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▎ Ọdịdị Motc
Isi mmalite: PubChem |
Usoro: MRWQEMGYIFYPRKLR Ụdị ihe omimi: C101H152N28O22S2 Ibu molekụla: 2174.6g/mol Nọmba CAS: 1627580-64-6 PubChem CID: 146675088 Okwu ndị yiri: UNII-A5CV6JFB78 |
▎ Motc Nchọpụta
Kedu ihe ndabere nyocha nke Motc?
Mitochondion bụ ebe dị mkpa maka metabolism ike n'ime sel. Ruo ogologo oge, ndị ọkà mmụta sayensị emeela nchọpụta dị ukwuu na nke miri emi banyere nhazi na ọrụ nke mitochondria. N'ime usoro a, a na-amata nke nta nke nta na mitochondria ọ bụghị nanị na-ekere òkè dị mkpa na mmepụta ume kamakwa ọ nwekwara ike isonye na usoro physiological ndị ọzọ nke mkpụrụ ndụ site na usoro ụfọdụ amaghị.
Site na ọganihu na-aga n'ihu nke teknụzụ nyocha, karịsịa mmepe nke genomics na teknụzụ proteomics, ọ na-ekwe omume ịchọta ụmụ irighiri ihe ọhụrụ metụtara mitochondria. Motc (mitochondrial mepere emepe nke 12S rRNA-c) bụ peptide sitere na mitochondria sitere na mpaghara 12S rRNA nke genome mitochondrial [1].
Site na nyocha miri emi nke genome mitochondrial, ndị ọkà mmụta sayensị achọpụtala ụfọdụ obere okpokolo agba emeghe (sORF), nke nwere ike itinye ụfọdụ peptides nwere ọrụ ụfọdụ. Ka emechara nyocha na nkwenye ọzọ, a chọpụtara Motc. Nnyocha achọpụtala na a na-egosipụta Motc n'ụdị anụ ahụ dị iche iche na mmadụ na anụmanụ. Ọ na-emekarị na akwara skeletal site na ọbara, na-abawanye nnabata na itinye n'ọrụ nke glucose, si otú a na-eme ka nguzogide insulin dịkwuo elu ma na-ahazi nguzozi nke metabolic [2]..
Site na nyocha miri emi nke nyocha, achọpụtara na mgbanwe nke okwu Motc nwere njikọ chiri anya na omume na mmepe nke ịka nká na ọrịa ndị metụtara afọ. Dịka ọmụmaatụ, ọkwa Motc na plasma na-ebelata ka afọ (Zheng Y, 2013). N'otu oge ahụ, egosipụtara na Motc bara uru maka ọrịa ndị metụtara afọ, gụnyere metabolism, ọrịa obi, osteoporosis, oke ibu postmenopausal, na ọrịa Alzheimer [3]..
Gịnị bụ usoro omume nke Motc?
Na-ahazi okwu mkpụrụ ndụ ihe nketa:
Motc nwere ike ịrụ ọrụ ya site n'ịhazi okwu mkpụrụ ndụ ihe nketa. Dịka ọmụmaatụ, ọ nwere ike ịhazi okwu nke mkpụrụ ndụ ihe nketa dịka GLUT4, STAT3, na IL-10. Motc na-arụ ọrụ ya site n'ịgbalite ụzọ akara AICAR-AMPK na imebi usoro folate-methionine na sel [4].
Na-akwalite nguzogide insulin:
Motc nwere ike belata nguzogide insulin ma gbochie ụdị 2 metabolism. Usoro ya nwere ike jikọta ya na mgbochi nke myostatin. Nnyocha achọpụtala na ọkwa plasma Motc na-adịghị mma na ọkwa myostatin dị na ahụ mmadụ. Motc nwere ike imeziwanye mmetụta insulin site na igbochi ọrụ nke ihe ntụgharị ederede FOXO1 na ibelata ọkwa myostatin [5].
Na-akwalite ọdịiche nke akwara:
N'ime mkpụrụ ndụ akwara, Motc na STAT3 na-emekọrịta ihe site na ntinye SH2 na-ejikọta motif na mpaghara YIFY, na-ebelata ọrụ ntụgharị nke STAT3, si otú ahụ na-eme ka nhazi myotube dịkwuo elu. Motc peptide ụdị anụ ọhịa nwere ike ịbawanye nguzobe myotube nke mmadụ (LHCN-M2) na òké (C2C12) sel progenitor muscle ma chebe mkpụrụ ndụ akwara site na mbelata nke myogenin myogenin nuklia kpatara interleukin-6 (IL-6) [6].
Na-ahazi ọrụ mitochondrial:
Motc nwere ike ịhazi metabolism nke mitochondrial. Nnyocha egosiwo na ịgwọ mkpụrụ ndụ mammalian na Motc nwere ike ịbawanye ọkwa protein nke mitochondrial biogenesis markers TFAM, COX4, na NRF1, mana nyocha nke cytometry na-egosi na ọnụ ọgụgụ nke mitochondria na-ebelata nke ọma mgbe ọgwụgwọ Motc gasịrị. Nnyocha ndị ọzọ achọpụtala na Motc nwere ike ịmekọrịta ngwakọta mitochondrial yana ịbawanye ọkwa protein nke GTPase abụọ, OPA1 na MFN2, nke dị oke mkpa maka njikọta nke mitochondria mammalian. Igbochi GTPases abụọ a ma ọ bụ ịkụda MFN2 site na siRNA ga-ewepụ ikike Motc iji kwalite ntụgharị GLUT4 na nnabata glucose [7].
Motc bụ ebumnuche ọgwụgwọ enwere ike maka ọtụtụ ọrịa metụtara ịka nká, gụnyere neurodegeneration, osteoporosis, ọrịa obi, atherosclerosis, sarcopenia, ụdị 2 metabolism, na oke ibu.
Isi mmalite: PubMed [8]
Kedu ihe bụ ngwa nke Motc?
Ịkwalite ọrịa ndị metụtara afọ
Mmekọrịta ya na ịka nká:
Motc bụ peptide sitere na mitochondria, na mgbanwe n'okwu ya nwere njikọ chiri anya na omume na mmepe nke ịka nká na ọrịa ndị metụtara afọ. Ka ndị mmadụ na-aka nká, ọkwa Motc na-ebelata. Nnyocha achọpụtala na mmega ahụ nwere mmetụta dị ukwuu na nkwupụta nke Motc, na Motc nwere ike ịkwado mmetụta mgbochi ịka nká nke mmega ahụ [3]..
Metabolism:
Motc nwere ike imeziwanye glucose nke anụ ahụ na metabolism lipid, kwalite ọrụ mitochondrial na sel, ma belata mmeghachi omume mkpali na-adịghị ala ala. Maka ndị ọrịa nwere ọrịa shuga, ọkwa Motc na plasma na-ebelata. Motc nwere ike ịhazi metabolism homeostasis site n'ịkwalite nnabata glucose na imeziwanye mmetụta insulin, ọ na-enwekwa mmetụta dị mma na igbochi ụdị 2 metabolism [8]..
Ọrịa obi:
Mgbanwe nhazi nke obi na arụ ọrụ bụ nsogbu nkịtị nke metabolism, na-ebutekarị ihe omume obi siri ike. Motc nwere ike imeziwanye ọrụ endothelial vaskụla ma bụrụ ebumnuche ọgwụgwọ ọhụrụ maka nsogbu obi vaskụla nke metabolism. Nnyocha egosiwo na Motc nwere ike ịrụzi mmebi nke mitochondrial myocardial na oke ndị na-arịa ọrịa shuga ma chebe systolic obi na ọrụ diastolic [9].
Osteoporosis: Motc nwere ike ịkwalite mmụba, ọdịiche, na mineralization nke osteoblasts, na-egbochi osteoclast genesis, ma na-achịkwa ọkpụkpụ ọkpụkpụ na nhazi ọkpụkpụ. Mmega ahụ nwere ike ịkwalite okwu Motc nke ọma, mana usoro a kapịrị ọnụ nke mmega ahụ na-achịkwa Motc n'ọkpụkpụ ka amabeghị [10].
Ọrịa ndị ọzọ
Fibrosis nke akpa ume:
Fibrosis nke pulmonary bụ ọrịa ngụgụ siri ike nke na-enwekwa amụma na-adịghị mma, na etiology ya na pathogenesis ka amabeghị. Oghere ịgụ akwụkwọ mitochondrial nke 12S rRNA-c (Motc) bụ peptide nke genome nke mitochondrial kpuchiri, nke nwere mmetụta dị mma na glucose na metabolism lipid, cellular na mitochondrial homeostasis, yana mbelata mmeghachi omume mkpali sistemu, ma nwee ike ịbụ mmega ahụ mimetic. Nyochaa a bu n'obi nyochaa akwụkwọ ndị dị ugbu a na ọrụ Motc nwere ike ime iji kwalite mmepe nke fibrosis pulmonary ma chọpụta ebumnuche ọgwụgwọ maka usoro ọgwụgwọ n'ọdịnihu [11].
Dystrophy muscular nke Duchenne:
Motc bụ peptide bioactive nke sitere na mitochondria nwere ihe na-akpachapụ anya akwara, nke nwere ike ime ka mmụba glycolytic na ike mmepụta ike nke akwara dystrophic na vitro na in vivo, si otú ahụ na-akwalite nnabata na ọrụ nke phosphonodiamidite morpholino oligomers (PMO) na mdx mice. Nlekọta ogologo oge nke Motc na PMO nwere ike ime ka ngosipụta nke usoro ọgwụgwọ nke dystrophin n'ime akwara dị n'akụkụ, melite ọrụ ahụ ike na pathology nke ụmụ oke mdx, na enweghị nsí doro anya [12].
Ibu na atrophy muscle:
Ibu ibu na ụdị 2 metabolism bụ ọrịa metabolic na-ejikọta ya na sarcopenia na arụ ọrụ akwara. Motc, dị ka homonụ sistemu, na-ekere òkè na homeostasis metabolic. Nnyocha achọpụtala na ọkwa plasma Motc na-adịghị mma na ọkwa myostatin dị na ahụ mmadụ. Motc nwere ike igbochi atrophy nke palmitic acid kpatara nke C2C12 myotubes dị iche ma belata ọkwa myostatin na plasma nke oke oke nri kpatara nri. Site na igbochi myostatin, Motc nwere ike ịbụ ọgwụgwọ enwere ike maka atrophy muscle skeletal kpatara site na nguzogide insulin na anụ ahụ ndị ọzọ atrophy phenotypes gụnyere sarcopenia [5].
Ihe ize ndụ nke ọrịa metabolic na ndị lanarịrị ọrịa ara ara:
Ụmụ nwanyị ndị natara ọgwụgwọ ọrịa kansa ara nọ n'ihe ize ndụ dị ukwuu nke ọrịa obi, metabolism, na oke ibu, na mmega ahụ nwere ike ibelata mmetụta ndị a. Motc nwere ọrụ mmega ahụ na-eṅomi ma nwee mmetụta bara uru na metabolism na ike mmega ahụ. Nnyocha achọpụtala na mmega ahụ nke ikuku nke izu 16 na mmegide mmega ahụ nwere ike ime ka ọkwa Motc dị na ndị na-abụghị ndị na-agbanarị ọrịa ara ara na-abụghị ndị Hispanic, mana ọ nweghị mmetụta dị ukwuu na ndị lanarịrị ọrịa ara ara Hispanic. Mmụba nke ọkwa Motc na-ebute site na mmega ahụ na ndị na-abụghị ndị Hispanic na-anwụghị na ara ara nwere ike jikọta ya na mmụba nke mmetụta insulin, si otú ahụ belata ihe ize ndụ nke comorbidities [13]..
N'ikpeazụ, dị ka 16-amino acid polypeptide nke mitochondrial genome, Motc na-arụ ọrụ bụ isi na nhazi usoro metabolic nke anụ ahụ, nchebe nchekasị, na mgbochi ọrịa na ọgwụgwọ. Ọ nwere ike melite homeostasis nke glucose na lipid metabolism, na-eme ka mmetụta insulin dịkwuo elu, na-egbochi nkwupụta nke myostatin, na-ebelata metabolism nke ụdị 2 nke ọma, oke ibu, na atrophy muscle metụtara ya. N'otu oge ahụ, site n'ịchịkwa mitochondrial biogenesis na ngwakọta, Motc na-eme ka ikike antioxidant nke cell dịkwuo elu ma na-egbochi nzaghachi mkpali, na-egosi ike ọgwụgwọ maka ọrịa na-adịghị ala ala dịka ọrịa obi, osteoporosis, na fibrosis pulmonary. Karịsịa, dị ka onye isi ogbugbo nke nkwurịta okwu mitochondria-nucleus, Motc nwere ike ime ka mmetụta nke mmega ahụ na-egbu oge usoro ịka nká. A na-ejikọta ọkwa ya na ọrịa ndị metụtara afọ na-adịghị mma, na mgbakwunye na exogenous nwere ike gbanwee nsogbu nke metabolic ma gbochie nje virus. A maara ya dị ka 'hormone mitochondrial'.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Dieli-Conwright CM bụ ọkà mmụta nwere mmetụta dị ukwuu na ngalaba interdisciplinary nke oncology na sayensị mmega ahụ. Ọ na-eje ozi ugbu a dị ka onye otu prọfesọ nke ọgwụ na Harvard Medical School na Dana-Farber Cancer Institute ma na-ejide ọnọdụ ngalaba na Ngalaba Nutrition na Harvard TH Chan School of Health Public. Nchọpụta Dr. Dieli-Conwright na-elekwasị anya n'ịchọpụta mmetụta mmega ahụ na-emetụta ndị ọrịa cancer, karịsịa otú mmega ahụ nwere ike isi meziwanye ọrụ anụ ahụ, ahụike ọkpụkpụ, na ndụ ndụ nke ndị ọrịa cancer. Nzụlite agụmakwụkwọ ya na-ekpuchi ọtụtụ ngalaba dị ka bayoloji, kinesiology, ahụike ọha na biokinesiology. Ọ gụsịrị akwụkwọ na ụlọ akwụkwọ dịka California State University, Northridge, na Mahadum Southern California wee mechaa nyocha postdoctoral ya na City of Hope National Medical Center. Akwukwo nyocha nke Dr. Dieli-Conwright na-ebipụta n'ọtụtụ ebe n'akwụkwọ akụkọ agụmakwụkwọ dị iche iche, ọrụ ya gụnyere ọtụtụ usoro dịka ahụike ọha na eze, nri nri, usoro obi, na obi, na-enye ihe akaebe sayensị dị mkpa maka nhazigharị na nlekọta ahụike nke ndị ọrịa cancer. Edepụtara Dieli-Conwright CM na ntụaka nke ntụaka [13].
