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1kits （10Ibikoresho）
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Imiterere ya Motc
Inkomoko: PubChem |
Urukurikirane: MRWQEMGYIFYPRKLR Inzira ya molekulari: C101H152N28O22S2 Uburemere bwa molekuline: 2174.6g / mol Numero ya CAS: 1627580-64-6 CID CID: 146675088 Synonyme: UNII-A5CV6JFB78 |
Research bwa Motc Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na Motc?
Mitochondrion ni urubuga rukomeye rwo guhinduranya ingufu mu ngirabuzimafatizo. Kuva kera, abahanga bakoze ubushakashatsi bwimbitse kandi bwimbitse ku miterere n'imikorere ya mitochondria. Muri iki gikorwa, byamenyekanye buhoro buhoro ko mitochondriya itagira uruhare runini mu kubyara ingufu gusa ahubwo ishobora no kugira uruhare mubindi bikorwa byimikorere ya selile binyuze muburyo butazwi.
Hamwe niterambere ryiterambere ryikoranabuhanga ryubushakashatsi, cyane cyane iterambere rya genomics na proteomics, byashobokaga kuvumbura molekile nshya zijyanye na mitochondria. Motc ..
Binyuze mu isesengura ryimbitse rya genoside ya mitochondrial, abahanga bavumbuye uduce duto duto two gusoma (sORFs), dushobora gushiramo peptide zimwe na zimwe zifite imirimo yihariye. Nyuma yubushakashatsi nubugenzuzi, Motc yamenyekanye. Ubushakashatsi bwerekanye ko Motc igaragarira mubice bitandukanye byabantu ninyamaswa. Ikora cyane cyane ku mitsi ya skeletale ikoresheje amaraso, ikongerera gufata no gukoresha glucose, bityo bigatuma insuline irwanya kandi ikanagabanya imiterere ya metabolike ..
Hamwe n’ubushakashatsi bwimbitse, byagaragaye ko impinduka mu mvugo ya Motc zifitanye isano rya bugufi no kubaho no gutera imbere gusaza n'indwara ziterwa n'imyaka. Kurugero, urwego rwa Motc muri plasma rugabanuka uko imyaka igenda ishira (Zheng Y, 2013). Muri icyo gihe, Motc byagaragaye ko ari ingirakamaro ku ndwara ziterwa n'imyaka, harimo metabolisme, indwara z'umutima n'imitsi, osteoporose, umubyibuho ukabije, ndetse n'indwara ya Alzheimer [3].
Ni ubuhe buryo bwo gukora bwa Motc?
Kugena imvugo ya gene:
Motc irashobora gukoresha imikorere yayo ya physiologique muguhuza imvugo ya gene. Kurugero, irashobora kugenga imvugo ya gen nka GLUT4, STAT3, na IL-10. Motc ikora cyane cyane mugukoresha inzira ya AICAR-AMPK yerekana inzira no guhagarika ingendo ya folate-methionine muri selile [4].
Kunoza insuline irwanya:
Motc irashobora kugabanya kurwanya insuline no kwirinda ubwoko bwa 2 metabolism. Uburyo bwibikorwa bushobora kuba bujyanye no kubuza myostatine. Ubushakashatsi bwerekanye ko plasma Motc urwego rufitanye isano ribi nurwego rwa myostatine mumubiri wumuntu. Motc irashobora kunoza insuline mu guhagarika ibikorwa byurwego rwo hejuru rwo kwandukura FOXO1 no kugabanya urwego rwa myostatine [5].
Guteza imbere gutandukanya imitsi:
Mu ngirangingo z'imitsi, Motc ikorana na STAT3 ikoresheje moteri ya SH2 ihuza motif mu karere ka YIFY, igabanya ibikorwa byo kwandukura STAT3, bityo ikazamura imitsi ya myotube. Ubwoko bwa Motc peptide yo mu gasozi burashobora kongera imiterere ya myotube yumuntu (LHCN-M2) nimbeba (C2C12) ingirabuzimafatizo kandi ikarinda ingirangingo z'imitsi kugabanuka kwa myogenine ya kirimbuzi iterwa na interleukin-6 (IL-6) [6].
Kugenga imikorere ya mitochondial:
Motc irashobora kugenga metabolism ya mitochondrial. Ubushakashatsi bwerekanye ko kuvura ingirangingo z’inyamabere hamwe na Motc bishobora kongera urugero rwa poroteyine y’ibimenyetso bya biogenezi ya mitochondrial TFAM, COX4, na NRF1, ariko isesengura rya cytometrie ryerekana ko umubare wa mitochondriya ugabanuka cyane nyuma yo kuvura Motc. Ubushakashatsi bwakozwe bwerekanye ko Motc ishobora guhuza ibikorwa bya mitochondial kandi ikongerera poroteyine za GTPase ebyiri, OPA1 na MFN2, zikaba ari ingenzi cyane mu guhuza mitochondriya y’inyamabere. Kubuza GTPase ebyiri cyangwa gukubita MFN2 ukoresheje siRNA bizakuraho ubushobozi bwa Motc bwo guteza imbere GLUT4 no guhinduranya glucose [7].
Motc ni intego yo kuvura indwara nyinshi ziterwa no gusaza, harimo neurodegeneration, osteoporose, indwara z'umutima-damura, aterosklerose, sarcopenia, ubwoko bwa 2 metabolism mellitus, n'umubyibuho ukabije.
Inkomoko: Byatangajwe [8]
Ni ubuhe buryo bukoreshwa na Motc?
Kunoza indwara ziterwa n'imyaka
Isano no gusaza:
Motc ni peptide ikomoka kuri mitochondriya, kandi impinduka mu mvugo zayo zifitanye isano rya bugufi no kubaho no gukura kw'indwara zisaza n'indwara. Iyo abantu basaza, urwego rwa Motc rugabanuka. Ubushakashatsi bwerekanye ko imyitozo ngororamubiri igira uruhare runini mu mvugo ya Motc, kandi Motc ishobora guhuza ingaruka zo kurwanya gusaza imyitozo [3].
Metabolism:
Motc irashobora kunoza glucose yumubiri na lipide metabolism, igateza imbere imikorere ya mitochondial selile, kandi ikagabanya uburyo bwa chronique inflammatory reaction. Ku barwayi ba diyabete, urwego rwa Motc muri plasma rugabanuka. Motc irashobora kugenga homeostasis ya metabolike yihutisha gufata glucose no kunoza insuline, kandi igira ingaruka nziza mukurinda metabolism yo mu bwoko bwa 2 [8].
Indwara z'umutima n'imitsi:
Kuvugurura imitima yumutima no kudakora ni ibintu bisanzwe biterwa na metabolism, akenshi biganisha kumutima ukomeye. Motc irashobora kunoza imikorere ya endoteliyale yimitsi kandi ni intego nshya yo kuvura ibibazo byumutima nimiyoboro yimitsi ya metabolism. Ubushakashatsi bwerekanye ko Motc ishobora gusana myocardial mitochondrial yangiritse ku mbeba za diyabete kandi ikarinda imikorere yimitsi yumutima na diastolique [9].
Osteoporose: Motc irashobora guteza imbere ikwirakwizwa, itandukaniro, hamwe nubutaka bwa osteoblasts, ikabuza genezasi ya osteoclast, kandi ikagenga metabolisme yamagufwa no kuvugurura amagufwa. Imyitozo ngororamubiri irashobora kugenzura neza imvugo ya Motc, ariko uburyo bwihariye imyitozo igenga Motc mu magufa ntibirasobanuka neza [10].
Izindi ndwara
Fibrosis yo mu bihaha:
Fibrosis yo mu bihaha ni indwara ikomeye y'ibihaha hamwe no kutamenya neza, kandi etiologiya yayo na patogenezi yayo ntibirasobanuka neza. Mitochondrial ifunguye yo gusoma ya 12S rRNA-c (Motc) ni peptide yashizwemo na genome ya mitochondrial, igira ingaruka nziza kuri metabolisme ya glucose na lipide, homeostasis ya selile na mitochondrial homeostasis, no kugabanya ibisubizo bya sisitemu yo gutwika, kandi birashobora kuba imyitozo yigana. Iri suzuma rigamije gusesengura byimazeyo ubuvanganzo buriho ku ruhare Motc ishobora kugira mu kuzamura iterambere rya fibrosis yo mu bihaha no kumenya intego zihariye zo kuvura ingamba zo kuvura ejo hazaza ..
Duchenne imitsi ya dystrofiya:
Motc ni mitochondriya ikomoka kuri bioactive peptide ifite imiterere yihariye yibasira imitsi, ishobora kongera umuvuduko wa glycolytike nubushobozi bwo gutanga ingufu zimitsi ya dystrofique muri vitro no muri vivo, bityo bikazamura ibikorwa nibikorwa bya fosifonodiamidite morpholino oligomers (PMO) mumbeba za mdx. Ubuyobozi bwigihe kirekire busubirwamo bwa Motc na PMO burashobora gutuma hagaragazwa urwego rwo kuvura dystrofine mumitsi ya peripheri, kunoza imikorere yimitsi na patologiya yimbeba za mdx, kandi nta burozi bugaragara [12].
Umubyibuho ukabije n'imitsi:
Umubyibuho ukabije hamwe na metabolism yo mu bwoko bwa 2 ni indwara ziterwa na metabolike akenshi zijyana na sarcopenie no kudakora neza kw'imitsi. Motc, nka hormone itunganijwe, igira uruhare muri metabolic homeostasis. Ubushakashatsi bwerekanye ko plasma Motc urwego rufitanye isano ribi nurwego rwa myostatine mumubiri wumuntu. Motc irashobora gukumira aside yitwa palmitike iterwa na myotubes ya C2C12 itandukanye kandi ikagabanya urugero rwa myostatine muri plasma yimbeba zifite umubyibuho ukabije. Muguhagarika myostatine, Motc irashobora kuba uburyo bwo kuvura imitsi ya skeletale iterwa no kurwanya insuline hamwe nizindi fenotipi yimitsi irimo sarcopenia [5].
Ibyago byindwara ziterwa na kanseri yamabere:
Abagore bakiriye kanseri y'ibere bafite ibyago byinshi byo kwandura indwara z'umutima n'imitsi, metabolisme, n'umubyibuho ukabije, kandi imyitozo ngororamubiri irashobora kugabanya izo ngaruka. Motc ifite ibikorwa-bigana imyitozo kandi igira ingaruka nziza kuri metabolism hamwe nubushobozi bwimyitozo ngororamubiri. Ubushakashatsi bwerekanye ko ibyumweru 16 by’imyitozo ngororamubiri yo mu kirere no kurwanya imyitozo bishobora kongera urwego rwa Motc ku barokotse kanseri y'ibere itari Hisipaniya, ariko nta ngaruka nini zigira ku barokotse kanseri y'ibere ya Hisipaniya. Ubwiyongere bw'urwego rwa Motc buterwa no gukora imyitozo ku barokotse kanseri y'ibere itari Hisipaniya bishobora kuba bifitanye isano no kunoza insuline, bityo bikagabanya ibyago byo kwandura [13].
Mu gusoza, nka polypeptide ya aside amine 16 yashizwemo na genoside ya mitochondrial, Motc igira uruhare runini muguhindura umubiri, kugenzura imihangayiko, no kwirinda indwara no kuvura. Irashobora kunoza cyane homeostasis ya glucose na lipide metabolism, ikongerera insuline ibyiyumvo, kandi ikabuza imvugo ya myostatine, igabanya neza metabolism yo mu bwoko bwa 2, umubyibuho ukabije, hamwe na atrophyi yimitsi ifitanye isano. Muri icyo gihe, mu kugenzura ibinyabuzima bya mitochondrial biogenezi no guhuza, Motc yongerera imbaraga antioxydants ya selile kandi ikabuza igisubizo cy’umuriro, ikerekana ubushobozi bwo kuvura indwara zidakira nk'indwara z'umutima n'imitsi, osteoporose, na fibrosis yo mu bihaha. By'umwihariko, nkumuhuza wingenzi witumanaho rya mitochondria-nucleus, Motc irashobora kwigana ingaruka zimyitozo ngororamubiri no gutinda gusaza. Urwego rwarwo rufitanye isano ribi n'indwara ziterwa n'imyaka, kandi inyongera ya exogenous irashobora guhindura imiterere ya metabolike kandi ikabuza kwandura virusi. Bizwi nka 'imisemburo ya mitochondrial '.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Dieli-Conwright CM ni intiti ifite uruhare runini mubice bitandukanye bya oncology na siporo yubumenyi. Kugeza ubu ni umwarimu wungirije w’ubuvuzi mu Ishuri Rikuru ry’Ubuvuzi rya Harvard n’Ikigo cya Dana-Farber Kanseri kandi afite umwanya w’ishami wungirije mu ishami ry’imirire mu ishuri ry’ubuzima rusange rya Harvard TH Chan. Ubushakashatsi bwa Dr. Dieli-Conwright bwibanze ku kumenya ingaruka z’imyitozo ngororamubiri ku barwayi ba kanseri, cyane cyane uburyo imyitozo ishobora kuzamura imikorere y’imiterere, ubuzima bw’amagufwa, ndetse n’ubuzima bw’abarwayi ba kanseri. Amashuri yize akubiyemo ibintu byinshi nka biologiya, kinesiologiya, ubuzima rusange, na biokinesiology. Yarangije amasomo ye mu bigo nka kaminuza ya Leta ya Californiya, Northridge, na kaminuza y’Amajyepfo ya Californiya kandi arangiza ubushakashatsi bwe bwa dogiteri mu kigo cy’ubuvuzi cya City of Hope. Ubushakashatsi bwa Dr. Dieli-Conwright bwagiye busohoka cyane mu binyamakuru bitandukanye by’amasomo, kandi umurimo we urimo amasomo menshi nk'ubuzima rusange, imirire, sisitemu y'umutima n'imitsi, ndetse n'indwara z'umutima, bitanga ibimenyetso bifatika bya siyansi bijyanye no gusubiza mu buzima busanzwe no gucunga ubuzima bw'abarwayi ba kanseri. Dieli-Conwright CM yashyizwe ku rutonde rwerekana [13].
