Cocer Peptides ye ŋlɔe 
ŋkeke 15 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Tsitsi ƒe Lãmetsiŋusẽ (GH) wɔa akpa vevi aɖe le ŋutilã ƒe dɔwɔwɔ geɖe me, siwo dometɔ aɖewoe nye tsitsi, tsitsi, kple lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie le nugbagbewo me. Ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe ɖoɖo sesẽ aɖee kpɔa eƒe dodo dzi nyuie, eye Growth Hormone-Releasing Peptides (GHRPs) nye nusiwo doa ŋusẽ tsitsi ƒe lãmetsiwo ƒe dodo, si hea numekulawo ƒe susu vevie. Ipamorelin, abe GHRP ƒomea me tɔ ene la, to vovo le eƒe wɔwɔme tɔxɛ kple ŋutete si dze ƒã be wòado tsitsi ƒe lãmetsiwo ƒe dodo ɖe ŋgɔ ta.
Le atikewo ƒe wɔwɔme ƒe nukpɔsusu nu la, Ipamorelin nye pentapeptide si wowɔ. Dɔwɔnu sia nana wòlɔ̃a Tsitsi ƒe Lãmetsiŋusẽ-Releasing Peptide Receptor (GHRP-R) ŋutɔ, si wɔnɛ be wòte ŋu wɔa dɔ nyuie le lãmenugbagbeviwo me eye wòdzea lãmenugbagbeviwo me dzesimɔ siwo kplɔ wo nɔewo ɖo gɔme, si wɔnɛ be wòdoa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ.
Ne wotsɔ Ipamorelin sɔ kple Tsitsi ƒe Lãmetsiŋusẽ (GHRH) la, viɖe tɔxɛ geɖe le eŋu. GHRH wɔa dɔ ɖe GHRH xɔla siwo le tsitsi ƒe lãmetsiŋusẽ ƒe lãmenugbagbevi siwo le ŋgɔgbe lãkusi me ƒe anyime koŋ dzi be wòaʋã tsitsi ƒe lãmetsi ƒe wɔwɔme kple eƒe dodo. Menye ɖeko ipamorelin wɔa dɔ ɖe lãkusi si me ʋu sina tona dzi tẽ ko o, ke eɖɔa tsitsi ƒe lãmetsiŋusẽ ƒe dodo hã ɖo le mɔ si mele tẽ o nu to dɔwɔwɔ ɖe hypothalamus kple nuto bubuwo dzi me, si naa dɔwɔwɔ ƒe mɔnu vovovo siwo to vovo wu. Ipamorelin ɖea tiatiawɔwɔ si lolo wu fiana le tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me, eɖea ŋusẽ si dzena wu si doa ŋusẽ ame ɖe tsitsi ƒe lãmetsi ƒe dodo dzi fiana esime mekpɔa ŋusẽ boo aɖeke ɖe ʋumenugbagbevi dzĩ me lãmetsi bubuwo abe lãkusi si doa ŋusẽ lãmetsi (FSH), luteinizing hormone (LH), prolactin (PRL), kple thyroid-stimulating hormone (TSH) ƒe agbɔsɔsɔ dzi boo o.
Le dodokpɔ siwo wowɔ le lãwo ŋu me la, Ipamorelin ɖee fia be ewɔa dɔ nyuie ŋutɔ le tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ le lã vovovowo me, siwo dometɔ aɖewoe nye sisiblisiwo, hawo, alẽwo, kple avuwo. Le dodokpɔ siwo wowɔ le sisiblisiwo ŋu me la, le Ipamorelin dodo vɔ megbe la, wokpɔ dzidziɖedzi kabakaba le ʋumenugbagbeviɣidɔlékuiwo ƒe agbɔsɔsɔ me, si ɖe ƒomedodo si nɔ te ɖe agbɔsɔsɔme si wozã dzi fia. Esia ɖee fia be Ipamorelin ate ŋu aɖɔ tsitsimeŋusẽ ƒe dodo ɖo nyuie, si ana dodokpɔ me kpeɖodzi sẽŋuwo le alesi woate ŋu azãe le lãwo ƒe tsitsi ƒe dɔwɔwɔ nyuie wu kple dɔléle siwo do ƒome kplii dada me ŋu.
Figure 1 Table 1 Pentapeptide yeye aɖewo ƒe wɔwɔme–dɔwɔwɔ ƒe ƒomedodowo le GH ƒe dodo tso rat pituitary cells me le vitro – tsɔtsɔ sɔ kple GHRP-1, GHRP-2, GHRP-6, kple GHRH. Woɖe emetsonuwo fia abe mama dedie ± SEM (n = 3–6 dodokpɔ vovovowo).
Mɔnu si dzi Ipamorelin wɔa dɔ le le tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me
Kadodo kple peptide xɔla si ɖea tsitsi ƒe lãmetsiwo ɖa
Afɔɖeɖe gbãtɔ vevitɔ le akpa si Ipamorelin wɔna le tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me enye eƒe kadodo tɔxɛ kple tsitsimeŋusẽ si ɖea peptide xɔla (GHRP-R). GHRP-R nye G protein-coupled receptor superfamily me tɔ eye wòkaka ɖe ŋgɔgbe lãkusi, hypothalamus, kple lãkusi bubuwo me. Ipamorelin ƒe pentapeptide ƒe wɔwɔme na wòte ŋu wɔa dɔ kple GHRP-R ƒe kotoku si blaa ligand la pɛpɛpɛ, si wɔnɛ be nɔnɔme ƒe tɔtrɔ va nɔa xɔla la me. Conformational change sia wɔa dɔ abe 'switch' ene tsɔ dzea lãmenugbagbeviwo me dzesi ƒe tɔtrɔ gɔme, si wɔnɛ be GHRP-R te ŋu wɔa nu kple G protein siwo le anyime eye wòwɔa dɔ.
GHRP-R si wowɔ dɔ la doa guanosine nucleotide ƒe asitɔtrɔ ɖe ŋgɔ le G protein α ƒe akpa sue si wotsɔ kpe ɖe eŋu me, eye wotsɔa GTP ɖɔlia GDP, si wɔnɛ be G protein α ƒe akpa suea ɖea eɖokui ɖa tso G protein βγ dimer gbɔ. G protein α subunit si woɖe ɖe vovo kple G protein βγ dimer ate ŋu ana dzesiwo ƒe tɔtrɔmɔ vovovo siwo le anyime la nawɔ dɔ geɖe wu, si ahe lãmenugbagbeviwo me nugbagbeŋusẽ ƒe ŋusẽkpɔɖeamedzi vovovowo vɛ, si ana tsitsi ƒe lãmetsiŋusẽ ƒe dodo nadzi ɖe edzi mlɔeba.
CJC-1295, abe tsitsime lãmetsiŋusẽ si wowɔ ene la, kpena ɖe ame ŋu le lolo dzi ɖeɖe kpɔtɔ, lãmekawo ƒe nyonyo, ŋutigbalẽ ƒe ɖekakpuiwɔwɔ, alɔ̃dɔdɔ ƒe nyonyo, kple abi ƒe dɔyɔyɔ me. Ipamorelin nye pentapeptide si wowɔ si le peptide siwo ɖea tsitsi ƒe lãmetsiwo (secretagogues) ƒe hatsotso me. Edoa ŋusẽ tsitsiŋusẽ ƒe dodo eye wòkpɔa ŋusẽ ɖe ŋutilã ƒe dɔwɔwɔ vovovowo dzi, siwo dometɔ aɖewoe nye dɔgbo ƒe ʋuʋu kabakaba, dɔgbo ƒe mɔxexeɖedɔléle ƒe dzesi siwo dzena le dɔwɔwɔ vɔ megbe ƒe nyonyo, insulin ƒe dodo, kple glucocorticoids ƒe catabolic ŋusẽkpɔɖeamedzi ɖe ƒunukpeƒeŋusẽ kple ƒu dzi nutsitsi. Nusɔsrɔ̃ tso atike eve siawo ƒe dɔwɔwɔ ɖekae ŋu ate ŋu ana woakpɔ ŋgɔyiyi yeyewo le lãmesẽnyawo, kamedefefewo ƒe atikewɔwɔ, kple dɔléle siwo do ƒome kplii dada me.
Figure 2 Plasma GH ƒe agbɔsɔsɔme tsɔtsɔ sɔ kple ɣeyiɣi si le ha me le iv ipamorelin ƒe agbɔsɔsɔme vovovowo dodo vɔ megbe.
Lãmenugbagbeviwo me dzesiwo ƒe tɔtrɔmɔwo ƒe dɔwɔwɔ
Phospholipase C - protein kinase C mɔ (PLC - PKC mɔ): G protein α ƒe akpa sue si wowɔ dɔ ate ŋu ana phospholipase C (PLC) nawɔ dɔ, si naa phosphatidylinositol-4,5-bisphosphate (PIP2) si le lãmenugbagbeviwo ƒe lãkusi dzi la ƒua tsi wòzua dɔla evelia vevi eve: inositol-1,4,5-trisphosphate (IP3) kple diacylglycerol (DAG). IP3 kaka ɖe lãmenugbagbeviwo me, blana ɖe IP3 xɔla siwo le endoplasmic reticulum dzi, eye wòdoa calcium ions (Ca 2+ ) ƒe dodo tso endoplasmic reticulum me ɖe ŋgɔ, si wɔnɛ be Ca 2+ ƒe agbɔsɔsɔ si le lãmenugbagbeviwo me dzina ɖe edzi kabakaba. DAG gakpɔtɔ nɔa lãmenugbagbeviwo ƒe lãkusi kple protein kinase C (PKC) si wɔa dɔ dzi. PKC ate ŋu aɖɔ domenyiŋusẽfianu siwo do ƒome kplii ƒe ɖeɖefia ɖo to phosphorylation na protein siwo le anyime, abe transcription factors ene, siwo to esia me doa tsitsi ƒe lãmetsi ƒe wɔwɔme kple eƒe dodo ɖe ŋgɔ. Ca⊃2;+ ƒe agbɔsɔsɔ si dzi ɖe edzi le lãmenugbagbeviwo me hã ate ŋu awɔ dɔ ɖe adzame ʋukawo dzi tẽ be wòado tsitsiŋusẽ ƒe dodo ɖe ŋgɔ.
Mitogen-activated protein kinase pathway (MAPK pathway): Tsɔ kpe ɖe PLC-PKC mɔa ŋu la, Ipamorelin naa mitogen-activated protein kinase pathway la wɔa dɔ le GHRP-R ƒe dɔwɔwɔ vɔ megbe be wòado tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ. G protein βγ dimer naa guanine nucleotide exchange factor (GEF) wɔa dɔ, si doa GDP si bla ɖe Ras protein ŋu ƒe tɔtrɔ ɖe GTP ŋu, si wɔnɛ be Ras protein wɔa dɔ. Ras protein si wowɔ dɔ gawɔa dɔ na Raf protein, si wɔa phosphorylate na mitogen-activated protein kinase kinase (MEK) eye wòwɔa dɔ. Emegbe wowɔa phosphorylation na MEK eye wònaa extracellular signal-regulated kinase (ERK) wɔa dɔ. Ne ERK ge ɖe lãmenugbagbeviwo ƒe nucleus me vɔ la, ewɔa phosphorylate na nuŋɔŋlɔ ƒe nusiwo kplɔ wo nɔewo ɖo, abe Elk-1 ene, si ɖɔa domenyiŋusẽfianu siwo do ƒome kple tsitsimeŋusẽ ƒe wɔwɔme kple eɖeɖe ɖe go ƒe ɖeɖefia dzi, si wɔnɛ be tsitsi ƒe lãmetsi ƒe wɔwɔ kple eƒe dodo ɖe ŋgɔ.
Hypothalamic-pituitary axis ƒe ɖoɖowɔwɔ
Hypothalamic-pituitary axis wɔa akpa vevi aɖe le tsitsime lãmetsiŋusẽ ƒe dodo dzi kpɔkpɔ me. Menye ɖeko ipamorelin wɔa dɔ ɖe tsitsi ƒe lãmetsiŋusẽ ƒe lãmenugbagbevi siwo le ŋgɔgbe lãkusi me dzi tẽ be wòado tsitsi ƒe lãmetsi ƒe dodo ɖe ŋgɔ ko o, ke ekpɔa ŋusẽ ɖe tsitsi ƒe lãmetsi ƒe dodo hã dzi le mɔ si mele tẽ o nu to hypothalamus ƒe ɖoɖowɔwɔ me. GHRH kple somatostatin (SST) siwo hypothalamus ɖena ɖe go la kpɔa ŋusẽ ɖe tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ kple mɔxexe ɖe enu dzi. Ipamorelin ate ŋu aɖɔ tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖo le mɔ si mele tẽ o nu to asitɔtrɔ le GHRH kple SST ƒe wɔwɔme kple woƒe dodo le hypothalamic ahɔhɔ̃mekawo me ŋu. Ipamorelin ate ŋu axe mɔ na SST ahɔhɔ̃mekawo ƒe dɔwɔwɔ le hypothalamus me, si aɖe SST ƒe dodo dzi akpɔtɔ, si ana SST ƒe mɔxexeɖedɔléle nu ƒe ŋusẽkpɔɖeamedzi ɖe tsitsi ƒe lãmetsiŋusẽ ƒe dodo dzi dzi akpɔtɔ. Ipamorelin ate ŋu ana GHRH ahɔhɔ̃mekawo ƒe dzidzɔkpɔkpɔ hã nadzi ɖe edzi, ado GHRH ƒe dodo ɖe ŋgɔ, eye wòagaʋã tsitsi ƒe lãmetsiwo ƒe dodo. Dɔwɔwɔ eve sia si kpɔa ŋusẽ ɖe hypothalamic-pituitary axis dzi la wɔnɛ be Ipamorelin te ŋu ɖɔa tsitsime lãmetsiŋusẽ ƒe dodo ƒe agbɔsɔsɔ ɖo.
Akpa si Ipamorelin wɔna le tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me
Tsitsi kple ŋgɔyiyi dodo ɖe ŋgɔ
Le lãwo ƒe tsitsi kple tsitsime la, tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le ɖoɖowɔwɔ me, eye Ipamorelin kpɔa ŋusẽ nyui ɖe lãwo ƒe tsitsi kple tsitsi dzi to tsitsi ƒe lãmetsi ƒe dodo ɖe ŋgɔ me. Le lã viwo gome la, Ipamorelin zazã dzia tsitsi ɖe edzi ŋutɔ. Ne míetsɔ sisiblisiwo wɔ kpɔɖeŋui la, ne wodo Ipamorelin ƒe agbɔsɔsɔ si sɔ vɔ la, sisiblisiwo ɖea woƒe kpekpeme dzina ɖe edzi kabakaba, ƒunukpeƒetetedɔ ƒe tsitsi ƒe agbawo ƒe dzidziɖedzi kple vovototodedeameme dzina ɖe edzi, eye ƒu didi ƒe didime dzina ɖe edzi. Woate ŋu agblɔ be esia tso nyateƒe si wònye be tsitsi ƒe lãmetsiŋusẽ doa ŋusẽ tsitsinu si le abe insulin ene (IGF-1) ƒe wɔwɔme le lãmenugbagbeviwo abe aklã ene me gbɔ. IGF-1 toa ʋukawo me yia lãkusiwo abe ƒuwo ene me, si doa ʋumenugbagbevi dzĩwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, si wɔnɛ be ƒuwo ƒe tsitsi nɔa bɔbɔe. Ipamorelin doa tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ, si wɔnɛ be IGF-1 ƒe wɔwɔ dzina ɖe edzi le mɔ si mele tẽ o nu, si wɔnɛ be ƒuwo ƒe tsitsi kple tsitsi kabakaba.
Ipamorelin doa lãmekawo ƒe tsitsi hã ɖe ŋgɔ. Tsitsi ƒe lãmetsi doa protein ƒe wɔwɔme ɖe ŋgɔ, xea mɔ na protein ƒe gbagbã, eye wòdzia lãmekawo ƒe lolome ɖe edzi. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, esi wodo Ipamorelin vɔ la, lãawo ɖe lãmekawo ƒe ka siwo le kpekpem wu fia eye woƒe lãmekawo ƒe ŋusẽ dzi ɖe edzi.
Dɔwɔɖoɖowo ƒe ŋusẽkpɔɖeamedzi ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi
Sukli ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe ɖoɖowɔwɔ: Ipamorelin doa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ, si kpɔa ŋusẽ aɖe ɖe sukli ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dzi. Akpa eve le tsitsi ƒe lãmetsi si le sukli ƒe asitɔtrɔ me. Le ŋutilã me la, tsitsi ƒe lãmetsi doa ŋusẽ insulin ƒe dodo, edoa sukli ƒe xɔxɔ kple eŋudɔwɔwɔ ɖe ŋgɔ, eye wòɖea sukli ƒe agbɔsɔsɔ le ʋu me dzi kpɔtɔna. Ne tsitsime lãmetsiŋusẽ sɔ gbɔ la, eɖea ŋusẽ si tsi tre ɖe insulin ŋu fiana, si xea mɔ na sukli si le lãmeka siwo le lãmekawo me ƒe xɔxlɔ̃ kple eŋudɔwɔwɔ, si wɔnɛ be sukli ƒe agbɔsɔsɔ le ʋu me dzina ɖe edzi. Ipamorelin kpɔa ŋusẽ ɖe sukli ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dadasɔ dzi le mɔ si mele tẽ o nu to tsitsime lãmetsiŋusẽ ƒe dodo dzi kpɔkpɔ me. Le lã siwo sɔ gome la, Ipamorelin ƒe agbɔsɔsɔ si sɔ ate ŋu ana sukli si le ʋu me nanɔ teƒe ɖeka vie, si woate ŋu agblɔ be edoa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ gbɔ, si hã doa ŋusẽ insulin ƒe dodo vaseɖe afi aɖe, si wɔnɛ be ʋumesukli ƒe agbɔsɔsɔme nɔa ɖoɖo nu. Le suklidɔlélawo ƒe lãwo ƒe kpɔɖeŋuwo me la, Ipamorelin ƒe ŋusẽkpɔɖeamedziwo sesẽ wu; ate ŋu ana insulin ƒe dɔlélenutsiŋutete nanyo ɖe edzi to tsitsime lãmetsiŋusẽ ƒe dodo dzi kpɔkpɔ me, si ana wòakpɔ ŋusẽ nyui ɖe ʋumesukli dzi ɖuɖu dzi.
Ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe ɖoɖowɔwɔ: Tsitsi ƒe lãmetsi doa ami ƒe gbagbã ɖe ŋgɔ, enaa ami ƒe oxidation dzina ɖe edzi hena ŋusẽ wɔwɔ, eye wòɖea ami ƒe ƒuƒoƒo dzi kpɔtɔna. Ipamorelin doa tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ, si wɔnɛ be ewɔa eƒe ɖoɖowɔwɔ ƒe ŋusẽ ɖe ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dzi. Le dodokpɔ siwo wowɔ le lãwo ŋu me la, esi wodo Ipamorelin vɔ la, ami si le lãawo ƒe ŋutilã me dzi ɖe kpɔtɔ, vevietɔ le teƒewo abe ƒodo ene. Esia le alea elabena tsitsi ƒe lãmetsi naa lãmetsiŋusẽ ƒe lipase (HSL) wɔa dɔ le ami lãmenugbagbeviwo me, si doa triglycerides ƒe tsi me ʋuʋu ɖe ŋgɔ wòzua ami kple glycerol. Emegbe amiwo gena ɖe mitochondria me hena β-oxidation be wòawɔ ŋusẽ. Tsitsi ƒe lãmetsi hã xea mɔ na ami ƒe lãmenugbagbeviwo ƒe vovototodedeameme, si wɔnɛ be woƒe xexlẽme dzi ɖena kpɔtɔna eye wògaɖea ami si le ŋutilã me dzi kpɔtɔna ɖe edzi. Ipamorelin, to tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me la, wɔa akpa aɖe le ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dzi kpɔkpɔ kple ŋutilã ƒe kpekpeme dzi ɖuɖu me.
Ŋusẽkpɔɖeamedzi ɖe lãmekawo dzadzraɖo kple wo gbugbɔgadzɔ dzi
Tsitsi ƒe lãmetsi wɔa akpa vevi aɖe le lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ me. Ipamorelin, to tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me la, naa nɔnɔme nyuiwo nɔa lãmekawo ɖɔɖɔɖo kple wo gbugbɔgawɔ me. Le lãkusi siwo gblẽ me la, tsitsi ƒe lãmetsi ate ŋu aʋã lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme, ado lãmenugbagbeviwo godo ƒe matrix ƒe akpawo abe collagen ene ƒe wɔwɔ ɖe ŋgɔ, eye wòana abi nahaya kabakaba. Le ŋutigbalẽ ƒe abixɔxɔ ƒe kpɔɖeŋuwo me la, ne wozã Ipamorelin vɔ la, fibroblast ƒe dzidziɖedzi le abiteƒea dzina ɖe edzi kabakaba, collagen ƒe sisi dzina ɖe edzi, eye abi ƒe dɔyɔɣi dzi ɖena kpɔtɔna. Woate ŋu agblɔ be esia tso tsitsi ƒe lãmetsi si doa fibroblast ƒe cytokines abe transforming growth factor-β (TGF-β) ƒe dodo ɖe ŋgɔ gbɔ, si gaʋãa fibroblast ƒe dzidziɖedzi kple collagen ƒe wɔwɔme. Tsitsi ƒe lãmetsi hã doa ʋuka me lãmenugbagbeviwo ƒe dzidziɖedzi kple ʋuʋu ɖe ŋgɔ, si wɔnɛ be ʋuka yeyewo ƒe wɔwɔ nɔa bɔbɔe be woana nunyiame kple ɔksidzin si sɔ lãmeka siwo gblẽ, si wɔnɛ be lãmenugbagbeviwo ɖɔɖɔɖo kabakaba. Akpa si Ipamorelin wɔna le lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ dodo ɖe ŋgɔ me na wònye amesi ŋugbe wodo be woate ŋu azãe le nuveviwɔame ƒe atikewɔwɔ, amekoko, kple dɔ bubuwo me.
Ipamorelin zazã le tsitsime lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ me
Nusiwo woate ŋu azã le atikewɔwɔ me
Tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ dada: Tsitsi ƒe lãmetsi ƒe anyimanɔmanɔ nye nɔnɔme si tso tsitsime lãmetsi si mesɔ gbɔ o gbɔ, si ƒe dzesi enye be eƒe kɔkɔme le kpuie eye wòhe ɖe megbe le tsitsi kple tsitsi me. Ne wotsɔe sɔ kple atike si wozãna tsɔ ɖɔlia tsitsimeŋusẽ si wozãna tsã la, Ipamorelin doa ŋusẽ tsitsimeŋusẽ si dona le lãme na ame, si ƒoa asa na nugbegblẽ aɖewo siwo dona tso tsitsimeŋusẽ si tso gota zazã ɣeyiɣi didi me. Dɔdaƒewo ƒe numekukuwo ɖee fia be le dɔnɔ aɖewo siwo ƒe tsitsime lãmetsiŋusẽ mele o gome la, Ipamorelin zazã dzia tsitsimeŋusẽ ƒe agbɔsɔsɔ ɖe edzi nyuie, enaa ame ƒe kɔkɔme tsina kabakaba, eye wònaa agbenɔnɔ nyona ɖe edzi.
Atikewɔwɔ si tsia tsitsi nu: Ne amewo le tsitsim la, tsitsime lãmetsiŋusẽ ƒe dodo dzi ɖena kpɔtɔna vivivi, si do ƒome kplikplikpli kple ŋutilã me tɔtrɔ geɖe siwo dona tso tsitsi me. Ipamorelin, si doa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ la wɔa akpa aɖe le tsitsi nutsitsi ƒe dɔwɔwɔ me. To tsitsime lãmetsiŋusẽ ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me la, Ipamorelin ate ŋu ana ame tsitsiwo ƒe ŋutilã ƒe wɔwɔme nanyo ɖe edzi, ana lãmekawo nadzi ɖe edzi, aɖe ami ƒe ƒuƒoƒo dzi akpɔtɔ, ana ƒuwo nalolo wu, eye ŋutigbalẽa nate ŋu asẽ ɖe edzi. Dɔdamɔnu dodokpɔwo ɖee fia be ame tsitsi siwo zãa Ipamorelin le agbɔsɔsɔ si sɔ me la ƒe ŋutilã ƒe dɔwɔwɔ, ŋusẽdodo, kple susu ƒe nɔnɔme nyona ɖe edzi.
Abi ƒe dɔyɔyɔ dodo ɖe ŋgɔ: Ipamorelin doa lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ to tsitsi ƒe lãmetsiŋusẽ ƒe dodo me. Le atikewɔwɔ me la, le dɔnɔ siwo xɔ abi aɖewo abe dzobibi alo gbagbã ene gome la, Ipamorelin zazã ate ŋu ana abi nahaya kabakaba eye wòaɖe kuxiwo ƒe dzɔdzɔ dzi akpɔtɔ. Le dɔnɔ siwo wotɔ dzoe gome la, Ipamorelin ate ŋu ana abi ƒe akpa si le abi la ƒe lãkusiwo nazu lãmenugbagbeviwo eye wòaɖe abi ƒe dzɔdzɔ dzi akpɔtɔ; le dɔnɔ siwo ƒe ƒu gbagbã gome la, ate ŋu ana ƒu ƒe ʋuʋudedi nawɔ eye wòana ƒu gbagbã ƒe dɔyɔyɔ kabakaba. Esia naa atikewɔwɔ kpeɖeŋutɔ ƒe tiatia yeye aɖe hena nuveviwɔame dzi kpɔkpɔ, si ate ŋu ana atikewɔwɔ me tsonu nanyo ɖe edzi.
Dɔwɔwɔ le Kamedefefewo ƒe Atikewɔwɔ me
Le ŋutete si le esi be wòaʋã tsitsi ƒe lãmetsiŋusẽ ƒe dodo ta la, ate ŋu ana lãmekawo nadzi ɖe edzi, ana kamedefefewo nawɔ dɔ nyuie wu, eye wòana ame nahaya kabakaba le kamedede megbe. Le kamedefefewɔla siwo le hehexɔxɔ sesẽ me gome la, Ipamorelin ate ŋu akpe ɖe wo ŋu woƒe ŋutilã ƒe ŋusẽ nagaɖo wo ŋu kaba, aɖe lãmekawo ƒe ɖeɖiteameŋu dzi akpɔtɔ, eye wòaɖe abixɔxɔ ƒe afɔkua dzi akpɔtɔ. Le dzidodo ƒe kamedefefewɔlawo gome la, Ipamorelin ate ŋu ana kamedede ƒe dzidodo nadzi ɖe edzi to ami ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu dodo ɖe ŋgɔ me; le kamedefefewɔla siwo ŋu ŋusẽ le gome la, ate ŋu ana lãmekawo ƒe ŋusẽ kple ŋusẽ nadzi ɖe edzi.
Nyanuwuwuw
Kpuie ko la, abe pentapeptide si doa tsitsi ƒe lãmetsiŋusẽ ƒe dodo ɖe ŋgɔ ene la, Ipamorelin ɖea akpa vevi siwo wòwɔna le tsitsi kple tsitsi, lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ, lãmenugbagbeviwo ɖɔɖɔɖo, kple dɔwɔwɔ ƒe akpa vovovo bubuwo fiana.
Dzɔtsoƒewo
[1] Papak M. Ipamorelin - struktura i funkcija, ƒe 2016[C]. https://api.semanticscholar.org/CorpusID: 78470780 ƒe ɣleti gbãtɔ me
[2] Adeghate E, Ponery AS, Emirates U A. ORIGINALARTICLE Mɔnu si ipamorelin-ʋãna insulin dona tso dɔgbo me le sisiblisi siwo sɔ kple suklidɔlélawo ƒe dɔgbo me, 2004[C]. https://api.semanticscholar.org/CorpusID: 74621068 ƒe ɣleti gbãtɔ me
[3] Raun K, Hansen B. S., Johansen N. L., kple ame bubuwo. Ipamorelin, si nye tsitsiŋusẽ ƒe lãmetsi gbãtɔ si tiaa atike.[J]. Europa ƒe Nyadzɔdzɔgbalẽ si Ku Ðe Dɔlékuiwutikewo Ŋu, 1998,139 5:552-561.
Adzɔnu si li na numekuku zazã ɖeɖeko:
