Los ntawm Cocer Peptides 
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Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam ntawm Cerebrolysin
Cerebrolysin muaj cov tshuaj tiv thaiv neuroprotective thiab neurotrophic zog. Txij li thaum nws nrhiav pom, nws tau txais kev saib xyuas tseem ceeb hauv kev kho mob paj hlwb. Xyoo 1949, Austrian tus kws tshawb fawb Gerhart Harrer los ntawm University of Innsbruck tau tshaj tawm tias Cerebrolysin, cov kua protein ua los ntawm enzymatic hydrolysis ntawm lub hlwb cov ntaub so ntswg, tuaj yeem tsim cov paj hlwb. Nws yog cov protein-raws li kua sib tov uas muaj 85% dawb amino acids thiab 15% bioactive low-molecular-weight amino acid sequences, uas muaj xws li low-molecular-weight neuropeptides xws li hlwb-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), paj hlwb kev loj hlob (CNF), paj hlwb kev loj hlob (CNF).
Mechanism ntawm Kev Ua ntawm Cerebrolysin
Ua raws li Kev Ua Haujlwm ntawm Neurotrophic Factors: Lub paj hlwb nquag neuropeptides hauv Cerebrolysin tuaj yeem nkag mus rau hauv cov ntshav-hlwb barrier thiab ua raws li kev ua haujlwm ntawm lub cev neurotrophic yam. Neurotrophic yam tseem ceeb yog qhov tseem ceeb rau kev muaj sia nyob, kev loj hlob, kev sib txawv, thiab synaptic plasticity. Brain-derived neurotrophic factor (BDNF) plays lub luag haujlwm tseem ceeb hauv kev tswj hwm kev ua haujlwm ntawm lub paj hlwb thiab txhawb kev tsim kho neural. Cov Cheebtsam zoo sib xws hauv Cerebrolysin tuaj yeem khi rau cov neeg txais kev sib raug zoo ntawm qhov chaw neuronal, ua kom cov kev taw qhia qis qis xws li PI3K-Akt thiab MAPK cov kev taw qhia txoj hauv kev, yog li txhawb kev muaj sia nyob thiab kev loj hlob thaum txo cov neuronal apoptosis.
Kev tswj hwm ntawm cov kab mob neurotransmitter: Nws tuaj yeem ua rau muaj kev tswj hwm ntawm cov kab mob neurotransmitter. Neurotransmitters ua lub luag haujlwm tseem ceeb hauv kev xa cov teeb liab ntawm cov neurons, thiab lawv qhov tsis txaus ntseeg yog cuam tshuam nrog ntau yam kev puas hlwb. Cerebrolysin tuaj yeem tswj hwm qhov sib npaug ntawm cov kab mob neurotransmitter los ntawm kev tswj cov kev tso tawm thiab cov metabolism hauv cov neurotransmitters xws li glutamate thiab gamma-aminobutyric acid (GABA). Thaum raug mob cerebral ischemia, ntau dhau glutamate tso tawm tuaj yeem ua rau excitotoxicity, ua rau cov neurons puas. Cerebrolysin tuaj yeem txo cov excitotoxicity-vim neuronal puas tsuaj los ntawm kev tswj cov glutamate transporters thiab txo cov glutamate tsub zuj zuj ntawm extracellular.
Antioxidant teebmeem kev ntxhov siab: Cov kab mob hauv lub paj hlwb feem ntau nrog kev txhim kho oxidative kev ntxhov siab, qhov twg ntau cov pa oxygen ntau dhau (ROS) ua rau cov cell membranes, proteins, thiab DNA. Cerebrolysin muaj peev xwm tiv thaiv kev ntxhov siab, txo qis ROS qib hauv cov cell thiab txo qis oxidative puas tsuaj. Nyob rau hauv vitro hypoxia-induced neuronal cytotoxicity qauv, Cerebrolysin tuaj yeem txo cov qib superoxide, tswj cellular metabolic kev ua si, thiab txo apoptosis. Nws cov txheej txheem tshwj xeeb yuav cuam tshuam rau kev ua kom cov kab mob hauv cov cellular antioxidant enzyme, xws li superoxide dismutase (SOD) thiab glutathione peroxidase (GPx), uas tuaj yeem tshem tawm ROS thiab tiv thaiv cov neurons los ntawm kev puas tsuaj oxidative.
Inhibition of inflammatory teb: Inflammatory teb kuj ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov kab mob neurological. Cerebrolysin tuaj yeem txo cov lus teb inflammatory los ntawm inhibiting qhov kev tso tawm ntawm cov kab mob inflammatory thiab tswj cov kab mob inflammatory. Nyob rau hauv tus qauv ntawm lub paj hlwb ischemia-reperfusion raug mob, Cerebrolysin tuaj yeem txo qhov kev qhia ntawm pro-inflammatory cytokines xws li qog necrosis factor-α (TNF-α) thiab interleukin-1β (IL-1β), thaum nce qib ntawm cov tshuaj tiv thaiv cytokines xws li interleukin-10 (IL-10), yog li ua kom muaj kev puas tsuaj rau necrosis. muaj nuj nqi.
Txhawb nqa neural plasticity: Neural plasticity yog hais txog lub paj hlwb lub peev xwm kho tus kheej thiab rov tsim kho tom qab raug mob. Cerebrolysin txhim kho neural plasticity los ntawm kev txhawb nqa axonal regeneration, dendritic spine, thiab synaptic reconstruction. Nws tuaj yeem ua tiav qhov no los ntawm kev ua kom muaj kev cuam tshuam txog kev taw qhia, xws li RhoA / ROCK signaling pathway, los tswj cov kev hloov pauv hauv cytoskeleton, yog li txhawb kev loj hlob ntawm axonal thiab txuas ntxiv. Cerebrolysin kuj tseem tuaj yeem ua rau kom muaj kev nthuav qhia ntawm cov proteins uas cuam tshuam nrog synapse, xws li synapsin, los txhawb kev tsim cov synapse thiab kev ua haujlwm zoo, muab lub hauv paus rau kev kho kom zoo ntawm neural muaj nuj nqi.
Cov teebmeem ntawm Cerebrolysin
Cov teebmeem ntawm mob stroke ischemic: Hauv kev kho mob ntawm ischemic stroke, Cerebrolysin tau pom tias muaj qee yam teebmeem zoo. Txawm hais tias kev sim tshuaj thaum ntxov, uas feem ntau tau sau npe rau cov neeg mob uas mob stroke me, nthuav tawm hauv pem teb lossis qab nthab thiab tsis ua kom pom tseeb qhov sib txawv ntawm cov pab pawg kho mob, pawg pab pawg soj ntsuam ntawm cov neeg mob uas mob stroke hnyav dua qhia nws cov txiaj ntsig zoo ntawm kev txhim kho kev rov zoo. Kev ua tau zoo ntawm Cerebrolysin nce nrog qhov mob stroke. Qee cov kev tshawb fawb tswj tau pom tias Cerebrolysin tuaj yeem ua rau muaj kev nyab xeeb nrog kev kho mob thrombolytic, thiab hauv cov neeg mob uas muaj mob hnyav mus rau mob stroke, nws qhia tau hais tias kev ua tau zoo tsis yog hauv kev tiv thaiv kab mob nkaus xwb tab sis kuj muaj peev xwm rov qab los. Piv rau neuro-rehabilitation ib leeg, kev sib xyaw ua ke ntawm Cerebrolysin thiab neuro-rehabilitation yields cuam tshuam ntau dua rau kev ua haujlwm zoo.
Cov teebmeem ntawm subarachnoid hemorrhage: Subarachnoid hemorrhage (SAH) yog ib qho mob ntawm lub paj hlwb nrog kev tuag siab thiab rov ua haujlwm tsis zoo. Raws li cov tshuaj siv rau kev kho mob stroke, suav nrog SAH, Cerebrolysin cov teebmeem ntawm SAH cov neeg mob tau nyiam. Kev tshuaj xyuas thiab kev tshuaj xyuas metabolic ntawm kev siv Cerebrolysin hauv SAH cov neeg mob tau qhia tias cov ntaub ntawv qhia tias Cerebrolysin muaj txiaj ntsig zoo rau kev tuag hauv SAH cov neeg mob.
Cov teebmeem ntawm neonatal hypoxic-ischemic encephalopathy (HIE): HIE yog lub hlwb ua haujlwm tsis zoo los ntawm perinatal asphyxia, thiab nws cov txheej txheem pathophysiological tseem tsis tau nkag siab tag nrho. Txoj kev kho tus qauv tam sim no yog kho hypothermia, tab sis nws cov txiaj ntsig tau txwv. Cerebrolysin, raws li kev kho mob neuroprotective, qhia tau tias muaj peev xwm hauv kev tswj hwm HIE. Cerebrolysin muaj qhov kev kho mob ntev txog rau lub hlis tom qab kev raug mob ischemic. Kev tswj hwm 0.1 ml / kg lub cev qhov hnyav ntawm Cerebrolysin ob zaug ib lub lim tiam tuaj yeem txhim kho tag nrho lub cev muaj zog thiab kev ua haujlwm ntawm cov lus tsis txaus rau cov menyuam mos, ua rau muaj txiaj ntsig zoo rau tag nrho cov txiaj ntsig.
Lub luag haujlwm tseem ceeb hauv kev raug mob lub hlwb: Kev raug mob ntawm lub hlwb (TBI) yog ib qho kev raug mob ntawm lub paj hlwb uas ua rau muaj kev puas hlwb thiab kev tuag, ua rau muaj ntau yam kev puas hlwb. Raws li Cerebrolysin's neuroprotective thiab neurotrophic zog, nws kuj tuav cov peev txheej hauv kev kho TBI. Cov kev tshawb fawb txog tsiaj txhu tau pom tias kev siv Cerebrolysin tuaj yeem txo qis neuronal apoptosis tom qab TBI thiab txhawb kev rov ua haujlwm ntawm cov paj hlwb. Nws cov txheej txheem ntawm kev ua haujlwm tuaj yeem cuam tshuam nrog ntau lub tswv yim, suav nrog kev ua raws li kev ua haujlwm neurotrophic, tswj cov kab mob neurotransmitter, kev ntxhov siab antioxidant, thiab inhibiting inflammatory teb. Los ntawm cov txheej txheem no, nws txo qis kev puas tsuaj tom qab TBI thiab txhawb kev kho neural thiab rov tsim dua tshiab.
Tej yam tshwm sim ntawm dementia: Dementia yog ib tug kab mob neurodegenerative uas tshwm sim los ntawm kev loj hlob ntawm kev txawj ntse, nrog nws cov kab mob cuam tshuam nrog neuronal degeneration thiab tuag, neurotransmitter imbalance, inflammatory teb, thiab oxidative stress. Cerebrolysin ntau lub tswv yim ntawm kev ua haujlwm ua rau nws muaj peev xwm kho tau tus neeg sawv cev rau kev dementia. Nws tuaj yeem txhawb kev muaj sia nyob thiab kev loj hlob ntawm neuronal los ntawm kev ua raws li cov haujlwm ntawm neurotrophic yam, yog li tiv thaiv cov neurons puas. Los ntawm kev tswj cov kab mob neurotransmitter, nws txhim kho neurotransmitter tsis txaus, xws li nce acetylcholine tso tawm, yog li txhim kho kev txawj ntse. Nws cov tshuaj tiv thaiv kab mob antioxidant thiab tiv thaiv kab mob kuj tseem pab txo qis neuroinflammation thiab oxidative puas tsuaj hauv lub hlwb ntawm cov neeg mob dementia, yog li ua rau cov kab mob qeeb zuj zus.
Xaus
Raws li cov tshuaj uas muaj cov tshuaj tiv thaiv neuroprotective thiab neurotrophic, Cerebrolysin tau pom tias muaj peev xwm kho tau hauv kev kho mob paj hlwb.
Cov ntaub ntawv
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[2] Mureșanu DF, Livinț PL, Chira D, et al. Lub luag haujlwm thiab qhov cuam tshuam ntawm Cerebrolysin rau Ischemic Stroke Care [J]. Phau ntawv Journal of Clinical Medicine, 2022,11(5).DOI:10.3390/jcm11051273.
[3] Fiani B, Chacon D, Jarrah R, et al. Neuroprotective tswv yim ntawm cerebrolysin rau kev kho mob ntawm cov me nyuam mos nrog neonatal hypoxic-ischemic encephalopathy [J]. Acta Neurologica Belgica, 2021,121(6):1401-1406.DOI:10.1007/s13760-021-01795-y.
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[6] Ziganshina LE, Abakumova T. Cerebrolysin rau mob ischemic stroke[J]. Cochrane Database of Systematic Reviews, 2015(6):CD7026.DOI:10.1002/14651858.CD007026.pub3.
[7] Hartwig K, Fackler V, Jaksch-Bogensperger H, et al. Cerebrolysin tiv thaiv PC12 hlwb los ntawm CoCl2-induced hypoxia employing GSK3β signaling [J]. International Journal of Developmental Neuroscience, 2014,38:52-58.DOI:10.1016/j.ijdevneu.2014.07.005.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
