Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa bitangwa kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake ya Cerebrolysin
Cerebrolysin ifite neuroprotective na neurotrophique. Kuva yavumburwa, imaze kwitabwaho cyane mubijyanye no kuvura indwara zifata ubwonko. Mu 1949, umuhanga wo muri Otirishiya Gerhart Harrer wo muri kaminuza ya Innsbruck yatangaje ko Cerebrolysin, amazi ashingiye kuri poroteyine yakozwe na hydrolysis ya enzymatique yo mu bwonko, ashobora gutera ingirabuzimafatizo. Nibintu bivangwa na poroteyine bivanze na aside irike ya 85% yubusa hamwe na 15% bioaktike nkeya-ifite uburemere buke bwa aminide aside amine, irimo na neuropeptide ifite uburemere buke nka neurotrophique ikomoka mu bwonko (BDNF), ingirabuzimafatizo zikomoka kuri neurotrophique (GDNF), ibintu bikura mu mitsi (NGF), na ciliary neurotrophique.
Uburyo bwibikorwa bya Cerebrolysin
Kwigana imikorere yibintu bya Neurotrophique: Ubwonko bukora ubwonko bwa neuropeptide muri Cerebrolysin burashobora kwinjira mu nzitizi yubwonko bwamaraso no kwigana imikorere yibintu bisanzwe bya neurotrophique. Ibintu bya Neurotrophique nibyingenzi mubuzima bwa neuronal, gukura, gutandukana, hamwe na plastike ya synaptic. Ubwonko bukomoka mu bwonko (BDNF) bugira uruhare runini mugukomeza imikorere isanzwe ya neuronal no guteza imbere imitekerereze mishya. Ibice bisa muri Cerebrolysin birashobora guhuza ibyakiriwe neza hejuru yubutaka bwa neuronal, bigakora inzira yerekana ibimenyetso byerekana inzira nka PI3K-Akt na MAPK byerekana inzira, bityo bigatuma ubuzima bwa neuronal bukura no gukura mugihe bigabanya apoptose ya neuronal.
Amabwiriza ya sisitemu ya neurotransmitter: Irashobora kugira ingaruka zubuyobozi kuri sisitemu ya neurotransmitter. Neurotransmitters igira uruhare runini mugukwirakwiza ibimenyetso hagati ya neuron, kandi ubusumbane bwabyo bufitanye isano nindwara zitandukanye zifata ubwonko. Cerebrolysin irashobora kugumana uburinganire bwa sisitemu ya neurotransmitter igenga irekurwa na metabolism ya neurotransmitter nka glutamate na acide gamma-aminobutyric (GABA). Mugihe cyo gukomeretsa ubwonko bwubwonko, kurekura glutamate birenze bishobora gutera excitotoxicity, byangiza neuron. Cerebrolysin irashobora kugabanya kwangirika kwatewe na neuronal kwangirika kwabatwara glutamate no kugabanya kwirundanya kwa glutamate.
Ingaruka ziterwa na antioxydeant: Indwara zifata ubwonko zikunze guherekezwa no kongera imbaraga za okiside itera imbaraga, aho ubwoko bwa ogisijeni bukabije (ROS) bwangiza imitsi ya selile, proteyine, na ADN. Cerebrolysin ifite ubushobozi bwo guhangayika antioxydeant, kugabanya urwego ROS rudasanzwe ndetse no kugabanya kwangiza okiside. Muri vitro hypoxia iterwa na neuronal cytotoxicity, Cerebrolysin irashobora kugabanya urugero rwa superoxide, gukomeza ibikorwa bya metabolike selile, no kugabanya apoptose. Uburyo bwihariye bushobora kuba bufitanye isano no gukora sisitemu yo mu bwoko bwa antioxydants ya antioxydeant, nka superoxide dismutase (SOD) na glutathione peroxidase (GPx), ishobora gusiba ROS no kurinda neurone kwangirika kwa okiside.
Kubuza ibisubizo byumuriro: Ibisubizo byumuriro nabyo bigira uruhare runini mugutezimbere indwara zifata ubwonko. Cerebrolysin irashobora koroshya ibisubizo byokubuza kurekura ibintu bitera umuriro no kugenzura inzira zerekana ibimenyetso. Mu buryo bwo gukomeretsa ubwonko bwitwa cerebral ischemia-reperfusion, Cerebrolysin irashobora kugabanya imvugo ya cytokine itera inflammatory nka tumor necrosis factor-α (TNF-α) na interleukin-1β (IL-1β), mugihe byongera urwego rwa cytokine zirwanya inflammatory nka interleukin-10 (IL-10), bityo bikagabanya kwangirika kwa neurone no kwanduza indwara.
Guteza imbere ubwonko bwa plastike: Plastike ya neural bivuga ubushobozi bwa sisitemu yubushobozi bwo kwikosora no gutunganya nyuma yimvune. Cerebrolysin yongerera imbaraga plastike iteza imbere kuvugurura imitsi, gukora urutirigongo rwa dendritic, no kwiyubaka kwa synaptic. Irashobora kubigeraho mugukoresha inzira zerekana ibimenyetso, nka RhoA / ROCK yerekana inzira, kugirango ihindure impinduka muri cytoskeleton, bityo biteze imbere gukura no kwaguka. Cerebrolysin irashobora kandi kongera imvugo ya proteine zijyanye na synaps, nka synapsin, kugirango iteze imbere synaps no gukira kwimikorere, itanga umusingi wuburyo bwo kugarura imikorere yimitsi.
Ingaruka za Cerebrolysin
Ingaruka kuri stroke ischemic stroke: Mu kuvura inkorora ikaze, Cerebrolysin yerekanye ingaruka nziza. Nubwo ibizamini byo kwa muganga hakiri kare byandikiraga abarwayi bafite ubwonko bworoheje, byagaragaje hasi cyangwa igisenge kandi ntibigaragaze neza itandukaniro rinini hagati yitsinda rivura, isesengura ryitsinda ry’abarwayi bafite ibibazo by’indwara zikomeye ryagaragaje ingaruka nziza zaryo mu kuzamura ubuzima. Imikorere ya Cerebrolysin yiyongera hamwe nuburemere bwubwonko. Ubushakashatsi bumwe na bumwe bwagenzuwe bwerekanye ko Cerebrolysin ishobora guhuzwa neza n’ubuvuzi bwa trombolique, kandi ku barwayi bafite ubwonko bukabije kandi bukabije, bugaragaza imikorere atari muri neuroprotection gusa ahubwo no mu bushobozi bwo gukira neuro. Ugereranije na neuro-rehabilitation yonyine, guhuza Cerebrolysin na neuro-reabilité bitanga ingaruka zikomeye kumikorere.
Ingaruka ku maraso ya subarachnoid: Amaraso ya Subarachnoid (SAH) ni indwara ikaze y’imyakura n’impfu nyinshi kandi ikananirwa gukira. Nkumuti ukoreshwa mu kuvura indwara yubwonko, harimo SAH, ingaruka za Cerebrolysin ku barwayi ba SAH zashimishije abantu. Isuzuma rifatika hamwe na meta-isesengura ry’imikoreshereze ya Cerebrolysin mu barwayi ba SAH byagaragaje ko amakuru yerekana ko Cerebrolysin igira ingaruka nziza ku rupfu rw’abarwayi ba SAH.
Ingaruka kuri neonatal hypoxic-ischemic encephalopathie (HIE): HIE ni imikorere mibi yubwonko iterwa na aspinxia perinatal, kandi uburyo bwayo bwa patrophysiologique ntiburasobanuka neza. Ubu buryo busanzwe bwo kuvura ni hypothermia ivura, ariko imikorere yayo ni mike. Cerebrolysin, nk'ubuvuzi bwa neuroprotective, bwerekana ubushobozi mu micungire ya HIE. Cerebrolysin ifite idirishya ryo kuvura amezi agera kuri atandatu nyuma yimvune. Gutanga 0.1 ml / kg uburemere bwumubiri wa Cerebrolysin kabiri mucyumweru birashobora kunoza imikorere mibi yimodoka nindimi ku mpinja, bikagira ingaruka nziza mubisubizo rusange.
Uruhare rushoboka mu gukomeretsa ubwonko: Gukomeretsa ubwonko (TBI) ni igikomere gisanzwe gitera ubwonko ndetse n’urupfu, biganisha ku mikorere mibi y’imitsi. Bishingiye ku miterere ya neuroprotective na neurotrophique ya Cerebrolysin, ifite kandi agaciro gashoboka mu kuvura TBI. Ubushakashatsi bwakozwe ku nyamaswa bwerekanye ko gukoresha Cerebrolysin bishobora kugabanya apoptose ya neuronal nyuma ya TBI kandi bigateza imbere imikorere yimitsi. Uburyo bwibikorwa byabwo bushobora kuba bufitanye isano nuburyo bwinshi, harimo kwigana imikorere yibintu bya neurotrophique, kugenzura sisitemu ya neurotransmitter, guhangayika antioxydeant, no kubuza ibisubizo byumuriro. Binyuze muri ubwo buryo, bugabanya ibyangiritse nyuma ya TBI kandi biteza imbere gusana no kuvugurura imitsi.
Ingaruka zishobora gutera indwara yo guta umutwe: Indwara yo guta umutwe ni indwara ya neurodegenerative irangwa no kutagira ubwenge bugenda bwiyongera, hamwe na virusi itera indwara yo kwangirika no gupfa, imitekerereze idahwitse ya neurotransmitter, ibisubizo bitera umuriro, hamwe na stress ya okiside. Uburyo bwa Cerebrolysin uburyo bwinshi bwibikorwa butuma bushobora kuvura indwara yo guta umutwe. Irashobora guteza imbere kubaho kwa neuronal no gukura yigana imikorere yibintu bya neurotrophique, bityo ikarinda neuron yangiritse. Mugutunganya sisitemu ya neurotransmitter, itezimbere ubusumbane bwa neurotransmitter, nko kongera irekurwa rya acetyloline, bityo bikazamura imikorere yubwenge. Ingaruka za antioxydeant na anti-inflammatory nazo zifasha kugabanya neuroinflammation no kwangiza okiside mu bwonko bw’abarwayi ba démée, bityo bikadindiza iterambere.
Umwanzuro
Nkumuti ufite imiterere ya neuroprotective na neurotrophique, Cerebrolysin yerekanye ubushobozi bwo kuvura mukuvura indwara zifata ubwonko.
Reba
[1] Kojder K, Jarosz K, Bosiacki M, n'abandi. Cerebrolysin mu barwayi bafite Amaraso ya Subarachnoid: Isubiramo rifatika hamwe na Meta-Isesengura [J]. Ikinyamakuru c'Ubuvuzi bwa Clinical, 2023,12. https://api.semanticscholar.org/CorpusID:264397999
[2] Mureșanu DF, Livinț PL, Chira D, n'abandi. Uruhare n'ingaruka za Cerebrolysin yo Kwita ku Ischemic Stroke [J]. Ikinyamakuru cyubuvuzi bwa Clinical, 2022,11 (5) .DOI: 10.3390 / jcm11051273.
[3] Fiani B, Chacon D, Jarrah R, n'abandi. Ingamba za Neuroprotective ya cerebrolysin yo kuvura impinja zifite hypoxic-ischemic encephalopathie [J]. Acta Neurologica Belgica, 2021,121 (6): 1401-1406.DOI: 10.1007 / s13760-021-01795-y.
[4] Al-Mosawi A J. Gukoresha ivuriro rya Cerebrolysin muri Neuropsychiatrie y'abana [J]. Ubumenyi Ikinyamakuru cyisi yubumenyi bwa farumasi, 2020. Https://api.semanticscholar.org/CorpusID:235912686
[5] Ubwonko M. Cerebrolysin: imiti igamije gukira nyuma yubwonko [J]. Impuguke zisubiramo Neurotherapeutics, 2018,18 (8): 681-687.DOI: 10.1080 / 14737175.2018.1500459.
[6] Ziganshina LE, Abakumova T. Cerebrolysin kubera inkorora ikaze [J]. Cochrane Ububiko bwibisobanuro bya sisitemu, 2015 (6): CD7026.DOI: 10.1002 / 14651858.CD007026.pub3.
[7] Hartwig K, Fackler V, Jaksch-Bogensperger H, n'abandi. Cerebrolysin irinda selile PC12 kwirinda hypoxia iterwa na CoCl2 ikoresha GSK3β yerekana [J]. Ikinyamakuru mpuzamahanga cyo guteza imbere Neuroscience, 2014,38: 52-58.DOI: 10.1016 / j.ijdevneu 2014.07.005.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
