamaiman hanyar da motsa jiki ke sarrafa Motc a cikin ƙasusuwa har yanzu ba a sani ba [10].
Sauran cututtuka
Fibrosis na huhu:
Fibrosis na huhu shine mummunar cutar huhu tare da rashin hangen nesa, kuma har yanzu ba a san ilimin abubuwan da ke haifar da cutar ba. Tsarin karatun mitochondrial na 12S rRNA-c (Motc) peptide ne wanda aka sanya shi ta hanyar genome na mitochondrial, wanda ke da tasiri mai kyau akan glucose da lipid metabolism, salon salula da mitochondrial homeostasis, da raguwar amsawar kumburin tsarin, kuma yana iya zama yuwuwar motsa jiki mimetic. Wannan bita yana nufin cikakken nazarin wallafe-wallafen da ake da su game da yuwuwar rawar Motc don inganta haɓakar fibrosis na huhu da kuma gano takamaiman maƙasudin warkewa don dabarun jiyya na gaba [11].
Duchenne muscular dystrophy:
Motc shine peptide bioactive na mitochondria wanda aka samu tare da abubuwan da ke haifar da tsoka, wanda zai iya haɓaka haɓakar glycolytic da ƙarfin samar da kuzari na tsokoki na dystrophic a cikin vitro da a cikin vivo, don haka haɓaka haɓakawa da ayyukan phosphonodiamidite morpholino oligomers (PMO) a cikin mdx mice. Gudanar da maimaitawa na dogon lokaci na Motc da PMO na iya haifar da bayyanar da matakan warkewa na dystrophin a cikin tsokoki na gefe, inganta aikin tsoka da ilimin cututtukan ƙwayoyin cuta na mice mdx, kuma ba shi da wani takamaiman guba [12].
Kiba da tsoka atrophy:
Kiba da nau'in metabolism na 2 sune cututtuka na rayuwa sau da yawa hade da sarcopenia da rashin aikin tsoka. Motc, a matsayin hormone na tsarin, yana shiga cikin homeostasis na rayuwa. Nazarin ya gano cewa matakin plasma Motc yana da alaƙa da mummunan alaƙa da matakin myostatin a cikin jikin ɗan adam. Motc na iya hana palmitic acid-induced atrophy na daban-daban C2C12 myotubes da kuma rage myostatin matakin a cikin plasma na rage cin abinci-jawo kiba mice. Ta hanyar hana myostatin, Motc na iya zama mai yuwuwar magani ga ƙwanƙwaran ƙwayar tsoka wanda ya haifar da juriya na insulin da sauran ƙwayoyin atrophy na tsoka ciki har da sarcopenia [5].
Hadarin cututtuka na rayuwa a cikin masu tsira da ciwon nono:
Matan da suka sami maganin cutar kansar nono suna cikin haɗarin kamuwa da cututtukan zuciya da jijiyoyin jini, metabolism, da kiba, kuma motsa jiki na iya rage waɗannan illolin. Motc yana da aikin kwaikwayon motsa jiki kuma yana da tasiri mai amfani akan metabolism da ƙarfin motsa jiki. Nazarin ya gano cewa aikin motsa jiki na mako-mako na 16 na motsa jiki da juriya na iya kara yawan matakin Motc a cikin wadanda ba su da ciwon nono na Hispanic, amma ba shi da wani tasiri mai mahimmanci ga wadanda suka tsira daga ciwon nono na Hispanic. Haɓakawa a matakin Motc wanda motsa jiki ya haifar a cikin waɗanda ba su da ciwon nono na Hispanic na iya kasancewa da alaƙa da haɓaka haɓakar insulin, don haka rage haɗarin kamuwa da cuta [13].
A ƙarshe, a matsayin 16-amino acid polypeptide wanda aka sanya ta hanyar genome na mitochondrial, Motc yana taka muhimmiyar rawa a cikin tsarin tsarin rayuwa na jiki, kare danniya, da rigakafin cututtuka da magani. Yana iya inganta haɓakar homeostasis na glucose da metabolism na lipid, haɓaka haɓakar insulin, da hana maganganun myostatin, yadda ya kamata yana rage nau'in metabolism na nau'in 2, kiba, da atrophy na tsoka mai alaƙa. A lokaci guda, ta hanyar daidaita mitochondrial biogenesis da fusion, Motc yana haɓaka ƙarfin antioxidant na tantanin halitta kuma yana hana amsawar kumburi, yana nuna yuwuwar warkewar cututtukan cututtukan cututtukan zuciya kamar cututtukan zuciya, osteoporosis, da fibrosis na huhu. Musamman mahimmanci, a matsayin maɓalli mai mahimmanci na sadarwar mitochondria-nucleus, Motc na iya kwatanta tasirin motsa jiki da jinkirta tsarin tsufa. Matsayinsa yana da alaƙa da alaƙa da cututtukan da ke da alaƙa da shekaru, kuma ƙari na waje zai iya juyar da rikice-rikice na rayuwa kuma yana hana kwafi. An san shi da 'hormone mitochondrial'.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Dieli-Conwright CM masani ne da ke da tasiri mai mahimmanci a cikin tsaka-tsakin fanni na oncology da kimiyyar motsa jiki. A halin yanzu tana aiki a matsayin abokiyar farfesa a fannin likitanci a Makarantar Kiwon Lafiya ta Harvard da Cibiyar Ciwon daji ta Dana-Farber kuma tana da matsayi na aboki a cikin Sashen Abinci a Harvard TH Chan Makarantar Kiwon Lafiyar Jama'a. Binciken Dr. Dieli-Conwright ya mayar da hankali ne kan gano tasirin motsa jiki ga masu ciwon daji, musamman yadda motsa jiki zai iya inganta aikin ilimin lissafi, lafiyar kashi, da kuma ingancin rayuwar masu ciwon daji. Ilimin iliminta ya ƙunshi fannoni da yawa kamar ilmin halitta, kinesiology, lafiyar jama'a, da ilimin halittu. Ta kammala karatunta a cibiyoyi kamar Jami'ar Jihar California, Northridge, da Jami'ar Kudancin California kuma ta kammala karatun digirinta a Cibiyar Kiwon Lafiya ta Kasa ta City of Hope. Dokta Dieli-Conwright ta nasarorin binciken da aka buga a ko'ina cikin mujallu na ilimi daban-daban, kuma aikinta ya ƙunshi fannoni da yawa kamar lafiyar jama'a, abinci mai gina jiki, tsarin zuciya da jijiyoyin jini, da ilimin zuciya, yana ba da shaida mai mahimmanci na kimiyya don gyarawa da kula da lafiyar masu ciwon daji. An jera Dieli-Conwright CM a cikin ambaton ambaton [13].
