By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
Rahoton da aka ƙayyade na Cerebrolysin
Cerebrolysin yana da kaddarorin neuroprotective da neurotrophic. Tun lokacin da aka gano shi, ya sami kulawa mai mahimmanci a fannin maganin cututtukan ƙwayoyin cuta. A cikin 1949, masanin kimiyya dan kasar Austria Gerhart Harrer daga Jami'ar Innsbruck ya ruwaito cewa Cerebrolysin, wani ruwa mai gina jiki wanda aka samar ta hanyar enzymatic hydrolysis na nama na kwakwalwa, zai iya motsa ƙwayoyin jijiya. Cakuda ne na tushen furotin wanda ke ɗauke da 85% amino acid kyauta da 15% bioactive low-molecular-weight amino acid jerin, waɗanda suka haɗa da ƙananan-nauyin neuropeptides kamar ƙwaƙwalwar ƙwayar cuta ta neurotrophic (BDNF), glial cell-derived neurotrophic factor (GDNF), jijiya girma factor (NGF), da kuma cili factorary (CN neurotrophic factor).
Mechanism na Action na Cerebrolysin
Yin kwaikwayon Ayyukan Abubuwan Neurotrophic: Neuropeptides na kwakwalwa masu aiki a cikin Cerebrolysin na iya shiga cikin shingen jini-kwakwalwa kuma suna kwaikwayon ayyukan abubuwan neurotrophic na halitta. Abubuwan Neurotrophic suna da mahimmanci don rayuwa ta neuronal, girma, bambance-bambance, da filastik synaptic. Factor neurotrophic-wanda aka samu na ƙwaƙwalwa (BDNF) yana taka muhimmiyar rawa wajen kiyaye aikin neuronal na yau da kullun da haɓaka haɓakawar jijiya. Abubuwan da ke kama da su a cikin Cerebrolysin na iya ɗaure masu karɓa masu dacewa a kan farfajiyar neuronal, suna kunna hanyoyin siginar ƙasa kamar hanyoyin siginar PI3K-Akt da MAPK, don haka inganta rayuwar neuronal da haɓaka yayin rage apoptosis na neuronal.
Tsarin tsarin neurotransmitter: Yana iya yin tasiri na tsari akan tsarin neurotransmitter. Neurotransmitters suna taka muhimmiyar rawa wajen watsa sigina tsakanin jijiyoyi, kuma rashin daidaituwarsu yana da alaƙa da cututtuka daban-daban. Cerebrolysin na iya kula da ma'auni na tsarin neurotransmitter ta hanyar daidaitawa da kuma daidaitawar kwayoyin halitta irin su glutamate da gamma-aminobutyric acid (GABA). A lokacin raunin ischemia na cerebral, yawan sakin glutamate zai iya haifar da excitotoxicity, lalata neurons. Cerebrolysin na iya rage lalacewar neuronal da ke haifar da excitotoxicity ta hanyar daidaita masu jigilar glutamate da rage tarin glutamate na waje.
Tasirin damuwa na Antioxidant: Cututtukan jijiyoyi galibi suna tare da haɓaka halayen danniya na oxidative, inda nau'in iskar oxygen da yawa (ROS) ke lalata membranes na sel neuronal, sunadarai, da DNA. Cerebrolysin yana da ƙarfin damuwa na antioxidant, yana rage matakan ROS na cikin salula da kuma rage lalacewar oxidative. A cikin in vitro hypoxia-induced neuronal cytotoxicity model, Cerebrolysin na iya rage superoxide matakan, kula da salon salula aiki na rayuwa, da kuma rage apoptosis. Ƙayyadaddun tsarinsa na iya kasancewa yana da alaƙa da kunna tsarin enzyme antioxidant na ciki, irin su superoxide dismutase (SOD) da glutathione peroxidase (GPx), wanda zai iya lalata ROS kuma ya kare neurons daga lalacewar oxidative.
Hana martani na kumburi: Har ila yau, martanin kumburi yana taka muhimmiyar rawa wajen haɓaka cututtukan jijiyoyin jini. Cerebrolysin na iya rage martanin kumburi ta hanyar hana sakin abubuwan da ke haifar da kumburi da daidaita hanyoyin siginar kumburi. A cikin samfurin raunin ƙwayar cuta na ischemia-reperfusion na kwakwalwa, Cerebrolysin na iya rage maganganun cytokines masu kumburi irin su ciwon daji necrosis factor-α (TNF-α) da interleukin-1β (IL-1β), yayin da ƙara matakan cytokines anti-mai kumburi irin su interleukin-10 (IL-10), ta haka ne ya haifar da lalatawar ƙwayoyin cuta.
Haɓaka filastik jijiyoyi: Ƙwararren ƙwayar cuta yana nufin ikon tsarin juyayi don gyara kansa da sake tsarawa bayan rauni. Cerebrolysin yana haɓaka filastik jijiya ta hanyar haɓaka farfadowar axonal, samuwar kashin baya na dendritic, da sake gina synaptic. Yana iya cimma wannan ta hanyar kunna hanyoyin sigina masu dacewa, kamar hanyar siginar RhoA/ROCK, don daidaita canje-canje a cikin cytoskeleton, ta haka inganta haɓakar axonal da haɓakawa. Cerebrolysin kuma na iya ƙara yawan maganganun sunadaran da ke da alaƙa da synapse, irin su synapsin, don haɓaka haɓakar synapse da dawo da aiki, samar da tushe mai tushe don maido da aikin jijiya.
Tasirin Cerebrolysin
Abubuwan da ke haifar da bugun jini na ischemic: A cikin maganin bugun jini mai tsanani, Cerebrolysin ya nuna wasu sakamako masu kyau. Kodayake gwaje-gwaje na asibiti na farko, wanda da farko ya rubuta marasa lafiya tare da ƙananan bugun jini, da aka nuna alamun bene ko rufi kuma sun kasa nuna bambanci tsakanin ƙungiyoyin jiyya, nazarin rukuni na marasa lafiya da ciwon bugun jini ya nuna tasiri mai kyau akan inganta farfadowa. Amfanin Cerebrolysin yana ƙaruwa tare da tsananin bugun jini. Wasu binciken da aka sarrafa sun nuna cewa Cerebrolysin za a iya haɗe shi da aminci tare da maganin thrombolytic, kuma a cikin marasa lafiya da matsakaicin matsakaicin matsakaici, yana nuna tasiri ba kawai a cikin neuroprotection ba har ma a cikin yiwuwar dawo da neuro. Idan aka kwatanta da neuro-rehabilitation kadai, haɗin Cerebrolysin da neuro-rehabilitation yana haifar da sakamako mai mahimmanci akan farfadowa na aiki.
Tasiri kan zub da jini na subarachnoid: Subarachnoid hemorrhage (SAH) wani yanayi ne mai saurin gaske tare da yawan mace-mace da raguwar farfadowa. A matsayin magani da ake amfani da shi don maganin bugun jini, ciki har da SAH, Cerebrolysin's effects on SAH marasa lafiya sun ja hankali. Wani nazari na yau da kullum da kuma nazarin meta-bincike na amfani da Cerebrolysin a cikin marasa lafiya na SAH ya nuna cewa bayanan sun nuna cewa Cerebrolysin yana da tasiri mai tasiri akan mace-mace a cikin SAH marasa lafiya.
Tasiri akan jaririn hypoxic-ischemic encephalopathy (HIE): HIE tabarbarewar kwakwalwa ne wanda ke haifar da asphyxia na mahaifa, kuma har yanzu ba a fahimci hanyoyin da ake amfani da su ba. Daidaitaccen magani na yanzu shine hypothermia na warkewa, amma ingancinsa yana iyakance. Cerebrolysin, a matsayin maganin neuroprotective, yana nuna yuwuwar gudanar da HIE. Cerebrolysin yana da taga magani har zuwa watanni shida bayan raunin ischemic. Gudanar da nauyin 0.1 ml/kg na Cerebrolysin sau biyu mako-mako na iya inganta ƙarancin aikin motsa jiki da aikin harshe a cikin jarirai, yana yin tasiri mai kyau akan sakamako gaba ɗaya.
Matsayi mai yuwuwa a cikin raunin ƙwaƙwalwa mai rauni: Raunin ƙwaƙwalwa mai rauni (TBI) rauni ne na yau da kullun wanda ke haifar da lalacewar jijiya da mutuwa, yana haifar da kewayon tabarbarewar jijiya. Dangane da kaddarorin neuroprotective da neurotrophic na Cerebrolysin, kuma yana da yuwuwar ƙimar aikace-aikacen maganin TBI. Nazarin gwaji na dabba ya nuna cewa yin amfani da Cerebrolysin na iya rage apoptosis na neuronal bayan TBI kuma ya inganta farfadowa na aikin jijiyoyi. Tsarin aikinsa na iya kasancewa yana da alaƙa da hanyoyi masu yawa, gami da kwaikwayon ayyukan abubuwan abubuwan neurotrophic, daidaita tsarin neurotransmitter, damuwa na antioxidant, da hana martanin kumburi. Ta hanyar waɗannan hanyoyin, yana sauƙaƙe lalacewa ta biyu bayan TBI kuma yana haɓaka gyaran jijiyoyi da sabuntawa.
Abubuwan da za su iya tasiri akan lalata: Dementia cuta ce ta neurodegenerative da ke nuna rashin daidaituwa na ci gaba, tare da pathogenesis da ke tattare da lalacewar neuronal da mutuwa, rashin daidaituwa na neurotransmitter, amsa mai kumburi, da damuwa na oxidative. Hanyoyin aiki da yawa na Cerebrolysin sun sa ya zama wakili na warkewa don ciwon hauka. Yana iya inganta rayuwar neuronal da girma ta hanyar yin kwaikwayon ayyukan abubuwan neurotrophic, ta haka ne ke kare ƙananan ƙwayoyin cuta. Ta hanyar daidaita tsarin neurotransmitter, yana haɓaka rashin daidaituwa na neurotransmitter, kamar haɓaka sakin acetylcholine, don haka haɓaka aikin fahimi. Its antioxidant da anti-mai kumburi effects kuma taimaka rage neuroinflammation da oxidative lalacewa a cikin kwakwalwar marasa lafiya dementia, game da shi jinkirin ci gaban cuta.
Kammalawa
A matsayin magani tare da kaddarorin neuroprotective da neurotrophic, Cerebrolysin ya nuna yuwuwar warkewa a cikin maganin cututtukan ƙwayoyin cuta.
Nassoshi
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Samfura akwai don amfani da bincike kawai:
