Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Cerebrolysin ƒe Nyatakaka Kpuie
Ahɔhɔ̃mekawo takpɔnu kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe ŋutete le cerebrolysin si. Tso esime woke ɖe eŋu la, amewo ƒe susu va le eŋu vevie le ahɔhɔ̃mekawo ƒe dɔlélewo dada me. Le ƒe 1949 me la, Austriatɔ dzɔdzɔmeŋutinunyala Gerhart Harrer si tso Innsbruck Yunivɛsiti ka nya ta be Cerebrolysin, si nye tsi si me protein le si wowɔna to ahɔhɔ̃mekawo ƒe enzymatic hydrolysis me, ate ŋu aʋã lãmekawo. Enye tsi tsakatsaka si wotu ɖe protein dzi si me amino acid siwo me woɖea mɔ le 85% kple amino acid siwo ƒe molecule ƒe kpekpeme mede o ƒe 15% le bioactive, siwo dometɔ aɖewoe nye neuropeptides siwo ƒe molecule ƒe kpekpeme mede o abe ahɔhɔ̃ me ahɔhɔ̃mekawo ƒe dɔwɔwɔ (BDNF), glial lãmenugbagbeviwo ƒe ahɔhɔ̃mekawo ƒe dɔwɔwɔ (GDNF), lãmekawo ƒe tsitsi ƒe nuwɔna (NGF), kple ciliary neurotrophic factor (CNTF).
Mɔnu si dzi Cerebrolysin Wɔna
Ahɔhɔ̃mekawo ƒe Dɔwɔwɔ Srɔ̃: Ahɔhɔ̃ me ahɔhɔ̃meka siwo le dɔ wɔm le Cerebrolysin me ate ŋu age ɖe ʋu kple ahɔhɔ̃ ƒe mɔxenu me eye woasrɔ̃ dzɔdzɔmenu siwo naa ahɔhɔ̃mekawo ƒe dɔwɔwɔ. Ahɔhɔ̃mekawo ƒe dɔwɔwɔ le vevie ŋutɔ na ahɔhɔ̃mekawo ƒe agbetsitsi, tsitsi, vovototodedeameme, kple lãmenugbagbeviwo ƒe ʋuʋu. Ahɔhɔ̃ me ahɔhɔ̃mekawo ƒe dɔwɔwɔ (BDNF) wɔa akpa vevi aɖe le ahɔhɔ̃mekawo ƒe dɔwɔwɔ nyuie me léle ɖe asi kple ahɔhɔ̃mekawo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ me. Nu mawo tɔgbe siwo le Cerebrolysin me ateŋu abla ɖe xɔla siwo sɔ ɖe enu le ahɔhɔ̃mekawo ƒe anyime, awɔ dɔ na dzesimɔ siwo le anyime abe PI3K-Akt kple MAPK dzesimɔwo ene, to esia me doa ahɔhɔ̃mekawo ƒe agbetsitsi kple tsitsi ɖe ŋgɔ esime wòɖea ahɔhɔ̃mekawo ƒe apoptosis dzi kpɔtɔna.
Ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe ɖoɖowɔwɔ: Ate ŋu awɔ ɖoɖowɔwɔ ƒe ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi. Ahɔhɔ̃mekawo wɔa akpa vevi aɖe le dzesiwo ƒe kaka ɖe ahɔhɔ̃mekawo dome me, eye woƒe dadasɔmakpɔmakpɔ do ƒome kple ahɔhɔ̃mekawo ƒe dɔléle vovovowo. Cerebrolysin ate ŋu ana ahɔhɔ̃mekawo ƒe dɔwɔwɔ nada asɔ to ahɔhɔ̃mekawo abe glutamate kple gamma-aminobutyric acid (GABA) ƒe dodo kple woƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi kpɔkpɔ me. Le ahɔhɔ̃mekawo ƒe ʋu ƒe sisi ƒe abixɔxɔ me la, glutamate ƒe dodo fũ ate ŋu ana excitotoxicity, si agblẽ nu le ahɔhɔ̃mekawo ŋu. Cerebrolysin ate ŋu aɖe ahɔhɔ̃mekawo ƒe gbegblẽ si excitotoxicity hena vɛ dzi akpɔtɔ to glutamate tsɔtsɔ yi teƒe bubuwo dzi kpɔkpɔ kple glutamate ƒe ƒoƒo ɖe lãmenugbagbeviwo godo dzi ɖeɖe kpɔtɔ me.
Antioxidant stress effects: Zi geɖe la, oxidative stress reactions si doa ŋusẽ ahɔhɔ̃mekawo ƒe dɔlélewo kpena ɖe eŋu, afisi oxygen ƒomevi siwo wɔa dɔ fũ akpa (ROS) gblẽa nu le ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe lãkusiwo, proteinwo, kple DNA ŋu. Nuteɖeamedzi ƒe ŋutete le cerebrolysin si, si ɖea ROS ƒe agbɔsɔsɔ si le lãmenugbagbeviwo me dzi kpɔtɔna eye wòɖea oxidative ƒe nugbegblẽ dzi kpɔtɔna. Le ahɔhɔ̃mekawo ƒe aɖiwuame ƒe kpɔɖeŋu si wowɔ le vitro me la, Cerebrolysin ate ŋu aɖe superoxide ƒe agbɔsɔsɔ dzi akpɔtɔ, alé lãmenugbagbeviwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖe te, eye wòaɖe apoptosis dzi akpɔtɔ. Eƒe mɔnu tɔxɛ ate ŋu atso lãmenugbagbeviwo me antioxidant enzyme systems, abe superoxide dismutase (SOD) kple glutathione peroxidase (GPx) ene, siwo ate ŋu axɔ ROS eye woakpɔ ahɔhɔ̃mekawo ta tso oxidative ƒe nugbegblẽ me ƒe dɔwɔwɔ gbɔ.
Mɔxexe ɖe dɔdzẽ ƒe ŋuɖoɖowo nu: Dzoxɔxɔ ƒe ŋuɖoɖowo hã wɔa akpa vevi aɖe le ahɔhɔ̃mekawo ƒe dɔlélewo ƒe dzɔdzɔ me. Cerebrolysin ate ŋu aɖe dɔdzẽ ƒe ŋuɖoɖowo dzi akpɔtɔ to dɔlékuiwutikewo ƒe dodo kple dɔdzẽ ƒe dzesimɔwo dzi kpɔkpɔ me. Le ahɔhɔ̃mekawo ƒe ischemia-reperfusion injury model me la, Cerebrolysin ate ŋu aɖe pro-inflammatory cytokines abe tumor necrosis factor-α (TNF-α) kple interleukin-1β (IL-1β) ƒe ɖeɖefia dzi akpɔtɔ, esime wòadzi anti-inflammatory cytokines abe interleukin-10 (IL-10) ƒe agbɔsɔsɔ ɖe edzi, to esia me aɖe dɔdzẽ ƒe nugbegblẽ le ahɔhɔ̃mekawo ŋu dzi akpɔtɔ eye si doa ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe hayahaya ɖe ŋgɔ.
Ahɔhɔ̃mekawo ƒe ʋuʋu dodo ɖe ŋgɔ: Ahɔhɔ̃mekawo ƒe ʋuʋu fia ŋutete si le ahɔhɔ̃mekawo ŋu be wòadzra eɖokui ɖo ahagbugbɔ awɔ ɖoɖo ɖe eŋu le abixɔxɔ vɔ megbe. Cerebrolysin doa ŋusẽ ahɔhɔ̃mekawo ƒe plasticity to axonal gbugbɔgadzɔ, dendritic spine formation, kple synaptic reconstruction dodo ɖe ŋgɔ me. Ate ŋu awɔ esia to dzesimɔ siwo sɔ, abe RhoA/ROCK dzesimɔ ene, ƒe dɔwɔwɔ me be wòaɖɔ tɔtrɔ siwo vaa lãmenugbagbeviwo ƒe ƒunukpeƒewo ɖo, si ana axonal ƒe tsitsi kple kekeɖenudɔwɔwɔ nado. Cerebrolysin ate ŋu ana protein siwo do ƒome kple synapse, abe synapsin ene, ƒe ɖeɖefia hã nadzi ɖe edzi be wòado synapse ƒe wɔwɔ kple dɔwɔwɔ ƒe hayahaya ɖe ŋgɔ, si ana xɔtuɖoɖo ƒe gɔmeɖoanyi na ahɔhɔ̃mekawo ƒe dɔwɔwɔ gbugbɔgaɖoanyi.
Cerebrolysin ƒe Ŋusẽkpɔɖeamedzi
Ŋusẽkpɔɖeamedzi ɖe ʋusɔgbɔdɔ sesẽ dzi: Le ʋusɔgbɔdɔ sesẽ dada me la, Cerebrolysin ɖe ŋusẽkpɔɖeamedzi nyui aɖewo fia. Togbɔ be dɔdamɔnu dodokpɔ gbãtɔ siwo me wotsɔ dɔnɔ siwo ŋu ʋusɔgbɔdɔ fafɛ le koŋ ŋlɔ ŋkɔ ɖe anyigba alo dzisasrã dzi ƒe ŋusẽkpɔɖeamedziwo fia eye womete ŋu ɖe vovototo gã aɖe fia kɔte le atikewɔhawo dome o hã la, ƒuƒoƒo suewo me dzodzro le dɔnɔ siwo ŋu ʋusɔgbɔdɔ sesẽ wu ŋu ɖe eƒe ŋusẽkpɔɖeamedzi nyui ɖedzesi siwo wòkpɔ ɖe hayahaya dzi ɖeɖe kpɔtɔ dzi fia. Cerebrolysin ƒe dɔwɔwɔ dzina ɖe edzi ne ʋusɔgbɔdɔa nu sẽ. Numekuku aɖewo siwo ŋu wokpɔ ŋusẽ ɖo ɖee fia be woate ŋu atsɔ Cerebrolysin akpe ɖe ʋuka me ʋu ƒe sisi ƒe atikewɔwɔ ŋu dedie, eye le dɔnɔ siwo ŋu ʋusɔgbɔdɔ le titina va ɖo esi nu sẽ gome la, eɖea dɔwɔwɔ fiana menye le ahɔhɔ̃mekawo takpɔkpɔ ɖeɖeko me o, ke le ahɔhɔ̃mekawo ƒe hayahaya ƒe ŋutete hã me. Ne wotsɔe sɔ kple ahɔhɔ̃mekawo ƒe ɖɔɖɔɖo ɖeɖeko la, Cerebrolysin kple ahɔhɔ̃mekawo ƒe gbugbɔgaɖɔɖo ƒe ƒuƒoƒo kpɔa ŋusẽ ɖe dɔwɔwɔ ƒe hayahaya dzi vevie wu.
Dɔ si wòkpɔna ɖe ʋu si dona le lãkusi te dzi: Ʋu si dona le lãkusi te (SAH) nye ahɔhɔ̃mekawo ƒe dɔléle sesẽ aɖe si me ame geɖe kuna le eye womete ŋu hayana o. Abe atike si wozãna tsɔ daa ʋusɔgbɔdɔ, si me SAH hã le ene la, Cerebrolysin ƒe ŋusẽkpɔɖeamedzi ɖe SAH dɔnɔwo dzi he amewo ƒe susu. Toto ɖe ɖoɖo nu kple meta-kuxiwo me dzodzro le Cerebrolysin zazã le SAH dɔnɔwo me ɖee fia be nyatakakaawo ɖee fia be Cerebrolysin kpɔa ŋusẽ nyui ɖe ku dzi le SAH dɔnɔwo me.
Ŋusẽ si wòkpɔna ɖe vidzĩwo ƒe tagbɔdɔléle si me ya mesɔ gbɔ ɖo o (HIE) dzi: HIE nye ahɔhɔ̃ ƒe dɔmawɔmawɔ nyuie si tsoa vidzidzi ƒe gbɔgbɔtsixetsixe gbɔ, eye womese eƒe dɔlélenutsiŋutete ƒe mɔnuwo gɔme bliboe haɖe o. Atikewɔwɔ si wozãna fifiae nye dzoxɔxɔ si nu sẽ si wozãna tsɔ daa dɔe, gake eƒe dɔwɔwɔ mede ŋgɔ boo o. Cerebrolysin, abe ahɔhɔ̃mekawo takpɔnu ene, ɖe ŋutete fia le HIE dzi kpɔkpɔ me. Cerebrolysin ƒe atikewɔwɔ ƒe fesre si ade ɣleti ade le abi si wòxɔ le ʋumenugbagbeviɣidɔ megbe. Cerebrolysin 0.1 ml/kg ƒe kpekpeme nana zi eve kwasiɖa sia kwasiɖa ate ŋu ana vidzĩwo ƒe lãmekawo kple gbegbɔgblɔ ƒe dɔwɔwɔ ƒe gbɔdzɔgbɔdzɔ gã nanyo ɖe edzi, si akpɔ ŋusẽ nyui ɖe emetsonuwo katã dzi.
Akpa si wòate ŋu awɔ le ahɔhɔ̃mekawo ƒe abixɔxɔ si me nuveviwɔame le me: Ahɔhɔ̃mekawo ƒe abixɔxɔ (TBI) nye ahɔhɔ̃mekawo ƒe abixɔxɔ si bɔ si hea ahɔhɔ̃mekawo ƒe gbegblẽ eye wòkuna, si hea ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie vovovowo vɛ. Wonɔ te ɖe Cerebrolysin ƒe ahɔhɔ̃mekawo takpɔnu kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi, eye asixɔxɔ si woate ŋu azã le TBI dada me hã le esi. Lãwo ƒe dodokpɔ me numekukuwo ɖee fia be Cerebrolysin zazã ate ŋu aɖe ahɔhɔ̃mekawo ƒe tsɔtsrɔ̃ dzi akpɔtɔ le TBI megbe eye wòado ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe hayahaya ɖe ŋgɔ. Eƒe dɔwɔwɔ ƒe mɔnu ate ŋu ado ƒome kple mɔnu vovovowo, siwo dometɔ aɖewoe nye ahɔhɔ̃mekawo ƒe dɔwɔwɔ sɔsrɔ̃, ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe ɖoɖowo dzi kpɔkpɔ, antioxidant ƒe nuteɖeamedzi, kple dɔdzẽ ƒe ŋuɖoɖowo nu tsitsi. To mɔnu siawo dzi la, eɖea nu evelia siwo gblẽna le TBI megbe dzi kpɔtɔna eye wòdoa ahɔhɔ̃mekawo ƒe ɖɔɖɔɖo kple wo gbugbɔgadzɔ ɖe ŋgɔ.
Dɔ si wòate ŋu akpɔ ɖe tagbɔdɔléle dzi: Tagbɔdɔléle nye ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie si ƒe dzesi enye be eƒe susu mewɔa dɔ nyuie o vivivi, eye eƒe dɔléle dzɔdzɔ lɔ ahɔhɔ̃mekawo ƒe gbegblẽ kple ku, ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, dɔdzẽ ƒe ŋuɖoɖo, kple oxidative stress ɖe eme. Mɔnu vovovo siwo dzi ahɔhɔ̃mekawo wɔa dɔ le la na wònye atike si ate ŋu ada tagbɔdɔléle. Ate ŋu ado ahɔhɔ̃mekawo ƒe agbetsitsi kple tsitsi ɖe ŋgɔ to ahɔhɔ̃mekawo ƒe dɔwɔwɔ sɔsrɔ̃ me, si ana wòakpɔ ahɔhɔ̃meka siwo gblẽ ta. To ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ me la, enaa ahɔhɔ̃mekawo ƒe dadasɔ masɔmasɔ, abe acetylcholine ƒe dodo dzina ɖe edzi ene, nyona ɖe edzi, si wɔnɛ be susu ƒe dɔwɔwɔ nyona ɖe edzi. Eƒe antioxidant kple anti-inflammatory ŋusẽkpɔɖeamedziwo hã kpena ɖe ahɔhɔ̃mekawo ƒe dɔdzẽ kple oxidative ƒe nugbegblẽ le ahɔhɔ̃ me le tagbɔdɔlélawo ƒe ahɔhɔ̃ me dzi kpɔtɔna, si wɔnɛ be dɔlélea ƒe ŋgɔyiyi dzi ɖena kpɔtɔna.
Nyanuwuwuw
Abe atike si kpɔa ahɔhɔ̃mekawo ta kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ ta ene la, Cerebrolysin ɖe atikewɔwɔ ƒe ŋutete fia le ahɔhɔ̃mekawo ƒe dɔlélewo dada me.
Nusiwo ŋu woke ɖo
[1] Kojder K, Jarosz K, Bosiacki M, kple ame bubuwo. Cerebrolysin le Dɔnɔ siwo ŋu Subarachnoid Hemorrhage le me: Totoɖeme si Wowɔ Ðe Ðoɖo Nu Kple Meta-Analysis[J]. Atikewɔwɔ ƒe Agbalẽ, 2023,12. https://api.semanticscholar.org/CorpusID: 264397999 ƒe ɣleti gbãtɔ me
[2] Mureșanu D. F., Livinț P. L., Chira D., kple ame bubuwo. Akpa si Cerebrolysin Wɔna Kple Ŋusẽkpɔɖeamedzi Na Ischemic Stroke Care[J]. Atikewɔwɔ ƒe Agbalẽ, 2022,11 (5).DOI: 10.3390 / jcm11051273.
[3] Fiani B, Chacon D, Jarrah R, kple ame bubuwo. Cerebrolysin ƒe ahɔhɔ̃mekawo takpɔmɔnu siwo wozãna tsɔ daa vidzĩ siwo ŋu neonatal hypoxic-ischemic encephalopathy le[J]. Acta ahɔhɔ̃ŋutinunya Belgica, 2021, 121 (6): 1401-1406.DOI: 10.1007 / s13760-021-01795-ƒe.
[4] Al-Mosawi A J. Cerebrolysin zazã le dɔdaƒewo le Ðeviwo ƒe Ahɔhɔ̃mekawo ƒe Tagbɔdɔléle me[J]. Dzɔdzɔmeŋutinunya Xexeame ƒe Atikeŋutinunya ƒe Agbalẽ, 2020. https://api.semanticscholar.org/CorpusID:235912686
[5] Brainin M. Cerebrolysin: atike si ŋu taɖodzinu geɖe le hena hayahaya le ʋusɔgbɔdɔ megbe[J]. Eŋutinunyala ƒe ŋkuléle ɖe ahɔhɔ̃mekawo ƒe atikewɔwɔ ŋu, 2018,18 (8): 681-687.DOI: 10.1080/14737175.2018.1500459.
[6] Ziganshina LE, Abakumova T. Cerebrolysin na ʋusɔgbɔdɔ sesẽ si me ʋu sina tona [J]. Cochrane Nyatakakadzraɖoƒe si ku ɖe ɖoɖowɔɖi me totowo ŋu, 2015 (6): CD7026.DOI: 10.1002/14651858.CD007026.pub3.
[7] Hartwig K, Fackler V, Jaksch-Bogensperger H, kple ame bubuwo. Cerebrolysin kpɔa PC12 lãmenugbagbeviwo ta tso CoCl2-si hea hypoxia vɛ me to GSK3β dzesiwo zazã me[J]. Dukɔwo Dome Nyadzɔdzɔgbalẽ si Ku Ðe Ŋgɔyiyi ƒe Ahɔhɔ̃ŋutinunya Ŋu, 2014,38:52-58.DOI:10.1016/j.ijdevneu.2014.07.005.
Adzɔnu si li na numekuku zazã ɖeɖeko:
